JP2024501832A5 - - Google Patents
Info
- Publication number
- JP2024501832A5 JP2024501832A5 JP2023538971A JP2023538971A JP2024501832A5 JP 2024501832 A5 JP2024501832 A5 JP 2024501832A5 JP 2023538971 A JP2023538971 A JP 2023538971A JP 2023538971 A JP2023538971 A JP 2023538971A JP 2024501832 A5 JP2024501832 A5 JP 2024501832A5
- Authority
- JP
- Japan
- Prior art keywords
- primer
- rnase
- hybrid
- dna polymerase
- template
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063130548P | 2020-12-24 | 2020-12-24 | |
| US63/130,548 | 2020-12-24 | ||
| US202163277273P | 2021-11-09 | 2021-11-09 | |
| US63/277,273 | 2021-11-09 | ||
| PCT/US2021/064879 WO2022140553A1 (en) | 2020-12-24 | 2021-12-22 | Rnase h2 mutants that reduce primer dimers and off-target amplification in rhpcr-based amplicon sequencing with high-fidelity dna polymerases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024501832A JP2024501832A (ja) | 2024-01-16 |
| JP2024501832A5 true JP2024501832A5 (https=) | 2025-01-06 |
Family
ID=80050536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023538971A Pending JP2024501832A (ja) | 2020-12-24 | 2021-12-22 | 高忠実度ＤＮＡポリメラーゼによるｒｈＰＣＲベース増幅産物シーケンシングにおいて、プライマー二量体及びオフターゲット増幅を低減するＲＮアーゼＨ２突然変異体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US12024742B2 (https=) |
| EP (1) | EP4267762B1 (https=) |
| JP (1) | JP2024501832A (https=) |
| KR (1) | KR20230124946A (https=) |
| AU (1) | AU2021409723A1 (https=) |
| CA (1) | CA3206360A1 (https=) |
| ES (1) | ES3060434T3 (https=) |
| WO (1) | WO2022140553A1 (https=) |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| ATE138106T1 (de) | 1988-07-20 | 1996-06-15 | David Segev | Verfahren zur amplifizierung und zum nachweis von nukleinsäuresequenzen |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| DE60027040T2 (de) | 1999-10-29 | 2006-11-23 | Stratagene California, La Jolla | Zusammensetzungen und methoden zur verwendung von dna polymerasen |
| US20090068643A1 (en) | 2005-11-23 | 2009-03-12 | Integrated Dna Technologies, Inc. | Dual Function Primers for Amplifying DNA and Methods of Use |
| US8911948B2 (en) | 2008-04-30 | 2014-12-16 | Integrated Dna Technologies, Inc. | RNase H-based assays utilizing modified RNA monomers |
| EP2644708B1 (en) * | 2008-04-30 | 2014-12-17 | Integrated Dna Technologies, Inc. | RNASE-H-based assays utilizing modified RNA monomers |
| EP2333109B1 (en) * | 2008-09-03 | 2013-08-07 | Takara Bio, Inc. | Composition for detection of rna |
| JP2016536995A (ja) * | 2013-11-14 | 2016-12-01 | インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド | 増大した鋳型識別活性を有するｄｎａポリメラーゼ突然変異体 |
| HK1247255A1 (zh) | 2014-12-15 | 2018-09-21 | Cepheid | 底数大於2的指数核酸扩增 |
| WO2018031625A2 (en) * | 2016-08-09 | 2018-02-15 | Integrated Dna Technologies, Inc. | Rnase h mutants in an emulsion |
| WO2018044831A1 (en) * | 2016-08-30 | 2018-03-08 | Integrated Dna Technologies, Inc. | Cleavable hairpin primers |
| CN112105745A (zh) * | 2018-05-07 | 2020-12-18 | 罗氏创新中心哥本哈根有限公司 | 用于寡核苷酸治疗剂的大规模平行发现方法 |
| JP2022515466A (ja) * | 2018-12-28 | 2022-02-18 | ナショナル ユニヴァーシティー オブ シンガポール | 標的化された相補的ｄｎａ富化のための方法 |
-
2021
- 2021-12-22 KR KR1020237022952A patent/KR20230124946A/ko active Pending
- 2021-12-22 ES ES21848391T patent/ES3060434T3/es active Active
- 2021-12-22 AU AU2021409723A patent/AU2021409723A1/en active Pending
- 2021-12-22 EP EP21848391.5A patent/EP4267762B1/en active Active
- 2021-12-22 CA CA3206360A patent/CA3206360A1/en active Pending
- 2021-12-22 WO PCT/US2021/064879 patent/WO2022140553A1/en not_active Ceased
- 2021-12-22 JP JP2023538971A patent/JP2024501832A/ja active Pending
- 2021-12-22 US US17/558,994 patent/US12024742B2/en active Active
-
2024
- 2024-05-17 US US18/667,876 patent/US20240318237A1/en active Pending
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