CN112236678B - 用于多发伤患者的创伤相关并发症预后的pro-adm - Google Patents
用于多发伤患者的创伤相关并发症预后的pro-adm Download PDFInfo
- Publication number
- CN112236678B CN112236678B CN201980037837.4A CN201980037837A CN112236678B CN 112236678 B CN112236678 B CN 112236678B CN 201980037837 A CN201980037837 A CN 201980037837A CN 112236678 B CN112236678 B CN 112236678B
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- proadm
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18176268.3A EP3578989A1 (en) | 2018-06-06 | 2018-06-06 | Pro-adm for prognosis of trauma-related complications in polytrauma patients |
| EP18176268.3 | 2018-06-06 | ||
| PCT/EP2019/064805 WO2019234165A1 (en) | 2018-06-06 | 2019-06-06 | Pro-adm for prognosis of trauma-related complications in polytrauma patients |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112236678A CN112236678A (zh) | 2021-01-15 |
| CN112236678B true CN112236678B (zh) | 2024-10-11 |
Family
ID=62562975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980037837.4A Active CN112236678B (zh) | 2018-06-06 | 2019-06-06 | 用于多发伤患者的创伤相关并发症预后的pro-adm |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12560620B2 (https=) |
| EP (2) | EP3578989A1 (https=) |
| JP (2) | JP7548823B2 (https=) |
| CN (1) | CN112236678B (https=) |
| WO (1) | WO2019234165A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102544219B1 (ko) * | 2021-08-17 | 2023-06-14 | 한림대학교 산학협력단 | 코펩틴의 농도를 이용한 외상성 뇌 손상의 진단 방법 |
| EP4658247A1 (en) * | 2023-01-31 | 2025-12-10 | Vivacelle Bio, Inc. | Compositions and methods for treating hyperprocalcitonemia |
| CN117964711B (zh) * | 2024-04-01 | 2024-06-11 | 中国科学院生物物理研究所 | 非天然抗菌肽及其应用 |
| WO2026013199A1 (en) | 2024-07-12 | 2026-01-15 | Cezanne S.A.S. | Clinical immunoassay with early signal measurement |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017089474A1 (en) * | 2015-11-27 | 2017-06-01 | Brahms Gmbh | MR-proADM AS MARKER FOR THE EXTRACELLULAR VOLUME STATUS OF A SUBJECT |
| WO2018029214A1 (en) * | 2016-08-09 | 2018-02-15 | B.R.A.H.M.S Gmbh | Histones and/or proadm as markers indicating an adverse event |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2570703B1 (fr) | 1984-09-26 | 1988-07-08 | Commissariat Energie Atomique | Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents |
| US4882733A (en) | 1987-03-13 | 1989-11-21 | Ford Aerospace Corporation | Method and apparatus for combining encoding and modulation |
| FR2664699B1 (fr) | 1990-07-13 | 1995-08-18 | Cis Bio Int | Procede d'amplification du signal d'emission d'un compose luminescent. |
| DE69602756T2 (de) | 1995-08-18 | 2000-02-10 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville | Funktionelle rolle von adrenomedullin(am) und dem gen-verwandten produkt(pamp) in der menschlichen pathologie und physiologie |
| KR100425525B1 (ko) | 2000-11-21 | 2004-03-30 | 재단법인서울대학교산학협력재단 | 조산과 태아감염 및 태아손상을 산전 진단하기 위한진단시약 및 진단키트 |
| DE10316583A1 (de) | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| DE102006034142A1 (de) | 2006-07-24 | 2008-01-31 | B.R.A.H.M.S. Aktiengesellschaft | Verfahren zur Steuerung der Therapie von Patienten mit Herzinsuffizienz anhand der vitro Bestimmung von Schwellenwerten von vasoaktiven Peptiden |
| DE102006060112A1 (de) | 2006-12-20 | 2008-06-26 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| US8298774B2 (en) * | 2007-03-12 | 2012-10-30 | Biomedica Medizinprodukte Gmbh & Co Kg | Diagnosis of septic complications |
| PL2185937T5 (pl) * | 2007-09-07 | 2014-12-31 | Univ Zuerich | Sposób wykrywania posocznicy u ludzi |
| ES2486268T3 (es) | 2007-11-16 | 2014-08-18 | Biocartis Nv | Biomarcadores y procedimientos de diagnóstico, predicción y/o pronóstico de septicemia y usos de los mismos |
| US9229013B2 (en) | 2009-05-05 | 2016-01-05 | B.R.A.H.M.S Gmbh | Vasoactive hormone-based stratification of patients suffering from diseases related to endothelial function/dysfunction |
| EP2438447B1 (en) | 2009-06-05 | 2015-02-18 | B.R.A.H.M.S GmbH | Detection of bacterial infections in subjects suffering from dyspnea. |
| US8383332B2 (en) | 2009-10-13 | 2013-02-26 | B.R.A.H.M.S. Gmbh | Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack |
| EP2545379B1 (en) | 2010-03-08 | 2015-09-30 | B.R.A.H.M.S GmbH | Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with non-specific complaints |
| WO2012059477A1 (en) | 2010-11-01 | 2012-05-10 | B.R.A.H.M.S Gmbh | Prognosis and risk assessment of patients with non-specific complaints |
| US10935548B2 (en) | 2011-12-08 | 2021-03-02 | Astute Medical, Inc. | Methods for diagnosis and prognosis of renal injury and renal failure using insulin-like growth factor-binding protein 7 and metalloproteinase inhibitor 2 |
| EP2976646B1 (en) * | 2013-03-20 | 2020-08-19 | sphingotec GmbH | Adrenomedullin to guide therapy of blood pressure decline |
| EP4231018A3 (en) | 2016-07-08 | 2023-11-15 | SphingoTec GmbH | Adrenomedullin for assessing congestion in a subject with acute heart failure |
| RU2764766C2 (ru) * | 2016-08-09 | 2022-01-21 | Б.Р.А.Х.М.С. Гмбх | Гистоны и/или proadm в качестве маркеров, свидетельствующих об органной дисфункции |
| ES2944613T3 (es) * | 2017-02-02 | 2023-06-22 | Brahms Gmbh | proADM y/o histonas como marcadores indicadores de un acontecimiento adverso |
-
2018
- 2018-06-06 EP EP18176268.3A patent/EP3578989A1/en not_active Withdrawn
-
2019
- 2019-06-06 WO PCT/EP2019/064805 patent/WO2019234165A1/en not_active Ceased
- 2019-06-06 JP JP2020567573A patent/JP7548823B2/ja active Active
- 2019-06-06 US US16/972,509 patent/US12560620B2/en active Active
- 2019-06-06 CN CN201980037837.4A patent/CN112236678B/zh active Active
- 2019-06-06 EP EP19728085.2A patent/EP3803417A1/en active Pending
-
2024
- 2024-04-01 JP JP2024058795A patent/JP2024091650A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017089474A1 (en) * | 2015-11-27 | 2017-06-01 | Brahms Gmbh | MR-proADM AS MARKER FOR THE EXTRACELLULAR VOLUME STATUS OF A SUBJECT |
| WO2018029214A1 (en) * | 2016-08-09 | 2018-02-15 | B.R.A.H.M.S Gmbh | Histones and/or proadm as markers indicating an adverse event |
Non-Patent Citations (2)
| Title |
|---|
| Biomarkers from distinct biological pathways improve early risk stratification in medical emergency patients: the multinational, prospective, observational TRIAGE study;Philipp Schuetz et al;《Critical Care》;第第19卷卷;第1-11页 * |
| Prediction about severity and out come of sepsis by proatrial natriuretic peptide and pro-adrenomedullin;wANGRuilan et al;《Chinese Journal of Traumatology 》;第第13卷卷(第第3期期);第152-157页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3803417A1 (en) | 2021-04-14 |
| WO2019234165A1 (en) | 2019-12-12 |
| US20210405070A1 (en) | 2021-12-30 |
| CN112236678A (zh) | 2021-01-15 |
| JP2021525879A (ja) | 2021-09-27 |
| EP3578989A1 (en) | 2019-12-11 |
| JP7548823B2 (ja) | 2024-09-10 |
| US12560620B2 (en) | 2026-02-24 |
| JP2024091650A (ja) | 2024-07-05 |
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| GR01 | Patent grant |