JP2023527354A5 - - Google Patents

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Publication number
JP2023527354A5
JP2023527354A5 JP2022572560A JP2022572560A JP2023527354A5 JP 2023527354 A5 JP2023527354 A5 JP 2023527354A5 JP 2022572560 A JP2022572560 A JP 2022572560A JP 2022572560 A JP2022572560 A JP 2022572560A JP 2023527354 A5 JP2023527354 A5 JP 2023527354A5
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JP
Japan
Application number
JP2022572560A
Other languages
Japanese (ja)
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JP2023527354A (ja
JPWO2021242903A5 (https=
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/034323 external-priority patent/WO2021242903A2/en
Publication of JP2023527354A publication Critical patent/JP2023527354A/ja
Publication of JPWO2021242903A5 publication Critical patent/JPWO2021242903A5/ja
Publication of JP2023527354A5 publication Critical patent/JP2023527354A5/ja
Pending legal-status Critical Current

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JP2022572560A 2020-05-26 2021-05-26 標的rnaを修飾するための組成物及び方法 Pending JP2023527354A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US202063030166P 2020-05-26 2020-05-26
US63/030,166 2020-05-26
US202063112329P 2020-11-11 2020-11-11
US63/112,329 2020-11-11
US202063119921P 2020-12-01 2020-12-01
US63/119,921 2020-12-01
US202163153175P 2021-02-24 2021-02-24
US63/153,175 2021-02-24
US202163178059P 2021-04-22 2021-04-22
US63/178,059 2021-04-22
PCT/US2021/034323 WO2021242903A2 (en) 2020-05-26 2021-05-26 Compositions and methods for modifying target rnas

Publications (3)

Publication Number Publication Date
JP2023527354A JP2023527354A (ja) 2023-06-28
JPWO2021242903A5 JPWO2021242903A5 (https=) 2024-06-03
JP2023527354A5 true JP2023527354A5 (https=) 2024-06-03

Family

ID=76502872

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022572560A Pending JP2023527354A (ja) 2020-05-26 2021-05-26 標的rnaを修飾するための組成物及び方法

Country Status (6)

Country Link
US (1) US20230193279A1 (https=)
EP (1) EP4158024A2 (https=)
JP (1) JP2023527354A (https=)
AU (1) AU2021280283A1 (https=)
CA (1) CA3177380A1 (https=)
WO (1) WO2021242903A2 (https=)

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EP3475424A1 (en) 2016-06-22 2019-05-01 ProQR Therapeutics II B.V. Single-stranded rna-editing oligonucleotides
US10941402B2 (en) 2016-09-01 2021-03-09 Proqr Therapeutics Ii B.V. Chemically modified single-stranded RNA-editing oligonucleotides
GB201808146D0 (en) 2018-05-18 2018-07-11 Proqr Therapeutics Ii Bv Stereospecific Linkages in RNA Editing Oligonucleotides
WO2023278436A1 (en) * 2021-06-29 2023-01-05 Shape Therapeutics Inc. Engineered guide rnas and polynucleotides
AU2022301997A1 (en) * 2021-06-29 2024-01-04 Shape Therapeutics Inc. Engineered guide rnas and polynucleotides
AU2022337146A1 (en) 2021-09-03 2024-03-14 Tacit Therapeutics, Inc. Rna editing via recruitment of spliceosome components
CA3236391A1 (en) * 2021-10-26 2023-05-04 Yiannis SAVVA Rna-editing compositions and methods of use
EP4441219A2 (en) * 2021-12-01 2024-10-09 Shape Therapeutics Inc. Engineered guide rnas and polynucleotides for rna editing targeting lrrk2
US20250154504A1 (en) 2022-02-14 2025-05-15 Proqr Therapeutics Ii B.V. Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia
WO2024013360A1 (en) 2022-07-15 2024-01-18 Proqr Therapeutics Ii B.V. Chemically modified oligonucleotides for adar-mediated rna editing
EP4555086A1 (en) 2022-07-15 2025-05-21 ProQR Therapeutics II B.V. Oligonucleotides for adar-mediated rna editing and use thereof
GB202215614D0 (en) 2022-10-21 2022-12-07 Proqr Therapeutics Ii Bv Heteroduplex rna editing oligonucleotide complexes
AR131145A1 (es) 2022-11-24 2025-02-19 Proqr Therapeutics Ii Bv Oligonucleótidos antisentido para el tratamiento de hemocromatosis hfe hereditaria
GB202218090D0 (en) 2022-12-01 2023-01-18 Proqr Therapeutics Ii Bv Antisense oligonucleotides for the treatment of aldehyde dehydrogenase 2 deficiency
CA3276262A1 (en) 2022-12-09 2024-06-13 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of cardiovascular disease
WO2024137991A2 (en) * 2022-12-23 2024-06-27 Shape Therapeutics Inc. Engineered guide rnas and polynucleotides
GB202300865D0 (en) 2023-01-20 2023-03-08 Proqr Therapeutics Ii Bv Delivery of oligonucleotides
EP4669753A1 (en) 2023-02-20 2025-12-31 ProQR Therapeutics II B.V. Antisense oligonucleotides for the treatment of atherosclerotic cardiovascular disease
WO2024206175A1 (en) 2023-03-24 2024-10-03 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of neurological disorders
GB202304363D0 (en) 2023-03-24 2023-05-10 Proqr Therapeutics Ii Bv Chemically modified antisense oligonucleotides for use in RNA editing
AU2024246572A1 (en) 2023-03-27 2025-10-30 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of liver disease
CN121152627A (zh) * 2023-03-31 2025-12-16 时夕(广州)生物科技有限公司 一种与rna编辑靶位点形成编辑底物的序列
WO2024256620A1 (en) 2023-06-16 2024-12-19 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of neurodegenerative disease
WO2025051946A1 (en) 2023-09-07 2025-03-13 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of metabolic disorders
WO2025104239A1 (en) 2023-11-16 2025-05-22 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of classic galactosemia
WO2025128134A1 (en) * 2023-12-14 2025-06-19 National Taiwan University Hospital Crispri targeting alpha-synuclein
WO2025132708A1 (en) 2023-12-20 2025-06-26 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of huntington's disease
GB202404661D0 (en) 2024-04-02 2024-05-15 Proqr Therapeutics Ii Bv Antisense oligoncleotides for the treatment of liver disease
GB202405143D0 (en) 2024-04-11 2024-05-29 Proqr Therapeutics Ii Bv Antisense oligonucleotides for the treatment of poly-q disease
WO2025224230A1 (en) 2024-04-25 2025-10-30 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of fatty liver disease
GB202410081D0 (en) 2024-07-11 2024-08-28 Proqr Therapeutics Ii Bv Antisense oligonucleotides for the treatment of cardiovascular disease
WO2026022136A1 (en) 2024-07-23 2026-01-29 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of metabolic disorders
WO2026060374A2 (en) 2024-09-16 2026-03-19 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of neurological disorders
WO2026068781A1 (en) 2024-09-30 2026-04-02 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for the treatment of liver disease

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US10676737B2 (en) * 2014-12-17 2020-06-09 Proqr Therapeutics Ii B.V. Targeted RNA editing
US10370667B2 (en) * 2015-11-18 2019-08-06 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
US11274300B2 (en) * 2017-01-19 2022-03-15 Proqr Therapeutics Ii B.V. Oligonucleotide complexes for use in RNA editing
WO2018213708A1 (en) * 2017-05-18 2018-11-22 The Broad Institute, Inc. Systems, methods, and compositions for targeted nucleic acid editing
US20210130800A1 (en) * 2017-10-23 2021-05-06 The Broad Institute, Inc. Systems, methods, and compositions for targeted nucleic acid editing

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