JP2024503895A5 - - Google Patents

Info

Publication number
JP2024503895A5
JP2024503895A5 JP2023544056A JP2023544056A JP2024503895A5 JP 2024503895 A5 JP2024503895 A5 JP 2024503895A5 JP 2023544056 A JP2023544056 A JP 2023544056A JP 2023544056 A JP2023544056 A JP 2023544056A JP 2024503895 A5 JP2024503895 A5 JP 2024503895A5
Authority
JP
Japan
Prior art keywords
aav
cells
culture
cell culture
reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023544056A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024503895A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/013250 external-priority patent/WO2022159662A1/en
Publication of JP2024503895A publication Critical patent/JP2024503895A/ja
Publication of JP2024503895A5 publication Critical patent/JP2024503895A5/ja
Pending legal-status Critical Current

Links

JP2023544056A 2021-01-21 2022-01-21 組換えポリペプチド及びウイルスの生成の改善 Pending JP2024503895A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163139992P 2021-01-21 2021-01-21
US63/139,992 2021-01-21
PCT/US2022/013250 WO2022159662A1 (en) 2021-01-21 2022-01-21 Improved production of recombinant polypeptides and viruses

Publications (2)

Publication Number Publication Date
JP2024503895A JP2024503895A (ja) 2024-01-29
JP2024503895A5 true JP2024503895A5 (https=) 2025-01-28

Family

ID=80623979

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023544056A Pending JP2024503895A (ja) 2021-01-21 2022-01-21 組換えポリペプチド及びウイルスの生成の改善

Country Status (10)

Country Link
US (1) US20240084329A1 (https=)
EP (1) EP4281568A1 (https=)
JP (1) JP2024503895A (https=)
KR (1) KR20230133314A (https=)
CN (1) CN116848255A (https=)
AU (1) AU2022210592A1 (https=)
CA (1) CA3205209A1 (https=)
IL (1) IL304204A (https=)
MX (1) MX2023008595A (https=)
WO (1) WO2022159662A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115109801B (zh) * 2022-08-25 2022-11-22 深圳市先康达生命科学有限公司 一种慢病毒转染助转剂及其应用
CN118286809B (zh) * 2024-04-02 2024-12-17 首都医科大学 一种可降解的嵌段共聚物及其在大气颗粒物污染防控中的应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4098372B2 (ja) * 1993-07-28 2008-06-11 三菱化学株式会社 ヘパリン結合性増殖因子の生産方法
US6989264B2 (en) 1997-09-05 2006-01-24 Targeted Genetics Corporation Methods for generating high titer helper-free preparations of released recombinant AAV vectors
CA2379166C (en) 1999-08-09 2013-03-26 Targeted Genetics Corporation Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms instrastrand base pairs
US6723551B2 (en) 2001-11-09 2004-04-20 The United States Of America As Represented By The Department Of Health And Human Services Production of adeno-associated virus in insect cells
MX359371B (es) 2001-11-13 2018-09-25 Univ Pennsylvania Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo.
PT1453547T (pt) 2001-12-17 2016-12-28 Univ Pennsylvania Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas
EP2345731B1 (en) 2003-09-30 2015-10-21 The Trustees of the University of Pennsylvania Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof
US7183969B2 (en) 2004-12-22 2007-02-27 Raytheon Company System and technique for calibrating radar arrays
ES2525067T3 (es) 2005-04-07 2014-12-17 The Trustees Of The University Of Pennsylvania Método de incremento de la función de un vector de AAV
JP4495210B2 (ja) 2005-06-09 2010-06-30 パナソニック株式会社 振幅誤差補償装置及び直交度誤差補償装置
ES2751999T3 (es) 2008-01-29 2020-04-02 Applied Genetic Tech Corporation Producción recombinante de virus adeno-asociados usando células BHK en suspensión
JP2011512156A (ja) 2008-02-19 2011-04-21 アムステルダム モレキュラー セラピューティクス ビー.ブイ. 昆虫細胞におけるパルボウイルスrep及びcapタンパク質の発現の最適化
EP2425000B1 (en) 2009-04-30 2019-02-20 The Trustees Of The University Of Pennsylvania Compositions for targeting conducting airway cells comprising adeno-associated virus constructs
US8609392B2 (en) 2009-05-12 2013-12-17 Transgene S.A. Method for orthopoxvirus production and purification
US8734809B2 (en) 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
US8628966B2 (en) 2010-04-30 2014-01-14 City Of Hope CD34-derived recombinant adeno-associated vectors for stem cell transduction and systemic therapeutic gene transfer
US8927514B2 (en) 2010-04-30 2015-01-06 City Of Hope Recombinant adeno-associated vectors for targeted treatment
WO2012057363A1 (ja) 2010-10-27 2012-05-03 学校法人自治医科大学 神経系細胞への遺伝子導入のためのアデノ随伴ウイルスビリオン
WO2012109570A1 (en) 2011-02-10 2012-08-16 The University Of North Carolina At Chapel Hill Viral vectors with modified transduction profiles and methods of making and using the same
CN105755044A (zh) 2011-04-22 2016-07-13 加利福尼亚大学董事会 具有变异衣壳的腺相关病毒病毒体及其使用方法
ES2857773T5 (es) 2011-08-24 2024-06-04 Univ Leland Stanford Junior Nuevas proteínas de la cápside de AAV para la transferencia de ácidos nucleicos
KR102102239B1 (ko) * 2012-01-09 2020-04-21 에이디씨 테라퓨틱스 에스에이 유방암을 치료하기 위한 방법
WO2013170078A1 (en) 2012-05-09 2013-11-14 Oregon Health & Science University Adeno associated virus plasmids and vectors
CA2905952A1 (en) 2013-03-13 2014-10-02 The Children's Hospital Of Philadelphia Adeno-associated virus vectors and methods of use thereof
MX388221B (es) 2013-04-20 2025-03-19 Res Institute At Nationwide Children´S Hospital ADMINISTRACIÓN DE VIRUS ADENO-ASOCIADO RECOMBINANTE DE CONSTRUCCIONES DE POLINUCLÉOTIDOS U7snRNA DIRIGIDA AL EXÓN 2.
IL297919A (en) 2013-07-22 2023-01-01 Childrens Hospital Philadelphia Variant aav and compositions, methods and uses for gene transfer to cells, organs and tissues
ES2739288T3 (es) 2013-09-13 2020-01-30 California Inst Of Techn Recuperación selectiva
CN106232618A (zh) 2013-10-11 2016-12-14 马萨诸塞眼科耳科诊所 预测祖先病毒序列的方法及其用途
WO2015164757A1 (en) 2014-04-25 2015-10-29 Oregon Health & Science University Methods of viral neutralizing antibody epitope mapping
EP3151866B1 (en) 2014-06-09 2023-03-08 Voyager Therapeutics, Inc. Chimeric capsids
AU2015320694B2 (en) 2014-09-24 2021-11-11 City Of Hope Adeno-associated virus vector variants for high efficiency genome editing and methods thereof
JP6665466B2 (ja) 2015-09-26 2020-03-13 日亜化学工業株式会社 半導体発光素子及びその製造方法
WO2017070491A1 (en) 2015-10-23 2017-04-27 Applied Genetic Technologies Corporation Ophthalmic formulations
CA3098565A1 (en) 2018-04-29 2019-11-07 Claire G. ZHANG Scalable clarification process for recombinant aav production
WO2019212922A1 (en) 2018-04-29 2019-11-07 Regenxbio Inc. Systems and methods of spectrophotometry for the determination of genome content, capsid content and full/empty ratios of adeno-associated virus particles
US12070702B2 (en) 2018-06-14 2024-08-27 Regenxbio Inc. Anion exchange chromatography for recombinant AAV production
EP3833745A1 (en) 2018-08-10 2021-06-16 REGENXBIO Inc. Scalable method for recombinant aav production
US11746360B2 (en) * 2019-02-11 2023-09-05 Florian M. Wurm Eukaryotic cell transfection systems and related methods
WO2020219897A1 (en) * 2019-04-24 2020-10-29 Biogen Ma Inc. Methods for production of recombinant adeno-associated viruses

Similar Documents

Publication Publication Date Title
JP2022190081A5 (https=)
US11261463B2 (en) Methods for producing preparations of recombinant AAV virions substantially free of empty capsids
Kotin Large-scale recombinant adeno-associated virus production
CN105636981B (zh) 腺相关病毒因子viii载体
JP2022520803A5 (https=)
JP2021526829A5 (https=)
US20120220492A1 (en) Viral Vectors with Improved Properties
JP2024144435A5 (https=)
JP2021514659A5 (https=)
WO2015031686A1 (en) High titer recombinant aav vector production in adherent and suspension cells
JP2018510648A5 (https=)
JP2022505106A5 (https=)
JP2024503895A5 (https=)
JP2022542828A5 (https=)
EP4689137A1 (en) Compositions and methods for recombinant aav production
US20220242917A1 (en) Compositions and methods for producing adeno-associated viral vectors
JP2023554389A5 (https=)
EP4229205B1 (en) Nucleic acid constructs for va rna transcription
US20240271160A1 (en) Production of adeno-associated virus vector in insect cells
WO2024143440A1 (ja) アデノ随伴ウイルスの製造方法、およびベクターのセット
EP4554604A1 (en) Method for producing recombinant aav particles
IL303882A (en) A producer cell has low levels of VA-RNA
US20260028598A1 (en) Method for separating full and empty AAV particles
WO2025171001A1 (en) Compositions and methods for improved production of aav viral vectors
WO2025207456A1 (en) Methods for purification of adeno associated virus particles by anion exchange chromatography