JP2023526090A5 - - Google Patents

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Publication number
JP2023526090A5
JP2023526090A5 JP2022570608A JP2022570608A JP2023526090A5 JP 2023526090 A5 JP2023526090 A5 JP 2023526090A5 JP 2022570608 A JP2022570608 A JP 2022570608A JP 2022570608 A JP2022570608 A JP 2022570608A JP 2023526090 A5 JP2023526090 A5 JP 2023526090A5
Authority
JP
Japan
Prior art keywords
oligonucleotide
bases
oligonucleotide according
modified
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022570608A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023526090A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/AU2021/050469 external-priority patent/WO2021232099A1/en
Publication of JP2023526090A publication Critical patent/JP2023526090A/ja
Publication of JP2023526090A5 publication Critical patent/JP2023526090A5/ja
Pending legal-status Critical Current

Links

JP2022570608A 2020-05-19 2021-05-19 オリゴヌクレオチド Pending JP2023526090A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2020901606 2020-05-19
AU2020901606A AU2020901606A0 (en) 2020-05-19 Oligonucleotides
PCT/AU2021/050469 WO2021232099A1 (en) 2020-05-19 2021-05-19 Oligonucleotides

Publications (2)

Publication Number Publication Date
JP2023526090A JP2023526090A (ja) 2023-06-20
JP2023526090A5 true JP2023526090A5 (https=) 2024-05-27

Family

ID=78708815

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022570608A Pending JP2023526090A (ja) 2020-05-19 2021-05-19 オリゴヌクレオチド

Country Status (10)

Country Link
US (2) US20230348903A1 (https=)
EP (1) EP4153751A4 (https=)
JP (1) JP2023526090A (https=)
KR (1) KR20230013266A (https=)
CN (1) CN115916978A (https=)
AU (1) AU2021276730A1 (https=)
BR (1) BR112022023310A2 (https=)
CA (1) CA3171986A1 (https=)
MX (1) MX2022014495A (https=)
WO (1) WO2021232099A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230013266A (ko) 2020-05-19 2023-01-26 허드슨 인스티튜트 오브 메디컬 리서치 올리고뉴클레오티드
WO2022213153A1 (en) * 2021-04-08 2022-10-13 Hudson Institute of Medical Research Oligonucleotides
CN118460654B (zh) * 2024-07-10 2025-02-14 凯莱英医药集团(天津)股份有限公司 一种Givosiran的制备方法
CN119592567B (zh) * 2024-12-10 2025-12-02 浙江大学 基于肿瘤剪接转换治疗的反义寡核苷酸及其应用

Family Cites Families (28)

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EP3006043B1 (en) 2002-04-04 2019-05-29 Zoetis Belgium S.A. Immunostimulatory g,u-containing oligoribonucleotides
US20050239733A1 (en) 2003-10-31 2005-10-27 Coley Pharmaceutical Gmbh Sequence requirements for inhibitory oligonucleotides
JP2007526253A (ja) * 2004-02-19 2007-09-13 コーリー ファーマシューティカル グループ,インコーポレイテッド 免疫刺激性ウイルスrnaオリゴヌクレオチド
EP1819226A4 (en) * 2004-12-08 2010-12-29 3M Innovative Properties Co COMBINATIONS AND METHODS OF IMMUNOSTIMULATION
US8003619B2 (en) 2004-12-09 2011-08-23 Alnylam Pharmaceuticals, Inc. Method of stimulating an immune response and inhibiting expression of a gene using an oligonucleotide
US20080009455A9 (en) * 2005-02-24 2008-01-10 Coley Pharmaceutical Group, Inc. Immunostimulatory oligonucleotides
EP1924284A1 (en) 2005-09-14 2008-05-28 Hartmann, Gunther Compositions comprising immunostimulatory rna oligonucleotides and methods for producing said rna oligonucleotides
EP1764107A1 (en) * 2005-09-14 2007-03-21 Gunther Hartmann Compositions comprising immunostimulatory RNA oligonucleotides and methods for producing said RNA oligonucleotides
WO2007038720A2 (en) * 2005-09-27 2007-04-05 Coley Pharmaceutical Gmbh Modulation of tlr-mediated immune responses using adaptor oligonucleotides
JP4538522B2 (ja) * 2005-11-25 2010-09-08 コーリー ファーマシューティカル ゲーエムベーハー 免疫刺激性オリゴリボヌクレオチド
CN101331229B (zh) * 2005-11-25 2012-08-29 科勒制药股份公司 免疫刺激性寡核糖核苷酸
KR101221589B1 (ko) * 2006-04-07 2013-01-15 이데라 파마슈티칼즈, 인코포레이티드 Tlr7 및 tlr8에 대한 안정화된 면역 조절성 rna〔simra〕 화합물
ATE502122T1 (de) 2006-06-01 2011-04-15 Trilink Biotechnologies Chemisch modifizierte oligonukleotidprimer zur nukleinsäureamplifikation
EP2046954A2 (en) * 2006-07-31 2009-04-15 Curevac GmbH NUCLEIC ACID OF FORMULA (I): GIXmGn, OR (II): CIXmCn, IN PARTICULAR AS AN IMMUNE-STIMULATING AGENT/ADJUVANT
ES2911034T3 (es) * 2006-08-08 2022-05-17 Univ Bonn Rheinische Friedrich Wilhelms Estructura y uso de oligonucleótidos 5' fosfato
US20080171716A1 (en) 2006-08-16 2008-07-17 Protiva Biotherapeutics, Inc. Nucleic acid modulation of toll-like receptor-mediated immune stimulation
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CA2704853C (en) * 2007-11-06 2017-08-15 Eugen Uhlmann Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties
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WO2016040589A1 (en) * 2014-09-12 2016-03-17 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting complement component c5 and methods of use thereof
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JP2020522510A (ja) * 2017-06-02 2020-07-30 ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. オリゴヌクレオチド組成物及びその使用方法
KR20230013266A (ko) 2020-05-19 2023-01-26 허드슨 인스티튜트 오브 메디컬 리서치 올리고뉴클레오티드

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