JP2023523083A5 - - Google Patents
Info
- Publication number
- JP2023523083A5 JP2023523083A5 JP2022565971A JP2022565971A JP2023523083A5 JP 2023523083 A5 JP2023523083 A5 JP 2023523083A5 JP 2022565971 A JP2022565971 A JP 2022565971A JP 2022565971 A JP2022565971 A JP 2022565971A JP 2023523083 A5 JP2023523083 A5 JP 2023523083A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- amino acid
- acid sequence
- seq
- bifunctional protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025115631A JP2025148434A (ja) | 2020-04-29 | 2025-07-09 | ＰＤ－１とＴＧＦ－βに対する二機能性タンパク質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010359751 | 2020-04-29 | ||
| CN202010359751.8 | 2020-04-29 | ||
| PCT/CN2021/089837 WO2021218895A1 (zh) | 2020-04-29 | 2021-04-26 | 针对PD-1和TGF-β的双功能蛋白 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025115631A Division JP2025148434A (ja) | 2020-04-29 | 2025-07-09 | ＰＤ－１とＴＧＦ－βに対する二機能性タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023523083A JP2023523083A (ja) | 2023-06-01 |
| JP2023523083A5 true JP2023523083A5 (https=) | 2024-05-07 |
| JP7711095B2 JP7711095B2 (ja) | 2025-07-22 |
Family
ID=78331777
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022565971A Active JP7711095B2 (ja) | 2020-04-29 | 2021-04-26 | ＰＤ－１とＴＧＦ－βに対する二機能性タンパク質 |
| JP2025115631A Pending JP2025148434A (ja) | 2020-04-29 | 2025-07-09 | ＰＤ－１とＴＧＦ－βに対する二機能性タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025115631A Pending JP2025148434A (ja) | 2020-04-29 | 2025-07-09 | ＰＤ－１とＴＧＦ－βに対する二機能性タンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230235057A1 (https=) |
| EP (1) | EP4144763A4 (https=) |
| JP (2) | JP7711095B2 (https=) |
| KR (1) | KR20230003178A (https=) |
| AU (1) | AU2021263650A1 (https=) |
| BR (1) | BR112022022020A2 (https=) |
| CA (1) | CA3181579A1 (https=) |
| MX (1) | MX2022013620A (https=) |
| WO (1) | WO2021218895A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109053895B (zh) | 2018-08-30 | 2020-06-09 | 中山康方生物医药有限公司 | 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途 |
| CN116970086A (zh) * | 2022-04-29 | 2023-10-31 | 广东菲鹏制药股份有限公司 | 一种重组抗体及其应用 |
| WO2025251034A1 (en) * | 2024-05-31 | 2025-12-04 | Amgen Inc. | Purification method |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD120103A1 (https=) | 1975-07-07 | 1976-05-20 | ||
| BR112016014952A2 (pt) * | 2014-02-10 | 2017-09-19 | Merck Patent Gmbh | Inibição direcionada de tgfbeta |
| EP3770171A1 (en) * | 2015-04-03 | 2021-01-27 | XOMA Technology Ltd. | Treatment of cancer using inhibitors of tgf-beta and pd-1 |
| CN106967172B (zh) * | 2016-08-23 | 2019-01-08 | 康方药业有限公司 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
| CN106977602B (zh) | 2016-08-23 | 2018-09-25 | 中山康方生物医药有限公司 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
| MY202480A (en) * | 2017-05-12 | 2024-04-30 | Shanghai hengrui pharmaceutical co ltd | Fusion protein containing tgf- receptor and medicinal uses thereof |
| US20200140547A1 (en) * | 2017-05-26 | 2020-05-07 | The Johns Hopkins University | Multifunctional antibody-ligand traps to modulate immune tolerance |
| CN112585165B8 (zh) * | 2018-04-25 | 2025-02-14 | 普罗米修斯生物科学公司 | 优化的抗tl1a抗体 |
| MX2020011684A (es) * | 2018-05-04 | 2020-12-10 | Merck Patent Gmbh | Inhibicion combinada de pd-1/pd-l1, tgfbeta y dna-pk para el tratamiento del cancer. |
| US10597453B2 (en) * | 2018-06-29 | 2020-03-24 | Gensun Biopharma, Inc. | Antitumor immune checkpoint regulator antagonists |
| AU2019301070B2 (en) * | 2018-07-09 | 2025-09-11 | Precigen, Inc. | Fusion constructs and methods of using thereof |
| CN109053895B (zh) * | 2018-08-30 | 2020-06-09 | 中山康方生物医药有限公司 | 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途 |
| CN114340735B (zh) * | 2019-06-28 | 2024-11-12 | 璟尚生物制药公司 | 突变的TGFβ1-RII胞外域和免疫球蛋白支架组成的抗肿瘤拮抗剂 |
| CN110734498A (zh) * | 2019-10-15 | 2020-01-31 | 上海科棋药业科技有限公司 | 一种用于解除免疫抑制的融合蛋白及其应用 |
| CN114616251B (zh) * | 2019-10-21 | 2024-05-24 | 南京维立志博生物科技有限公司 | 靶向PD-1和TGFβ的重组蛋白 |
-
2021
- 2021-04-26 BR BR112022022020A patent/BR112022022020A2/pt unknown
- 2021-04-26 US US17/922,122 patent/US20230235057A1/en active Pending
- 2021-04-26 MX MX2022013620A patent/MX2022013620A/es unknown
- 2021-04-26 JP JP2022565971A patent/JP7711095B2/ja active Active
- 2021-04-26 EP EP21795280.3A patent/EP4144763A4/en active Pending
- 2021-04-26 CA CA3181579A patent/CA3181579A1/en active Pending
- 2021-04-26 KR KR1020227041823A patent/KR20230003178A/ko active Pending
- 2021-04-26 AU AU2021263650A patent/AU2021263650A1/en active Pending
- 2021-04-26 WO PCT/CN2021/089837 patent/WO2021218895A1/zh not_active Ceased
-
2025
- 2025-07-09 JP JP2025115631A patent/JP2025148434A/ja active Pending
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