JP2023519602A - 安定化ＩｇＧ４抗体及びその使用 - Google Patents

安定化ＩｇＧ４抗体及びその使用 Download PDF

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Publication number
JP2023519602A
JP2023519602A JP2022559368A JP2022559368A JP2023519602A JP 2023519602 A JP2023519602 A JP 2023519602A JP 2022559368 A JP2022559368 A JP 2022559368A JP 2022559368 A JP2022559368 A JP 2022559368A JP 2023519602 A JP2023519602 A JP 2023519602A
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JP
Japan
Prior art keywords
antibody
igg4
disease
igg4 antibody
cancer
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Pending
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JP2022559368A
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English (en)
Japanese (ja)
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JP2023519602A5 (enExample
Inventor
ダブリュー ハンドロッグテン，マイケル
ダッラクア，ウィリアム
アフジャ，サンジーブ
ペン，リ
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メディミューン，エルエルシー
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Application filed by メディミューン，エルエルシー filed Critical メディミューン，エルエルシー
Publication of JP2023519602A publication Critical patent/JP2023519602A/ja
Publication of JP2023519602A5 publication Critical patent/JP2023519602A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022559368A 2020-03-31 2021-03-29 安定化ＩｇＧ４抗体及びその使用 Pending JP2023519602A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063002631P 2020-03-31 2020-03-31
US63/002,631 2020-03-31
PCT/IB2021/052589 WO2021198880A1 (en) 2020-03-31 2021-03-29 Stabilized igg4 antibodies and uses thereof

Publications (2)

Publication Number Publication Date
JP2023519602A true JP2023519602A (ja) 2023-05-11
JP2023519602A5 JP2023519602A5 (enExample) 2024-04-09

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ID=77928189

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JP2022559368A Pending JP2023519602A (ja) 2020-03-31 2021-03-29 安定化ＩｇＧ４抗体及びその使用

Country Status (5)

Country Link
US (1) US20250270325A1 (enExample)
EP (1) EP4126045A4 (enExample)
JP (1) JP2023519602A (enExample)
CN (1) CN115379855A (enExample)
WO (1) WO2021198880A1 (enExample)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013538052A (ja) * 2010-08-20 2013-10-10 ユセベ ファルマ ソシエテ アノニム クラスＩｇＧ４の改良型抗体
JP2015513537A (ja) * 2012-02-22 2015-05-14 ユセベ ファルマ ソシエテ アノニム 配列対称形に修飾されたＩｇＧ４二重特異性抗体
JP2015514684A (ja) * 2012-02-22 2015-05-21 ユセベ ファルマ ソシエテ アノニム 配列非対称形に修飾されたＩｇＧ４二重特異性抗体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI635098B (zh) * 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
KR20190057083A (ko) * 2016-10-06 2019-05-27 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 공정 불순물에 대한 결합이 감소된 항체

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013538052A (ja) * 2010-08-20 2013-10-10 ユセベ ファルマ ソシエテ アノニム クラスＩｇＧ４の改良型抗体
JP2015513537A (ja) * 2012-02-22 2015-05-14 ユセベ ファルマ ソシエテ アノニム 配列対称形に修飾されたＩｇＧ４二重特異性抗体
JP2015514684A (ja) * 2012-02-22 2015-05-21 ユセベ ファルマ ソシエテ アノニム 配列非対称形に修飾されたＩｇＧ４二重特異性抗体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MICHAEL W. HANDLOGTEN ET AL.: ""Prevention of Fab-arm exchange andantibody reduction via stabilization of the IgG4 hinge region"", MABS, vol. Vol. 12，No. 1，e1779974, JPN6025008884, 1 January 2020 (2020-01-01), pages 1 - 11, ISSN: 0005542894 *

Also Published As

Publication number Publication date
EP4126045A1 (en) 2023-02-08
WO2021198880A1 (en) 2021-10-07
EP4126045A4 (en) 2024-04-10
CN115379855A (zh) 2022-11-22
US20250270325A1 (en) 2025-08-28

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