JP2023536119A - 選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子 - Google Patents

選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子 Download PDF

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Publication number
JP2023536119A
JP2023536119A JP2023505918A JP2023505918A JP2023536119A JP 2023536119 A JP2023536119 A JP 2023536119A JP 2023505918 A JP2023505918 A JP 2023505918A JP 2023505918 A JP2023505918 A JP 2023505918A JP 2023536119 A JP2023536119 A JP 2023536119A
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pdgf
macrophages
formulation
cells
hypoxia
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JP2023505918A
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Japanese (ja)
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JP2023536119A5 (enExample
Inventor
ダブリュー． マーク サルツマン，
アグライア ヌトコウ，
ダニエル グライフ，
エイミー カウフマン，
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Yale University
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Yale University
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Publication of JP2023536119A publication Critical patent/JP2023536119A/ja
Publication of JP2023536119A5 publication Critical patent/JP2023536119A5/ja
Priority to JP2026022890A priority Critical patent/JP2026086758A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2023505918A 2020-07-28 2021-07-28 選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子 Pending JP2023536119A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2026022890A JP2026086758A (ja) 2020-07-28 2026-02-16 選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063057626P 2020-07-28 2020-07-28
US63/057,626 2020-07-28
US17/332,175 2021-05-27
US17/332,175 US20220031633A1 (en) 2020-07-28 2021-05-27 Poly(amine-co-ester) polymeric particles for selective pulmonary delivery
PCT/US2021/043514 WO2022026585A1 (en) 2020-07-28 2021-07-28 Poly(amine-co-ester) polymeric particles for selective pulmonary delivery

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2026022890A Division JP2026086758A (ja) 2020-07-28 2026-02-16 選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子

Publications (2)

Publication Number Publication Date
JP2023536119A true JP2023536119A (ja) 2023-08-23
JP2023536119A5 JP2023536119A5 (enExample) 2024-08-01

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JP2023505918A Pending JP2023536119A (ja) 2020-07-28 2021-07-28 選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子
JP2026022890A Pending JP2026086758A (ja) 2020-07-28 2026-02-16 選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子

Family Applications After (1)

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JP2026022890A Pending JP2026086758A (ja) 2020-07-28 2026-02-16 選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子

Country Status (10)

Country Link
US (2) US20220031633A1 (enExample)
EP (1) EP4188342A1 (enExample)
JP (2) JP2023536119A (enExample)
KR (1) KR20230047126A (enExample)
CN (1) CN116137812A (enExample)
AU (1) AU2021315545A1 (enExample)
BR (1) BR112023001379A2 (enExample)
CA (1) CA3185957A1 (enExample)
MX (1) MX2023000850A (enExample)
WO (1) WO2022026585A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3183351A1 (en) 2020-06-19 2021-12-23 Yale University Poly(amine-co-ester) polymers with modified end groups and enhanced pulmonary delivery

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140342003A1 (en) * 2011-12-02 2014-11-20 Yale University Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9126677D0 (en) 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds
GB9400411D0 (en) 1994-01-11 1994-03-09 Johnson Matthey Plc Improvements in chemical compounds
MXPA03000905A (es) 2000-08-02 2003-06-24 Slil Biomedical Corp Compuestos de poliamina ciclicos como tratamiento contra el cancer.
CN100523215C (zh) 2000-12-01 2009-08-05 马普科技促进协会 介导rna干涉的小rna分子
US9241898B2 (en) 2008-03-11 2016-01-26 Yale University Compositions and methods for controlled delivery of inhibitory ribonucleic acids
US8883819B2 (en) * 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
WO2013082529A1 (en) 2011-12-02 2013-06-06 Yale University Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
US9895451B2 (en) 2011-12-02 2018-02-20 Yale University Formulations for targeted release of agents to low pH tissue environments or cellular compartments and methods of use thereof
US10465042B2 (en) 2011-12-02 2019-11-05 Yale University Poly(amine-co-ester) nanoparticles and methods of use thereof
WO2017151623A1 (en) 2016-03-01 2017-09-08 Alexion Pharmaceuticals, Inc. Biodegradable activated polymers for therapeutic delivery
WO2017197128A1 (en) 2016-05-11 2017-11-16 Yale University Poly(amine-co-ester) nanoparticles and methods of use thereof
RU2763525C2 (ru) * 2016-10-27 2021-12-30 Пульмокин, Инк. Комбинированная терапия для лечения легочной гипертензии

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140342003A1 (en) * 2011-12-02 2014-11-20 Yale University Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AM J RESPIR CRIT CARE MED, vol. 201, JPN6026025775, 2020, pages 2677, ISSN: 0005887861 *
AMERICAN JOURNAL OF RESPIRATRY AND CRITICAL CARE MEDICINE, vol. 201, no. 1, JPN6025020630, May 2020 (2020-05-01), pages 2677, ISSN: 0005600020 *
NANO LETT., vol. 20, no. 2, JPN6025020629, February 2020 (2020-02-01), pages 1117 - 1123, ISSN: 0005887862 *

Also Published As

Publication number Publication date
EP4188342A1 (en) 2023-06-07
MX2023000850A (es) 2023-02-15
WO2022026585A1 (en) 2022-02-03
US20220031633A1 (en) 2022-02-03
CN116137812A (zh) 2023-05-19
JP2026086758A (ja) 2026-05-26
KR20230047126A (ko) 2023-04-06
AU2021315545A1 (en) 2023-02-16
BR112023001379A2 (pt) 2023-02-14
US20260151352A1 (en) 2026-06-04
CA3185957A1 (en) 2022-02-03

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