JP2024091650A5 - - Google Patents
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- JP2024091650A5 JP2024091650A5 JP2024058795A JP2024058795A JP2024091650A5 JP 2024091650 A5 JP2024091650 A5 JP 2024091650A5 JP 2024058795 A JP2024058795 A JP 2024058795A JP 2024058795 A JP2024058795 A JP 2024058795A JP 2024091650 A5 JP2024091650 A5 JP 2024091650A5
- Authority
- JP
- Japan
- Prior art keywords
- level
- sample
- fragments
- proadm
- trauma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012634 fragment Substances 0.000 claims 13
- 208000004221 Multiple Trauma Diseases 0.000 claims 9
- 208000014674 injury Diseases 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 230000008733 trauma Effects 0.000 claims 8
- 208000023637 Multiple injury Diseases 0.000 claims 4
- 239000000090 biomarker Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 206010029803 Nosocomial infection Diseases 0.000 claims 1
- 206010053159 Organ failure Diseases 0.000 claims 1
- 206010039020 Rhabdomyolysis Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 238000012502 risk assessment Methods 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 238000013517 stratification Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18176268.3A EP3578989A1 (en) | 2018-06-06 | 2018-06-06 | Pro-adm for prognosis of trauma-related complications in polytrauma patients |
| EP18176268.3 | 2018-06-06 | ||
| JP2020567573A JP7548823B2 (ja) | 2018-06-06 | 2019-06-06 | 多発外傷患者の外傷関連合併症の予後診断のためのｐｒｏ－ａｄｍ |
| PCT/EP2019/064805 WO2019234165A1 (en) | 2018-06-06 | 2019-06-06 | Pro-adm for prognosis of trauma-related complications in polytrauma patients |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020567573A Division JP7548823B2 (ja) | 2018-06-06 | 2019-06-06 | 多発外傷患者の外傷関連合併症の予後診断のためのｐｒｏ－ａｄｍ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024091650A JP2024091650A (ja) | 2024-07-05 |
| JP2024091650A5 true JP2024091650A5 (https=) | 2025-04-01 |
Family
ID=62562975
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020567573A Active JP7548823B2 (ja) | 2018-06-06 | 2019-06-06 | 多発外傷患者の外傷関連合併症の予後診断のためのｐｒｏ－ａｄｍ |
| JP2024058795A Pending JP2024091650A (ja) | 2018-06-06 | 2024-04-01 | 多発外傷患者の外傷関連合併症の予後診断のためのｐｒｏ－ａｄｍ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020567573A Active JP7548823B2 (ja) | 2018-06-06 | 2019-06-06 | 多発外傷患者の外傷関連合併症の予後診断のためのｐｒｏ－ａｄｍ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12560620B2 (https=) |
| EP (2) | EP3578989A1 (https=) |
| JP (2) | JP7548823B2 (https=) |
| CN (1) | CN112236678B (https=) |
| WO (1) | WO2019234165A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102544219B1 (ko) * | 2021-08-17 | 2023-06-14 | 한림대학교 산학협력단 | 코펩틴의 농도를 이용한 외상성 뇌 손상의 진단 방법 |
| EP4658247A1 (en) * | 2023-01-31 | 2025-12-10 | Vivacelle Bio, Inc. | Compositions and methods for treating hyperprocalcitonemia |
| CN117964711B (zh) * | 2024-04-01 | 2024-06-11 | 中国科学院生物物理研究所 | 非天然抗菌肽及其应用 |
| WO2026013199A1 (en) | 2024-07-12 | 2026-01-15 | Cezanne S.A.S. | Clinical immunoassay with early signal measurement |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2570703B1 (fr) | 1984-09-26 | 1988-07-08 | Commissariat Energie Atomique | Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents |
| US4882733A (en) | 1987-03-13 | 1989-11-21 | Ford Aerospace Corporation | Method and apparatus for combining encoding and modulation |
| FR2664699B1 (fr) | 1990-07-13 | 1995-08-18 | Cis Bio Int | Procede d'amplification du signal d'emission d'un compose luminescent. |
| DE69602756T2 (de) | 1995-08-18 | 2000-02-10 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville | Funktionelle rolle von adrenomedullin(am) und dem gen-verwandten produkt(pamp) in der menschlichen pathologie und physiologie |
| KR100425525B1 (ko) | 2000-11-21 | 2004-03-30 | 재단법인서울대학교산학협력재단 | 조산과 태아감염 및 태아손상을 산전 진단하기 위한진단시약 및 진단키트 |
| DE10316583A1 (de) | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| DE102006034142A1 (de) | 2006-07-24 | 2008-01-31 | B.R.A.H.M.S. Aktiengesellschaft | Verfahren zur Steuerung der Therapie von Patienten mit Herzinsuffizienz anhand der vitro Bestimmung von Schwellenwerten von vasoaktiven Peptiden |
| DE102006060112A1 (de) | 2006-12-20 | 2008-06-26 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| US8298774B2 (en) * | 2007-03-12 | 2012-10-30 | Biomedica Medizinprodukte Gmbh & Co Kg | Diagnosis of septic complications |
| PL2185937T5 (pl) * | 2007-09-07 | 2014-12-31 | Univ Zuerich | Sposób wykrywania posocznicy u ludzi |
| ES2486268T3 (es) | 2007-11-16 | 2014-08-18 | Biocartis Nv | Biomarcadores y procedimientos de diagnóstico, predicción y/o pronóstico de septicemia y usos de los mismos |
| US9229013B2 (en) | 2009-05-05 | 2016-01-05 | B.R.A.H.M.S Gmbh | Vasoactive hormone-based stratification of patients suffering from diseases related to endothelial function/dysfunction |
| EP2438447B1 (en) | 2009-06-05 | 2015-02-18 | B.R.A.H.M.S GmbH | Detection of bacterial infections in subjects suffering from dyspnea. |
| US8383332B2 (en) | 2009-10-13 | 2013-02-26 | B.R.A.H.M.S. Gmbh | Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack |
| EP2545379B1 (en) | 2010-03-08 | 2015-09-30 | B.R.A.H.M.S GmbH | Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with non-specific complaints |
| WO2012059477A1 (en) | 2010-11-01 | 2012-05-10 | B.R.A.H.M.S Gmbh | Prognosis and risk assessment of patients with non-specific complaints |
| US10935548B2 (en) | 2011-12-08 | 2021-03-02 | Astute Medical, Inc. | Methods for diagnosis and prognosis of renal injury and renal failure using insulin-like growth factor-binding protein 7 and metalloproteinase inhibitor 2 |
| EP2976646B1 (en) * | 2013-03-20 | 2020-08-19 | sphingotec GmbH | Adrenomedullin to guide therapy of blood pressure decline |
| US20180348235A1 (en) * | 2015-11-27 | 2018-12-06 | B.R.A.H.M.S Gmbh | MR-proADM as marker for the extracellular volume status of a subject |
| EP4231018A3 (en) | 2016-07-08 | 2023-11-15 | SphingoTec GmbH | Adrenomedullin for assessing congestion in a subject with acute heart failure |
| RU2764766C2 (ru) * | 2016-08-09 | 2022-01-21 | Б.Р.А.Х.М.С. Гмбх | Гистоны и/или proadm в качестве маркеров, свидетельствующих об органной дисфункции |
| CA3033094A1 (en) * | 2016-08-09 | 2018-02-15 | B.R.A.H.M.S Gmbh | Histones and/or proadm as markers indicating an adverse event |
| ES2944613T3 (es) * | 2017-02-02 | 2023-06-22 | Brahms Gmbh | proADM y/o histonas como marcadores indicadores de un acontecimiento adverso |
-
2018
- 2018-06-06 EP EP18176268.3A patent/EP3578989A1/en not_active Withdrawn
-
2019
- 2019-06-06 WO PCT/EP2019/064805 patent/WO2019234165A1/en not_active Ceased
- 2019-06-06 JP JP2020567573A patent/JP7548823B2/ja active Active
- 2019-06-06 US US16/972,509 patent/US12560620B2/en active Active
- 2019-06-06 CN CN201980037837.4A patent/CN112236678B/zh active Active
- 2019-06-06 EP EP19728085.2A patent/EP3803417A1/en active Pending
-
2024
- 2024-04-01 JP JP2024058795A patent/JP2024091650A/ja active Pending
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