JP2023542985A - メラノコルチン－４受容体経路関連障害の治療方法 - Google Patents

メラノコルチン－４受容体経路関連障害の治療方法 Download PDF

Info

Publication number
JP2023542985A
JP2023542985A JP2023518779A JP2023518779A JP2023542985A JP 2023542985 A JP2023542985 A JP 2023542985A JP 2023518779 A JP2023518779 A JP 2023518779A JP 2023518779 A JP2023518779 A JP 2023518779A JP 2023542985 A JP2023542985 A JP 2023542985A
Authority
JP
Japan
Prior art keywords
arg
cys
ala
phe
trp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023518779A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023542985A5 (https=
JPWO2022067086A5 (https=
Inventor
デル プルーフ， レオナルドゥス エイチ．ティー． ファン
アラステア ガーフィールド，
バビック ピー． シャー，
Original Assignee
リズム ファーマシューティカルズ， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by リズム ファーマシューティカルズ， インコーポレイテッド filed Critical リズム ファーマシューティカルズ， インコーポレイテッド
Publication of JP2023542985A publication Critical patent/JP2023542985A/ja
Publication of JP2023542985A5 publication Critical patent/JP2023542985A5/ja
Publication of JPWO2022067086A5 publication Critical patent/JPWO2022067086A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
JP2023518779A 2020-09-24 2021-09-24 メラノコルチン－４受容体経路関連障害の治療方法 Pending JP2023542985A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063082867P 2020-09-24 2020-09-24
US63/082,867 2020-09-24
PCT/US2021/052032 WO2022067086A1 (en) 2020-09-24 2021-09-24 Methods of treating melanocortin-4 receptor pathway-associated disorders

Publications (3)

Publication Number Publication Date
JP2023542985A true JP2023542985A (ja) 2023-10-12
JP2023542985A5 JP2023542985A5 (https=) 2024-10-02
JPWO2022067086A5 JPWO2022067086A5 (https=) 2024-10-02

Family

ID=80845850

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023518779A Pending JP2023542985A (ja) 2020-09-24 2021-09-24 メラノコルチン－４受容体経路関連障害の治療方法

Country Status (13)

Country Link
US (1) US20240058414A1 (https=)
EP (1) EP4216979A4 (https=)
JP (1) JP2023542985A (https=)
KR (1) KR20230095956A (https=)
CN (1) CN116507353A (https=)
AR (1) AR123603A1 (https=)
AU (1) AU2021350017A1 (https=)
CA (1) CA3192873A1 (https=)
CL (1) CL2023000823A1 (https=)
CO (1) CO2022009561A2 (https=)
MX (1) MX2023003360A (https=)
TW (1) TW202228760A (https=)
WO (1) WO2022067086A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2023308310A1 (en) * 2022-07-12 2025-01-16 Rhythm Pharmaceuticals, Inc. Methods for treating obesity with an mc4r agonist
EP4618952A2 (en) * 2022-11-18 2025-09-24 Rhythm Pharmaceuticals, Inc. Methods for treating obesity with an mc4r agonist
WO2025106751A1 (en) * 2023-11-14 2025-05-22 Rhythm Pharmaceuticals, Inc. Combinations of a potassium channel activator and an mc4r agonist and related methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016516719A (ja) * 2013-03-15 2016-06-09 リズム・ファーマシューティカルズ・インコーポレイテッド ペプチド組成物
JP2018531937A (ja) * 2015-09-30 2018-11-01 リズム ファーマシューティカルズ， インコーポレイテッド メラノコルチン４受容体経路関連障害を治療する方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2286825T3 (pl) * 2005-07-08 2017-06-30 Ipsen Pharma Ligandy receptora melanokortyny

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016516719A (ja) * 2013-03-15 2016-06-09 リズム・ファーマシューティカルズ・インコーポレイテッド ペプチド組成物
JP2018531937A (ja) * 2015-09-30 2018-11-01 リズム ファーマシューティカルズ， インコーポレイテッド メラノコルチン４受容体経路関連障害を治療する方法

Also Published As

Publication number Publication date
CL2023000823A1 (es) 2023-09-15
AU2021350017A1 (en) 2023-05-04
AU2021350017A9 (en) 2024-10-03
MX2023003360A (es) 2023-06-23
US20240058414A1 (en) 2024-02-22
EP4216979A1 (en) 2023-08-02
WO2022067086A1 (en) 2022-03-31
CN116507353A (zh) 2023-07-28
EP4216979A4 (en) 2024-11-06
AR123603A1 (es) 2022-12-21
CO2022009561A2 (es) 2022-07-19
CA3192873A1 (en) 2022-03-31
KR20230095956A (ko) 2023-06-29
TW202228760A (zh) 2022-08-01

Similar Documents

Publication Publication Date Title
JP7752373B2 (ja) メラノコルチン４受容体経路関連障害を治療する方法
JP2023542985A (ja) メラノコルチン－４受容体経路関連障害の治療方法
US10167312B2 (en) Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers
JP2025523017A (ja) Ｍｃ４ｒアゴニストにより肥満を治療する方法
RU2785889C1 (ru) Способ лечения нарушений, ассоциированных с путем рецептора меланокортина 4
HK40077660A (en) Melanocortin-4 receptor agonists for the treatment of disorders characterised by pomc gene hypermethylation
HK40073416A (en) Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240924

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240924

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250918

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20251216

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260318