JP2023550466A5 - - Google Patents
Info
- Publication number
- JP2023550466A5 JP2023550466A5 JP2023530598A JP2023530598A JP2023550466A5 JP 2023550466 A5 JP2023550466 A5 JP 2023550466A5 JP 2023530598 A JP2023530598 A JP 2023530598A JP 2023530598 A JP2023530598 A JP 2023530598A JP 2023550466 A5 JP2023550466 A5 JP 2023550466A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- amino
- carboxamide
- quinoline
- dihydrofl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063117937P | 2020-11-24 | 2020-11-24 | |
| US63/117,937 | 2020-11-24 | ||
| PCT/US2021/060332 WO2022115377A1 (en) | 2020-11-24 | 2021-11-22 | Tricyclic carboxamide derivatives as prmt5 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023550466A JP2023550466A (ja) | 2023-12-01 |
| JP2023550466A5 true JP2023550466A5 (https=) | 2024-11-08 |
Family
ID=78957958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023530598A Pending JP2023550466A (ja) | 2020-11-24 | 2021-11-22 | Ｐｒｍｔ５阻害剤としての三環式カルボキサミド誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20240101570A1 (https=) |
| EP (1) | EP4251624B1 (https=) |
| JP (1) | JP2023550466A (https=) |
| KR (1) | KR20230113339A (https=) |
| CN (1) | CN116783191A (https=) |
| AU (1) | AU2021386149A1 (https=) |
| CA (1) | CA3202141A1 (https=) |
| CL (1) | CL2023001461A1 (https=) |
| CO (1) | CO2023007504A2 (https=) |
| CR (1) | CR20230286A (https=) |
| ES (1) | ES3058979T3 (https=) |
| IL (1) | IL302820B1 (https=) |
| JO (1) | JOP20230113A1 (https=) |
| MX (1) | MX2023006145A (https=) |
| PE (1) | PE20231312A1 (https=) |
| SA (1) | SA523440916B1 (https=) |
| WO (1) | WO2022115377A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11077101B1 (en) | 2018-07-18 | 2021-08-03 | Tango Therapeutics, Inc. | Compounds and methods of use |
| US12403137B2 (en) | 2019-10-28 | 2025-09-02 | Tango Therapeutics, Inc. | Compounds and methods of use |
| WO2022026892A1 (en) | 2020-07-31 | 2022-02-03 | Tango Therapeutics, Inc. | Piperidin-1- yl-n-pyrydi ne-3-yl-2-oxoacet am ide derivatives useful for the treatment of mtap-deficient and/or mt a-accumulating cancers |
| CN116462676A (zh) * | 2022-01-20 | 2023-07-21 | 上海和誉生物医药科技有限公司 | 一种多稠环prmt5抑制剂及其制备方法和应用 |
| CN116462677A (zh) * | 2022-01-20 | 2023-07-21 | 上海和誉生物医药科技有限公司 | 一种多稠环prmt5抑制剂及其制备方法和应用 |
| US12552760B2 (en) * | 2022-04-22 | 2026-02-17 | The Board Of Trustees Of The University Of Illinois | Compounds for increasing the nicotinamide adenine dinucleotide in a subject and methods of use thereof |
| WO2023246873A1 (zh) * | 2022-06-23 | 2023-12-28 | 南京明德新药研发有限公司 | 氨基取代的杂芳基衍生物及其应用 |
| EP4549440A4 (en) * | 2022-07-01 | 2026-04-22 | Cytosinlab Therapeutics Co Ltd | CLASS OF PRMT5 INHIBITORS AND THEIR USES |
| CN117362304A (zh) * | 2022-07-07 | 2024-01-09 | 深圳微芯生物科技股份有限公司 | 一种甲酰胺取代的杂三环类衍生物、其制备方法及其应用 |
| KR20250004026A (ko) * | 2022-07-15 | 2025-01-07 | 아비스코 테라퓨틱스 컴퍼니 리미티드 | Prmt5 억제제, 그 제조 방법과 약학에서의 응용 |
| KR20250002472A (ko) * | 2022-08-03 | 2025-01-07 | 아비스코 테라퓨틱스 컴퍼니 리미티드 | 질소 함유 삼중 축합고리 prmt5 억제제 및 이의 제조 방법 및 약학적 용도 |
| WO2024032572A1 (zh) * | 2022-08-09 | 2024-02-15 | 上海湃隆生物科技有限公司 | 新型prmt5抑制剂及其应用 |
| AU2023327684A1 (en) | 2022-08-15 | 2025-03-20 | Astrazeneca Ab | Mta-cooperative prmt5 inhibitors for use in the treatment of cancer |
| CN118613482B (zh) * | 2022-09-26 | 2025-09-30 | 上海湃隆生物科技有限公司 | 新型prmt5抑制剂及其应用 |
| AU2023409398A1 (en) * | 2022-12-22 | 2025-06-05 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| CN120418246A (zh) * | 2022-12-23 | 2025-08-01 | 成都微芯药业有限公司 | 一类含炔基取代的杂环酰胺衍生物、其制备方法及其应用 |
| CN118103373A (zh) * | 2023-01-18 | 2024-05-28 | 上海德琪医药科技有限公司 | Prmt5抑制化合物和其用途 |
| WO2024170488A1 (en) | 2023-02-13 | 2024-08-22 | Astrazeneca Ab | Prmt5 inhibitor for use in cancer therapy |
| TW202438054A (zh) * | 2023-03-30 | 2024-10-01 | 瑞士商百濟神州瑞士有限責任公司 | 作為ＭＴＡ－協同ＰＲＭＴ５抑制劑的５－胺基－６，８－二氫－１Ｈ－呋喃并［３，４－ｄ］吡咯并［３，２－ｂ］吡啶－２－甲醯胺衍生物 |
| CR20250446A (es) * | 2023-04-21 | 2025-12-02 | Gilead Sciences Inc | Inhibidores de prmt5 y usos de los mismos |
| WO2024234821A1 (zh) * | 2023-05-17 | 2024-11-21 | 四川科伦博泰生物医药股份有限公司 | 三并环酰胺化合物、包含其的药物组合物及其制备方法和用途 |
| AU2024275020A1 (en) * | 2023-05-24 | 2025-11-13 | Ryvu Therapeutics S.A. | Prmt5 inhibitors |
| TW202513565A (zh) * | 2023-06-02 | 2025-04-01 | 香港商英矽智能科技知識產權有限公司 | Prmt5抑制劑及其用途 |
| WO2025016323A1 (zh) | 2023-07-14 | 2025-01-23 | 江苏亚虹医药科技股份有限公司 | 蛋白质精氨酸酶甲基转移酶-5抑制剂及其医药用途 |
| WO2025026381A1 (zh) * | 2023-08-02 | 2025-02-06 | 成都微芯药业有限公司 | 杂环炔基取代的酰胺衍生物、其制备方法及其应用 |
| TW202521525A (zh) | 2023-08-09 | 2025-06-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 雜芳基化合物、其製備方法及其在醫藥上的應用 |
| WO2025039979A1 (zh) | 2023-08-18 | 2025-02-27 | 江苏亚虹医药科技股份有限公司 | 蛋白质精氨酸酶甲基转移酶-5抑制剂及其医药用途 |
| US11858935B1 (en) | 2023-09-06 | 2024-01-02 | King Faisal University | Pyrrolo[2,3-c][1,7]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors |
| US11891394B1 (en) | 2023-09-06 | 2024-02-06 | King Faisal University | Pyrrolo[2,3-c][1,6]naphthyridine-8-carboxylic acid compounds as CK2 inhibitors |
| WO2025113705A1 (zh) * | 2023-12-01 | 2025-06-05 | 上海翰森生物医药科技有限公司 | N-取代酰胺类衍生物抑制剂、其制备方法和应用 |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025166260A1 (en) * | 2024-02-02 | 2025-08-07 | Ideaya Biosciences, Inc. | Amide substituted tricyclic guanidino compounds as prmt5 inhibitors |
| WO2025166257A1 (en) * | 2024-02-02 | 2025-08-07 | Ideaya Biosciences, Inc. | Amide substituted triheterocyclic guanidino compounds as prmt5 inhibitors |
| WO2025180517A1 (zh) * | 2024-03-01 | 2025-09-04 | 武汉人福创新药物研发中心有限公司 | 含sf5类喹啉衍生物及其作为p2x7拮抗剂的用途 |
| WO2025218671A1 (en) * | 2024-04-16 | 2025-10-23 | Shanghai Apeiron Therapeutics Company Limited | Novel prmt5 proteolysis targeting chimeric molecules and associated methods of use |
| CN119552151B (zh) * | 2025-01-24 | 2025-05-02 | 赛岚(杭州)生物医药科技有限公司 | Prmt5抑制剂及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201604022D0 (en) * | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| JP7091336B2 (ja) * | 2016-12-22 | 2022-06-27 | グローバル ブラッド セラピューティクス インコーポレイテッド | ヒストンメチルトランスフェラーゼ阻害剤 |
| PT3704120T (pt) * | 2017-11-24 | 2024-07-03 | Jubilant Episcribe Llc | Compostos heterocíclicos como inibidores de prmt5 |
| PE20210160A1 (es) * | 2018-04-25 | 2021-01-26 | Innate Tumor Immunity Inc | Moduladores de nlrp3 |
-
2021
- 2021-11-22 WO PCT/US2021/060332 patent/WO2022115377A1/en not_active Ceased
- 2021-11-22 AU AU2021386149A patent/AU2021386149A1/en active Pending
- 2021-11-22 KR KR1020237021023A patent/KR20230113339A/ko active Pending
- 2021-11-22 US US18/255,575 patent/US20240101570A1/en active Pending
- 2021-11-22 EP EP21827727.5A patent/EP4251624B1/en active Active
- 2021-11-22 CR CR20230286A patent/CR20230286A/es unknown
- 2021-11-22 JP JP2023530598A patent/JP2023550466A/ja active Pending
- 2021-11-22 ES ES21827727T patent/ES3058979T3/es active Active
- 2021-11-22 CA CA3202141A patent/CA3202141A1/en active Pending
- 2021-11-22 CN CN202180091440.0A patent/CN116783191A/zh active Pending
- 2021-11-22 PE PE2023001721A patent/PE20231312A1/es unknown
- 2021-11-22 MX MX2023006145A patent/MX2023006145A/es unknown
-
2023
- 2023-05-10 IL IL302820A patent/IL302820B1/en unknown
- 2023-05-22 CL CL2023001461A patent/CL2023001461A1/es unknown
- 2023-05-23 JO JOJO/P/2023/0113A patent/JOP20230113A1/ar unknown
- 2023-05-24 SA SA523440916A patent/SA523440916B1/ar unknown
- 2023-06-06 CO CONC2023/0007504A patent/CO2023007504A2/es unknown
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