JP2023535790A5 - - Google Patents
Info
- Publication number
- JP2023535790A5 JP2023535790A5 JP2023505743A JP2023505743A JP2023535790A5 JP 2023535790 A5 JP2023535790 A5 JP 2023535790A5 JP 2023505743 A JP2023505743 A JP 2023505743A JP 2023505743 A JP2023505743 A JP 2023505743A JP 2023535790 A5 JP2023535790 A5 JP 2023535790A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- unsubstituted
- compound according
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063057536P | 2020-07-28 | 2020-07-28 | |
| US63/057,536 | 2020-07-28 | ||
| PCT/EP2021/071212 WO2022023447A2 (en) | 2020-07-28 | 2021-07-28 | Fused bicyclic raf inhibitors and methods for use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023535790A JP2023535790A (ja) | 2023-08-21 |
| JP2023535790A5 true JP2023535790A5 (cg-RX-API-DMAC7.html) | 2024-08-06 |
Family
ID=77499800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023505743A Pending JP2023535790A (ja) | 2020-07-28 | 2021-07-28 | 縮合二環式ｒａｆ阻害薬及びその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11858930B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP4188552A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2023535790A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20230058399A (cg-RX-API-DMAC7.html) |
| CN (1) | CN116601150A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2021314955A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112023001557A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3187514A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL300113A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2023001275A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2022023447A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4188552A2 (en) | 2020-07-28 | 2023-06-07 | Jazz Pharmaceuticals Ireland Limited | Fused bicyclic raf inhibitors and methods for use thereof |
| CN116143633A (zh) * | 2022-12-30 | 2023-05-23 | 浙江巍华新材料股份有限公司 | 一种制备2,5-二氯-4-三氟甲基苯胺的方法 |
| AU2024223957A1 (en) * | 2023-02-17 | 2025-09-04 | Jazz Pharmaceuticals Ireland Limited | Methods of treating solid tumors with mitogen activated protein kinase (mapk) pathway alterations |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932657A (en) | 1973-11-12 | 1976-01-13 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome encapsulation of chelating agents |
| GB1575343A (en) | 1977-05-10 | 1980-09-17 | Ici Ltd | Method for preparing liposome compositions containing biologically active compounds |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4452747A (en) | 1982-03-22 | 1984-06-05 | Klaus Gersonde | Method of and arrangement for producing lipid vesicles |
| JPS6058915A (ja) | 1983-09-12 | 1985-04-05 | Fujisawa Pharmaceut Co Ltd | 薬物含有脂質小胞体製剤 |
| US4744989A (en) | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
| US5077056A (en) | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US5736155A (en) | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4830858A (en) | 1985-02-11 | 1989-05-16 | E. R. Squibb & Sons, Inc. | Spray-drying method for preparing liposomes and products produced thereby |
| US4921757A (en) | 1985-04-26 | 1990-05-01 | Massachusetts Institute Of Technology | System for delayed and pulsed release of biologically active substances |
| JPH0617309B2 (ja) | 1985-11-29 | 1994-03-09 | 株式会社ビタミン研究所 | アドリアマイシン包埋リポソ−ム製剤 |
| DE3611229A1 (de) | 1986-04-04 | 1987-10-08 | Basf Ag | Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinoidpraeparaten |
| MX9203808A (es) | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5766635A (en) | 1991-06-28 | 1998-06-16 | Rhone-Poulenc Rorer S.A. | Process for preparing nanoparticles |
| US5698550A (en) | 1993-06-14 | 1997-12-16 | Pfizer Inc. | Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases |
| WO1995022963A1 (en) | 1994-02-28 | 1995-08-31 | Medinova Medical Consulting Gmbh | Drug targeting system, method for preparing same and its use |
| US5800833A (en) | 1995-02-27 | 1998-09-01 | University Of British Columbia | Method for loading lipid vesicles |
| WO1996032930A1 (en) | 1995-04-18 | 1996-10-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
| US6465445B1 (en) | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| US8137699B2 (en) | 2002-03-29 | 2012-03-20 | Trustees Of Princeton University | Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use |
| FI20011507A0 (fi) | 2001-07-10 | 2001-07-10 | Orion Corp | Uusia yhdisteitä |
| US7850990B2 (en) | 2001-10-03 | 2010-12-14 | Celator Pharmaceuticals, Inc. | Compositions for delivery of drug combinations |
| AU2002331481B2 (en) | 2001-10-03 | 2008-04-24 | Celator Pharmaceuticals, Inc. | Liposome loading with metal ions |
| ES2387886T3 (es) | 2001-11-13 | 2012-10-03 | Celator Pharmaceuticals, Inc. | Composiciones que transportan lípidos con una mejor estabilidad sanguínea |
| FI20030030A0 (fi) | 2003-01-09 | 2003-01-09 | Orion Corp | Uusia yhdisteitä |
| CN1690056A (zh) | 2004-04-30 | 2005-11-02 | 北京大学 | 三个化合物及其制备方法和用途 |
| GB0503506D0 (en) | 2005-02-21 | 2005-03-30 | 4 Aza Bioscience Nv | Substituted pyrido(2,3-d) pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
| WO2006124874A2 (en) | 2005-05-12 | 2006-11-23 | Kalypsys, Inc. | Inhibitors of b-raf kinase |
| WO2007067444A1 (en) | 2005-12-08 | 2007-06-14 | Millennium Pharmaceuticals, Inc. | Bicyclic compounds with kinase inhibitory activity |
| US10144736B2 (en) | 2006-07-20 | 2018-12-04 | Gilead Sciences, Inc. | Substituted pteridines useful for the treatment and prevention of viral infections |
| US7968536B2 (en) * | 2007-06-29 | 2011-06-28 | Millennium Pharmaceuticals, Inc. | Heterocyclic compounds useful as RAF kinase inhibitors |
| PL2797888T3 (pl) | 2011-12-31 | 2016-12-30 | Połączone związki tricykliczne jako inhibitory kinazy raf | |
| GB201416186D0 (en) * | 2014-09-12 | 2014-10-29 | Redx Pharma Ltd | Compounds |
| CN109503659B (zh) | 2019-01-03 | 2021-06-18 | 凯特立斯（深圳）科技有限公司 | 氧杂螺环双膦配体及其在α,β-不饱和羧酸不对称氢化中的应用 |
| EP4188552A2 (en) | 2020-07-28 | 2023-06-07 | Jazz Pharmaceuticals Ireland Limited | Fused bicyclic raf inhibitors and methods for use thereof |
| IL300110A (en) | 2020-07-28 | 2023-03-01 | Jazz Pharmaceuticals Ireland Ltd | Chiral synthesis of fused bicyclic raf inhibitors |
-
2021
- 2021-07-28 EP EP21759247.6A patent/EP4188552A2/en active Pending
- 2021-07-28 MX MX2023001275A patent/MX2023001275A/es unknown
- 2021-07-28 AU AU2021314955A patent/AU2021314955A1/en active Pending
- 2021-07-28 JP JP2023505743A patent/JP2023535790A/ja active Pending
- 2021-07-28 KR KR1020237006991A patent/KR20230058399A/ko active Pending
- 2021-07-28 IL IL300113A patent/IL300113A/en unknown
- 2021-07-28 WO PCT/EP2021/071212 patent/WO2022023447A2/en not_active Ceased
- 2021-07-28 CN CN202180066002.9A patent/CN116601150A/zh active Pending
- 2021-07-28 US US17/387,049 patent/US11858930B2/en active Active
- 2021-07-28 CA CA3187514A patent/CA3187514A1/en active Pending
- 2021-07-28 BR BR112023001557A patent/BR112023001557A2/pt unknown
-
2023
- 2023-11-16 US US18/511,344 patent/US12304912B2/en active Active
-
2025
- 2025-05-12 US US19/205,876 patent/US20260092063A1/en active Pending
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