JP2024501109A - 細胞培養培地調整容器および灌流バイオリアクタシステム - Google Patents

細胞培養培地調整容器および灌流バイオリアクタシステム Download PDF

Info

Publication number
JP2024501109A
JP2024501109A JP2023530602A JP2023530602A JP2024501109A JP 2024501109 A JP2024501109 A JP 2024501109A JP 2023530602 A JP2023530602 A JP 2023530602A JP 2023530602 A JP2023530602 A JP 2023530602A JP 2024501109 A JP2024501109 A JP 2024501109A
Authority
JP
Japan
Prior art keywords
medium
cell culture
container
culture medium
conditioning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023530602A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024501109A5 (https=
Inventor
ジョゼフ カラッチ，ステファン
アンドリュー シュルテス，ジョエル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corning Inc
Original Assignee
Corning Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corning Inc filed Critical Corning Inc
Publication of JP2024501109A publication Critical patent/JP2024501109A/ja
Publication of JP2024501109A5 publication Critical patent/JP2024501109A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2023530602A 2020-11-30 2021-11-19 細胞培養培地調整容器および灌流バイオリアクタシステム Pending JP2024501109A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063119045P 2020-11-30 2020-11-30
US202063119007P 2020-11-30 2020-11-30
US63/119,045 2020-11-30
US63/119,007 2020-11-30
PCT/US2021/060040 WO2022115319A1 (en) 2020-11-30 2021-11-19 Cell culture media conditioning vessels and perfusion bioreactor system

Publications (2)

Publication Number Publication Date
JP2024501109A true JP2024501109A (ja) 2024-01-11
JP2024501109A5 JP2024501109A5 (https=) 2024-11-22

Family

ID=79024220

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023530602A Pending JP2024501109A (ja) 2020-11-30 2021-11-19 細胞培養培地調整容器および灌流バイオリアクタシステム

Country Status (4)

Country Link
US (1) US20240002771A1 (https=)
EP (1) EP4251724A1 (https=)
JP (1) JP2024501109A (https=)
WO (1) WO2022115319A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3146693A1 (fr) * 2023-03-17 2024-09-20 Ifremer : Institut Francais De Recherche Pour L'exploitation De La Mer Procede d'alimentation en milieu de culture d’un bioreacteur et un systeme associe

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6312274A (ja) * 1986-07-03 1988-01-19 Takashi Mori バイオリアクタ
JPH06269274A (ja) * 1993-03-19 1994-09-27 Hitachi Ltd 生体の細胞の培養装置及び培養方法
JP2007535961A (ja) * 2004-05-06 2007-12-13 グラクソ　グループ　リミテッド バイオリアクター
JP2008501347A (ja) * 2004-06-04 2008-01-24 エクセラーエックス， インコーポレイテッド 使い捨て可能なバイオリアクターシステムおよび方法
CN107723236A (zh) * 2017-10-31 2018-02-23 广州迈普再生医学科技有限公司 动态灌流培养系统

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4833083A (en) 1987-05-26 1989-05-23 Sepragen Corporation Packed bed bioreactor
US5262320A (en) 1990-06-18 1993-11-16 Massachusetts Institute Of Technology Cell-culturing apparatus and method employing a macroporous support
JP3080647B2 (ja) * 1990-10-09 2000-08-28 エーザイ株式会社 細胞培養装置
WO1994017178A1 (en) 1993-01-29 1994-08-04 New Brunswick Scientific Co., Inc. Method and apparatus for anchorage and suspension cell culture
US20060033222A1 (en) * 2004-08-11 2006-02-16 Godfrey Scott A Devices for introducing a gas into a liquid and methods of using the same
WO2007142664A1 (en) * 2006-06-08 2007-12-13 Amprotein Corporation A method to increase dissolved oxygen in a culture vessel
WO2010068912A2 (en) * 2008-12-12 2010-06-17 Smartin Technologies, Llc Bioreactor recirculation loop device
US20150093775A1 (en) * 2013-07-08 2015-04-02 Govind Rao System and method for analyte sensing and monitoring

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6312274A (ja) * 1986-07-03 1988-01-19 Takashi Mori バイオリアクタ
JPH06269274A (ja) * 1993-03-19 1994-09-27 Hitachi Ltd 生体の細胞の培養装置及び培養方法
JP2007535961A (ja) * 2004-05-06 2007-12-13 グラクソ　グループ　リミテッド バイオリアクター
JP2008501347A (ja) * 2004-06-04 2008-01-24 エクセラーエックス， インコーポレイテッド 使い捨て可能なバイオリアクターシステムおよび方法
CN107723236A (zh) * 2017-10-31 2018-02-23 广州迈普再生医学科技有限公司 动态灌流培养系统

Also Published As

Publication number Publication date
US20240002771A1 (en) 2024-01-04
EP4251724A1 (en) 2023-10-04
WO2022115319A1 (en) 2022-06-02

Similar Documents

Publication Publication Date Title
US20250027018A1 (en) Fixed bed bioreactor and methods of using the same
US20160319234A1 (en) Continuously controlled hollow fiber bioreactor
US20230009199A1 (en) Stacked fixed bed bioreactor and methods of using the same
US20230348834A1 (en) Fixed bed bioreactor vessel and methods of using the same
JP2024513245A (ja) 固定床反応器用の細胞培養試料採取基体
JP2023503589A (ja) 固定床細胞培養・収穫システムおよびそれを使用する方法
US20240010972A1 (en) Packed bed bioreactors with controlled zonal porosity
JP2024501109A (ja) 細胞培養培地調整容器および灌流バイオリアクタシステム
CN117561324A (zh) 用于细胞培养和收获的固定床生物反应器及其相关方法
CN116568801A (zh) 细胞培养基调节容器和灌注生物反应器系统
US20230010639A1 (en) Radial flow fixed bed bioreactor and methods of using the same
US20230392105A1 (en) Bioreactor media condition system and related methods
JP2025540055A (ja) かん流バイオリアクタ内で培養培地を酸素化するためのシステム及び方法
US20240287431A1 (en) Rolled cell culture substrates for fixed bed bioreactors with controlled perfusion zones
JP2025537024A (ja) バイオリアクタ基材をコーティングするためのシステム及び方法
US20230242854A1 (en) Tubular packed-bed cell culture vessels, systems, and related methods
WO2025049667A1 (en) Perfusion bioreactors and systems for large scale cell culture
JP2025535621A (ja) バイオリアクタ内で幹細胞を分化させるシステム及び方法
WO2025117320A1 (en) Cell culture bioreactor system with bidirectional perfusion and related methods
JP2025520498A (ja) 基体アライメントおよび試料採取のための固定床細胞培養反応器

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20241114

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20241114

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20251217

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20251224

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20260324