JP2024502473A - Ｓｔｉｎｇ活性に関連する状態を治療するためのオキサルアミド化合物および組成物 - Google Patents
Ｓｔｉｎｇ活性に関連する状態を治療するためのオキサルアミド化合物および組成物 Download PDFInfo
- Publication number
- JP2024502473A JP2024502473A JP2023541528A JP2023541528A JP2024502473A JP 2024502473 A JP2024502473 A JP 2024502473A JP 2023541528 A JP2023541528 A JP 2023541528A JP 2023541528 A JP2023541528 A JP 2023541528A JP 2024502473 A JP2024502473 A JP 2024502473A
- Authority
- JP
- Japan
- Prior art keywords
- group
- independently selected
- optionally substituted
- alkyl
- ring atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163135303P | 2021-01-08 | 2021-01-08 | |
| US63/135,303 | 2021-01-08 | ||
| PCT/US2022/011551 WO2022150549A1 (en) | 2021-01-08 | 2022-01-07 | Oxalamide compounds and compositions for treating conditions associated with sting activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024502473A true JP2024502473A (ja) | 2024-01-19 |
| JP2024502473A5 JP2024502473A5 (https=) | 2025-01-15 |
Family
ID=80123502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023541528A Pending JP2024502473A (ja) | 2021-01-08 | 2022-01-07 | Ｓｔｉｎｇ活性に関連する状態を治療するためのオキサルアミド化合物および組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240083879A1 (https=) |
| EP (1) | EP4274826A1 (https=) |
| JP (1) | JP2024502473A (https=) |
| CN (1) | CN116964045A (https=) |
| WO (1) | WO2022150549A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4274824A1 (en) | 2021-01-08 | 2023-11-15 | IFM Due, Inc. | Heterobicyclic compounds having an urea or analogue and their compositions for treating conditions associated with sting activity |
| IL310724A (en) | 2021-08-10 | 2024-04-01 | Ifm Due Inc | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH STING ACTIVITY |
| WO2024064358A1 (en) | 2022-09-23 | 2024-03-28 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012506446A (ja) * | 2008-10-22 | 2012-03-15 | アレイ バイオファーマ、インコーポレイテッド | ＴＲＫキナーゼ阻害剤としての置換ピラゾロ［１，５−ａ］ピリミジン化合物 |
| WO2020010092A1 (en) * | 2018-07-03 | 2020-01-09 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| WO2020236586A1 (en) * | 2019-05-17 | 2020-11-26 | Ifm Due, Inc. | N-hetaryl-squaramide compounds for treating conditions associated with sting activity |
| WO2021067791A1 (en) * | 2019-10-03 | 2021-04-08 | Ifm Due, Inc. | Oxalamide compounds and compositions for treating conditions associated with sting activity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| EP1558252B1 (en) * | 2002-08-02 | 2007-10-10 | Merck & Co., Inc. | Substituted furo [2,3-b]pyridine derivatives |
| US8497285B2 (en) | 2010-12-03 | 2013-07-30 | The Trustees Of The University Of Pennsylvania | Therapy of autoimmune colitis using a TIP60 inhibitor |
| CA2944198C (en) * | 2013-04-26 | 2021-11-16 | Indiana University Research & Technology Corporation | Hydroxyindole carboxylic acid based inhibitors for oncogenic src homology-2 domain containing protein tyrosine phosphatase-2 (shp2) |
| CA2927009C (en) | 2013-10-21 | 2019-04-23 | Drexel University | Use of sting agonists to treat chronic hepatitis b virus infection |
-
2022
- 2022-01-07 JP JP2023541528A patent/JP2024502473A/ja active Pending
- 2022-01-07 US US18/271,186 patent/US20240083879A1/en active Pending
- 2022-01-07 EP EP22701780.3A patent/EP4274826A1/en not_active Withdrawn
- 2022-01-07 WO PCT/US2022/011551 patent/WO2022150549A1/en not_active Ceased
- 2022-01-07 CN CN202280019954.XA patent/CN116964045A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012506446A (ja) * | 2008-10-22 | 2012-03-15 | アレイ バイオファーマ、インコーポレイテッド | ＴＲＫキナーゼ阻害剤としての置換ピラゾロ［１，５−ａ］ピリミジン化合物 |
| WO2020010092A1 (en) * | 2018-07-03 | 2020-01-09 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| WO2020236586A1 (en) * | 2019-05-17 | 2020-11-26 | Ifm Due, Inc. | N-hetaryl-squaramide compounds for treating conditions associated with sting activity |
| WO2021067791A1 (en) * | 2019-10-03 | 2021-04-08 | Ifm Due, Inc. | Oxalamide compounds and compositions for treating conditions associated with sting activity |
Also Published As
| Publication number | Publication date |
|---|---|
| US20240083879A1 (en) | 2024-03-14 |
| WO2022150549A1 (en) | 2022-07-14 |
| EP4274826A1 (en) | 2023-11-15 |
| CN116964045A (zh) | 2023-10-27 |
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