JP2024502236A - 心房性不整脈を有する対象におけるカルディオバージョンの誘導のためのキットおよび方法 - Google Patents

心房性不整脈を有する対象におけるカルディオバージョンの誘導のためのキットおよび方法 Download PDF

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JP2024502236A
JP2024502236A JP2023537307A JP2023537307A JP2024502236A JP 2024502236 A JP2024502236 A JP 2024502236A JP 2023537307 A JP2023537307 A JP 2023537307A JP 2023537307 A JP2023537307 A JP 2023537307A JP 2024502236 A JP2024502236 A JP 2024502236A
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Prior art keywords
pharmaceutically acceptable
acceptable salt
flecainide
channel blocker
pharmaceutical composition
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JP2023537307A
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Japanese (ja)
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JP2024502236A5 (https=
Inventor
ベラーディネリ，ルイス
シューラー，カルロス
グズマン，ミゲル
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インカーダ セラピューティクス， インコーポレイテッド
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Publication of JP2024502236A publication Critical patent/JP2024502236A/ja
Publication of JP2024502236A5 publication Critical patent/JP2024502236A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2023537307A 2020-12-17 2021-12-17 心房性不整脈を有する対象におけるカルディオバージョンの誘導のためのキットおよび方法 Pending JP2024502236A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063127089P 2020-12-17 2020-12-17
US63/127,089 2020-12-17
US202163153492P 2021-02-25 2021-02-25
US63/153,492 2021-02-25
PCT/US2021/064213 WO2022133317A1 (en) 2020-12-17 2021-12-17 Kits and methods for induction of cardioversion in subjects with atrial arrhythmias

Publications (2)

Publication Number Publication Date
JP2024502236A true JP2024502236A (ja) 2024-01-18
JP2024502236A5 JP2024502236A5 (https=) 2024-12-24

Family

ID=82058359

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JP2023537307A Pending JP2024502236A (ja) 2020-12-17 2021-12-17 心房性不整脈を有する対象におけるカルディオバージョンの誘導のためのキットおよび方法

Country Status (6)

Country Link
US (2) US12059414B2 (https=)
EP (1) EP4262764A4 (https=)
JP (1) JP2024502236A (https=)
AU (1) AU2021400335A1 (https=)
CA (1) CA3200432A1 (https=)
WO (1) WO2022133317A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020323594B2 (en) * 2019-08-01 2022-02-03 Incarda Therapeutics, Inc. Antiarrhythmic formulation
CA3200432A1 (en) * 2020-12-17 2022-06-23 Incarda Therapeutics, Inc. Kits and methods for induction of cardioversion in subjects with atrial arrhythmias
US20260061000A1 (en) * 2022-08-16 2026-03-05 Lankenau Institute For Medical Research Compositions and methods for the treatment of cardiac arrhythmias, including atrial fibrillation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012520890A (ja) * 2009-03-18 2012-09-10 インカーダ セラピューティクス， インコーポレイテッド 経肺投与によって心疾患を治療するための単位用量、エアロゾル、キット、および方法

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US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US20020161018A1 (en) * 2001-02-23 2002-10-31 Smith Forrest L. Enhancement of the potency and efficacy of local anesthetics with ibutilide and other methanesulfonamide drugs
US6968226B2 (en) * 2002-01-30 2005-11-22 Medtronic, Inc. Method and system for terminating an atrial arrhythmia
US8106099B2 (en) * 2003-03-18 2012-01-31 Sanofi-Aventis Deutschland Gmbh Combination of phenylcarboxamides with blockers of the IKr channel and their use for the treatment of atrial arrhythmias
EP1781360A1 (en) * 2004-08-12 2007-05-09 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
JP2008513445A (ja) * 2004-09-20 2008-05-01 コラス ファーマ インコーポレイテッド 吸入による送達で治療効果のある薬剤の許容性の改善方法
CN101262846A (zh) * 2005-07-15 2008-09-10 Map药物公司 在离散的吸入粒子中结合的多种活性药物成分及其制剂
HK1201455A1 (en) 2012-01-27 2015-09-04 Gilead Sciences Inc Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2013185764A2 (en) * 2012-06-13 2013-12-19 Acesion Pharma Pharmaceutical compositions for combination therapy
US9597302B1 (en) * 2015-09-24 2017-03-21 Heart Rhythm Solutions, Inc. Combination of dofetilide and mexiletine for the prevention and treatment of atrial fibrillation
CN109069495A (zh) * 2016-02-01 2018-12-21 英凯达治疗公司 电子监测联合吸入药理学疗法管理包括心房颤动在内的心律失常
AU2018266199A1 (en) 2017-05-10 2019-11-07 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
US10744087B2 (en) 2018-03-22 2020-08-18 Incarda Therapeutics, Inc. Method to slow ventricular rate
CN112533664A (zh) 2018-06-05 2021-03-19 英凯达治疗公司 使用气雾剂诊断Brugada综合征的方法
AU2020323594B2 (en) 2019-08-01 2022-02-03 Incarda Therapeutics, Inc. Antiarrhythmic formulation
US11007185B2 (en) 2019-08-01 2021-05-18 Incarda Therapeutics, Inc. Antiarrhythmic formulation
CN116669715A (zh) 2020-11-18 2023-08-29 Fb-Hrs有限责任公司 含有多非利特和美西律的组合物及其应用
CA3200432A1 (en) * 2020-12-17 2022-06-23 Incarda Therapeutics, Inc. Kits and methods for induction of cardioversion in subjects with atrial arrhythmias

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012520890A (ja) * 2009-03-18 2012-09-10 インカーダ セラピューティクス， インコーポレイテッド 経肺投与によって心疾患を治療するための単位用量、エアロゾル、キット、および方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. AM. COLL. CARDIOL., vol. 44, JPN6025037920, 2004, pages 864 - 868, ISSN: 0005686904 *
J. CARDIOVASC. PHARMACOL. THER., vol. 5(3), JPN6025037921, 2000, pages 177 - 181, ISSN: 0005686905 *

Also Published As

Publication number Publication date
EP4262764A1 (en) 2023-10-25
EP4262764A4 (en) 2024-11-13
US12059414B2 (en) 2024-08-13
WO2022133317A1 (en) 2022-06-23
US20220226301A1 (en) 2022-07-21
US20230226032A1 (en) 2023-07-20
CA3200432A1 (en) 2022-06-23
AU2021400335A9 (en) 2024-09-12
AU2021400335A1 (en) 2023-06-22
US12576074B2 (en) 2026-03-17

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