JP2023546597A5 - - Google Patents
Info
- Publication number
- JP2023546597A5 JP2023546597A5 JP2023524355A JP2023524355A JP2023546597A5 JP 2023546597 A5 JP2023546597 A5 JP 2023546597A5 JP 2023524355 A JP2023524355 A JP 2023524355A JP 2023524355 A JP2023524355 A JP 2023524355A JP 2023546597 A5 JP2023546597 A5 JP 2023546597A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- reverse transcriptase
- sequence
- binding
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063094803P | 2020-10-21 | 2020-10-21 | |
| US63/094,803 | 2020-10-21 | ||
| US202163222550P | 2021-07-16 | 2021-07-16 | |
| US63/222,550 | 2021-07-16 | ||
| PCT/US2021/056006 WO2022087235A1 (en) | 2020-10-21 | 2021-10-21 | Systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023546597A JP2023546597A (ja) | 2023-11-06 |
| JP2023546597A5 true JP2023546597A5 (enExample) | 2024-10-15 |
Family
ID=78821040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023524355A Pending JP2023546597A (ja) | 2020-10-21 | 2021-10-21 | 部位特異的標的化エレメントによるプログラム可能な付加（ｐａｓｔｅ）を使用した部位特異的遺伝子操作のためのシステム、方法及び組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (7) | US20220145293A1 (enExample) |
| EP (1) | EP4232583A1 (enExample) |
| JP (1) | JP2023546597A (enExample) |
| KR (1) | KR20230091894A (enExample) |
| CN (1) | CN116419975A (enExample) |
| AU (2) | AU2021364781B2 (enExample) |
| CA (1) | CA3196116A1 (enExample) |
| IL (1) | IL301368A (enExample) |
| MX (1) | MX2023004383A (enExample) |
| WO (1) | WO2022087235A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| CN114258398A (zh) | 2019-06-13 | 2022-03-29 | 总医院公司 | 工程化的人内源性病毒样颗粒及使用其递送至细胞的方法 |
| KR20220097875A (ko) | 2019-09-03 | 2022-07-08 | 마이얼로이드 테라퓨틱스, 인크. | 게놈 통합을 위한 방법 및 조성물 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN116670154A (zh) | 2020-07-24 | 2023-08-29 | 总医院公司 | 增强的病毒样颗粒及使用其递送至细胞的方法 |
| AU2021364781B2 (en) | 2020-10-21 | 2025-10-09 | Massachusetts Institute Of Technology | Systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste) |
| GB202113933D0 (en) * | 2021-09-29 | 2021-11-10 | Genome Res Ltd | Methods for gene editing |
| WO2023076898A1 (en) * | 2021-10-25 | 2023-05-04 | The Broad Institute, Inc. | Methods and compositions for editing a genome with prime editing and a recombinase |
| WO2023077148A1 (en) * | 2021-11-01 | 2023-05-04 | Tome Biosciences, Inc. | Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo |
| US20230287441A1 (en) * | 2021-12-17 | 2023-09-14 | Massachusetts Institute Of Technology | Programmable insertion approaches via reverse transcriptase recruitment |
| EP4452335A1 (en) | 2021-12-22 | 2024-10-30 | Tome Biosciences, Inc. | Co-delivery of a gene editor construct and a donor template |
| EP4493706A4 (en) * | 2022-03-14 | 2026-03-18 | Univ California | INTEGRATION OF LARGE NUCLEIC ACIDS INTO GENOMES |
| WO2023205744A1 (en) * | 2022-04-20 | 2023-10-26 | Tome Biosciences, Inc. | Programmable gene insertion compositions |
| EP4511486A1 (en) | 2022-04-20 | 2025-02-26 | Massachusetts Institute Of Technology | Site specific genetic engineering utilizing trans-template rnas |
| WO2023205710A1 (en) | 2022-04-20 | 2023-10-26 | Massachusetts Institute Of Technology | Programmable gene editing using guide rna pair |
| WO2023215831A1 (en) * | 2022-05-04 | 2023-11-09 | Tome Biosciences, Inc. | Guide rna compositions for programmable gene insertion |
| WO2023225670A2 (en) * | 2022-05-20 | 2023-11-23 | Tome Biosciences, Inc. | Ex vivo programmable gene insertion |
| CN120344660A (zh) | 2022-07-18 | 2025-07-18 | 雷纳嘉德医疗管理公司 | 基因编辑组分、系统和使用方法 |
| WO2024020587A2 (en) * | 2022-07-22 | 2024-01-25 | Tome Biosciences, Inc. | Pleiopluripotent stem cell programmable gene insertion |
| EP4615960A1 (en) | 2022-11-09 | 2025-09-17 | C3S2 GmbH | Methods for manufacturing engineered immune cells |
| CN116004586B (zh) * | 2022-12-01 | 2025-08-26 | 上海药明生物医药有限公司 | 通过优化提高Bxb1酶的重组效率的方法 |
| WO2024138194A1 (en) | 2022-12-22 | 2024-06-27 | Tome Biosciences, Inc. | Platforms, compositions, and methods for in vivo programmable gene insertion |
| IL321929A (en) * | 2023-01-05 | 2025-09-01 | Prime Medicine Inc | Genome editors and methods of use |
| WO2024168147A2 (en) * | 2023-02-09 | 2024-08-15 | The Broad Institute, Inc. | Evolved recombinases for editing a genome in combination with prime editing |
| CN118546903A (zh) * | 2023-02-24 | 2024-08-27 | 尧唐(上海)生物科技有限公司 | 能介导大片段dna整合到哺乳动物基因组的酶及其应用 |
| WO2024220407A2 (en) * | 2023-04-17 | 2024-10-24 | Massachusetts Institute Of Technology | Systems, methods, and compositions for cystic fibrosis gene editing |
| WO2024234006A1 (en) | 2023-05-11 | 2024-11-14 | Tome Biosciences, Inc. | Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs) |
| WO2024238595A2 (en) * | 2023-05-16 | 2024-11-21 | Sarepta Therapeutics, Inc. | Fusion proteins comprising cas enzymes and dna-binding proteins |
| MX2025013657A (es) * | 2023-05-16 | 2026-02-03 | Prime Medicine Inc | Composiciones y métodos de uso de edición del genoma con el gen b2m como objetivo |
| EP4731757A2 (en) | 2023-06-26 | 2026-04-29 | University of Hawaii | Evolved integrases and methods of using the same for genome editing |
| WO2025049959A2 (en) | 2023-09-01 | 2025-03-06 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025050069A1 (en) | 2023-09-01 | 2025-03-06 | Tome Biosciences, Inc. | Programmable gene insertion using engineered integration enzymes |
| WO2025117544A1 (en) | 2023-11-29 | 2025-06-05 | The Broad Institute, Inc. | Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025147545A1 (en) | 2024-01-03 | 2025-07-10 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids and related methods and uses |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
| CN117720672B (zh) * | 2024-02-07 | 2024-04-30 | 深锐(天津)生物医学有限公司 | 先导编辑系统及其应用 |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025193915A1 (en) | 2024-03-14 | 2025-09-18 | Massachusetts Institute Of Technology | High efficiency integrases for gene editing |
| EP4677108A1 (en) | 2024-04-22 | 2026-01-14 | Basecamp Research Ltd | Method and compositions for detecting off-target editing |
| WO2025226730A1 (en) * | 2024-04-22 | 2025-10-30 | Transit Therapeutics, Inc. | Revision of genetic material using direct replacement editing |
| WO2025224182A2 (en) | 2024-04-23 | 2025-10-30 | Basecamp Research Ltd | Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo |
| EP4703469A1 (en) | 2024-08-26 | 2026-03-04 | Charité - Universitätsmedizin Berlin Körperschaft des öffentlichen Rechts | Fusion proteins, methods and compositions for efficient serine integrase-mediated gene transfer in human cells |
| WO2026046974A1 (en) | 2024-08-26 | 2026-03-05 | Charité - Universitätsmedizin Berlin Körperschaft des öffentlichen Rechts | Fusion proteins, methods and compositions for efficient serine integrase-mediated gene transfer in human cells |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8889394B2 (en) | 2009-09-07 | 2014-11-18 | Empire Technology Development Llc | Multiple domain proteins |
| LT3401400T (lt) | 2012-05-25 | 2019-06-10 | The Regents Of The University Of California | Būdai ir kompozicijos, skirtos rnr molekulės nukreipiamai tikslinės dnr modifikacijai ir rnr molekulės nukreipiamam transkripcijos moduliavimui |
| EP2931898B1 (en) | 2012-12-12 | 2016-03-09 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| SG10201912991WA (en) | 2012-12-17 | 2020-03-30 | Harvard College | Rna-guided human genome engineering |
| SG11201507378UA (en) | 2013-03-14 | 2015-10-29 | Caribou Biosciences Inc | Compositions and methods of nucleic acid-targeting nucleic acids |
| US20140349400A1 (en) * | 2013-03-15 | 2014-11-27 | Massachusetts Institute Of Technology | Programmable Modification of DNA |
| US10563225B2 (en) | 2013-07-26 | 2020-02-18 | President And Fellows Of Harvard College | Genome engineering |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9388430B2 (en) * | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| JP2017518082A (ja) | 2014-06-17 | 2017-07-06 | ポセイダ セラピューティクス， インコーポレイテッド | ゲノム中の特異的遺伝子座にタンパク質を指向させるための方法およびその使用 |
| US10059940B2 (en) | 2015-01-27 | 2018-08-28 | Minghong Zhong | Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents |
| WO2016205728A1 (en) | 2015-06-17 | 2016-12-22 | Massachusetts Institute Of Technology | Crispr mediated recording of cellular events |
| WO2017151719A1 (en) | 2016-03-01 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Molecular cell diary system |
| EP3443088B1 (en) | 2016-04-13 | 2024-09-18 | Editas Medicine, Inc. | Grna fusion molecules, gene editing systems, and methods of use thereof |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| WO2018049168A1 (en) | 2016-09-09 | 2018-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | High-throughput precision genome editing |
| CN110291434B (zh) | 2016-09-12 | 2021-11-05 | 麦斯卓有限公司 | Mems致动系统和方法 |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| US11649442B2 (en) | 2017-09-08 | 2023-05-16 | The Regents Of The University Of California | RNA-guided endonuclease fusion polypeptides and methods of use thereof |
| CN111801417B (zh) | 2017-12-14 | 2024-10-29 | 克里斯珀医疗股份公司 | 新的rna-可编程的内切核酸酶系统及其在基因组编辑和其他应用中的用途 |
| CN113286880A (zh) | 2018-08-28 | 2021-08-20 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| EP3942043A2 (en) * | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US10837021B1 (en) | 2019-06-06 | 2020-11-17 | Inscripta, Inc. | Curing for recursive nucleic acid-guided cell editing |
| KR20220097875A (ko) | 2019-09-03 | 2022-07-08 | 마이얼로이드 테라퓨틱스, 인크. | 게놈 통합을 위한 방법 및 조성물 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| EP4085141A4 (en) * | 2019-12-30 | 2024-03-06 | The Broad Institute, Inc. | GENOME EDITING USING REVERSE TRANSCRIPTASE FOR FULLY ACTIVE CRISPR COMPLEXES |
| AU2021236683A1 (en) | 2020-03-19 | 2022-11-17 | Intellia Therapeutics, Inc. | Methods and compositions for directed genome editing |
| BR112022022603A2 (pt) | 2020-05-08 | 2023-01-17 | Broad Inst Inc | Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla |
| WO2022060749A1 (en) * | 2020-09-15 | 2022-03-24 | Inscripta, Inc. | Crispr editing to embed nucleic acid landing pads into genomes of live cells |
| JP2023543803A (ja) | 2020-09-24 | 2023-10-18 | ザ ブロード インスティテュート，インコーポレーテッド | プライム編集ガイドｒｎａ、その組成物、及びその使用方法 |
| AU2021364781B2 (en) | 2020-10-21 | 2025-10-09 | Massachusetts Institute Of Technology | Systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste) |
| EP4240840A4 (en) | 2020-11-05 | 2025-01-01 | University of Washington | PRECISE GENOME DELETION AND REPLACEMENT METHOD BASED ON PRIMARY EDITING |
-
2021
- 2021-10-21 AU AU2021364781A patent/AU2021364781B2/en active Active
- 2021-10-21 KR KR1020237013187A patent/KR20230091894A/ko active Pending
- 2021-10-21 WO PCT/US2021/056006 patent/WO2022087235A1/en not_active Ceased
- 2021-10-21 IL IL301368A patent/IL301368A/en unknown
- 2021-10-21 JP JP2023524355A patent/JP2023546597A/ja active Pending
- 2021-10-21 MX MX2023004383A patent/MX2023004383A/es unknown
- 2021-10-21 CN CN202180072013.8A patent/CN116419975A/zh active Pending
- 2021-10-21 CA CA3196116A patent/CA3196116A1/en active Pending
- 2021-10-21 EP EP21819624.4A patent/EP4232583A1/en active Pending
- 2021-10-21 US US17/451,734 patent/US20220145293A1/en not_active Abandoned
-
2022
- 2022-01-28 US US17/649,308 patent/US11572556B2/en active Active
- 2022-12-14 US US18/066,233 patent/US11834658B2/en active Active
- 2022-12-14 US US18/066,223 patent/US11827881B2/en active Active
-
2023
- 2023-10-16 US US18/487,610 patent/US12195733B2/en active Active
- 2023-10-16 US US18/487,744 patent/US11952571B2/en active Active
-
2024
- 2024-11-27 US US18/962,390 patent/US20250092390A1/en active Pending
-
2025
- 2025-12-24 AU AU2025287334A patent/AU2025287334B2/en active Active
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