JP2023533218A5 - - Google Patents
Info
- Publication number
- JP2023533218A5 JP2023533218A5 JP2022580159A JP2022580159A JP2023533218A5 JP 2023533218 A5 JP2023533218 A5 JP 2023533218A5 JP 2022580159 A JP2022580159 A JP 2022580159A JP 2022580159 A JP2022580159 A JP 2022580159A JP 2023533218 A5 JP2023533218 A5 JP 2023533218A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- cancer
- compound according
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063043771P | 2020-06-24 | 2020-06-24 | |
| US63/043,771 | 2020-06-24 | ||
| PCT/US2021/038781 WO2021262910A2 (en) | 2020-06-24 | 2021-06-23 | Tubulysins and protein-tubulysin conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023533218A JP2023533218A (ja) | 2023-08-02 |
| JP2023533218A5 true JP2023533218A5 (https=) | 2024-07-04 |
Family
ID=76959103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022580159A Pending JP2023533218A (ja) | 2020-06-24 | 2021-06-23 | ツブリシン及びタンパク質－ツブリシンコンジュゲート |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20230069722A1 (https=) |
| EP (1) | EP4171653A2 (https=) |
| JP (1) | JP2023533218A (https=) |
| KR (1) | KR20230028325A (https=) |
| CN (1) | CN115867563B (https=) |
| AU (1) | AU2021296449A1 (https=) |
| BR (1) | BR112022024361A2 (https=) |
| CA (1) | CA3185601A1 (https=) |
| CL (1) | CL2022003715A1 (https=) |
| CO (1) | CO2022019161A2 (https=) |
| IL (1) | IL299254A (https=) |
| MA (1) | MA58646A1 (https=) |
| MX (1) | MX2022015769A (https=) |
| PH (1) | PH12023550032A1 (https=) |
| WO (1) | WO2021262910A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2524356T3 (es) | 2010-07-22 | 2014-12-05 | Gilead Sciences, Inc. | Métodos y compuestos para tratar infecciones provocadas por virus Paramyxoviridae |
| JP7590328B2 (ja) | 2018-12-21 | 2024-11-26 | レゲネロン ファーマシューティカルス，インコーポレーテッド | ツブリシン及びタンパク質－ツブリシンコンジュゲート |
| BR112023018676A2 (pt) | 2021-03-18 | 2023-10-10 | Seagen Inc | Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco |
| US20230414775A1 (en) | 2021-12-29 | 2023-12-28 | Regeneron Pharmaceuticals, Inc. | Tubulysins and protein-tubulysin conjugates |
| KR20240154647A (ko) | 2022-03-02 | 2024-10-25 | 길리애드 사이언시즈, 인코포레이티드 | 바이러스성 감염 치료를 위한 화합물 및 방법 |
| CN116747315A (zh) * | 2023-06-20 | 2023-09-15 | 中国科学院长春应用化学研究所 | 高dar值的抗体-免疫调节药物偶联物及其制备方法和应用 |
| CN121568720A (zh) | 2023-07-10 | 2026-02-24 | 瑞泽恩制药公司 | 抗人类cacng1抗体-药物缀合物及其用途 |
| WO2025078841A2 (en) | 2023-10-11 | 2025-04-17 | Antikor Biopharma Limited | Antibodies, conjugates, and uses thereof |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| US20070258987A1 (en) | 2000-11-28 | 2007-11-08 | Seattle Genetics, Inc. | Recombinant Anti-Cd30 Antibodies and Uses Thereof |
| AR048098A1 (es) | 2004-03-15 | 2006-03-29 | Wyeth Corp | Conjugados de caliqueamicina |
| NZ579482A (en) | 2004-06-01 | 2011-02-25 | Genentech Inc | Antibody drug conjugates and methods |
| JP2008521828A (ja) | 2004-11-29 | 2008-06-26 | シアトル ジェネティックス， インコーポレイテッド | 操作された抗体およびイムノコンジュゲート |
| US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| WO2008122039A2 (en) | 2007-04-02 | 2008-10-09 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selenocysteine mediated hybrid antibody molecules |
| WO2008138561A1 (en) | 2007-05-10 | 2008-11-20 | R & D Biopharmaceuticals Gmbh | Tubulysine derivatives |
| EP2167963B1 (en) | 2007-05-23 | 2019-04-17 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
| CN101909441B (zh) * | 2007-10-25 | 2015-05-13 | 恩多塞特公司 | 微管蛋白抑制剂及其制备方法 |
| SG189817A1 (en) | 2008-04-30 | 2013-05-31 | Immunogen Inc | Potent conjugates and hydrophilic linkers |
| KR101000067B1 (ko) | 2008-12-30 | 2010-12-10 | 엘지전자 주식회사 | 고효율 태양전지용 레이저 소성장치 및 고효율 태양전지 제조방법 |
| US8394922B2 (en) * | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| SI2528625T1 (sl) | 2010-04-15 | 2013-11-29 | Spirogen Sarl | Pirolobenzodiazepini in njihovi konjugati |
| US20130244905A1 (en) | 2010-07-06 | 2013-09-19 | Ed Grabczyk | Reporter for RNA Polymerase II Termination |
| CN110078789A (zh) | 2011-05-27 | 2019-08-02 | Ambrx 公司 | 含有非天然氨基酸连接的海兔毒素衍生物的组合物、涉及该海兔毒素衍生物的方法及其用途 |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| CN103997893B (zh) | 2011-10-14 | 2019-04-12 | 西雅图基因公司 | 吡咯并苯并二氮杂卓和靶向结合物 |
| CA2850373C (en) | 2011-10-14 | 2019-07-16 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| BR112014009070B1 (pt) | 2011-10-14 | 2021-11-23 | Medimmune Limited | Método de síntese e intermediários úteis na preparação de pirrolobenzo-diazepinas |
| EP2751111B1 (en) | 2011-10-14 | 2017-04-26 | MedImmune Limited | Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases |
| WO2013068874A1 (en) | 2011-11-11 | 2013-05-16 | Pfizer Inc. | Antibody-drug conjugates |
| ES2781523T3 (es) * | 2012-07-12 | 2020-09-02 | Hangzhou Dac Biotech Co Ltd | Conjugados de moléculas de unión celular con agentes citotóxicos |
| CN105142672B (zh) | 2012-10-23 | 2019-04-05 | 西纳福克斯股份有限公司 | 经修饰的抗体、抗体-缀合物及其制备方法 |
| CA2896058A1 (en) * | 2012-12-24 | 2014-07-03 | Abbvie Inc. | Prolactin receptor binding proteins and uses thereof |
| LT2956173T (lt) * | 2013-02-14 | 2017-06-26 | Bristol-Myers Squibb Company | Tubulizino junginiai, gavimo ir panaudojimo būdai |
| TWI641620B (zh) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | 抗－ｐｒｌｒ抗體及其用途 |
| WO2015113760A1 (en) * | 2014-01-28 | 2015-08-06 | Tube Pharmaceuticals Gmbh | Cytotoxic tubulysin compounds for conjugation |
| EA032203B1 (ru) * | 2014-04-11 | 2019-04-30 | МЕДИММЬЮН ЭлЭлСи | Производные тубулизина |
| FI3900742T3 (fi) * | 2014-09-11 | 2024-08-16 | Seagen Inc | Tertiääristä amiinia sisältävien lääkeaineiden kohdennettu antaminen |
| US10077287B2 (en) * | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
| EP3411371A1 (en) * | 2016-02-01 | 2018-12-12 | Pfizer Inc | Tubulysin analogs and methods for their preparation |
| EP3419670A2 (en) * | 2016-02-26 | 2019-01-02 | Regeneron Pharmaceuticals, Inc. | Optimized transglutaminase site-specific antibody conjugation |
| CN109069665A (zh) * | 2016-05-10 | 2018-12-21 | 百时美施贵宝公司 | 具有增强的稳定性的微管溶素类似物的抗体-药物缀合物 |
| MY199468A (en) * | 2016-09-23 | 2023-10-31 | Regeneron Pharma | Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof |
| MX2020004691A (es) * | 2017-11-07 | 2020-08-20 | Regeneron Pharma | Enlazadores hidrofilicos para conjugados anticuerpo-farmaco. |
| JP7590328B2 (ja) * | 2018-12-21 | 2024-11-26 | レゲネロン ファーマシューティカルス，インコーポレーテッド | ツブリシン及びタンパク質－ツブリシンコンジュゲート |
| CN114040781A (zh) * | 2019-06-24 | 2022-02-11 | 杭州多禧生物科技有限公司 | Tubulysin衍生物与细胞结合分子偶联物的制剂配方 |
| KR20220148200A (ko) * | 2020-02-28 | 2022-11-04 | 리제너론 파마슈티칼스 인코포레이티드 | Her2에 결합하는 이중특이적 항원 결합 분자 및 이의 사용 방법 |
-
2021
- 2021-06-23 WO PCT/US2021/038781 patent/WO2021262910A2/en not_active Ceased
- 2021-06-23 IL IL299254A patent/IL299254A/en unknown
- 2021-06-23 MA MA58646A patent/MA58646A1/fr unknown
- 2021-06-23 PH PH1/2023/550032A patent/PH12023550032A1/en unknown
- 2021-06-23 CA CA3185601A patent/CA3185601A1/en active Pending
- 2021-06-23 JP JP2022580159A patent/JP2023533218A/ja active Pending
- 2021-06-23 EP EP21742993.5A patent/EP4171653A2/en active Pending
- 2021-06-23 AU AU2021296449A patent/AU2021296449A1/en active Pending
- 2021-06-23 KR KR1020227046382A patent/KR20230028325A/ko active Pending
- 2021-06-23 CN CN202180044933.9A patent/CN115867563B/zh active Active
- 2021-06-23 MX MX2022015769A patent/MX2022015769A/es unknown
- 2021-06-23 US US17/356,497 patent/US20230069722A1/en active Pending
- 2021-06-23 BR BR112022024361A patent/BR112022024361A2/pt unknown
-
2022
- 2022-12-22 CL CL2022003715A patent/CL2022003715A1/es unknown
- 2022-12-28 CO CONC2022/0019161A patent/CO2022019161A2/es unknown
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