JP2024051122A - Composition for external use - Google Patents

Abstract

To provide a composition that suppresses ethanol-induced drying upon application to the skin, even if the ethanol content is relatively high, and delivers a good user experience.SOLUTION: Provided is a composition for external use, which contains (A) ethanol and (B) at least one selected from the group consisting of erythritol, sorbitol, and xylitol, with the content of ethanol (A) being 32 to 85 mass%.SELECTED DRAWING: Figure 1

Description

The present invention relates to a composition for external use. More specifically, the present invention relates to a composition for external use that is suitable for maintaining the cleanliness of the skin and protecting the skin.

Ethanol has a disinfecting effect against bacteria and viruses, and is used in hand sanitizers and other products. It is also sometimes added to cosmetics, where it has an astringent effect to tighten the skin, a cleansing effect to lift and remove sebum and dirt, and a cooling effect due to the heat dissipation that occurs when it evaporates.

However, in today's society where bacterial and viral infections have a major impact, it is expected that there will be an increasing need for cosmetic products that contain higher concentrations of ethanol.

Because ethanol is a volatile ingredient, it has a disinfecting effect, but when it evaporates it strips the skin of its oils and moisture, weakening the skin's barrier function and promoting the evaporation of moisture, making the skin prone to dryness.

In products that meet the above-mentioned social needs, in addition to containing high concentrations of ethanol, they are also likely to be used frequently, and it is assumed that problems such as dryness and rough skin caused by ethanol are likely to become apparent. Due to these characteristics of ethanol, Patent Document 1 indicates that it is difficult to provide cosmetics that contain a relatively large amount of ethanol and are suitable for people with dry or sensitive skin.

JP 2005-132750 A

Moisturizing agents such as glycerin are used to maintain moisture when applied to the skin and prevent or alleviate dryness. However, as shown in the comparative example below, it has been confirmed that in topical compositions containing a relatively large amount of ethanol, the glycerin makes the skin feel sticky, reducing the sensation of use.

Even for topical compositions that contain a relatively large amount of ethanol, there is a need for a formulation that suppresses drying caused by ethanol when applied to the skin and provides an excellent feel when used.

In order to solve the above problems, the inventors conducted extensive research and discovered that by adding a specific component (B) to a composition containing a relatively large amount of ethanol, the sensation of use when applied to the skin, etc., is excellent, leading to the completion of the present invention.

That is, the present invention provides the compositions described below.
[1]
(A) ethanol, and
(B) at least one selected from the group consisting of erythritol, sorbitol, and xylitol;
(A) A composition for external use having an ethanol content of 32 to 85% by mass.
[2]
The composition for external use described in [1], wherein the content of the (B) component is 0.01 to 0.5 parts by mass per 1 part by mass of the (A) ethanol.
[3]
The composition for external use according to [1] or [2] further contains (C) water in an amount of 10% by mass or more.
[4]
The composition for external use according to any one of [1] to [3], which is for disinfection.
[5]
The composition for external use according to any one of [1] to [3], which is for maintaining the cleanliness of the skin and/or for protecting the skin.
[6]
(B) A usability improving agent for an external composition containing 32 to 85% by mass of ethanol (A), characterized by containing at least one selected from the group consisting of erythritol, sorbitol, and xylitol.
[7]
(A) a composition for external use containing 32 to 85% by mass of ethanol,
(B) A method for improving the usability of a composition for external use, characterized by blending at least one selected from the group consisting of erythritol, sorbitol, and xylitol.

According to the present invention, it is possible to provide a topical composition that contains a relatively large amount of ethanol and yet has an excellent feel when applied to the skin.

FIG. 1 is a graph showing the evaluation results of the quick-drying property of the topical composition in Test Example 2.

[External Composition]
In one embodiment, the topical composition of the present invention contains (A) ethanol and (B) at least one selected from the group consisting of erythritol, sorbitol, and xylitol.

[Component (A)]
The topical composition of the present invention contains ethanol as component (A). Ethanol may be produced by alcohol fermentation from sugars such as glucose, or a commercially available product may be used.

In order to achieve the most pronounced effects of the present invention, the content of ethanol in the topical composition is 32 to 85% by mass relative to the total amount of the topical composition. By including a relatively large amount of ethanol, it is possible to maintain the cleanliness of the skin.

In addition, the ethanol content can be, without limitation, for example, 34% by mass or more, 36% by mass or more, 38% by mass or more, 40% by mass or more, 42% by mass or more, 44% by mass or more, 46% by mass or more, 48% by mass or more, 50% by mass or more, 52% by mass or more, 54% by mass or more, 56% by mass or more, 58% by mass or more, 60% by mass or more, 63% by mass or more, 65% by mass or more, 69% by mass or more, or 70% by mass or more, based on the total amount of the topical composition, from the viewpoint of significantly achieving the effects of the present invention.

In addition, the ethanol content can be, without limitation, for example, 84% by mass or less, 83% by mass or less, 82% by mass or less, 81% by mass or less, 80% by mass or less, 79% by mass or less, 78% by mass or less, 77% by mass or less, 76% by mass or less, 75% by mass or less, 74% by mass or less, 73% by mass or less, or 72% by mass or less, based on the total amount of the topical composition, from the viewpoint of significantly achieving the effects of the present invention.

In addition, the content of ethanol may be, for example, 34-84% by mass, 36-83% by mass, 38-82% by mass, 40-81% by mass, 42-80% by mass, 44-80% by mass, 46-80% by mass, 48-80% by mass, 50-80% by mass, 52-80% by mass, 54-80% by mass, 56-80% by mass, 58-80% by mass, 60-80% by mass, 63-78% by mass, 65-75% by mass, or 69-75% by mass relative to the total amount of the topical composition, from the viewpoint of significantly achieving the effects of the present invention, but is not limited thereto.

In another embodiment, from the viewpoint of use as a disinfectant for preventing bacterial or viral infections, the ethanol content is preferably 60 to 80% by mass, more preferably 63 to 78% by mass, even more preferably 65 to 75% by mass, and particularly preferably 69 to 75% by mass.

In another embodiment, the ethanol content in volume percent is as follows:
Although not limited, the ethanol content can be, for example, 50 volume% or more, 55 volume% or more, 60 volume% or more, 65 volume% or more, 70 volume% or more, or 75 volume% or more relative to the total volume of the topical composition, in order to prominently exhibit the effects of the present invention.

In addition, the ethanol content can be, but is not limited to, 95% by volume or less, 90% by volume or less, or 85% by volume or less of the total volume of the topical composition, from the viewpoint of significantly achieving the effects of the present invention.

In addition, the ethanol content can be, for example, 50-95 volume%, 55-90 volume%, 60-85 volume%, 65-85 volume%, 70-85 volume%, or 75-82 volume% of the total volume of the topical composition, from the viewpoint of significantly achieving the effects of the present invention, but is not limited thereto.

[Component (B)]
The topical composition of the present invention contains at least one selected from the group consisting of erythritol, sorbitol, and xylitol as component (B). Component (B) may be produced by hydrogenating (reducing) raw sugar, or a commercially available product may be used. From the viewpoint of significantly achieving the effects of the present invention, component (B) is preferably erythritol and/or sorbitol.

From the viewpoint of achieving a significant effect of the present invention, the content of component (B) is, for example, preferably 0.01 to 20% by mass, more preferably 0.05 to 15% by mass, even more preferably 0.1 to 10% by mass, particularly preferably 0.5 to 5% by mass, even more preferably 1 to 4% by mass, and most preferably 2 to 3% by mass, based on the total amount of the topical composition.

The blending ratio of the (B) component to the (A) component is not limited and may be changed as appropriate depending on the type and content of the (B) component, the form of the formulation, etc. From the viewpoint of achieving a significant effect of the present invention, for example, the content of the (B) component per 1 part by mass of the (A) ethanol content may be 0.01 to 0.5 parts by mass, preferably 0.01 to 0.4 parts by mass, more preferably 0.02 to 0.3 parts by mass, even more preferably 0.03 to 0.2 parts by mass, particularly preferably 0.04 to 0.1 parts by mass, and most preferably 0.04 to 0.08 parts by mass.

[(C) Water]
The topical composition of the present invention is not limited, but it is preferable that it contains water in order to prevent precipitation of component (B).
From the viewpoint of significantly achieving the effects of the present invention, the water content is, for example, preferably 5 to 65% by mass, more preferably 10 to 50% by mass, even more preferably 20 to 40% by mass, particularly preferably 20 to 30% by mass, and most preferably 22 to 28% by mass, relative to the total amount of the topical composition.

[Application]
The topical composition of the present invention contains, but is not limited to, a relatively large amount of ethanol, and is therefore expected to inhibit bacterial growth on the skin and/or attenuate viruses. In another embodiment, the topical composition of the present invention is applied to the skin to maintain the cleanliness of the skin.

In addition, when a relatively large amount of ethanol is contained, dryness and roughness of the skin can become a problem, but in the topical composition of the present invention, component (B) coexists with component (A), so it is possible to provide a moisturized feeling to the skin and suppress dryness caused by ethanol. Due to this action, by applying the topical composition of the present invention to the skin, it is possible to prevent the barrier function of the skin from being impaired and to protect the skin.

Specifically, the topical composition of the present invention can be used, for example, to sterilize and disinfect hands and skin, to disinfect and treat wounds and to prevent wounds from suppurating by sterilization, to sterilize and disinfect general wounds, abrasions and cuts, and to sterilize and disinfect wound surfaces. The topical composition of the present invention can also be used, for example, to moisturize the skin, to astringent the skin, and to improve the skin texture. In particular, the topical composition of the present invention is preferably used for at least one type selected from the group consisting of skin sterilization, disinfection, and moisturizing the skin.

In the case where the topical composition of the present invention is used as a cosmetic, it is required to have an excellent feeling of use when applied to the skin, although this is not limited thereto. In the topical composition of the present invention, since the component (B) coexists in addition to the component (A), the quick-drying property is improved when applied to the skin, and a more preferable smooth feeling can be obtained. In this specification, the smooth feeling refers to a surface shape of a certain substance that has a non-sticky feel, such as the feel of sand when powder such as sand flows. In addition, when a topical composition having a smooth feeling is applied, the kinetic friction force after application is reduced compared to before application. In addition, it is expected that the convenience during use is improved. In one embodiment, the feeling of use when the topical composition is applied to the skin preferably means, for example, suppressing drying of the skin due to ethanol, improving and improving quick-drying, and/or obtaining a smooth feeling, and more preferably means two or more of these three types at the same time, and particularly preferably means suppressing drying of the skin due to ethanol, improving and improving quick-drying, and obtaining a smooth feeling (meaning these three types at the same time).

Although not limited thereto, by adding 65% by mass or more of ethanol to the topical composition of the present invention, it becomes possible to use it for disinfection purposes. In the topical composition of the present invention, component (B) coexists in addition to component (A), so it is expected to dry quickly and have an enhanced disinfecting effect against bacteria and viruses. It is also expected to be more convenient to use.

The area to which the topical composition is applied is not particularly limited as long as it is an area where disinfecting effects and cleanliness are required, and examples include skin, hair, nails, etc. Among these, the area to which the topical composition is applied is preferably skin, more preferably the skin of the hands (palms and fingers), face, feet, scalp, neck, chest, armpits, and back, and particularly preferably the skin of the palms, fingers, and armpits.

[Dosage Form]
The composition for external use of the present invention can be used as a skin external preparation in the form of, but not limited to, a medicine, a quasi-drug, or a cosmetic. In the case of a skin external preparation, the composition can be mixed with a known base or carrier added to a skin external preparation (cosmetics, quasi-drug, or medicine) to form a composition, within a range that does not impair the effect of the present invention.

The topical composition of the present invention may be in the form of a known medicine, quasi-drug, or cosmetic, such as a liquid (particularly, an aerosol-type spray), suspension, emulsion, cream, ointment, gel, liniment, lotion, aerosol, powder, cataplasm, or sheet of nonwoven fabric or the like impregnated with a medicinal liquid. Of these, the composition is preferably used in the form of a liquid (particularly, an aerosol-type spray), suspension, emulsion, gel, or lotion.

Although not limited thereto, the topical composition of the present invention is preferably a spray formulation in the form of a mist type spray, from the viewpoint that the surface area of the droplets increases due to the atomization upon application, thereby enhancing the quick-drying property. Also, although not limited thereto, from the viewpoint of reducing the possibility of using an excessive amount upon application, it is preferable that the composition be a spray formulation in the form of a mist type spray.

Specific examples of the cosmetic formulations include skin lotions, milky lotions, creams, beauty essences, sunscreen cosmetics, and basic cosmetics such as body lotions.

Such topical compositions are preferably intended for people who are susceptible to the effects of containing relatively large amounts of ethanol, and more preferably are intended for babies, infants, children, people with weak skin, sensitive skin, dry skin, sensitive skin, and troubled skin.

[container]
The container for filling the topical composition of the present invention is not particularly limited, and may be used as a container for topical medicinal preparations, quasi-drugs, and cosmetics. Examples of such container materials include containers whose contact surface with the topical composition is made of at least one material selected from the group consisting of polyolefin resin, acrylic resin, polyester, polycarbonate, fluororesin, polyvinyl chloride, polyamide, ABS resin, AS resin, polyacetal, modified polyphenylene ether, polyarylate, polysulfone, polyimide, cellulose acetate, aluminum, and glass.

From the viewpoint of ease of handling of the formulation, the container material is preferably, for example, polyethylene (PE) (including high density polyethylene (HDPE), low density polyethylene (LDPE), very low density polyethylene, linear low density polyethylene (LLDPE), ultra-high molecular weight polyethylene, etc.), polypropylene (PP) (including isotactic polypropylene, syndiotactic polypropylene, atactic polypropylene, etc.), polyolefin resins such as ethylene-propylene copolymer, polymethylpentene, polybutene-1,1,2-polybutadiene, polyester resins such as polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, etc., with polyethylene, polypropylene, and polyethylene terephthalate being more preferred.

The topical composition of the present invention may contain various ingredients commonly used in the fields of medicines, quasi-drugs, or cosmetics, such as surfactants, moisturizers, vegetable oils, blood circulation promoters, thickeners, cooling agents, lubricants, preservatives, antioxidants, colorants, dispersants, chelating agents, pH adjusters, fragrances, antibacterial ingredients, anti-inflammatory ingredients, astringent ingredients, vitamins, peptides or derivatives thereof, amino acids or derivatives thereof, keratin softening ingredients, and cell activating ingredients, as necessary, within a quantitative and qualitative range that does not impair the effects of the present invention. These ingredients may be blended alone or in any combination of two or more. Furthermore, these ingredients may be mixed with a known base or carrier and blended into the topical composition. The topical composition of the present invention can be manufactured by mixing these ingredients according to a conventional method.

Examples of bases or carriers include hydrocarbons such as liquid paraffin, squalane, gelling hydrocarbons (such as Plastibase), ozokerite, α-olefin oligomers, and light liquid paraffin; methylpolysiloxane, crosslinked methylpolysiloxane, highly polymerized methylpolysiloxane, cyclic silicone, alkyl-modified silicone, crosslinked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, crosslinked polyether-modified silicone, crosslinked alkyl polyether-modified silicone, silicone/alkyl chain co-modified polyether-modified silicone, and silicone. Silicone oils such as glycerol-modified branched silicone, polyether-modified branched silicone, polyglycerol-modified branched silicone, acrylic silicone, phenyl-modified silicone, and silicone resin; butylene glycol adipate polyester; esters such as isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, and pentaerythritol tetra 2-ethylhexanoate; lauryl alcohol, myristyl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, Examples of the base include higher alcohols such as arachidyl alcohol, behenyl alcohol, and isostearyl alcohol; higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, and oleic acid; cellulose derivatives such as ethyl cellulose, hydroxypropyl cellulose, and hydroxypropyl methylcellulose; polyvinylpyrrolidone; carrageenan; polyvinyl butyrate; polyethylene glycol; dioxane; polysaccharides such as dextrin and maltodextrin; isopropanol; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, and dipropylene glycol monopropyl ether; and aqueous bases such as polyhydric alcohols such as polyethylene glycol, propylene glycol, 1,3-butylene glycol, and isoprene glycol.

The base or carrier may be used alone or in combination of two or more.

Examples of surfactants include sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monoisostearate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexyl acid, and diglycerol sorbitan tetra-2-ethylhexyl acid; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), and polyoxyethylene hydrogenated castor oil 80; polyoxyethylene (20) sorbitan monolaurate (polysorbate 20), monostearate, and the like. Examples of such surfactants include polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan phosphate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80), and polyoxyethylene (20) sorbitan isostearate; polyoxyethylene monococoate glyceryl; polyglyceryl monolaurate; glycerin alkyl ethers; alkyl glucosides; polyoxyalkylene alkyl ethers such as polyoxyethylene cetyl ether; amines such as stearylamine and oleylamine; silicone surfactants such as polyoxyethylene-methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and PEG-9 polydimethylsiloxyethyl dimethicone.

Examples of moisturizing agents include polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, polyethylene glycol, and diglycerin trehalose; polymeric compounds such as sodium hyaluronate, heparinoids, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, and chitosan; amino acids such as glycine, aspartic acid, and arginine; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidone carboxylate; lipids such as ceramide, cholesterol, and phospholipids; and plant extracts such as chamomile extract, witch hazel extract, tea extract, and perilla extract.

Examples of vegetable oils include avocado oil, linseed oil, camellia oil, peanut oil, macadamia nut oil, walnut oil, corn oil, olive oil, safflower oil, apricot kernel oil, cinnamon oil, jojoba oil, grape seed oil, sunflower oil, almond oil, camellia oil, rapeseed oil, sesame oil, castor oil, coconut oil, hardened coconut oil, palm oil, palm kernel oil, Japan wax kernel oil, Japan wax, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, evening primrose oil, kukui nut oil, hazelnut oil, orange oil, and chamomile oil.

Examples of blood circulation promoters include acetylcholine, ichthammol, caffeine, capsaicin, cantharides tincture, gamma oryzanol, rhododendron tincture, zingerone, cepharanthine, Swertia japonica extract, tannic acid, capsicum tincture, tolazoline, tocopherol nicotinate, and benzyl nicotinate.

Examples of thickening agents include guar gum, locust bean gum, carrageenan, xanthan gum, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydrophobized hydroxypropylmethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, acrylate/alkyl methacrylate copolymer, polyethylene glycol, bentonite, (hydroxyethyl acrylate/sodium acryloyldimethyltaurate) copolymer, (ammonium acryloyldimethyltaurate/vinylpyrrolidone) copolymer, etc.

Examples of cooling agents include menthol and its derivatives, terpenes such as camphor, borneol, geraniol, cineole, anethole, limonene, and eugenol (which may be in the d-, l-, or dl-form); and essential oils such as eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose oil, and turpentine.

Examples of lubricants include silica, talc, zinc oxide, magnesium oxide, titanium oxide, silicic anhydride, kaolin, sericite, hydroxyapatite, stearic acid, calcium stearate, magnesium stearate, boric acid, polyethylene glycol, etc.

Examples of preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, phenoxyethanol, and chlorobutanol.

Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, and L-cysteine hydrochloride.

Colorants include, for example, inorganic pigments, natural dyes, etc.

Examples of dispersants include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinylpyrrolidone, methyl vinyl ether/maleic anhydride crosslinked copolymer, organic acids, etc.

Examples of chelating agents include disodium EDTA, calcium disodium EDTA, phytic acid, gluconic acid, polyphosphoric acid, and metaphosphoric acid. Of these, sodium edetate is preferred.

Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.), and organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.).

Examples of antibacterial ingredients include chlorhexidine, salicylic acid, benzalkonium chloride, cetyltrimethylammonium bromide, acrinol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer No. 101, photosensitizer No. 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, piroctone olamine, and miconazole.

Examples of anti-inflammatory ingredients include allantoin and its derivatives (e.g., alcloxa, allantoin, etc.), calamine, tranexamic acid, glycyrrhizic acid or its derivatives or salts thereof (e.g., dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, etc.), glycyrrhetinic acid or its derivatives or salts thereof (e.g., glycyrrhetinic acid, stearyl glycyrrhetinate, etc.), zinc oxide, aminocaproic acid, azulene and its derivatives (e.g., guaiazulene, azulene, etc.), tocopherol acetate, pyridoxine hydrochloride, menthol, camphor, turpentine oil, indomethacin, salicylic acid or its derivatives, steroids or their derivatives or salts thereof (e.g., hydrocortisone, prednisolone), ufenamate, bufexamac, ibuprofen piconol, azelaic acid, and ingredients derived from plants (e.g., comfrey, coptis japonica, dokudami, chamomile, bilberry, rosa robur, emmeiso, etc.), etc.

Examples of astringent ingredients include metal salts such as alum, aluminum chloride, aluminum allantoin salt, zinc sulfocarbonate, basic aluminum zinc lactate, zinc oxide, zinc sulfate, and potassium aluminum sulfate; organic acids such as tannic acid, citric acid, lactic acid, and succinic acid; and ingredients derived from plants (e.g., seaweed, thyme, black tea, oolong tea, green tea, Hypericum perforatum, witch hazel, loquat, moutan tree, saxifrage, rooibos, astragalus, artichoke, chamomile, eucalyptus, lemon, rosemary, and burnet).

Examples of vitamins include vitamin E, such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, and dl-α-tocopherol calcium succinate; vitamin B2, such as riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, and riboflavin tetranicotinate; nicotinic acid, benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, and 1-(4-methyl-2-phenylpropionate) nicotinate. nicotinic acids such as nicotinamide and nicotinic acid ethyl; vitamin C such as ascorbic acid, ascorbigen A, ascorbyl stearate, ascorbyl palmitate, L-ascorbyl dipalmitate, 3-O-ethyl ascorbic acid, trisodium ascorbyl palmitate phosphate, sodium ascorbate, ascorbyl 2-glucoside, dehydroascorbic acid, sodium ascorbyl phosphate, and magnesium ascorbyl phosphate; vitamin D such as methylhesperidin, ergocalciferol, and cholecalciferol. vitamin K such as phylloquinone and farnoquinone, γ-oryzanol, dibenzoylthiamine, dibenzoylthiamine hydrochloride; vitamin B1 such as thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate ester, thiamine diphosphate ester, thiamine diphosphate ester hydrochloride, thiamine triphosphate ester, and thiamine triphosphate ester monophosphate; pyridoxine hydrochloride, pyridoxine acetate, and other vitamin B1 Vitamin B6 such as doxine, pyridoxal hydrochloride, 5'-pyridoxal phosphate, and pyridoxamine hydrochloride; vitamin B12 such as cyanocobalamin, hydroxocobalamin, and deoxyadenosylcobalamin; folic acids such as folic acid and pteroylglutamic acid; pantothenic acids such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-panthesine, D-pantethine, coenzyme A, and pantothenyl ethyl ether; biotins such as biotin and bioticin; and vitamin-like action factors such as carnitine, ferulic acid, α-lipoic acid, and orotic acid.

Examples of peptides or derivatives thereof include keratin hydrolyzed peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin hydrolyzed peptides, collagen hydrolyzed peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin hydrolyzed peptides, conchiolin hydrolyzed peptides, hydrolyzed conchiolin, silk proteolytic peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean proteolytic peptides, hydrolyzed soybean protein, wheat protein, wheat proteolytic peptides, hydrolyzed wheat protein, casein hydrolyzed peptides, acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.), etc.

Examples of amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine, etc.

Examples of keratin softening ingredients include lactic acid, salicylic acid, salicylic acid glycolic acid, gluconic acid, citric acid, malic acid, phytic acid, urea, sulfur, etc.

Examples of cell activation ingredients include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid, vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids, α-hydroxy acids such as glycolic acid and lactic acid, tannins, flavonoids, saponin, allantoin, and photosensitizer No. 301.

As for the fragrance, in addition to known fragrances, plant-derived or animal-derived essential oils can be used. In addition, ingredients that contain plant oils can also be used as fragrances because they give off a scent.

[(A) Usability improving agent in topical composition containing 32 to 85% by mass of ethanol]
In another embodiment, the present invention relates to a usability improving agent in an external composition containing 32 to 85% by mass of ethanol (A), characterized in that the composition contains at least one selected from the group consisting of erythritol, sorbitol, and xylitol (B).
The type and content of the (B) component, the blending ratio of the (A) component and the (B) component, the dosage form, applications, etc., are as described above in the [External Composition].

[Method for improving the feel of a topical composition]
In another embodiment, the present invention relates to a method for improving the usability of a topical composition, comprising blending (B) at least one selected from the group consisting of erythritol, sorbitol, and xylitol with (A) a topical composition containing 32 to 85% by mass of ethanol.
The type and content of the (B) component, the blending ratio of the (A) component and the (B) component, the dosage form, applications, etc., are as described above in the [External Composition].

[Production method]
The topical composition of the present invention can be prepared by dissolving each component while stirring at room temperature or by heating to 20 to 80°C. Any known stirring method can be used, and for example, a blade stirrer, a disperser, a homogenizer, or the like can be used. The topical composition of the present invention can be obtained by cooling the dissolved and homogenized mixture to room temperature.

[Embodiment]
The present invention is not limited to the above-described embodiment, but discloses the following embodiments.

(A) ethanol, and
(B) at least one selected from the group consisting of erythritol, sorbitol, and xylitol;
(A) A composition for external use having an ethanol content of 32 to 85% by mass.

(A) ethanol, and
(B) at least one selected from the group consisting of erythritol, sorbitol, and xylitol;
(A) A composition for external use having an ethanol content of 50 to 95% by volume.

The above topical composition, in which component (B) is erythritol and/or sorbitol.

The composition for external use described above, in which the content of component (B) is 0.01 to 20% by mass.

The composition for external use described above, in which the content of component (B) is 0.01 to 0.5 parts by mass per part by mass of ethanol (A).

The above topical composition further contains (C) water in an amount of 10% by mass or more.

(C) The above composition for external use, in which the water content is 10 to 50% by mass.

(C) The above composition for external use, in which the water content is 20 to 40% by mass.

The above topical composition for disinfection.

The above topical composition is for inhibiting bacterial growth on the skin.

The above-mentioned topical composition is for maintaining the cleanliness of the skin and/or for protecting the skin.

The above composition for external use is an aerosol spray.

(B) A usability improving agent for a topical composition containing 32 to 85% by mass of ethanol (A), characterized by containing at least one selected from the group consisting of erythritol, sorbitol, and xylitol.

(B) A usability improving agent for a topical composition containing 50 to 95% by volume of ethanol (A), characterized by containing at least one selected from the group consisting of erythritol, sorbitol, and xylitol.

(B) A method for improving the feel of a topical composition containing 32 to 85% by mass of ethanol (A), the composition containing at least one selected from the group consisting of erythritol, sorbitol-BR> and xylitol.

(B) A method for improving the feel of a topical composition (A) containing 50 to 95% by volume of ethanol, the composition containing at least one selected from the group consisting of erythritol, sorbitol, and xylitol.

The agent or method described above, wherein the component (B) is erythritol and/or sorbitol.

The agent or method described above, in which the content of component (B) is 0.01 to 20 mass %.

The agent or method described above, in which the content of component (B) is 0.01 to 0.5 parts by mass per part by mass of ethanol (A).

The above agent or method further contains (C) water in an amount of 10% by mass or more.

(C) The above agent or method, in which the water content is 10 to 50 mass %.

The agent or method described above is an aerosol spray agent.

Next, the present invention will be specifically described with reference to examples, but the present invention is not limited to the following examples. In addition, "%" shown in the examples indicates the mass % of the dry solid content or the actual components unless otherwise specified.

[Test Example 1: Evaluation of the usability of a topical composition by VAS test]
According to the recipe in Table 1, a topical composition was prepared by a conventional method. Using a 10 cm straight line marked with 0 (left end) and 100 (right end) in Table 2 or Table 3, the prepared topical composition was applied to the skin and the feeling of use (moisturizing feeling (suppression of drying by ethanol) (Table 2), smooth feeling (Table 3)) was evaluated by the VAS (Visual Analog Scale) method. Specifically, five expert panelists applied an appropriate amount (about 1 ml) of the prepared topical composition to their fingers and immediately rubbed it into their hands. After application, a VAS evaluation was entered regarding the feeling of use at the application site during the process of the formulation penetrating and evaporating. For the VAS evaluation, the length from the left end of the 10 cm line to the diagonal line position was measured for each question item, and the answer value was recorded. For example, in the case of the item of moisturizing feeling (suppression of drying by ethanol) (Table 2), "feeling moist as if wet (not feeling dry at all)" is 100, which is the best state, and "feeling dry as if rough skin (very dry)" is 0, which is the worst state. When both moisturizing feeling (suppression of drying by ethanol) (Table 2) and smooth feeling (Table 3) score 100, it is evaluated that the skin is moist as if wet, but the touch of the application site is smooth as sand. The external compositions were provided to the panelists without knowing the formulation, and after each external composition evaluation, the skin was washed and dried by hand, and care was taken to ensure that no residue was left on the application site at the time of the next evaluation. The average scores of the VAS evaluation results are shown in Table 4.

As shown in Table 4, in Reference Example 1-1, the ethanol content was low and the water content was high, so it was evaluated that there was almost no dryness felt. However, the wet feeling persisted due to the remaining moisture, so no dry feeling was obtained.

In addition, in Comparative Example 1-1, which had a high ethanol content, moisture was less likely to remain on the skin after the ethanol evaporated, so the skin felt smooth, but was less moisturized, and the skin felt dry due to the ethanol.

In Comparative Example 1-2, the effect of coexisting ethanol with glycerin, a polyhydric alcohol frequently used as a moisturizer, was evaluated. Although a moisturizing feeling was obtained from glycerin, the smooth feeling was significantly reduced and the skin was evaluated as feeling sticky.

In contrast to the above, Examples 1-1 to 1-4 demonstrated that a smooth feeling could be obtained in addition to a moist feeling. While providing a smooth feeling, the excessive drying caused by ethanol was not felt, and the results showed that a moderate moist feeling was obtained, which is a unique feeling when used with the topical composition of the present invention.

In Example 1-1, in comparison with Comparative Example 1-1, the moist feeling was improved, but the smooth feeling was not impaired, and high evaluation was obtained. In Example 1-2, which used erythritol as the (B) component, the smooth feeling was expected to be impaired in consideration of the results of Comparative Example 1-2, but surprisingly, both the moist feeling and the smooth feeling were improved. In Examples 1-3 and 1-4, xylitol and sorbitol, respectively, were used as the (B) component, and results were obtained in which both the moist feeling and the smooth feeling were improved, similar to the tendency in Example 1-2.

[Test Example 2-1: Evaluation of quick-drying properties of topical composition]
According to the formulation shown in Table 5, a composition for external use was prepared in a conventional manner to obtain a test solution.
About 3 g of each test liquid was added to a 7 cm diameter petri dish at 27°C and 50±5% RH, and the weight was measured at 1 minute, 5 minutes, and 10 minutes after the initial weight at the start of the measurement. This was done three times, and the average weight per time was plotted against time, and the slope of the straight line was determined using the linear approximation straight line creation function (least squares method) of Microsoft Office Excel. Since the test liquid evaporates over time and the weight decreases, this slope takes a negative value, and the test liquid that is more likely to evaporate (dry) has a larger absolute value. In addition, the r-squared value was 0.9980 or more for all straight lines, confirming that the linear approximation is appropriate. The results for each test liquid are shown in Figure 1.

In Comparative Example 2-1, which contained only ethanol, the slope of the linear approximation line was "-0.0281", but in Comparative Example 2-2, in which glycerin was added to the formulation of Comparative Example 2-1, the slope of the linear approximation line was "-0.0254", resulting in a significant decrease in quick-drying properties. On the other hand, it was confirmed that when ethanol and component (B) were added, the quick-drying properties were superior to those of Comparative Example 2-2. In particular, it was confirmed that Examples 2-1 and 2-2, which contained erythritol or sorbitol as component (B), were superior in quick-drying properties to Comparative Example 2-1, which contained only ethanol.

[Test Example 2-2: Evaluation of quick-drying properties of topical composition]
According to the formulations shown in Table 6, the external composition was prepared by a conventional method to obtain a test solution. The weight change over time due to evaporation of the test solution was examined by the same method as in Test Example 2-1, and the slope of the straight line obtained by the linear approximation straight line creation function (least squares method) was obtained. In addition, the r-squared value was 0.9950 or more for all straight lines, and it was confirmed that the linear approximation was appropriate. The results are also shown in Table 6.

In Comparative Examples 2-3 and 2-4, which contained only ethanol, the slopes of the linear approximation lines were -0.0249 and -0.0270, respectively. However, in Examples 2-4 to 2-7, which contained erythritol or sorbitol as component (B), the slopes increased at each ethanol concentration, confirming that the quick-drying properties improved.

In this way, the ability to reduce the feeling of dryness while increasing quick-drying properties is an effect that would normally be unexpected.

[Test Example 3: Evaluation of frictional force of topical composition]
According to the formulation described in Table 7, a topical composition was prepared by a conventional method to obtain a test solution. Then, the following friction test was performed at 27°C and RH 50±5%. That is, an artificial leather (Idemitsu Technofine Co., Ltd., product number: PBZ13001, black) with a length of 2 cm x width of 7 cm was placed on the moving stage of a BR>A static and dynamic friction measuring instrument (TL201Sa Trinity Lab), and the dynamic friction coefficient of the test site (a section 5 cm from the center of the horizontal direction of the artificial leather) was measured using a tactile contactor under the conditions of a load of 50 g and a moving speed of 2 mm/min. Then, 30 μL of the preparation was applied to the test site, and after leaving it for 2 minutes, the dynamic friction coefficient was measured in the same manner. Then, the change rate of the dynamic friction coefficient of the artificial leather after applying the topical composition and leaving it for 2 minutes relative to the dynamic friction coefficient of the artificial leather before applying the topical composition was calculated. The results are also shown in Table 7.

Compared to Comparative Example 3-1, which contained only ethanol, Example 3-1, which contained ethanol and component (B), showed a lower dynamic friction coefficient and improved smoothness.

The formulation examples are shown below. All contents in the formulation examples are in mass %.

Claims (1)

(A) ethanol, and
(B) at least one selected from the group consisting of erythritol, sorbitol, and xylitol;
(A) A composition for external use having an ethanol content of 32 to 85% by mass.