JP2023546205A - コンジュゲートｔｌｒ７およびｎｏｄ２アゴニスト - Google Patents

コンジュゲートｔｌｒ７およびｎｏｄ２アゴニスト Download PDF

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Publication number
JP2023546205A
JP2023546205A JP2023524121A JP2023524121A JP2023546205A JP 2023546205 A JP2023546205 A JP 2023546205A JP 2023524121 A JP2023524121 A JP 2023524121A JP 2023524121 A JP2023524121 A JP 2023524121A JP 2023546205 A JP2023546205 A JP 2023546205A
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Japan
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alkyl
alkoxy
mmol
compound
cycloalkyl
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JP2023524121A
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English (en)
Japanese (ja)
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JP2023546205A5 (enExample
Inventor
ジャコピン ジーガ
グゼリ サモ
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University of Ljubljana
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University of Ljubljana
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Application filed by University of Ljubljana filed Critical University of Ljubljana
Publication of JP2023546205A publication Critical patent/JP2023546205A/ja
Publication of JP2023546205A5 publication Critical patent/JP2023546205A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2023524121A 2020-10-21 2021-10-20 コンジュゲートｔｌｒ７およびｎｏｄ２アゴニスト Pending JP2023546205A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
LULU102145 2020-10-21
LU102145 2020-10-21
PCT/EP2021/079141 WO2022084417A1 (en) 2020-10-21 2021-10-20 Conjugated tlr7 and nod2 agonists

Publications (2)

Publication Number Publication Date
JP2023546205A true JP2023546205A (ja) 2023-11-01
JP2023546205A5 JP2023546205A5 (enExample) 2024-09-06

Family

ID=74175904

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023524121A Pending JP2023546205A (ja) 2020-10-21 2021-10-20 コンジュゲートｔｌｒ７およびｎｏｄ２アゴニスト

Country Status (7)

Country Link
US (1) US20230382886A1 (enExample)
EP (1) EP4232094A1 (enExample)
JP (1) JP2023546205A (enExample)
CN (1) CN116600830A (enExample)
AU (1) AU2021363606A1 (enExample)
CA (1) CA3196221A1 (enExample)
WO (1) WO2022084417A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024102639A1 (en) * 2022-11-08 2024-05-16 The Scripps Research Institute N-arylpyrazole nod2 agonists as promoters of immune checkpoint inhibitor therapy
WO2025040743A1 (en) * 2023-08-22 2025-02-27 Univerza V Ljubljani Conjugated tlr7 and rig-i agonists

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010518082A (ja) * 2007-02-07 2010-05-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 合成ｔｌｒアゴニストの結合体およびそのための使用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200702235A1 (ru) 2005-05-04 2008-04-28 Пфайзер Лимитед Производные 2-амидо-6-амино-8-оксопурина в качестве модуляторов toll-подобных рецепторов для лечения рака и вирусных инфекций, таких как гепатит с
CA2620182A1 (en) 2005-08-22 2007-03-01 Dennis A. Carson Tlr agonists
JP2009542645A (ja) 2006-07-05 2009-12-03 アストラゼネカ・アクチエボラーグ Ｔｌｒ７のモジュレーターとして作用する８−オキソアデニン誘導体
CN102176911B (zh) 2008-08-11 2014-12-10 葛兰素史密丝克莱恩有限责任公司 新的腺嘌呤衍生物
KR20110117705A (ko) 2009-02-11 2011-10-27 더 리전트 오브 더 유니버시티 오브 캘리포니아 톨-유사 수용체 조정제 및 질병의 치료
EP2563404B1 (en) 2010-04-30 2016-09-21 Urogen Pharma Ltd. Phospholipid drug analogs
WO2012038058A1 (en) 2010-09-21 2012-03-29 Telormedix Sa Treatment of conditions by toll-like receptor modulators
US10471139B2 (en) * 2013-08-15 2019-11-12 The University Of Kansas Toll-like receptor agonists
SI3507276T1 (sl) * 2016-09-02 2022-01-31 Gilead Sciences, Inc. Spojine modulatorja toličnih receptorjev
US10508115B2 (en) 2017-08-16 2019-12-17 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
US10457681B2 (en) 2017-08-16 2019-10-29 Bristol_Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
US10472361B2 (en) 2017-08-16 2019-11-12 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor
WO2019197598A1 (en) 2018-04-13 2019-10-17 Glaxosmithkline Biologicals Sa Tlr7 and / or tlr8 agonists
WO2019209811A1 (en) 2018-04-24 2019-10-31 Bristol-Myers Squibb Company Macrocyclic toll-like receptor 7 (tlr7) agonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010518082A (ja) * 2007-02-07 2010-05-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 合成ｔｌｒアゴニストの結合体およびそのための使用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EBIOMEDICINE, vol. 58, JPN6025031834, 30 July 2020 (2020-07-30), pages 102922, ISSN: 0005847105 *
J． MED. CHEM., vol. 61, JPN6025031835, 2018, pages 2707 - 2724, ISSN: 0005847106 *

Also Published As

Publication number Publication date
EP4232094A1 (en) 2023-08-30
CA3196221A1 (en) 2022-04-28
US20230382886A1 (en) 2023-11-30
AU2021363606A9 (en) 2025-01-09
AU2021363606A1 (en) 2023-06-01
WO2022084417A1 (en) 2022-04-28
CN116600830A (zh) 2023-08-15

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