JP2023521227A - 癌の併用療法 - Google Patents

癌の併用療法 Download PDF

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Publication number
JP2023521227A
JP2023521227A JP2022562594A JP2022562594A JP2023521227A JP 2023521227 A JP2023521227 A JP 2023521227A JP 2022562594 A JP2022562594 A JP 2022562594A JP 2022562594 A JP2022562594 A JP 2022562594A JP 2023521227 A JP2023521227 A JP 2023521227A
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JP
Japan
Prior art keywords
binding protein
seq
cycles
dose
amino acid
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Pending
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JP2022562594A
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English (en)
Japanese (ja)
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JP2023521227A5 (https=
JPWO2021209356A5 (https=
Inventor
マーク、エス．バラス
キャサリン、イー．エリス
スティーブン、ハーシュフェルド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Intellectual Property Development Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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Application filed by GlaxoSmithKline Intellectual Property Development Ltd filed Critical GlaxoSmithKline Intellectual Property Development Ltd
Publication of JP2023521227A publication Critical patent/JP2023521227A/ja
Publication of JP2023521227A5 publication Critical patent/JP2023521227A5/ja
Publication of JPWO2021209356A5 publication Critical patent/JPWO2021209356A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2022562594A 2020-04-14 2021-04-12 癌の併用療法 Pending JP2023521227A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063009565P 2020-04-14 2020-04-14
US63/009,565 2020-04-14
US202063110101P 2020-11-05 2020-11-05
US63/110,101 2020-11-05
PCT/EP2021/059376 WO2021209356A1 (en) 2020-04-14 2021-04-12 Combination treatment for cancer

Publications (3)

Publication Number Publication Date
JP2023521227A true JP2023521227A (ja) 2023-05-23
JP2023521227A5 JP2023521227A5 (https=) 2024-04-23
JPWO2021209356A5 JPWO2021209356A5 (https=) 2024-04-23

Family

ID=75497923

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022562594A Pending JP2023521227A (ja) 2020-04-14 2021-04-12 癌の併用療法

Country Status (7)

Country Link
US (1) US20230131598A1 (https=)
EP (1) EP4136112A1 (https=)
JP (1) JP2023521227A (https=)
CN (1) CN115397861A (https=)
AU (1) AU2021257570A1 (https=)
CA (1) CA3171597A1 (https=)
WO (1) WO2021209356A1 (https=)

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US12162940B2 (en) 2021-05-05 2024-12-10 Immatics Biotechnologies Gmbh BMA031 antigen binding polypeptides
US20220396623A1 (en) 2021-05-18 2022-12-15 Kymab Limited Uses of anti-icos antibodies
US20250340641A1 (en) 2022-05-18 2025-11-06 Kymab Limited Uses of anti-icos antibodies
WO2024030956A2 (en) * 2022-08-03 2024-02-08 Mozart Therapeutics, Inc. Cd39-specific binding agents and methods of using the same

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WO2018201096A1 (en) * 2017-04-27 2018-11-01 Tesaro, Inc. Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof
JP2019529368A (ja) * 2016-08-30 2019-10-17 ゼンコア インコーポレイテッド 共刺激受容体およびチェックポイント受容体に連結する二重特異性免疫調節抗体
JP2020502198A (ja) * 2016-12-20 2020-01-23 カイマブ・リミテッド 癌免疫療法のための併用療法での多重特異性抗体

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GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
JP4212278B2 (ja) 2001-03-01 2009-01-21 日本たばこ産業株式会社 移植片拒絶反応抑制剤
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KR101814408B1 (ko) 2008-09-26 2018-01-04 다나-파버 캔서 인스티튜트 인크. 인간 항-ｐｄ-１, ｐｄ-ｌ１, 및 ｐｄ-ｌ2 항체 및 그의 용도
JP5933975B2 (ja) 2008-11-12 2016-06-15 メディミューン，エルエルシー 抗体製剤
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ES2612914T3 (es) 2011-03-31 2017-05-19 Inserm - Institut National De La Santé Et De La Recherche Médicale Anticuerpos dirigidos contra Icos y usos de los mismos
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WO2018115859A1 (en) * 2016-12-20 2018-06-28 Kymab Limited Multispecific antibody with combination therapy for immuno-oncology
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JP2018505177A (ja) * 2015-01-28 2018-02-22 グラクソスミスクライン、インテレクチュアル、プロパテ アゴニスト性ｉｃｏｓ結合タンパク質
JP2019529368A (ja) * 2016-08-30 2019-10-17 ゼンコア インコーポレイテッド 共刺激受容体およびチェックポイント受容体に連結する二重特異性免疫調節抗体
JP2020502198A (ja) * 2016-12-20 2020-01-23 カイマブ・リミテッド 癌免疫療法のための併用療法での多重特異性抗体
WO2018201096A1 (en) * 2017-04-27 2018-11-01 Tesaro, Inc. Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof

Also Published As

Publication number Publication date
WO2021209356A1 (en) 2021-10-21
US20230131598A1 (en) 2023-04-27
EP4136112A1 (en) 2023-02-22
CA3171597A1 (en) 2021-10-21
CN115397861A (zh) 2022-11-25
AU2021257570A1 (en) 2022-11-03

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