JP2023531750A - ゴーシェ病を処置するためのアリモクロモル - Google Patents

ゴーシェ病を処置するためのアリモクロモル Download PDF

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Publication number
JP2023531750A
JP2023531750A JP2022580356A JP2022580356A JP2023531750A JP 2023531750 A JP2023531750 A JP 2023531750A JP 2022580356 A JP2022580356 A JP 2022580356A JP 2022580356 A JP2022580356 A JP 2022580356A JP 2023531750 A JP2023531750 A JP 2023531750A
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Prior art keywords
active pharmaceutical
pharmaceutical ingredient
use according
day
dose
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Japanese (ja)
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JP2023531750A5 (cg-RX-API-DMAC7.html
Inventor
トマス キルケゴール イェンセン，
アンダース モルケベルグ ヒンスビー，
カトリン コルスター フォグトゥネセン，
リンダ インゲマン，
ダリ， クリスティーネ イ
Original Assignee
ケムファーム デンマーク アー／エス
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Publication of JP2023531750A publication Critical patent/JP2023531750A/ja
Publication of JP2023531750A5 publication Critical patent/JP2023531750A5/ja
Priority to JP2026001474A priority Critical patent/JP7849574B2/ja
Priority to JP2026064507A priority patent/JP2026104910A/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2022580356A 2020-06-24 2021-06-24 ゴーシェ病を処置するためのアリモクロモル Withdrawn JP2023531750A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2026001474A JP7849574B2 (ja) 2020-06-24 2026-01-07 ゴーシェ病を処置するためのアリモクロモル
JP2026064507A JP2026104910A (ja) 2020-06-24 2026-04-09 ゴーシェ病を処置するためのアリモクロモル

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20182067.7 2020-06-24
EP20182067 2020-06-24
PCT/EP2021/067366 WO2021260120A1 (en) 2020-06-24 2021-06-24 Arimoclomol for treating gaucher disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2026001474A Division JP7849574B2 (ja) 2020-06-24 2026-01-07 ゴーシェ病を処置するためのアリモクロモル

Publications (2)

Publication Number Publication Date
JP2023531750A true JP2023531750A (ja) 2023-07-25
JP2023531750A5 JP2023531750A5 (cg-RX-API-DMAC7.html) 2024-07-02

Family

ID=71143584

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2022580356A Withdrawn JP2023531750A (ja) 2020-06-24 2021-06-24 ゴーシェ病を処置するためのアリモクロモル
JP2026001474A Active JP7849574B2 (ja) 2020-06-24 2026-01-07 ゴーシェ病を処置するためのアリモクロモル
JP2026064507A Pending JP2026104910A (ja) 2020-06-24 2026-04-09 ゴーシェ病を処置するためのアリモクロモル

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2026001474A Active JP7849574B2 (ja) 2020-06-24 2026-01-07 ゴーシェ病を処置するためのアリモクロモル
JP2026064507A Pending JP2026104910A (ja) 2020-06-24 2026-04-09 ゴーシェ病を処置するためのアリモクロモル

Country Status (14)

Country Link
US (1) US20230226036A1 (cg-RX-API-DMAC7.html)
EP (1) EP4171559B1 (cg-RX-API-DMAC7.html)
JP (3) JP2023531750A (cg-RX-API-DMAC7.html)
KR (1) KR20230035586A (cg-RX-API-DMAC7.html)
CN (1) CN116075305A (cg-RX-API-DMAC7.html)
AU (1) AU2021295437A1 (cg-RX-API-DMAC7.html)
BR (1) BR112022026396A2 (cg-RX-API-DMAC7.html)
CA (1) CA3183559A1 (cg-RX-API-DMAC7.html)
DK (1) DK4171559T3 (cg-RX-API-DMAC7.html)
ES (1) ES3056005T3 (cg-RX-API-DMAC7.html)
IL (1) IL299250A (cg-RX-API-DMAC7.html)
MX (1) MX2023000033A (cg-RX-API-DMAC7.html)
PT (1) PT4171559T (cg-RX-API-DMAC7.html)
WO (1) WO2021260120A1 (cg-RX-API-DMAC7.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9662375B2 (en) * 2010-11-30 2017-05-30 Orphazyme Aps Methods for increasing intracellular activity of Hsp70

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019518725A (ja) * 2016-04-29 2019-07-04 オーファザイム エー／エス グルコセレブロシダーゼ関連障害を治療するためのアリモクロモル

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU222994B1 (hu) 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
HUP9900475D0 (en) 1999-02-26 1999-04-28 Biorex Kutato Fejlesztoe Kft O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
HUP0001583A2 (hu) 2000-04-18 2002-11-28 BIOREX Kutató és Fejlesztő Rt. Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké
JP5616336B2 (ja) * 2008-06-26 2014-10-29 オルファザイム エーピーエスＯｒｐｈａｚｙｍｅ Ａｐｓ 酵素活性の調節因子としてのＨｓｐ７０の使用
AU2010281403B2 (en) * 2009-07-28 2016-03-10 Takeda Pharmaceutical Company Limited Compositions and methods for treating Gaucher disease
US10709700B2 (en) * 2014-09-15 2020-07-14 Orphazyme A/S Arimoclomol formulation
KR102279347B1 (ko) * 2016-12-15 2021-07-21 한국생명공학연구원 피리딘계 화합물을 유효성분으로 함유하는 dyrk 관련 질환의 예방 또는 치료용 약학적 조성물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019518725A (ja) * 2016-04-29 2019-07-04 オーファザイム エー／エス グルコセレブロシダーゼ関連障害を治療するためのアリモクロモル

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"STUDY OF ARIMOCLOMOL IN PATIENTS DIAGNOSED WITH GAUCHER DISEASE TYPE 1 OR 3", JPN6025032658, September 2019 (2019-09-01), ISSN: 0005660114 *
BIORXIV, JPN6025032662, 2018, pages 1 - 26, ISSN: 0005660115 *
EBIOMEDICINE, vol. 38, JPN6025032656, 2018, pages 144 - 155, ISSN: 0005660113 *
MOLECULAR GENETICS AND METABOLISM, vol. 123, no. 2, JPN6025032664, 2018, pages 79, ISSN: 0005660116 *

Also Published As

Publication number Publication date
IL299250A (en) 2023-02-01
AU2021295437A1 (en) 2023-02-02
EP4171559A1 (en) 2023-05-03
BR112022026396A2 (pt) 2023-03-14
KR20230035586A (ko) 2023-03-14
MX2023000033A (es) 2023-04-10
WO2021260120A1 (en) 2021-12-30
JP7849574B2 (ja) 2026-04-21
JP2026042936A (ja) 2026-03-11
EP4171559B1 (en) 2025-09-10
ES3056005T3 (en) 2026-02-17
CN116075305A (zh) 2023-05-05
CA3183559A1 (en) 2021-12-30
PT4171559T (pt) 2025-12-16
US20230226036A1 (en) 2023-07-20
DK4171559T3 (da) 2025-12-15
JP2026104910A (ja) 2026-06-25

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