JP2024503703A - 武装型セネカバレーウイルス腫瘍溶解療法組成物およびその方法 - Google Patents

武装型セネカバレーウイルス腫瘍溶解療法組成物およびその方法 Download PDF

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JP2024503703A
JP2024503703A JP2023543064A JP2023543064A JP2024503703A JP 2024503703 A JP2024503703 A JP 2024503703A JP 2023543064 A JP2023543064 A JP 2023543064A JP 2023543064 A JP2023543064 A JP 2023543064A JP 2024503703 A JP2024503703 A JP 2024503703A
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cancer
armed
seneca valley
valley virus
seq
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ハレンベック、ポール、エル．
チャダ、スニル
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セネカ セラピューティクス、インク．
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JP2023543064A 2021-01-19 2022-01-19 武装型セネカバレーウイルス腫瘍溶解療法組成物およびその方法 Pending JP2024503703A (ja)

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US202163138999P 2021-01-19 2021-01-19
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PCT/US2022/013001 WO2022159508A1 (en) 2021-01-19 2022-01-19 Armed seneca valley virus oncolytic therapy compositions and methods thereof

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US (1) US20240307470A1 (https=)
EP (1) EP4281549A4 (https=)
JP (1) JP2024503703A (https=)
KR (1) KR20230134524A (https=)
CN (1) CN116761883A (https=)
AU (1) AU2022210419A1 (https=)
CA (1) CA3207261A1 (https=)
IL (1) IL304280A (https=)
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US20240076343A1 (en) 2022-06-16 2024-03-07 Cephalon Llc Anti-pd-1 antibody-attenuated il-2 immunoconjugates and uses thereof
WO2024177972A2 (en) * 2023-02-20 2024-08-29 The Wistar Institute Of Anatomy And Biology Antibody-cytokine chimeras

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017522025A (ja) * 2014-07-16 2017-08-10 トランジェーヌ、ソシエテ、アノニムＴｒａｎｓｇｅｎｅ Ｓ．Ａ． 免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス
CN111154806A (zh) * 2020-01-08 2020-05-15 深圳普菲科生命科技有限公司 一种嵌合外源超级细胞因子的溶瘤病毒载体系统及其在药物中的应用
WO2020142725A1 (en) * 2019-01-04 2020-07-09 Oncorus, Inc. Encapsulated rna polynucleotides and methods of use
JP2020524174A (ja) * 2017-06-19 2020-08-13 メディシナ セラピューティクス インコーポレイテッド Ｉｌ−２スーパーアゴニスト、アゴニスト、およびそれらの融合体の使用および方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638318B2 (en) * 2003-09-26 2009-12-29 Norvartis Ag Seneca Valley virus based compositions and methods for treating disease
SG192673A1 (en) * 2011-02-10 2013-09-30 Roche Glycart Ag Mutant interleukin-2 polypeptides
EA201892619A1 (ru) * 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
MX2021001883A (es) * 2018-08-16 2021-07-15 Musc Found For Res Dev Virus recombinantes del mixoma y usos de los mismos.
US20220000921A1 (en) * 2018-11-20 2022-01-06 Innovative Cellular Therapeutics Holdings, Ltd. Modified Cell Expressing Therapeutic Agent and Uses thereof
US20220119478A1 (en) * 2019-01-15 2022-04-21 Caerus Therapeutics, Corp. Advanced chimeric antigen receptor vectors for targeting solid tumors
CA3207860A1 (en) * 2021-01-11 2022-07-14 Seneca Therapeutics, Inc. Seneca valley virus combination therapy to treat a cancer refractory to a checkpoint inhibitor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017522025A (ja) * 2014-07-16 2017-08-10 トランジェーヌ、ソシエテ、アノニムＴｒａｎｓｇｅｎｅ Ｓ．Ａ． 免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス
JP2020524174A (ja) * 2017-06-19 2020-08-13 メディシナ セラピューティクス インコーポレイテッド Ｉｌ−２スーパーアゴニスト、アゴニスト、およびそれらの融合体の使用および方法
WO2020142725A1 (en) * 2019-01-04 2020-07-09 Oncorus, Inc. Encapsulated rna polynucleotides and methods of use
CN111154806A (zh) * 2020-01-08 2020-05-15 深圳普菲科生命科技有限公司 一种嵌合外源超级细胞因子的溶瘤病毒载体系统及其在药物中的应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BURKE MJ. ET AL.: "Oncolytic Seneca Valley Virus: past perspectives and future directions", ONCOLYTIC VIROTHER., vol. 5, JPN6025051246, 2016, pages 81 - 89, ISSN: 0005753996 *
LIU F. ET AL.: "Construction of eGFP-Tagged Senecavirus A for Facilitating Virus Neutralization Test and Antiviral A", VIRUSES, vol. vol.12(3),283, JPN6025051245, 5 March 2020 (2020-03-05), pages 1 - 17, ISSN: 0005753995 *

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EP4281549A1 (en) 2023-11-29
EP4281549A4 (en) 2025-05-07
AU2022210419A1 (en) 2023-07-20
AU2022210419A9 (en) 2025-03-06
WO2022159508A1 (en) 2022-07-28
CN116761883A (zh) 2023-09-15
CA3207261A1 (en) 2022-07-28
KR20230134524A (ko) 2023-09-21
US20240307470A1 (en) 2024-09-19
IL304280A (en) 2023-09-01

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