TW202228768A - 用於治療疼痛之化合物及方法 - Google Patents

用於治療疼痛之化合物及方法 Download PDF

Info

Publication number
TW202228768A
TW202228768A TW110136070A TW110136070A TW202228768A TW 202228768 A TW202228768 A TW 202228768A TW 110136070 A TW110136070 A TW 110136070A TW 110136070 A TW110136070 A TW 110136070A TW 202228768 A TW202228768 A TW 202228768A
Authority
TW
Taiwan
Prior art keywords
amino acid
gly
cys
seq
pain
Prior art date
Application number
TW110136070A
Other languages
English (en)
Chinese (zh)
Inventor
里查 詹金斯
佛拉瑟 威爾旭
薩拉尼 雀瑟爾
凱特 譚
索爾 奧斯騰費爾德
Original Assignee
英商梅迪繆思有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 英商梅迪繆思有限公司 filed Critical 英商梅迪繆思有限公司
Publication of TW202228768A publication Critical patent/TW202228768A/zh

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW110136070A 2020-09-28 2021-09-28 用於治療疼痛之化合物及方法 TW202228768A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063084358P 2020-09-28 2020-09-28
US63/084,358 2020-09-28

Publications (1)

Publication Number Publication Date
TW202228768A true TW202228768A (zh) 2022-08-01

Family

ID=78085879

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110136070A TW202228768A (zh) 2020-09-28 2021-09-28 用於治療疼痛之化合物及方法

Country Status (11)

Country Link
US (1) US20240026036A1 (cg-RX-API-DMAC10.html)
EP (1) EP4217388A1 (cg-RX-API-DMAC10.html)
JP (1) JP2023543005A (cg-RX-API-DMAC10.html)
KR (1) KR20230084199A (cg-RX-API-DMAC10.html)
CN (1) CN117279942A (cg-RX-API-DMAC10.html)
AU (1) AU2021350424A1 (cg-RX-API-DMAC10.html)
BR (1) BR112023004840A2 (cg-RX-API-DMAC10.html)
CA (1) CA3195380A1 (cg-RX-API-DMAC10.html)
IL (1) IL301548A (cg-RX-API-DMAC10.html)
TW (1) TW202228768A (cg-RX-API-DMAC10.html)
WO (1) WO2022064043A1 (cg-RX-API-DMAC10.html)

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681718A (en) 1986-03-14 1997-10-28 Celltech Limited Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
KR20100132559A (ko) 2001-05-30 2010-12-17 제넨테크, 인크. 다양한 질환의 치료에 유용한 항-엔지에프 항체
GB0216648D0 (en) 2002-07-18 2002-08-28 Lonza Biologics Plc Method of expressing recombinant protein in CHO cells
WO2004032870A2 (en) 2002-10-08 2004-04-22 Rinat Neuroscience Corp. Methods for treating post-surgical pain by admisnistering a nerve growth factor antagonist and compositions containing the same
EP1725585A2 (en) 2004-03-10 2006-11-29 Lonza Ltd Method for producing antibodies
US20080312425A1 (en) 2004-08-30 2008-12-18 Lonza Biologics Plc. Ion Exchange Chromatography and Purification of Antibodies
JP5096167B2 (ja) 2005-01-24 2012-12-12 メドイミューン リミテッド Ｎｇｆに対する特異的結合メンバー
US7691980B2 (en) 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
PL2187964T3 (pl) 2007-08-10 2015-03-31 Regeneron Pharma Ludzkie przeciwciała o wysokim powinowactwie przeciw ludzkiemu czynnikowi wzrostu nerwu
US8093364B2 (en) 2008-01-18 2012-01-10 Bio-Rad Laboratories, Inc. Enhanced purification of antibodies and antibody fragments by apatite chromatography
AR078651A1 (es) * 2009-10-15 2011-11-23 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
CN103906533A (zh) 2011-11-07 2014-07-02 米迪缪尼有限公司 多特异性和多价结合蛋白及其用途
CA2938066C (en) * 2014-02-02 2025-05-06 Medimmune Limited CHIMERIC PROTEIN COMPOSED OF NERVE GROWTH FACTOR ANTAGONIST DOMAIN AND TUMOR NECROSIS FACTOR-ANTAGONIST DOMAIN-A
FI3863647T3 (fi) * 2018-10-10 2024-03-01 Paradigm Biopharmaceuticals Ltd Pahanlaatuisen luustokivun hoitaminen pentosaanipolysulfaatilla

Also Published As

Publication number Publication date
AU2021350424A1 (en) 2023-06-01
CA3195380A1 (en) 2022-03-31
CN117279942A (zh) 2023-12-22
BR112023004840A2 (pt) 2023-04-18
KR20230084199A (ko) 2023-06-12
EP4217388A1 (en) 2023-08-02
AU2021350424A9 (en) 2025-01-16
US20240026036A1 (en) 2024-01-25
WO2022064043A1 (en) 2022-03-31
IL301548A (en) 2023-05-01
JP2023543005A (ja) 2023-10-12

Similar Documents

Publication Publication Date Title
JP7520070B2 (ja) ＮＧＦアンタゴニストドメインおよびＴＮＦαアンタゴニストドメインから構成されるキメラタンパク質
JP6392471B2 (ja) 片頭痛の治療または予防法
US8999343B2 (en) Antibodies that bind myostatin, compositions and methods
US20210009671A1 (en) Compounds and methods for treating pain
US20240026036A1 (en) Compounds and methods for treating pain
RU2788122C2 (ru) Химерный белок, составленный из домена антагониста NGF и домена антагониста TNFα
HK40028980A (en) Chimeric protein composed of ngf antagonist domain and a tnfa antagonist domain
HK1231905A1 (en) Chimeric protein composed of ngf antagonist domain and a tnfa antagonist domain