JP2023536462A - 変異体リンパ腫を処置する方法 - Google Patents

変異体リンパ腫を処置する方法 Download PDF

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Publication number
JP2023536462A
JP2023536462A JP2023505922A JP2023505922A JP2023536462A JP 2023536462 A JP2023536462 A JP 2023536462A JP 2023505922 A JP2023505922 A JP 2023505922A JP 2023505922 A JP2023505922 A JP 2023505922A JP 2023536462 A JP2023536462 A JP 2023536462A
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compound
pharmaceutically acceptable
acceptable salt
administered
patient
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JP2023536462A5 (https=
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ダンカン ウォーカー，
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カイメラ セラピューティクス， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2023505922A 2020-07-30 2021-07-29 変異体リンパ腫を処置する方法 Pending JP2023536462A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063058891P 2020-07-30 2020-07-30
US63/058,891 2020-07-30
US202063109854P 2020-11-04 2020-11-04
US63/109,854 2020-11-04
US202163202242P 2021-06-02 2021-06-02
US63/202,242 2021-06-02
PCT/US2021/071048 WO2022027058A1 (en) 2020-07-30 2021-07-29 Methods of treating mutant lymphomas

Publications (2)

Publication Number Publication Date
JP2023536462A true JP2023536462A (ja) 2023-08-25
JP2023536462A5 JP2023536462A5 (https=) 2024-08-14

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JP2023505922A Pending JP2023536462A (ja) 2020-07-30 2021-07-29 変異体リンパ腫を処置する方法

Country Status (13)

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US (2) US11857535B2 (https=)
EP (1) EP4188374A4 (https=)
JP (1) JP2023536462A (https=)
KR (1) KR20230044480A (https=)
CN (1) CN116133692A (https=)
AU (1) AU2021316053A1 (https=)
BR (1) BR112023001638A2 (https=)
CA (1) CA3187255A1 (https=)
IL (1) IL300175A (https=)
MX (1) MX2023001217A (https=)
PH (1) PH12023550237A1 (https=)
TW (1) TW202220653A (https=)
WO (1) WO2022027058A1 (https=)

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PH12022500002A1 (en) 2019-06-28 2023-04-03 Kymera Therapeutics Inc Irak degraders and uses thereof
WO2021011868A1 (en) 2019-07-17 2021-01-21 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2021119159A1 (en) 2019-12-10 2021-06-17 Kymera Therapeutics, Inc. Irak degraders and uses thereof
KR20220145325A (ko) 2019-12-17 2022-10-28 카이메라 쎄라퓨틱스 인코포레이티드 Irak 분해제 및 이의 용도
CN116867758A (zh) 2020-12-30 2023-10-10 凯麦拉医疗公司 Irak降解剂和其用途
US20240383887A1 (en) * 2021-05-07 2024-11-21 Kymera Therapeutics, Inc. Deuterated irak degraders and uses thereof
CA3243560A1 (en) 2022-01-31 2023-08-03 Kymera Therapeutics, Inc. Iraqi Degradation Agents and Their Uses
WO2024073507A1 (en) 2022-09-28 2024-04-04 Theseus Pharmaceuticals, Inc. Macrocyclic compounds and uses thereof
CN115572768B (zh) * 2022-11-04 2023-12-19 山东第一医科大学附属省立医院(山东省立医院) 一种针对弥漫大b细胞淋巴瘤的预后评估及联合治疗
WO2024148049A1 (en) * 2023-01-04 2024-07-11 Kymera Therapeutics, Inc. Irak4 degraders and uses thereof
WO2024191788A1 (en) * 2023-03-10 2024-09-19 Kymera Therapeutics, Inc. Irak4 degraders and uses thereof

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WO2019160915A1 (en) * 2018-02-14 2019-08-22 Dana-Farber Cancer Institute, Inc. Irak degraders and uses thereof
WO2020092907A1 (en) * 2018-11-02 2020-05-07 Dana-Farber Cancer Institute, Inc. Acetylation writer inhibitor development and uses thereof
WO2021127190A1 (en) * 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof

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US20190192668A1 (en) * 2017-12-26 2019-06-27 Kymera Therapeutics, Inc. Irak degraders and uses thereof
WO2019160915A1 (en) * 2018-02-14 2019-08-22 Dana-Farber Cancer Institute, Inc. Irak degraders and uses thereof
WO2020092907A1 (en) * 2018-11-02 2020-05-07 Dana-Farber Cancer Institute, Inc. Acetylation writer inhibitor development and uses thereof
WO2021127190A1 (en) * 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof

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Publication number Publication date
US20240316004A1 (en) 2024-09-26
EP4188374A1 (en) 2023-06-07
US11857535B2 (en) 2024-01-02
IL300175A (en) 2023-03-01
WO2022027058A1 (en) 2022-02-03
CN116133692A (zh) 2023-05-16
TW202220653A (zh) 2022-06-01
MX2023001217A (es) 2023-03-03
CA3187255A1 (en) 2022-02-03
EP4188374A4 (en) 2024-08-14
AU2021316053A1 (en) 2023-03-02
US20220054453A1 (en) 2022-02-24
KR20230044480A (ko) 2023-04-04
BR112023001638A2 (pt) 2023-02-23
PH12023550237A1 (en) 2024-04-29

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