JP2021526829A5 - - Google Patents
Info
- Publication number
- JP2021526829A5 JP2021526829A5 JP2020568998A JP2020568998A JP2021526829A5 JP 2021526829 A5 JP2021526829 A5 JP 2021526829A5 JP 2020568998 A JP2020568998 A JP 2020568998A JP 2020568998 A JP2020568998 A JP 2020568998A JP 2021526829 A5 JP2021526829 A5 JP 2021526829A5
- Authority
- JP
- Japan
- Prior art keywords
- aav
- raav particles
- feed composition
- concentration
- anion exchange
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862684835P | 2018-06-14 | 2018-06-14 | |
| US62/684,835 | 2018-06-14 | ||
| PCT/US2019/037013 WO2019241535A2 (en) | 2018-06-14 | 2019-06-13 | Anion exchange chromatography for recombinant aav production |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021526829A JP2021526829A (ja) | 2021-10-11 |
| JPWO2019241535A5 JPWO2019241535A5 (https=) | 2022-06-20 |
| JP2021526829A5 true JP2021526829A5 (https=) | 2022-06-20 |
| JP7385603B2 JP7385603B2 (ja) | 2023-11-22 |
Family
ID=67513723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020568998A Active JP7385603B2 (ja) | 2018-06-14 | 2019-06-13 | 組換えａａｖ生成のためのアニオン交換クロマトグラフィー |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12070702B2 (https=) |
| EP (1) | EP3807405A2 (https=) |
| JP (1) | JP7385603B2 (https=) |
| KR (1) | KR102930150B1 (https=) |
| CN (1) | CN112469822A (https=) |
| AU (1) | AU2019285186B2 (https=) |
| CA (1) | CA3102817A1 (https=) |
| IL (2) | IL319002A (https=) |
| WO (1) | WO2019241535A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11028372B2 (en) | 2015-12-11 | 2021-06-08 | The Trustees Of The University Of Pennsylvania | Scalable purification method for AAVRH10 |
| WO2017100676A1 (en) | 2015-12-11 | 2017-06-15 | The Trustees Of The University Of Pennsylvania | Scalable purification method for aav8 |
| EP3387138B1 (en) | 2015-12-11 | 2022-01-26 | The Trustees Of The University Of Pennsylvania | Scalable purification method for aav9 |
| HUE064411T2 (hu) | 2019-04-11 | 2024-03-28 | Regenxbio Inc | Méretkizárásos kromatográfiás módszerek rekombináns adeno-asszociált víruskészítmények jellemzésére |
| US20220143115A1 (en) | 2019-04-19 | 2022-05-12 | Regenxbio Inc. | Adeno-Associated Virus Vector Formulations and Methods |
| WO2021158915A1 (en) * | 2020-02-06 | 2021-08-12 | Precision Biosciences, Inc. | Recombinant adeno-associated virus compositions and methods for producing and using the same |
| AU2021320395A1 (en) * | 2020-08-07 | 2023-04-13 | Janssen Biotech, Inc. | Formulations for highly purified viral particles |
| JP2023539163A (ja) * | 2020-08-18 | 2023-09-13 | ザルトリウス ビーアイエー セパレーションズ ディー．オー．オー． | 宿主細胞ｄｎａの金属アフィニティー抽出 |
| AU2021356684A1 (en) | 2020-10-09 | 2023-05-11 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of fabry disease |
| IL302127A (en) | 2020-10-18 | 2023-06-01 | Univ Pennsylvania | An improved adeno-associated virus (AAV) vector and its uses |
| AU2021369793A1 (en) | 2020-10-29 | 2023-06-08 | The Trustees Of The University Of Pennsylvania | Aav capsids and compositions containing same |
| JP2023548816A (ja) * | 2020-11-03 | 2023-11-21 | ファイザー・インク | 陰イオン交換クロマトグラフィーによるａａｖベクターの精製方法 |
| EP4263841A1 (en) | 2020-12-16 | 2023-10-25 | REGENXBIO Inc. | Method of producing a recombinant adeno-associated virus particle |
| EP4281568A1 (en) | 2021-01-21 | 2023-11-29 | RegenxBio Inc. | Improved production of recombinant polypeptides and viruses |
| EP4281552A4 (en) * | 2021-01-21 | 2025-03-12 | AskBio Inc. | Method for purifying recombinant viral particles |
| JP7683230B2 (ja) * | 2021-01-27 | 2025-05-27 | 東ソー株式会社 | アデノ随伴ウイルスの精製方法 |
| KR20230154039A (ko) * | 2021-03-09 | 2023-11-07 | 제이씨알 파마 가부시키가이샤 | 재조합 aav9 비리온의 제조 방법 |
| WO2023060113A1 (en) | 2021-10-05 | 2023-04-13 | Regenxbio Inc. | Compositions and methods for recombinant aav production |
| CN118202060A (zh) | 2021-10-05 | 2024-06-14 | 再生生物股份有限公司 | 用于重组aav生产的组合物和方法 |
| WO2023102517A1 (en) | 2021-12-02 | 2023-06-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of fabry disease |
| CN114317464B (zh) * | 2021-12-27 | 2023-07-04 | 武汉汇研生物科技股份有限公司 | 腺相关病毒rAAV9的分离纯化方法 |
| WO2023183623A1 (en) | 2022-03-25 | 2023-09-28 | Regenxbio Inc. | Dominant-negative tumor necrosis factor alpha adeno-associated virus gene therapy |
| US20230303983A1 (en) * | 2022-03-28 | 2023-09-28 | President And Fellows Of Harvard College | High efficiency purification of divergent aav serotypes using aavx affinity chromatography |
| WO2023239627A2 (en) | 2022-06-08 | 2023-12-14 | Regenxbio Inc. | Methods for recombinant aav production |
| WO2024015966A2 (en) | 2022-07-15 | 2024-01-18 | The Trustees Of The University Of Pennsylvania | Recombinant aav having aav clade d and clade e capsids and compositions containing same |
| WO2024038365A1 (en) * | 2022-08-16 | 2024-02-22 | Pfizer Inc. | Methods for purification of aav vectors by anion exchange chromatography |
| WO2024211780A1 (en) | 2023-04-07 | 2024-10-10 | Regenxbio Inc. | Compositions and methods for recombinant aav production |
| EP4709866A2 (en) | 2023-05-07 | 2026-03-18 | REGENXBIO Inc. | Compositions and methods for recombinant aav production |
| JPWO2024242150A1 (https=) * | 2023-05-23 | 2024-11-28 | ||
| WO2024243563A1 (en) * | 2023-05-25 | 2024-11-28 | Juno Therapeutics, Inc. | Aav purification method |
| TW202515999A (zh) * | 2023-06-20 | 2025-04-16 | 美商再生元醫藥公司 | 純化填充的腺相關病毒殼體之方法 |
| WO2025090962A1 (en) | 2023-10-25 | 2025-05-01 | Regenxbio Inc. | Compositions and methods for recombinant aav production |
| TW202540433A (zh) * | 2023-11-21 | 2025-10-16 | 美商再生元醫藥公司 | 藉由活體外接合產生共價表面修飾之腺相關病毒及共價表面修飾的腺相關病毒之純化 |
| EP4606892A1 (en) * | 2024-02-23 | 2025-08-27 | Merck Patent GmbH | Methods for the production of viral particles |
| WO2025226558A1 (en) * | 2024-04-22 | 2025-10-30 | Ultragenyx Pharmaceutical Inc. | Multi-step filtration and clarification methods for recombinant adeno-associated virus purification |
| WO2025228321A1 (en) * | 2024-04-29 | 2025-11-06 | Skyline Therapeutics (Shanghai) Co., Ltd. | METHOD OF SEPARATING RECOMBINANT ADENO-ASSOCIATED VIRUS (rAAV) PARTICLES |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6995006B2 (en) | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| PT1916258E (pt) | 1999-08-09 | 2014-07-29 | Genzyme Corp | Aumento da expressão de uma sequência nucleotídica heteróloga de cadeia simples a partir de vectores virais recombinantes por concepção da sequência de maneira que esta forme pares de bases intracadeia |
| WO2001048155A2 (en) | 1999-12-29 | 2001-07-05 | Genzyme Corporation | Method using filtration aids for the separation of virus vectors from nucleic acids and other cellular contaminants |
| WO2002000337A1 (en) | 2000-06-27 | 2002-01-03 | Bia Separations D.O.O. | A chromatography material and a process of manufacturing that material |
| US6593123B1 (en) | 2000-08-07 | 2003-07-15 | Avigen, Inc. | Large-scale recombinant adeno-associated virus (rAAV) production and purification |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| NZ532635A (en) | 2001-11-13 | 2007-05-31 | Univ Pennsylvania | A method of identifying unknown adeno-associated virus (AAV) sequences and a kit for the method |
| DK2359869T3 (en) | 2001-12-17 | 2019-04-15 | Univ Pennsylvania | Sequences of adeno-associated virus (AAV) serotype 8, vectors containing these, and uses thereof |
| DE602004030327D1 (de) | 2003-05-21 | 2011-01-13 | Genzyme Corp | Verfahren zur herstellung von präparationen rekombinanter aav-virionen, die weitgehend frei von leeren capsiden sind |
| CN1856576B (zh) | 2003-09-30 | 2011-05-04 | 宾夕法尼亚州立大学托管会 | 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用 |
| US7183969B2 (en) | 2004-12-22 | 2007-02-27 | Raytheon Company | System and technique for calibrating radar arrays |
| WO2006110689A2 (en) | 2005-04-07 | 2006-10-19 | The Trustees Of The University Of Pennsylvania | Method of increasing the function of an aav vector |
| EP1777906A1 (en) | 2005-06-09 | 2007-04-25 | Matsushita Electric Industrial Co., Ltd. | Amplitude error compensating apparatus and orthogonality error compensating apparatus |
| DK2242840T3 (da) | 2008-01-29 | 2019-10-21 | Applied Genetic Tech Corporation | Produktion af rekombinant adeno-associeret virus under anvendelse af bhk-celler i suspension |
| EP3257937B1 (en) | 2008-02-19 | 2022-08-03 | uniQure IP B.V. | Optimisation of expression of parvoviral rep and cap proteins in insect cells |
| ES2724122T3 (es) | 2009-04-30 | 2019-09-06 | Univ Pennsylvania | Composiciones para dirigir células de las vías respiratorias de conducción que comprenden construcciones de virus adenoasociado |
| WO2010138263A2 (en) | 2009-05-28 | 2010-12-02 | University Of Massachusetts | Novel aav 's and uses thereof |
| US8927514B2 (en) | 2010-04-30 | 2015-01-06 | City Of Hope | Recombinant adeno-associated vectors for targeted treatment |
| US8628966B2 (en) | 2010-04-30 | 2014-01-14 | City Of Hope | CD34-derived recombinant adeno-associated vectors for stem cell transduction and systemic therapeutic gene transfer |
| EP2634253B1 (en) | 2010-10-27 | 2016-05-11 | Jichi Medical University | Adeno-associated virus virions for transferring genes into neural cells |
| WO2012109570A1 (en) | 2011-02-10 | 2012-08-16 | The University Of North Carolina At Chapel Hill | Viral vectors with modified transduction profiles and methods of making and using the same |
| HRP20171334T1 (hr) | 2011-04-22 | 2017-11-17 | The Regents Of The University Of California | Virioni adeno-povezanog virusa s kapsid varijantom i postupci njihove upotrebe |
| ES2857773T5 (es) | 2011-08-24 | 2024-06-04 | Univ Leland Stanford Junior | Nuevas proteínas de la cápside de AAV para la transferencia de ácidos nucleicos |
| WO2013170078A1 (en) | 2012-05-09 | 2013-11-14 | Oregon Health & Science University | Adeno associated virus plasmids and vectors |
| EP2970946A4 (en) | 2013-03-13 | 2016-09-07 | Philadelphia Children Hospital | ADENOASSOZED VIRUS VECTORS AND METHOD FOR USE THEREOF |
| KR102413498B1 (ko) | 2013-04-20 | 2022-06-24 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 엑손 2-표적 U7snRNA 폴리뉴클레오티드 작제물의 재조합형 아데노 부속 바이러스 전달 |
| KR20240090694A (ko) | 2013-07-22 | 2024-06-21 | 더 칠드런스 호스피탈 오브 필라델피아 | 변종 ａａｖ 및 조성물, 세포, 기관 및 조직으로의 유전자 전이를 위한 방법 및 용도 |
| US9585971B2 (en) | 2013-09-13 | 2017-03-07 | California Institute Of Technology | Recombinant AAV capsid protein |
| HUE052676T2 (hu) | 2013-10-11 | 2021-05-28 | Massachusetts Eye & Ear Infirmary | Eljárások õsi vírusszekvenciák elõrejelzésére és alkalmazásaik |
| WO2015164757A1 (en) | 2014-04-25 | 2015-10-29 | Oregon Health & Science University | Methods of viral neutralizing antibody epitope mapping |
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| BR112017005892A2 (pt) | 2014-09-24 | 2017-12-12 | Hope City | variantes de vetor de vírus adeno-associado para edição de genoma de alta eficácia e métodos da mesma |
| EP3054007A1 (en) | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
| JP6665466B2 (ja) | 2015-09-26 | 2020-03-13 | 日亜化学工業株式会社 | 半導体発光素子及びその製造方法 |
| WO2017070491A1 (en) | 2015-10-23 | 2017-04-27 | Applied Genetic Technologies Corporation | Ophthalmic formulations |
| WO2017100676A1 (en) * | 2015-12-11 | 2017-06-15 | The Trustees Of The University Of Pennsylvania | Scalable purification method for aav8 |
| US11015173B2 (en) * | 2015-12-11 | 2021-05-25 | The Trustees Of The University Of Pennsylvania | Scalable purification method for AAV1 |
| US11028372B2 (en) | 2015-12-11 | 2021-06-08 | The Trustees Of The University Of Pennsylvania | Scalable purification method for AAVRH10 |
| EP3387138B1 (en) * | 2015-12-11 | 2022-01-26 | The Trustees Of The University Of Pennsylvania | Scalable purification method for aav9 |
| WO2017160704A1 (en) | 2016-03-14 | 2017-09-21 | Perumala Corporation | Photovoltaic systems with intermittent and continuous recycling of light |
| WO2019178495A1 (en) * | 2018-03-16 | 2019-09-19 | Biogen Ma Inc. | Methods for purifying recombinant adeno-associated viruses |
-
2019
- 2019-06-13 WO PCT/US2019/037013 patent/WO2019241535A2/en not_active Ceased
- 2019-06-13 JP JP2020568998A patent/JP7385603B2/ja active Active
- 2019-06-13 AU AU2019285186A patent/AU2019285186B2/en active Active
- 2019-06-13 CN CN201980048303.1A patent/CN112469822A/zh active Pending
- 2019-06-13 EP EP19748612.9A patent/EP3807405A2/en active Pending
- 2019-06-13 CA CA3102817A patent/CA3102817A1/en active Pending
- 2019-06-13 IL IL319002A patent/IL319002A/en unknown
- 2019-06-13 IL IL279193A patent/IL279193B2/en unknown
- 2019-06-13 US US17/251,869 patent/US12070702B2/en active Active
- 2019-06-13 KR KR1020217000909A patent/KR102930150B1/ko active Active
-
2024
- 2024-07-19 US US18/777,913 patent/US20250186904A1/en active Pending
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