JP2023538284A5 - - Google Patents
Info
- Publication number
- JP2023538284A5 JP2023538284A5 JP2023507996A JP2023507996A JP2023538284A5 JP 2023538284 A5 JP2023538284 A5 JP 2023538284A5 JP 2023507996 A JP2023507996 A JP 2023507996A JP 2023507996 A JP2023507996 A JP 2023507996A JP 2023538284 A5 JP2023538284 A5 JP 2023538284A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally
- nucleotide
- rnai oligonucleotide
- sense strand
- antisense strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063061040P | 2020-08-04 | 2020-08-04 | |
| US63/061,040 | 2020-08-04 | ||
| US202163151445P | 2021-02-19 | 2021-02-19 | |
| US63/151,445 | 2021-02-19 | ||
| PCT/US2021/044541 WO2022031847A2 (en) | 2020-08-04 | 2021-08-04 | Compositions and methods for inhibiting plp1 expression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023538284A JP2023538284A (ja) | 2023-09-07 |
| JP2023538284A5 true JP2023538284A5 (https=) | 2024-09-20 |
Family
ID=77519814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023507996A Pending JP2023538284A (ja) | 2020-08-04 | 2021-08-04 | Ｐｌｐ１発現を阻害するための組成物及び方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240084309A1 (https=) |
| EP (1) | EP4192478A2 (https=) |
| JP (1) | JP2023538284A (https=) |
| KR (1) | KR20230058412A (https=) |
| AU (1) | AU2021321430A1 (https=) |
| CA (1) | CA3190481A1 (https=) |
| CL (1) | CL2023000371A1 (https=) |
| IL (1) | IL300286A (https=) |
| MX (1) | MX2023001450A (https=) |
| TW (1) | TW202221121A (https=) |
| WO (1) | WO2022031847A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4172338A4 (en) | 2020-06-29 | 2025-06-11 | Ionis Pharmaceuticals, Inc. | COMPOUNDS AND METHODS FOR MODULATING PLP1 |
| EP4499831A2 (en) * | 2022-03-24 | 2025-02-05 | Ionis Pharmaceuticals, Inc. | Rnai agents of modulating plp1 |
| CN119173631A (zh) * | 2022-05-12 | 2024-12-20 | 迪克纳制药公司 | 用于抑制mapt表达的组合物和方法 |
| IL316843A (en) * | 2022-05-13 | 2025-01-01 | Dicerna Pharmaceuticals Inc | Compounds and methods for inhibiting SNCA deactivation |
| WO2024040041A1 (en) * | 2022-08-15 | 2024-02-22 | Dicerna Pharmaceuticals, Inc. | Regulation of activity of rnai molecules |
| TW202430192A (zh) * | 2022-10-11 | 2024-08-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於治療nash之劑量方案 |
| TW202430191A (zh) * | 2022-10-11 | 2024-08-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於治療伴有晚期纖維化及/或硬化之nash的方法 |
| WO2024097821A1 (en) * | 2022-11-02 | 2024-05-10 | Sanegene Bio Usa Inc. | Nucleotide-based enhancement agent for rna delivery and therapy |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6469158B1 (en) | 1992-05-14 | 2002-10-22 | Ribozyme Pharmaceuticals, Incorporated | Synthesis, deprotection, analysis and purification of RNA and ribozymes |
| US5977343A (en) | 1992-05-14 | 1999-11-02 | Ribozyme Pharmaceuticals, Inc. | Synthesis, deprotection, analysis and purification of RNA and ribozymes |
| US5804683A (en) | 1992-05-14 | 1998-09-08 | Ribozyme Pharmaceuticals, Inc. | Deprotection of RNA with alkylamine |
| ATE227342T1 (de) | 1993-09-02 | 2002-11-15 | Ribozyme Pharm Inc | Enzymatische nukleiksaüre die nicht-nukleotide enthaltet |
| US5889136A (en) | 1995-06-09 | 1999-03-30 | The Regents Of The University Of Colorado | Orthoester protecting groups in RNA synthesis |
| US5998203A (en) | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
| US6111086A (en) | 1998-02-27 | 2000-08-29 | Scaringe; Stephen A. | Orthoester protecting groups |
| CA2429814C (en) | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20050159378A1 (en) | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
| WO2003040395A2 (en) | 2001-11-07 | 2003-05-15 | Applera Corporation | Universal nucleotides for nucleic acid analysis |
| AU2003295600A1 (en) * | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| WO2005116204A1 (ja) * | 2004-05-11 | 2005-12-08 | Rnai Co., Ltd. | Ｒｎａ干渉を生じさせるポリヌクレオチド、および、これを用いた遺伝子発現抑制方法 |
| WO2008020435A2 (en) * | 2006-08-15 | 2008-02-21 | Quark Pharmaceuticals, Inc | Compositions and methods for treatment of mood disorders |
| WO2009099991A2 (en) * | 2008-01-31 | 2009-08-13 | The Brigham And Women's Hospital, Inc. | Treatment of cancer |
| DK2341943T3 (en) * | 2008-09-22 | 2019-02-25 | Dicerna Pharmaceuticals Inc | COMPOSITIONS AND METHODS OF SPECIFIC INHIBITION OF DSRNA REPRINT WITH MODIFICATIONS |
| US20100249214A1 (en) | 2009-02-11 | 2010-09-30 | Dicerna Pharmaceuticals | Multiplex dicer substrate rna interference molecules having joining sequences |
| KR101728655B1 (ko) | 2008-12-18 | 2017-04-19 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
| WO2011005860A2 (en) | 2009-07-07 | 2011-01-13 | Alnylam Pharmaceuticals, Inc. | 5' phosphate mimics |
| WO2011133871A2 (en) | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | 5'-end derivatives |
| AU2012328680A1 (en) | 2011-10-25 | 2014-05-01 | Ionis Pharmaceuticals, Inc. | Antisense modulation of GCCR expression |
| DK3569711T3 (da) | 2014-12-15 | 2021-02-22 | Dicerna Pharmaceuticals Inc | Ligandmodificerede dobbeltstrengede nukleinsyrer |
| HUE059718T2 (hu) | 2016-09-02 | 2022-12-28 | Dicerna Pharmaceuticals Inc | 4'-foszfát analógok és azokat tartalmazó oligonukleotidok |
| EP3551754B1 (en) * | 2016-12-08 | 2023-08-30 | Case Western Reserve University | Methods and compositions for enhancing functional myelin production |
| TW201945009A (zh) * | 2018-02-07 | 2019-12-01 | 國立研究開發法人國立精神 神經醫療研究中心 | 寡樹突細胞專一性啟動子、對PLP1基因具專一性之miRNA、包含該啟動子及/或該miRNA之載體與包含該載體之醫藥組合物 |
| WO2020123083A1 (en) * | 2018-12-12 | 2020-06-18 | Dicerna Pharmaceuticals, Inc. | Double-stranded nucleic acid inhibitor molecules containing a triloop |
-
2021
- 2021-08-04 CA CA3190481A patent/CA3190481A1/en active Pending
- 2021-08-04 KR KR1020237007697A patent/KR20230058412A/ko not_active Withdrawn
- 2021-08-04 AU AU2021321430A patent/AU2021321430A1/en not_active Withdrawn
- 2021-08-04 TW TW110128729A patent/TW202221121A/zh unknown
- 2021-08-04 JP JP2023507996A patent/JP2023538284A/ja active Pending
- 2021-08-04 WO PCT/US2021/044541 patent/WO2022031847A2/en not_active Ceased
- 2021-08-04 US US18/019,531 patent/US20240084309A1/en active Pending
- 2021-08-04 IL IL300286A patent/IL300286A/en unknown
- 2021-08-04 MX MX2023001450A patent/MX2023001450A/es unknown
- 2021-08-04 EP EP21762244.8A patent/EP4192478A2/en not_active Withdrawn
-
2023
- 2023-02-03 CL CL2023000371A patent/CL2023000371A1/es unknown
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