JP2023523716A - ウイルス及び抗原のコンジュゲーションによって形成されるワクチン - Google Patents

ウイルス及び抗原のコンジュゲーションによって形成されるワクチン Download PDF

Info

Publication number
JP2023523716A
JP2023523716A JP2022563927A JP2022563927A JP2023523716A JP 2023523716 A JP2023523716 A JP 2023523716A JP 2022563927 A JP2022563927 A JP 2022563927A JP 2022563927 A JP2022563927 A JP 2022563927A JP 2023523716 A JP2023523716 A JP 2023523716A
Authority
JP
Japan
Prior art keywords
antigen
virus
tmv
vaccine
rbd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022563927A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2021216205A5 (zh
Inventor
ヒューム,スティーブン・ディー
バーデン,リー
モートン,ジョシュア
ポーグ,グレッグ
ブラッチャー,バリー
ヘイドン,ヒュー・エイ
シンプソン,キャリー・エイ
パーティン,ニック
オー,ヨンジュン
シェパード,ジョン・ダブリュ
パウリー,マイケル・エイチ
Original Assignee
クビオ・ホールディングス・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/919,943 external-priority patent/US11696948B2/en
Priority claimed from US17/186,941 external-priority patent/US11690907B2/en
Application filed by クビオ・ホールディングス・リミテッド filed Critical クビオ・ホールディングス・リミテッド
Publication of JP2023523716A publication Critical patent/JP2023523716A/ja
Publication of JPWO2021216205A5 publication Critical patent/JPWO2021216205A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/20011Coronaviridae
    • C12N2770/20034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2022563927A 2020-04-21 2021-03-05 ウイルス及び抗原のコンジュゲーションによって形成されるワクチン Pending JP2023523716A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063013284P 2020-04-21 2020-04-21
US63/013,284 2020-04-21
US202063047629P 2020-07-02 2020-07-02
US63/047,629 2020-07-02
US16/919,943 2020-07-02
US16/919,943 US11696948B2 (en) 2018-06-12 2020-07-02 Vaccines formed by virus and antigen conjugation
US17/186,941 US11690907B2 (en) 2018-06-12 2021-02-26 Vaccines formed by virus and antigen conjugation
US17/186,941 2021-02-26
PCT/US2021/021087 WO2021216205A1 (en) 2020-04-21 2021-03-05 Vaccines formed by virus and antigen conjugation

Publications (2)

Publication Number Publication Date
JP2023523716A true JP2023523716A (ja) 2023-06-07
JPWO2021216205A5 JPWO2021216205A5 (zh) 2023-10-13

Family

ID=78270938

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022563927A Pending JP2023523716A (ja) 2020-04-21 2021-03-05 ウイルス及び抗原のコンジュゲーションによって形成されるワクチン

Country Status (4)

Country Link
EP (1) EP4121105A4 (zh)
JP (1) JP2023523716A (zh)
CN (1) CN115996750A (zh)
WO (1) WO2021216205A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116789847B (zh) * 2023-01-13 2024-04-16 广州医科大学附属第一医院(广州呼吸中心) 融合蛋白、病毒样颗粒以及疫苗

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101353375A (zh) * 1995-05-26 2009-01-28 Mg-Pmc有限公司 生产流感血凝素多价疫苗的方法
SK782002A3 (en) * 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
WO2005091753A2 (en) * 2004-03-25 2005-10-06 Large Scale Biology Corporation Flexible vaccine assembly and vaccine delivery platform
GB0505518D0 (en) * 2005-03-17 2005-04-27 Chiron Srl Combination vaccines with whole cell pertussis antigen
EP1934335A4 (en) * 2005-09-08 2010-05-05 Large Scale Biology Corp MODIFIED TOBACCO MOSAIC VIRUS PARTICLES AS MEDIA FOR THE DISPOSAL OF PROTEIN ANTIGENS FOR VACCINE APPLICATIONS
US20130280298A1 (en) * 2006-11-15 2013-10-24 Folia Biotech Inc. Immunogenic Affinity-Conjugated Antigen Systems Based on Papaya Mosaic Virus and Uses Thereof
WO2014134439A1 (en) * 2013-03-01 2014-09-04 New York Blood Center, Inc. Immunogenic composition for mers coronavirus infection
WO2018094241A1 (en) * 2016-11-18 2018-05-24 New York Blood Center, Inc. Immunogenic composition for mers coronavirus infection
US20160362473A1 (en) * 2015-06-12 2016-12-15 Ubi Pharma Inc Immunoglobulin fusion proteins and uses thereof
KR102231217B1 (ko) * 2015-09-24 2021-03-24 한미약품 주식회사 면역글로불린 단편의 특정 위치를 연결 부위로 이용한 단백질 결합체
CN106046176B (zh) * 2016-08-16 2019-09-10 中国药科大学 一种高活性长效降糖融合蛋白及其制备方法与医药用途
US11529413B2 (en) * 2018-06-12 2022-12-20 Kbio Holdings Limited Virus and antigen purification and conjugation

Also Published As

Publication number Publication date
CN115996750A (zh) 2023-04-21
WO2021216205A1 (en) 2021-10-28
EP4121105A1 (en) 2023-01-25
EP4121105A4 (en) 2024-05-15

Similar Documents

Publication Publication Date Title
US11696948B2 (en) Vaccines formed by virus and antigen conjugation
US11655461B2 (en) Antigen purification
US11529413B2 (en) Virus and antigen purification and conjugation
RU2571223C2 (ru) Вирусоподобные частицы, содержащие белки-мишени, слитые с белками оболочки растительных вирусов
JP2017538672A (ja) Cmv由来改変ウイルス様粒子
US11078491B2 (en) Vaccines against Zika virus based on Zika structure proteins
JP6877143B2 (ja) インフルエンザワクチンおよび治療
US11207404B2 (en) Compositions and uses
US10117923B2 (en) Production of an immunogen using a plant virus
US11690907B2 (en) Vaccines formed by virus and antigen conjugation
JP2023523716A (ja) ウイルス及び抗原のコンジュゲーションによって形成されるワクチン
US20230149532A1 (en) Vaccines formed by virus and antigen conjugation
JP2023506160A (ja) ウイルス及び抗原精製及びコンジュゲーション
US20230321217A1 (en) Compositions comprising complexes displaying antigens and methods of using the compositions
US20040161432A1 (en) Subunit vaccines and processes for the production thereof
US20240092840A1 (en) Vaccine formulation comprising recombinant overlapping peptides and native proteins
Phiri et al. Development of a Candidate TMV Epitope Display Vaccine against SARS-CoV-2
US20150274784A1 (en) Production of an Immunogen Using a Plant Virus

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230919

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230919

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20230919

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231004

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20231219

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240314

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240618