JP2023553094A - 中枢神経系障害の治療のためのセロトニン作動性薬としての３位環－アミンインドール誘導体 - Google Patents
中枢神経系障害の治療のためのセロトニン作動性薬としての３位環－アミンインドール誘導体 Download PDFInfo
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- JP2023553094A JP2023553094A JP2023534880A JP2023534880A JP2023553094A JP 2023553094 A JP2023553094 A JP 2023553094A JP 2023534880 A JP2023534880 A JP 2023534880A JP 2023534880 A JP2023534880 A JP 2023534880A JP 2023553094 A JP2023553094 A JP 2023553094A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063122181P | 2020-12-07 | 2020-12-07 | |
| US63/122,181 | 2020-12-07 | ||
| PCT/CA2021/051755 WO2022120475A1 (en) | 2020-12-07 | 2021-12-07 | 3-cyclic amine-indole derivatives as serotonergic agents for the treatment of cns disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023553094A true JP2023553094A (ja) | 2023-12-20 |
| JP2023553094A5 JP2023553094A5 (https=) | 2024-12-06 |
Family
ID=81973031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023534880A Pending JP2023553094A (ja) | 2020-12-07 | 2021-12-07 | 中枢神経系障害の治療のためのセロトニン作動性薬としての３位環－アミンインドール誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240051978A1 (https=) |
| EP (1) | EP4255913A4 (https=) |
| JP (1) | JP2023553094A (https=) |
| KR (1) | KR20230117597A (https=) |
| CN (1) | CN116917305A (https=) |
| AU (1) | AU2021394129A1 (https=) |
| CA (1) | CA3201080A1 (https=) |
| IL (1) | IL303467A (https=) |
| MX (1) | MX2023006652A (https=) |
| WO (1) | WO2022120475A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3519816A4 (en) | 2016-09-29 | 2020-05-06 | The Regents of the University of California | CONNECTIONS FOR INCREASING NEURONAL PLASTICITY |
| KR102946120B1 (ko) | 2019-02-27 | 2026-03-30 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 뇌 장애를 치료하기 위한 아제피노-인돌 및 다른 헤테로사이클 |
| US20240286998A1 (en) * | 2021-06-02 | 2024-08-29 | Saint Joseph's University | Fluorinated tryptamine compounds, analogues thereof, and methods using same |
| IL313455A (en) | 2021-12-15 | 2024-08-01 | Delix Therapeutics Inc | Phenoxy and benzyloxy modified psychroplastogens and their uses |
| WO2023114472A1 (en) * | 2021-12-16 | 2023-06-22 | Icahn School Of Medicine At Mount Sinai | Heterocyclic compounds as 5ht2a biased agonists |
| WO2023168023A1 (en) | 2022-03-04 | 2023-09-07 | Reset Pharmaceuticals, Inc. | Co-crystals or salts comprising psilocin |
| US20250325516A1 (en) * | 2022-07-08 | 2025-10-23 | Institut Curie | Serotonin analogues for use in treating metalloptosis-associated disorders |
| US12396981B2 (en) | 2023-03-09 | 2025-08-26 | William Shulman | Methods of using DMT |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5789402A (en) * | 1995-01-17 | 1998-08-04 | Eli Lilly Company | Compounds having effects on serotonin-related systems |
| US5846982A (en) * | 1996-06-14 | 1998-12-08 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| JP2002514642A (ja) * | 1998-05-13 | 2002-05-21 | エリー リリー アンド カンパニー リミテッド | ５−ｈｔ２ａリガンドとしての、及びセロトニン再取り込み抑制剤としてのインドール誘導体 |
| JP2002542241A (ja) * | 1999-04-21 | 2002-12-10 | アレリックス バイオファーマスーティカルス インコーポレーテッド | ５−ｈｔ６親和性を有するピペリジン−インドール化合物 |
| WO2004069828A1 (ja) * | 2003-02-04 | 2004-08-19 | Mitsubishi Pharma Corporation | ピペリジン化合物およびその医薬用途 |
| WO2005066157A1 (en) * | 2004-01-02 | 2005-07-21 | Suven Life Sciences | 3-(pyrolidin-3-l) indoles as 5-ht6 receptor modulators |
| JP2010519171A (ja) * | 2006-02-17 | 2010-06-03 | メモリー・ファーマシューティカルズ・コーポレイション | ５−ｈｔ６受容体親和性を有する化合物 |
| WO2011019738A1 (en) * | 2009-08-10 | 2011-02-17 | Galenea Corporation | Compounds and methods of use thereof |
| WO2022094719A1 (en) * | 2020-11-06 | 2022-05-12 | Pacific Myco Biosciences Ltd. | A method of treating depression by immune modulation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6133287A (en) * | 1998-03-24 | 2000-10-17 | Allelix Biopharmaceuticals Inc. | Piperidine-indole compounds having 5-HT6 affinity |
-
2021
- 2021-12-07 JP JP2023534880A patent/JP2023553094A/ja active Pending
- 2021-12-07 CN CN202180092982.XA patent/CN116917305A/zh active Pending
- 2021-12-07 US US18/265,286 patent/US20240051978A1/en active Pending
- 2021-12-07 WO PCT/CA2021/051755 patent/WO2022120475A1/en not_active Ceased
- 2021-12-07 CA CA3201080A patent/CA3201080A1/en active Pending
- 2021-12-07 KR KR1020237023111A patent/KR20230117597A/ko active Pending
- 2021-12-07 EP EP21901751.4A patent/EP4255913A4/en active Pending
- 2021-12-07 IL IL303467A patent/IL303467A/en unknown
- 2021-12-07 AU AU2021394129A patent/AU2021394129A1/en active Pending
- 2021-12-07 MX MX2023006652A patent/MX2023006652A/es unknown
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5789402A (en) * | 1995-01-17 | 1998-08-04 | Eli Lilly Company | Compounds having effects on serotonin-related systems |
| US5846982A (en) * | 1996-06-14 | 1998-12-08 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| JP2000512296A (ja) * | 1996-06-14 | 2000-09-19 | イーライ・リリー・アンド・カンパニー | セロトニン再取込み阻害 |
| JP2002514642A (ja) * | 1998-05-13 | 2002-05-21 | エリー リリー アンド カンパニー リミテッド | ５−ｈｔ２ａリガンドとしての、及びセロトニン再取り込み抑制剤としてのインドール誘導体 |
| JP2002542241A (ja) * | 1999-04-21 | 2002-12-10 | アレリックス バイオファーマスーティカルス インコーポレーテッド | ５−ｈｔ６親和性を有するピペリジン−インドール化合物 |
| WO2004069828A1 (ja) * | 2003-02-04 | 2004-08-19 | Mitsubishi Pharma Corporation | ピペリジン化合物およびその医薬用途 |
| WO2005066157A1 (en) * | 2004-01-02 | 2005-07-21 | Suven Life Sciences | 3-(pyrolidin-3-l) indoles as 5-ht6 receptor modulators |
| JP2010519171A (ja) * | 2006-02-17 | 2010-06-03 | メモリー・ファーマシューティカルズ・コーポレイション | ５−ｈｔ６受容体親和性を有する化合物 |
| WO2011019738A1 (en) * | 2009-08-10 | 2011-02-17 | Galenea Corporation | Compounds and methods of use thereof |
| WO2022094719A1 (en) * | 2020-11-06 | 2022-05-12 | Pacific Myco Biosciences Ltd. | A method of treating depression by immune modulation |
Non-Patent Citations (4)
| Title |
|---|
| EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 22(1), JPN6025039599, 1987, pages 33 - 43, ISSN: 0005697599 * |
| HALBERSTADT, ADAM L. ET AL.: "Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administ", PSYCHOPHARMACOLOGY, vol. 221, no. 4, JPN6025015715, 2012, pages 709 - 718, ISSN: 0005697601 * |
| JOURNAL OF MEDICINAL CHEMISTRY, vol. 42(20), JPN6025039598, 1999, pages 4257 - 4263, ISSN: 0005697598 * |
| REGISTRY（STN）[ONLINE]、2017.08.08[検索日 2025.08.27], JPN6025039600, 2017, ISSN: 0005697600 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3201080A1 (en) | 2022-06-16 |
| WO2022120475A1 (en) | 2022-06-16 |
| AU2021394129A1 (en) | 2023-07-20 |
| MX2023006652A (es) | 2023-09-21 |
| KR20230117597A (ko) | 2023-08-08 |
| EP4255913A4 (en) | 2024-11-06 |
| US20240051978A1 (en) | 2024-02-15 |
| IL303467A (en) | 2023-08-01 |
| CN116917305A (zh) | 2023-10-20 |
| EP4255913A1 (en) | 2023-10-11 |
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