JP2023528300A - 封入されたｒｎａレプリコンおよび使用方法 - Google Patents

封入されたｒｎａレプリコンおよび使用方法 Download PDF

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JP2023528300A
JP2023528300A JP2022571787A JP2022571787A JP2023528300A JP 2023528300 A JP2023528300 A JP 2023528300A JP 2022571787 A JP2022571787 A JP 2022571787A JP 2022571787 A JP2022571787 A JP 2022571787A JP 2023528300 A JP2023528300 A JP 2023528300A
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coding region
recombinant rna
rna replicon
sequence
replicon
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JPWO2021243172A5 (https=
JP2023528300A5 (https=
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ロレーナ ラーナー，
エドワード エム． ケネディ，
ジェニファー エス． リー，
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オンコラス， インコーポレイテッド
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    • C07—ORGANIC CHEMISTRY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23016—HIV-1 retropepsin (3.4.23.16)
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    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2319/00—Fusion polypeptide
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JP2022571787A 2020-05-29 2021-05-28 封入されたｒｎａレプリコンおよび使用方法 Withdrawn JP2023528300A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063032000P 2020-05-29 2020-05-29
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CN113166783B (zh) 2018-10-09 2024-10-11 不列颠哥伦比亚大学 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法
AU2023259636A1 (en) * 2022-04-29 2024-10-10 Elevatebio Technologies, Inc. Production of rna polynucleotides encoding picornavirus
WO2023223183A1 (en) * 2022-05-16 2023-11-23 Crispr Therapeutics Ag Picornaviral vectors for gene editing
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WO2025072371A2 (en) * 2023-09-27 2025-04-03 The General Hospital Corporation Highly active myeloid therapy
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040498A1 (en) * 2001-03-14 2003-02-27 Ansardi David Calvert Oncolytic RNA replicons
JP2005508610A (ja) * 2001-05-23 2005-04-07 インスティティ・パスツール 異種タンパク質の製造に有用なプラス鎖ｒｎａウイルスゲノムに由来するレプリコン
WO2014171526A1 (ja) * 2013-04-17 2014-10-23 国立大学法人九州大学 遺伝子改変コクサッキーウイルス
JP2018506283A (ja) * 2015-02-13 2018-03-08 タケダ ヴァクシーンズ， インコーポレイテッド ワクチン製造用ウイルスの製造方法
WO2019014623A1 (en) * 2017-07-14 2019-01-17 Oncorus, Inc. Encapsulated polynucleotides and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100129406A1 (en) * 2006-09-01 2010-05-27 Anza Therapeutics, Inc. Holin-enhanced vaccines and reagents, and methods of use thereof
EP3876951A1 (en) * 2018-11-06 2021-09-15 Calidi Biotherapeutics, Inc. Enhanced systems for cell-mediated oncolytic viral therapy

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040498A1 (en) * 2001-03-14 2003-02-27 Ansardi David Calvert Oncolytic RNA replicons
JP2005508610A (ja) * 2001-05-23 2005-04-07 インスティティ・パスツール 異種タンパク質の製造に有用なプラス鎖ｒｎａウイルスゲノムに由来するレプリコン
WO2014171526A1 (ja) * 2013-04-17 2014-10-23 国立大学法人九州大学 遺伝子改変コクサッキーウイルス
JP2018506283A (ja) * 2015-02-13 2018-03-08 タケダ ヴァクシーンズ， インコーポレイテッド ワクチン製造用ウイルスの製造方法
WO2019014623A1 (en) * 2017-07-14 2019-01-17 Oncorus, Inc. Encapsulated polynucleotides and methods of use

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