|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
US5525491A
(en)
|
1991-02-27 |
1996-06-11 |
Creative Biomolecules, Inc. |
Serine-rich peptide linkers
|
|
US5387484A
(en)
|
1992-07-07 |
1995-02-07 |
International Business Machines Corporation |
Two-sided mask for patterning of materials with electromagnetic radiation
|
|
WO1994012520A1
(en)
|
1992-11-20 |
1994-06-09 |
Enzon, Inc. |
Linker for linked fusion polypeptides
|
|
JPH10501686A
(ja)
|
1994-04-13 |
1998-02-17 |
ザ ロックフェラー ユニヴァーシティ |
神経系の細胞へのdnaのaav仲介送達
|
|
US6204059B1
(en)
|
1994-06-30 |
2001-03-20 |
University Of Pittsburgh |
AAV capsid vehicles for molecular transfer
|
|
US5625048A
(en)
|
1994-11-10 |
1997-04-29 |
The Regents Of The University Of California |
Modified green fluorescent proteins
|
|
WO1996017947A1
(en)
|
1994-12-06 |
1996-06-13 |
Targeted Genetics Corporation |
Packaging cell lines for generation of high titers of recombinant aav vectors
|
|
US5741657A
(en)
|
1995-03-20 |
1998-04-21 |
The Regents Of The University Of California |
Fluorogenic substrates for β-lactamase and methods of use
|
|
US6281010B1
(en)
|
1995-06-05 |
2001-08-28 |
The Trustees Of The University Of Pennsylvania |
Adenovirus gene therapy vehicle and cell line
|
|
US5741683A
(en)
|
1995-06-07 |
1998-04-21 |
The Research Foundation Of State University Of New York |
In vitro packaging of adeno-associated virus DNA
|
|
US5688676A
(en)
|
1995-06-07 |
1997-11-18 |
Research Foundation Of State University Of New York |
In vitro packaging of adeno-associated virus DNA
|
|
US6265389B1
(en)
|
1995-08-31 |
2001-07-24 |
Alkermes Controlled Therapeutics, Inc. |
Microencapsulation and sustained release of oligonucleotides
|
|
US5962313A
(en)
|
1996-01-18 |
1999-10-05 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a gene encoding a lyosomal enzyme
|
|
US5858351A
(en)
|
1996-01-18 |
1999-01-12 |
Avigen, Inc. |
Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors
|
|
US5846528A
(en)
|
1996-01-18 |
1998-12-08 |
Avigen, Inc. |
Treating anemia using recombinant adeno-associated virus virions comprising an EPO DNA sequence
|
|
WO1998010086A1
(en)
|
1996-09-06 |
1998-03-12 |
Trustees Of The University Of Pennsylvania |
Methods using cre-lox for production of recombinant adeno-associated viruses
|
|
AU4645697A
(en)
|
1996-09-11 |
1998-04-02 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Aav4 vector and uses thereof
|
|
CA2270285A1
(en)
|
1996-12-18 |
1998-06-25 |
Targeted Genetics Corporation |
Aav split-packaging genes and cell lines comprising such genes for use in the production of recombinant aav vectors
|
|
JP2000514094A
(ja)
|
1997-04-17 |
2000-10-24 |
レオネ,パオラ |
脳への遺伝子治療のための送達システム
|
|
US6156303A
(en)
|
1997-06-11 |
2000-12-05 |
University Of Washington |
Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
|
|
WO2000024916A1
(en)
|
1998-10-27 |
2000-05-04 |
Crucell Holland B.V. |
Improved aav vector production
|
|
EP1135468B1
(en)
|
1998-11-10 |
2010-01-06 |
University Of North Carolina At Chapel Hill |
Virus vectors and methods of making and administering the same
|
|
US6225113B1
(en)
|
1998-12-04 |
2001-05-01 |
Genvec, Inc. |
Use of trans-activation and cis-activation to modulate the persistence of expression of a transgene in an at least E4-deficient adenovirus
|
|
DE19905501B4
(de)
|
1999-02-10 |
2005-05-19 |
MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie |
Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels
|
|
US6365394B1
(en)
|
1999-09-29 |
2002-04-02 |
The Trustees Of The University Of Pennsylvania |
Cell lines and constructs useful in production of E1-deleted adenoviruses in absence of replication competent adenovirus
|
|
WO2001023001A2
(en)
|
1999-09-29 |
2001-04-05 |
The Trustees Of The University Of Pennsylvania |
Rapid peg-modification
|
|
WO2001089583A2
(en)
|
2000-05-23 |
2001-11-29 |
Neurologix, Inc. |
Glutamic acid decarboxylase (gad)_delivery system for treating neurodegenerative diseases
|
|
US7465583B2
(en)
|
2000-06-01 |
2008-12-16 |
The University Of North Carolina At Chapel Hill |
Duplexed parvovirus vectors
|
|
US20020106381A1
(en)
|
2000-06-13 |
2002-08-08 |
High Katherine A. |
Methods for administering recombinant adeno-associated virus virions to humans previously exposed to adeno-associated virus
|
|
ES2288993T3
(es)
|
2000-08-17 |
2008-02-01 |
Keiya Ozawa |
Distribucion de factores angiogenicos mediada por virus adenoasociados.
|
|
US7588757B2
(en)
|
2001-03-14 |
2009-09-15 |
Genzyme Corporation |
Methods of treating Parkinson's disease using recombinant adeno-associated virus virions
|
|
CN103589692B
(zh)
|
2001-11-13 |
2018-07-24 |
宾夕法尼亚大学托管会 |
检测和/或鉴定腺伴随病毒(aav)序列以及分离所鉴定的新型序列的方法
|
|
EP1463805B1
(en)
|
2001-12-17 |
2014-10-22 |
The Trustees of The University of Pennsylvania |
Adeno-associated virus (aav) serotype 9 sequences, vectors containing same, and uses therefor
|
|
CA2469658A1
(en)
|
2001-12-19 |
2003-07-03 |
Lijun Wang |
Adeno-associated virus-mediated delivery of gdnf to skeletal muscles
|
|
US8946151B2
(en)
|
2003-02-24 |
2015-02-03 |
Northern Bristol N.H.S. Trust Frenchay Hospital |
Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
|
|
US7951557B2
(en)
|
2003-04-27 |
2011-05-31 |
Protalix Ltd. |
Human lysosomal proteins from plant cell culture
|
|
WO2005017101A2
(en)
|
2003-05-19 |
2005-02-24 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH |
Avian adenoassociated virus (aaav) and uses thereof
|
|
JP4888876B2
(ja)
|
2003-06-13 |
2012-02-29 |
田平 武 |
アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター
|
|
PL2657248T3
(pl)
|
2003-06-19 |
2017-09-29 |
Genzyme Corporation |
Wiriony AAV o zmniejszonej immunoreaktywności i ich zastosowanie
|
|
US9233131B2
(en)
|
2003-06-30 |
2016-01-12 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US9441244B2
(en)
|
2003-06-30 |
2016-09-13 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
EP1668143B1
(en)
|
2003-09-30 |
2013-03-20 |
The Trustees of The University of Pennsylvania |
Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor
|
|
WO2005056807A2
(en)
|
2003-12-04 |
2005-06-23 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health |
Bovine adeno-associated viral (baav) vector and uses thereof
|
|
US20060166363A1
(en)
|
2004-01-27 |
2006-07-27 |
Sergei Zolotukhin |
Modified baculovirus expression system for production of pseudotyped rAAV vector
|
|
US7427396B2
(en)
|
2004-06-03 |
2008-09-23 |
Genzyme Corporation |
AAV vectors for gene delivery to the lung
|
|
DE23193606T1
(de)
|
2005-04-07 |
2024-02-15 |
The Trustees Of The University Of Pennsylvania |
Verfahren zur erhöhung der funktion eines aav-vektors
|
|
US8283151B2
(en)
|
2005-04-29 |
2012-10-09 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes
|
|
EP1857552A1
(en)
|
2006-05-20 |
2007-11-21 |
Cargill Incorporated |
Thermostable xylose isomerase enzyme
|
|
PT3272872T
(pt)
|
2005-10-20 |
2020-06-26 |
Uniqure Ip Bv |
Vetores aav melhorados produzidos em células de insetos
|
|
US7588772B2
(en)
|
2006-03-30 |
2009-09-15 |
Board Of Trustees Of The Leland Stamford Junior University |
AAV capsid library and AAV capsid proteins
|
|
WO2007148971A2
(en)
|
2006-06-21 |
2007-12-27 |
Amsterdam Molecular Therapeutics B.V. |
Vectors with modified initiation codon for the translation of aav-rep78 useful for production of aav in insect cells
|
|
WO2008052322A1
(en)
|
2006-10-30 |
2008-05-08 |
Viventia Biotech Inc. |
Immunotoxγn fusions comprising an antibody fragment and a plant toxin linked by protease cleavable linkers
|
|
EP2158211B1
(en)
|
2007-05-31 |
2016-08-10 |
Medigene AG |
Mutated structural protein of a parvovirus
|
|
HUE029744T2
(en)
|
2007-07-26 |
2017-04-28 |
Uniqure Ip Bv |
Baculoviral vectors comprising repeated coding sequences with differential codon biases
|
|
EP2396343B1
(en)
|
2009-02-11 |
2017-05-17 |
The University of North Carolina At Chapel Hill |
Modified virus vectors and methods of making and using the same
|
|
US8734809B2
(en)
|
2009-05-28 |
2014-05-27 |
University Of Massachusetts |
AAV's and uses thereof
|
|
WO2011101869A1
(en)
|
2010-02-22 |
2011-08-25 |
Transgene Biotek Ltd. |
Adeno-associated virus 2/8 - micro rna-101 therapy for liver cancer
|
|
EP2394667A1
(en)
|
2010-06-10 |
2011-12-14 |
Laboratorios Del Dr. Esteve, S.A. |
Vectors and sequences for the treatment of diseases
|
|
US10738326B2
(en)
|
2010-10-27 |
2020-08-11 |
Jichi Medical University |
Adeno-associated virus vector for gene transfer to nervous system cells
|
|
JP6091435B2
(ja)
|
2011-02-22 |
2017-03-08 |
カリフォルニア インスティチュート オブ テクノロジー |
アデノ随伴ウイルス(aav)ベクターを用いたタンパク質の送達
|
|
EP3219313B1
(en)
|
2011-04-18 |
2020-10-28 |
National Center of Neurology and Psychiatry |
Drug delivery particle and method for producing the same
|
|
EP3795581A3
(en)
|
2011-08-24 |
2021-06-09 |
The Board of Trustees of the Leland Stanford Junior University |
New avv capsid proteins for nucleic acid transfer
|
|
US20140359799A1
(en)
|
2011-12-23 |
2014-12-04 |
Case Western Reserve University |
Targeted gene modification using hybrid recombinant adeno-associated virus
|
|
WO2013151664A1
(en)
*
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins
|
|
CN104411338A
(zh)
*
|
2012-04-02 |
2015-03-11 |
现代治疗公司 |
用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸
|
|
PL2900686T3
(pl)
|
2012-09-28 |
2021-01-25 |
The University Of North Carolina At Chapel Hill |
Wektory aav ukierunkowane na oligodendrocyty
|
|
WO2014124282A1
(en)
|
2013-02-08 |
2014-08-14 |
The Trustees Of The University Of Pennsylvania |
Enhanced aav-mediated gene transfer for retinal therapies
|
|
ES2926774T3
(es)
|
2013-03-15 |
2022-10-28 |
Univ North Carolina Chapel Hill |
Métodos y composiciones para vectores AAV de doble unión de glicano
|
|
BR112015027336A2
(pt)
|
2013-05-01 |
2017-09-26 |
Genzyme Corp |
composições e processos para tratamento de atrofia muscular espinhal
|
|
US11136557B2
(en)
|
2013-05-31 |
2021-10-05 |
The Regents Of The University Of California |
Adeno-associated virus variants and methods of use thereof
|
|
EP3564379A1
(en)
|
2013-09-13 |
2019-11-06 |
California Institute of Technology |
Selective recovery
|
|
EP3049527A4
(en)
|
2013-09-26 |
2017-08-16 |
University of Florida Research Foundation, Inc. |
Synthetic combinatorial aav capsid library for targeted gene therapy
|
|
US10087224B2
(en)
|
2013-11-01 |
2018-10-02 |
Cornell University |
Gene therapy for Alzheimer's and other neurodegenerative diseases and conditions
|
|
GB201403684D0
(en)
|
2014-03-03 |
2014-04-16 |
King S College London |
Vector
|
|
LT3137497T
(lt)
|
2014-05-02 |
2021-07-26 |
Genzyme Corporation |
Aav vektoriai, skirti tinklainės ir cns genų terapijai
|
|
US10577627B2
(en)
|
2014-06-09 |
2020-03-03 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
WO2016049230A1
(en)
|
2014-09-24 |
2016-03-31 |
City Of Hope |
Adeno-associated virus vector variants for high efficiency genome editing and methods thereof
|
|
WO2016065001A1
(en)
|
2014-10-21 |
2016-04-28 |
University Of Massachusetts |
Recombinant aav variants and uses thereof
|
|
CA2977355A1
(en)
|
2015-02-20 |
2016-08-25 |
University Of Iowa Research Foundation |
Methods and compositions for treating genetic eye diseases
|
|
WO2017015102A1
(en)
|
2015-07-17 |
2017-01-26 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for achieving high levels of transduction in human liver cells
|
|
IL314171A
(en)
|
2015-09-28 |
2024-09-01 |
Univ Florida |
Methods and compositions for antibody-evading virus vectors
|
|
WO2017066764A2
(en)
|
2015-10-16 |
2017-04-20 |
William Marsh Rice University |
Modification of n-terminal region of capsid proteins for enhanced properties of adeno-associated viruses
|
|
EP3374494A4
(en)
|
2015-11-11 |
2019-05-01 |
Coda Biotherapeutics, Inc. |
CRISPR COMPOSITIONS AND METHODS OF USE THEREOF FOR GENE THERAPY
|
|
US10240145B2
(en)
|
2015-11-25 |
2019-03-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
CRISPR/Cas-mediated genome editing to treat EGFR-mutant lung cancer
|
|
AU2016366549B2
(en)
|
2015-12-11 |
2022-11-10 |
California Institute Of Technology |
Targeting peptides for directing adeno-associated viruses (AAVs)
|
|
TWI833178B
(zh)
*
|
2016-12-26 |
2024-02-21 |
日商Jcr製藥股份有限公司 |
通過血腦障壁之新穎抗人類運鐵蛋白受體抗體
|
|
CN111542549A
(zh)
|
2017-10-03 |
2020-08-14 |
普利维尔治疗公司 |
用于溶酶体障碍的基因疗法
|
|
EP3692158A4
(en)
*
|
2017-10-03 |
2021-08-04 |
Prevail Therapeutics, Inc. |
GENE THERAPIES FOR LYSOSOMAL DISEASES
|
|
WO2019134741A1
(en)
*
|
2018-01-03 |
2019-07-11 |
Albert-Ludwigs-Universität Freiburg |
Single-channel multianalyte biosensor
|
|
WO2019136484A1
(en)
|
2018-01-08 |
2019-07-11 |
Prevail Therapeutics, Inc. |
Pet imaging ligands for in vivo detection of gba1
|
|
EP3762505A4
(en)
*
|
2018-03-09 |
2021-12-01 |
Avrobio, Inc. |
COMPOSITIONS AND METHODS OF TREATMENT FOR PARKINSON'S DISEASE
|
|
TW202344691A
(zh)
|
2018-04-30 |
2023-11-16 |
美商阿米庫斯醫療股份有限公司 |
基因治療構築體及使用方法
|
|
WO2019222444A2
(en)
*
|
2018-05-16 |
2019-11-21 |
Voyager Therapeutics, Inc. |
Directed evolution
|
|
MX2021007600A
(es)
|
2018-12-21 |
2021-08-11 |
Univ Pennsylvania |
Composiciones para la reduccion de la expresion transgenica especifica de drg.
|