CA3192873A1 - Methods of treating melanocortin-4 receptor pathway-associated disorders - Google Patents

Methods of treating melanocortin-4 receptor pathway-associated disorders

Info

Publication number
CA3192873A1
CA3192873A1 CA3192873A CA3192873A CA3192873A1 CA 3192873 A1 CA3192873 A1 CA 3192873A1 CA 3192873 A CA3192873 A CA 3192873A CA 3192873 A CA3192873 A CA 3192873A CA 3192873 A1 CA3192873 A1 CA 3192873A1
Authority
CA
Canada
Prior art keywords
arg
cys
seq
phe
trp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3192873A
Other languages
English (en)
French (fr)
Inventor
Leonardus H.T. Van Der Ploeg
Alastair GARFIELD
Bhavik P. SHAH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhythm Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA3192873A1 publication Critical patent/CA3192873A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
CA3192873A 2020-09-24 2021-09-24 Methods of treating melanocortin-4 receptor pathway-associated disorders Pending CA3192873A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063082867P 2020-09-24 2020-09-24
US63/082,867 2020-09-24
PCT/US2021/052032 WO2022067086A1 (en) 2020-09-24 2021-09-24 Methods of treating melanocortin-4 receptor pathway-associated disorders

Publications (1)

Publication Number Publication Date
CA3192873A1 true CA3192873A1 (en) 2022-03-31

Family

ID=80845850

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3192873A Pending CA3192873A1 (en) 2020-09-24 2021-09-24 Methods of treating melanocortin-4 receptor pathway-associated disorders

Country Status (13)

Country Link
US (1) US20240058414A1 (https=)
EP (1) EP4216979A4 (https=)
JP (1) JP2023542985A (https=)
KR (1) KR20230095956A (https=)
CN (1) CN116507353A (https=)
AR (1) AR123603A1 (https=)
AU (1) AU2021350017A1 (https=)
CA (1) CA3192873A1 (https=)
CL (1) CL2023000823A1 (https=)
CO (1) CO2022009561A2 (https=)
MX (1) MX2023003360A (https=)
TW (1) TW202228760A (https=)
WO (1) WO2022067086A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2023308310A1 (en) * 2022-07-12 2025-01-16 Rhythm Pharmaceuticals, Inc. Methods for treating obesity with an mc4r agonist
EP4618952A2 (en) * 2022-11-18 2025-09-24 Rhythm Pharmaceuticals, Inc. Methods for treating obesity with an mc4r agonist
WO2025106751A1 (en) * 2023-11-14 2025-05-22 Rhythm Pharmaceuticals, Inc. Combinations of a potassium channel activator and an mc4r agonist and related methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2286825T3 (pl) * 2005-07-08 2017-06-30 Ipsen Pharma Ligandy receptora melanokortyny
RU2020120797A (ru) * 2013-03-15 2020-07-02 Ритм Фармасьютикалз, Инк. Пептидные композиции
MA43040A (fr) * 2015-09-30 2018-08-08 Univ Berlin Charite Méthode de traitement de troubles associés à la voie du récepteur de la mélanocortine 4

Also Published As

Publication number Publication date
CL2023000823A1 (es) 2023-09-15
AU2021350017A1 (en) 2023-05-04
JP2023542985A (ja) 2023-10-12
AU2021350017A9 (en) 2024-10-03
MX2023003360A (es) 2023-06-23
US20240058414A1 (en) 2024-02-22
EP4216979A1 (en) 2023-08-02
WO2022067086A1 (en) 2022-03-31
CN116507353A (zh) 2023-07-28
EP4216979A4 (en) 2024-11-06
AR123603A1 (es) 2022-12-21
CO2022009561A2 (es) 2022-07-19
KR20230095956A (ko) 2023-06-29
TW202228760A (zh) 2022-08-01

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US10167312B2 (en) Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers
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RU2785889C1 (ru) Способ лечения нарушений, ассоциированных с путем рецептора меланокортина 4
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