CN116600830A - 缀合的tlr7和nod2激动剂 - Google Patents
缀合的tlr7和nod2激动剂 Download PDFInfo
- Publication number
- CN116600830A CN116600830A CN202180085916.XA CN202180085916A CN116600830A CN 116600830 A CN116600830 A CN 116600830A CN 202180085916 A CN202180085916 A CN 202180085916A CN 116600830 A CN116600830 A CN 116600830A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- compound
- alkoxy
- cycloalkyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LULU102145 | 2020-10-21 | ||
| LU102145 | 2020-10-21 | ||
| PCT/EP2021/079141 WO2022084417A1 (en) | 2020-10-21 | 2021-10-20 | Conjugated tlr7 and nod2 agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116600830A true CN116600830A (zh) | 2023-08-15 |
Family
ID=74175904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180085916.XA Pending CN116600830A (zh) | 2020-10-21 | 2021-10-20 | 缀合的tlr7和nod2激动剂 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230382886A1 (enExample) |
| EP (1) | EP4232094A1 (enExample) |
| JP (1) | JP2023546205A (enExample) |
| CN (1) | CN116600830A (enExample) |
| AU (1) | AU2021363606A1 (enExample) |
| CA (1) | CA3196221A1 (enExample) |
| WO (1) | WO2022084417A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024102639A1 (en) * | 2022-11-08 | 2024-05-16 | The Scripps Research Institute | N-arylpyrazole nod2 agonists as promoters of immune checkpoint inhibitor therapy |
| WO2025040743A1 (en) * | 2023-08-22 | 2025-02-27 | Univerza V Ljubljani | Conjugated tlr7 and rig-i agonists |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160166681A1 (en) * | 2013-08-15 | 2016-06-16 | Sunil Abraham David | Toll-like receptor agonists |
| US20180065938A1 (en) * | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200702235A1 (ru) | 2005-05-04 | 2008-04-28 | Пфайзер Лимитед | Производные 2-амидо-6-амино-8-оксопурина в качестве модуляторов toll-подобных рецепторов для лечения рака и вирусных инфекций, таких как гепатит с |
| CA2620182A1 (en) | 2005-08-22 | 2007-03-01 | Dennis A. Carson | Tlr agonists |
| JP2009542645A (ja) | 2006-07-05 | 2009-12-03 | アストラゼネカ・アクチエボラーグ | Ｔｌｒ７のモジュレーターとして作用する８−オキソアデニン誘導体 |
| EP2510946B1 (en) * | 2007-02-07 | 2015-08-05 | The Regents of The University of California | Conjugates of synthetic tlr agonists and uses therefor |
| CN102176911B (zh) | 2008-08-11 | 2014-12-10 | 葛兰素史密丝克莱恩有限责任公司 | 新的腺嘌呤衍生物 |
| KR20110117705A (ko) | 2009-02-11 | 2011-10-27 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 톨-유사 수용체 조정제 및 질병의 치료 |
| EP2563404B1 (en) | 2010-04-30 | 2016-09-21 | Urogen Pharma Ltd. | Phospholipid drug analogs |
| WO2012038058A1 (en) | 2010-09-21 | 2012-03-29 | Telormedix Sa | Treatment of conditions by toll-like receptor modulators |
| US10508115B2 (en) | 2017-08-16 | 2019-12-17 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor |
| US10457681B2 (en) | 2017-08-16 | 2019-10-29 | Bristol_Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor |
| US10472361B2 (en) | 2017-08-16 | 2019-11-12 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor |
| WO2019197598A1 (en) | 2018-04-13 | 2019-10-17 | Glaxosmithkline Biologicals Sa | Tlr7 and / or tlr8 agonists |
| WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
-
2021
- 2021-10-20 EP EP21791419.1A patent/EP4232094A1/en active Pending
- 2021-10-20 WO PCT/EP2021/079141 patent/WO2022084417A1/en not_active Ceased
- 2021-10-20 CA CA3196221A patent/CA3196221A1/en active Pending
- 2021-10-20 CN CN202180085916.XA patent/CN116600830A/zh active Pending
- 2021-10-20 AU AU2021363606A patent/AU2021363606A1/en active Pending
- 2021-10-20 US US18/032,612 patent/US20230382886A1/en active Pending
- 2021-10-20 JP JP2023524121A patent/JP2023546205A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160166681A1 (en) * | 2013-08-15 | 2016-06-16 | Sunil Abraham David | Toll-like receptor agonists |
| US20180065938A1 (en) * | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
Non-Patent Citations (3)
| Title |
|---|
| ALICE GUTJAHR ET AL.: "New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses", 《EBIOMEDICINE. 》, vol. 58, 30 July 2020 (2020-07-30), pages 5 * |
| GEOFFROY P.P. GENTIAL: "Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》, vol. 29, no. 11, 1 June 2019 (2019-06-01), pages 1 * |
| MARTINA GOBEC: "Discovery of Nanomolar Desmuramylpeptide Agonists of the Innate Immune Receptor Nucleotide-Binding Oligomerization Domain-Containing Protein 2 (NOD2) Possessing Immunostimulatory Properties", 《J MED CHEM.》, vol. 61, no. 7, 12 April 2018 (2018-04-12), pages 9 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4232094A1 (en) | 2023-08-30 |
| CA3196221A1 (en) | 2022-04-28 |
| JP2023546205A (ja) | 2023-11-01 |
| US20230382886A1 (en) | 2023-11-30 |
| AU2021363606A9 (en) | 2025-01-09 |
| AU2021363606A1 (en) | 2023-06-01 |
| WO2022084417A1 (en) | 2022-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |