JP2023543005A - 疼痛を処置するための化合物及び方法 - Google Patents

疼痛を処置するための化合物及び方法 Download PDF

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Publication number
JP2023543005A
JP2023543005A JP2023519051A JP2023519051A JP2023543005A JP 2023543005 A JP2023543005 A JP 2023543005A JP 2023519051 A JP2023519051 A JP 2023519051A JP 2023519051 A JP2023519051 A JP 2023519051A JP 2023543005 A JP2023543005 A JP 2023543005A
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Japan
Prior art keywords
amino acid
seq
pain
subject
acid sequence
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JP2023519051A
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English (en)
Japanese (ja)
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JP2023543005A5 (cg-RX-API-DMAC10.html
Inventor
ウェルシュ，フレイザー
チェッセル，タラニ
タン，キース
オステンフェルド，ソー
ジェンキンス，リチャード
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MedImmune Ltd
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MedImmune Ltd
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Publication date
Application filed by MedImmune Ltd filed Critical MedImmune Ltd
Publication of JP2023543005A publication Critical patent/JP2023543005A/ja
Publication of JP2023543005A5 publication Critical patent/JP2023543005A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2023519051A 2020-09-28 2021-09-27 疼痛を処置するための化合物及び方法 Pending JP2023543005A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063084358P 2020-09-28 2020-09-28
US63/084,358 2020-09-28
PCT/EP2021/076524 WO2022064043A1 (en) 2020-09-28 2021-09-27 Compounds and methods for treating pain

Publications (2)

Publication Number Publication Date
JP2023543005A true JP2023543005A (ja) 2023-10-12
JP2023543005A5 JP2023543005A5 (cg-RX-API-DMAC10.html) 2024-10-04

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Family Applications (1)

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JP2023519051A Pending JP2023543005A (ja) 2020-09-28 2021-09-27 疼痛を処置するための化合物及び方法

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US (1) US20240026036A1 (cg-RX-API-DMAC10.html)
EP (1) EP4217388A1 (cg-RX-API-DMAC10.html)
JP (1) JP2023543005A (cg-RX-API-DMAC10.html)
KR (1) KR20230084199A (cg-RX-API-DMAC10.html)
CN (1) CN117279942A (cg-RX-API-DMAC10.html)
AU (1) AU2021350424A1 (cg-RX-API-DMAC10.html)
BR (1) BR112023004840A2 (cg-RX-API-DMAC10.html)
CA (1) CA3195380A1 (cg-RX-API-DMAC10.html)
IL (1) IL301548A (cg-RX-API-DMAC10.html)
TW (1) TW202228768A (cg-RX-API-DMAC10.html)
WO (1) WO2022064043A1 (cg-RX-API-DMAC10.html)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013507928A (ja) * 2009-10-15 2013-03-07 アボット・ラボラトリーズ 二重可変ドメイン免疫グロブリンおよびその使用
JP2017509323A (ja) * 2014-02-02 2017-04-06 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ＮＧＦアンタゴニストドメインおよびＴＮＦαアンタゴニストドメインから構成されるキメラタンパク質

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681718A (en) 1986-03-14 1997-10-28 Celltech Limited Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
KR20100132559A (ko) 2001-05-30 2010-12-17 제넨테크, 인크. 다양한 질환의 치료에 유용한 항-엔지에프 항체
GB0216648D0 (en) 2002-07-18 2002-08-28 Lonza Biologics Plc Method of expressing recombinant protein in CHO cells
WO2004032870A2 (en) 2002-10-08 2004-04-22 Rinat Neuroscience Corp. Methods for treating post-surgical pain by admisnistering a nerve growth factor antagonist and compositions containing the same
EP1725585A2 (en) 2004-03-10 2006-11-29 Lonza Ltd Method for producing antibodies
US20080312425A1 (en) 2004-08-30 2008-12-18 Lonza Biologics Plc. Ion Exchange Chromatography and Purification of Antibodies
JP5096167B2 (ja) 2005-01-24 2012-12-12 メドイミューン リミテッド Ｎｇｆに対する特異的結合メンバー
US7691980B2 (en) 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
PL2187964T3 (pl) 2007-08-10 2015-03-31 Regeneron Pharma Ludzkie przeciwciała o wysokim powinowactwie przeciw ludzkiemu czynnikowi wzrostu nerwu
US8093364B2 (en) 2008-01-18 2012-01-10 Bio-Rad Laboratories, Inc. Enhanced purification of antibodies and antibody fragments by apatite chromatography
CN103906533A (zh) 2011-11-07 2014-07-02 米迪缪尼有限公司 多特异性和多价结合蛋白及其用途
FI3863647T3 (fi) * 2018-10-10 2024-03-01 Paradigm Biopharmaceuticals Ltd Pahanlaatuisen luustokivun hoitaminen pentosaanipolysulfaatilla

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013507928A (ja) * 2009-10-15 2013-03-07 アボット・ラボラトリーズ 二重可変ドメイン免疫グロブリンおよびその使用
JP2017509323A (ja) * 2014-02-02 2017-04-06 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ＮＧＦアンタゴニストドメインおよびＴＮＦαアンタゴニストドメインから構成されるキメラタンパク質

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CLIN. ORTHOP. RELAT. RES., vol. 474, JPN6025034875, 2016, pages 1886 - 1893, ISSN: 0005822400 *
JOURNAL OF INFLAMMATION RESEARCH, vol. 2, JPN6025034876, 2009, pages 29 - 36, ISSN: 0005822399 *
SEMINARS IN ARTHRITIS AND RHEUMATISM, vol. 46, JPN6025034877, 2017, pages 687 - 691, ISSN: 0005822398 *

Also Published As

Publication number Publication date
AU2021350424A1 (en) 2023-06-01
CA3195380A1 (en) 2022-03-31
CN117279942A (zh) 2023-12-22
BR112023004840A2 (pt) 2023-04-18
KR20230084199A (ko) 2023-06-12
EP4217388A1 (en) 2023-08-02
AU2021350424A9 (en) 2025-01-16
TW202228768A (zh) 2022-08-01
US20240026036A1 (en) 2024-01-25
WO2022064043A1 (en) 2022-03-31
IL301548A (en) 2023-05-01

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