JP2024503437A5 - - Google Patents
Info
- Publication number
- JP2024503437A5 JP2024503437A5 JP2023542569A JP2023542569A JP2024503437A5 JP 2024503437 A5 JP2024503437 A5 JP 2024503437A5 JP 2023542569 A JP2023542569 A JP 2023542569A JP 2023542569 A JP2023542569 A JP 2023542569A JP 2024503437 A5 JP2024503437 A5 JP 2024503437A5
- Authority
- JP
- Japan
- Prior art keywords
- prime editing
- factor according
- editing factor
- amino acid
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163136194P | 2021-01-11 | 2021-01-11 | |
| US63/136,194 | 2021-01-11 | ||
| US202163176202P | 2021-04-16 | 2021-04-16 | |
| US202163176180P | 2021-04-16 | 2021-04-16 | |
| US63/176,202 | 2021-04-16 | ||
| US63/176,180 | 2021-04-16 | ||
| US202163194865P | 2021-05-28 | 2021-05-28 | |
| US202163194913P | 2021-05-28 | 2021-05-28 | |
| US63/194,865 | 2021-05-28 | ||
| US63/194,913 | 2021-05-28 | ||
| US202163231230P | 2021-08-09 | 2021-08-09 | |
| US63/231,230 | 2021-08-09 | ||
| US202163255897P | 2021-10-14 | 2021-10-14 | |
| US63/255,897 | 2021-10-14 | ||
| PCT/US2022/012054 WO2022150790A2 (en) | 2021-01-11 | 2022-01-11 | Prime editor variants, constructs, and methods for enhancing prime editing efficiency and precision |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024503437A JP2024503437A (ja) | 2024-01-25 |
| JP2024503437A5 true JP2024503437A5 (enExample) | 2025-01-22 |
Family
ID=80119064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023542569A Pending JP2024503437A (ja) | 2021-01-11 | 2022-01-11 | プライム編集効率及び精度を向上させるためのプライム編集因子バリアント、構築物、及び方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP4274894A2 (enExample) |
| JP (1) | JP2024503437A (enExample) |
| AU (1) | AU2022206476A1 (enExample) |
| CA (1) | CA3203876A1 (enExample) |
| WO (1) | WO2022150790A2 (enExample) |
Families Citing this family (46)
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| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN116209756A (zh) | 2020-03-04 | 2023-06-02 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| KR20230053735A (ko) | 2020-03-04 | 2023-04-21 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 게놈의 조정을 위한 개선된 방법 및 조성물 |
| CA3231712A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Pah-modulating compositions and methods |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| EP4437106A2 (en) * | 2021-11-24 | 2024-10-02 | Prime Medicine, Inc. | Methods and compositions for inhibiting mismatch repair |
| WO2023108153A2 (en) | 2021-12-10 | 2023-06-15 | Flagship Pioneering Innovations Vi, Llc | Cftr-modulating compositions and methods |
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| CN116064512A (zh) * | 2022-07-15 | 2023-05-05 | 山西大学 | 一种改进的引导编辑系统及其应用 |
| WO2024026344A1 (en) * | 2022-07-27 | 2024-02-01 | Inscripta, Inc. | Modulating cellular repair mechanisms for genomic editing |
| WO2024077267A1 (en) | 2022-10-07 | 2024-04-11 | The Broad Institute, Inc. | Prime editing methods and compositions for treating triplet repeat disorders |
| WO2024178144A1 (en) * | 2023-02-22 | 2024-08-29 | Prime Medicine, Inc. | Methods and compositions for editing nucleotide sequences |
| EP4677117A1 (en) * | 2023-03-09 | 2026-01-14 | The Regents of the University of California | High throughput prime editing screens identify functional dna variants in the human genome |
| WO2024192141A1 (en) | 2023-03-13 | 2024-09-19 | Dana-Farber Cancer Institute, Inc. | Treatment of cancers having a drug-resistant mesenchymal cell state |
| WO2024197185A1 (en) | 2023-03-21 | 2024-09-26 | The Broad Institute, Inc. | Methods and compositions for dissecting organelle physiology |
| WO2024206125A1 (en) * | 2023-03-24 | 2024-10-03 | The Broad Institute, Inc. | Use of prime editing for treating sickle cell disease |
| WO2024215712A2 (en) * | 2023-04-11 | 2024-10-17 | University Of Washington | Methods for identifying epigenetic factors influencing gene editing and modulating gene editing outcome via epigenetic modulation |
| CN118792282A (zh) * | 2023-04-13 | 2024-10-18 | 深圳大学 | Un1Cas12f1突变体及其应用 |
| WO2024226838A2 (en) | 2023-04-25 | 2024-10-31 | The Brigham And Women's Hospital, Inc. | Treatment of autoimmune diseases having a pathogenic t cell state |
| WO2024243415A1 (en) | 2023-05-23 | 2024-11-28 | The Broad Institute, Inc. | Evolved and engineered prime editors with improved editing efficiency |
| WO2025017030A1 (en) * | 2023-07-17 | 2025-01-23 | Institut National de la Santé et de la Recherche Médicale | Prime editing of the -200 region in the hbg1 and/or hbg2 promoter for increasing fetal hemoglobin content in a eukaryotic cell |
| WO2025017033A1 (en) * | 2023-07-17 | 2025-01-23 | Institut National de la Santé et de la Recherche Médicale | Prime editing of the -115 region in the hbg1 and/or hbg2 promoter for increasing fetal hemoglobin content in a eukaryotic cell |
| AU2024301706A1 (en) | 2023-07-21 | 2026-02-05 | Crispr Therapeutics Ag | Modulating expression of alas1 (5'-aminolevulinate synthase 1) gene |
| WO2025049563A1 (en) * | 2023-08-28 | 2025-03-06 | University Of Florida Research Foundation, Inc. | A programmable gene correction technology using cas-polymerase constructs |
| WO2025049788A1 (en) | 2023-08-29 | 2025-03-06 | The Broad Institute, Inc. | Optical genetic screens of intracellular and intercellular transcriptional circuits with perturb-fish |
| WO2025049928A1 (en) * | 2023-09-01 | 2025-03-06 | Arbor Biotechnologies, Inc. | Reverse transcription-mediated gene editing systems and uses thereof |
| WO2025096936A2 (en) | 2023-11-03 | 2025-05-08 | The Broad Institute, Inc. | Use of prime editing in correcting mutations in cdkl5 |
| WO2025096916A1 (en) | 2023-11-03 | 2025-05-08 | The Broad Institute, Inc. | Multi-site editing in living cells |
| WO2025129158A1 (en) | 2023-12-15 | 2025-06-19 | The Broad Institute, Inc. | Engineered arc delivery vesicles and uses thereof |
| CN118185999B (zh) * | 2024-01-03 | 2025-11-14 | 福州大学 | 一种PE-NRGEER mRNA体外转录模板质粒、PE碱基编辑器及其应用 |
| WO2025151814A1 (en) | 2024-01-10 | 2025-07-17 | The Broad Institute, Inc. | Use of prime editing in correcting mutations in cftr |
| WO2025217616A1 (en) | 2024-04-12 | 2025-10-16 | The Broad Institute, Inc. | Prime editing and base editing of the atp1a3 gene for the treatment of alternating hemiplegia of childhood |
| WO2026015480A1 (en) * | 2024-07-08 | 2026-01-15 | Integrated Dna Technologies, Inc. | Cas9 and reverse transcriptase mutants with improved activity in prime editing applications |
| WO2026069163A1 (en) | 2024-09-25 | 2026-04-02 | Crispr Therapeutics Ag | Differentiation method for producing immature beta cells |
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| WO2020180975A1 (en) * | 2019-03-04 | 2020-09-10 | President And Fellows Of Harvard College | Highly multiplexed base editing |
| WO2020181202A1 (en) * | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | A:t to t:a base editing through adenine deamination and oxidation |
| WO2020181193A1 (en) * | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | T:a to a:t base editing through adenosine methylation |
| WO2020181180A1 (en) * | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | A:t to c:g base editors and uses thereof |
| WO2020181195A1 (en) * | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | T:a to a:t base editing through adenine excision |
| WO2020181178A1 (en) * | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | T:a to a:t base editing through thymine alkylation |
| WO2020191233A1 (en) * | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) * | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
-
2022
- 2022-01-11 EP EP22702103.7A patent/EP4274894A2/en active Pending
- 2022-01-11 CA CA3203876A patent/CA3203876A1/en active Pending
- 2022-01-11 JP JP2023542569A patent/JP2024503437A/ja active Pending
- 2022-01-11 WO PCT/US2022/012054 patent/WO2022150790A2/en not_active Ceased
- 2022-01-11 AU AU2022206476A patent/AU2022206476A1/en active Pending
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