JP2023517243A5 - - Google Patents
Info
- Publication number
- JP2023517243A5 JP2023517243A5 JP2022554833A JP2022554833A JP2023517243A5 JP 2023517243 A5 JP2023517243 A5 JP 2023517243A5 JP 2022554833 A JP2022554833 A JP 2022554833A JP 2022554833 A JP2022554833 A JP 2022554833A JP 2023517243 A5 JP2023517243 A5 JP 2023517243A5
- Authority
- JP
- Japan
- Prior art keywords
- bcma
- subject
- nilogacestat
- dihydrobromide
- cell maturation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025139609A JP2025168430A (ja) | 2020-03-13 | 2025-08-25 | ニロガセスタットとｂｃｍａ指向療法での併用療法およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062989372P | 2020-03-13 | 2020-03-13 | |
| US62/989,372 | 2020-03-13 | ||
| PCT/US2021/022177 WO2021183934A1 (en) | 2020-03-13 | 2021-03-12 | A combination therapy with nirogacestat and a bcma-directed therapy and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025139609A Division JP2025168430A (ja) | 2020-03-13 | 2025-08-25 | ニロガセスタットとｂｃｍａ指向療法での併用療法およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023517243A JP2023517243A (ja) | 2023-04-24 |
| JP2023517243A5 true JP2023517243A5 (enExample) | 2024-03-21 |
| JP7781764B2 JP7781764B2 (ja) | 2025-12-08 |
Family
ID=75396879
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022554833A Active JP7781764B2 (ja) | 2020-03-13 | 2021-03-12 | ニロガセスタットとｂｃｍａ指向療法での併用療法およびその使用 |
| JP2025139609A Pending JP2025168430A (ja) | 2020-03-13 | 2025-08-25 | ニロガセスタットとｂｃｍａ指向療法での併用療法およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025139609A Pending JP2025168430A (ja) | 2020-03-13 | 2025-08-25 | ニロガセスタットとｂｃｍａ指向療法での併用療法およびその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20230121547A1 (enExample) |
| EP (1) | EP4132515A1 (enExample) |
| JP (2) | JP7781764B2 (enExample) |
| KR (1) | KR20230009873A (enExample) |
| CN (1) | CN115916188A (enExample) |
| AR (1) | AR121566A1 (enExample) |
| AU (1) | AU2021236340A1 (enExample) |
| BR (1) | BR112022018251A2 (enExample) |
| CA (1) | CA3171267A1 (enExample) |
| CL (1) | CL2022002479A1 (enExample) |
| CO (1) | CO2022014388A2 (enExample) |
| IL (1) | IL296075A (enExample) |
| MX (1) | MX2022011258A (enExample) |
| PE (1) | PE20230614A1 (enExample) |
| TW (1) | TW202200132A (enExample) |
| WO (1) | WO2021183934A1 (enExample) |
| ZA (1) | ZA202209989B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022339841A1 (en) | 2021-09-01 | 2024-03-28 | Springworks Therapeutics, Inc. | Synthesis of nirogacestat |
| WO2023064872A1 (en) * | 2021-10-14 | 2023-04-20 | Precision Biosciences, Inc. | Combinations of anti-bcma car t cells and gamma secretase inhibitors |
| CN118338900A (zh) * | 2021-11-05 | 2024-07-12 | 斯普林渥克斯治疗有限公司 | 含尼罗加司他的组合物和治疗 |
| CN118302412A (zh) * | 2021-11-23 | 2024-07-05 | 梯瓦制药国际有限责任公司 | Nirogacestat盐的固态形式 |
| US11951096B2 (en) | 2022-05-20 | 2024-04-09 | Springworks Therapeutics, Inc. | Treatments with nirogacestat |
| US12036207B2 (en) | 2022-05-20 | 2024-07-16 | Springworks Therapeutics, Inc. | Treatments with nirogacestat |
| US12138246B2 (en) | 2022-05-20 | 2024-11-12 | Springworks Therapeutics, Inc. | Treatments with nirogacestat |
| KR20250013187A (ko) * | 2022-05-20 | 2025-01-31 | 스프링웍스 테라퓨틱스, 인크. | 니로가세스타트를 사용한 치료 |
| KR20250155587A (ko) * | 2023-03-09 | 2025-10-30 | 크리스탈 파마슈티컬 (쑤저우) 씨오., 엘티디. | 니로가세스타트 디히드로브로마이드의 결정형, 및 이의 제조 방법 및 이의 용도 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015120065A1 (en) * | 2014-02-05 | 2015-08-13 | The Trustees Of Columbia University In The City Of New York | Gamma-secretase inhibition reduce apoc3 levels and plasma triglycerides |
| WO2017019496A1 (en) * | 2015-07-24 | 2017-02-02 | Berenson James Richard | Gamma secretase modulators for the treatment of immune system dysfunction |
| MX2019009552A (es) * | 2017-02-17 | 2019-10-02 | Hutchinson Fred Cancer Res | Terapias de combinacion para el tratamiento de canceres relacionados con el antigeno de maduracion de celulas b (bcma) y trastornos autoinmunitarios. |
| US20200179511A1 (en) * | 2017-04-28 | 2020-06-11 | Novartis Ag | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| EP3615055A1 (en) * | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| CN110622566B (zh) * | 2017-05-05 | 2021-04-20 | 华为技术有限公司 | 一种辅助数据传输方法、设备及系统 |
| MX2020004568A (es) * | 2017-11-06 | 2020-10-05 | Juno Therapeutics Inc | Combinación de una terapia celular y un inhibidor de gamma secretasa. |
| US11970542B2 (en) * | 2017-11-08 | 2024-04-30 | Fred Hutchinson Cancer Center | Bispecific antibodies specific for treating hematological malignancies |
| US20210069194A1 (en) * | 2018-01-17 | 2021-03-11 | Mingsight Pharmaceuticals, Inc. | Combination therapy for the treatment of cancer |
| EP3801551A4 (en) * | 2018-05-24 | 2022-04-06 | Ayala Pharmaceuticals Inc. | COMPOSITIONS WITH BISFLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS AND IMMUNOTHERAPEUTICS AND METHODS OF USE THEREOF |
| KR102870868B1 (ko) * | 2018-06-01 | 2025-10-15 | 노파르티스 아게 | Bcma에 대한 결합 분자 및 이의 용도 |
| CN113924318B (zh) * | 2019-04-10 | 2025-06-20 | 葛兰素史密斯克莱知识产权发展有限公司 | 具有抗BCMA抗体和gamma分泌酶抑制剂的联合疗法 |
| KR102772889B1 (ko) * | 2019-08-09 | 2025-02-26 | 화이자 인코포레이티드 | (s)-2-(((s)-6,8-디플루오로-1,2,3,4-테트라하이드로나프탈렌-2-일)아미노)-n-(1-(2-메틸-1-(네오펜틸아미노)프로판-2-일)-1h-이미다졸-4-일)펜탄아미드의 고체 상태 형태 및 이의 용도 |
-
2021
- 2021-03-12 BR BR112022018251A patent/BR112022018251A2/pt unknown
- 2021-03-12 IL IL296075A patent/IL296075A/en unknown
- 2021-03-12 AR ARP210100641A patent/AR121566A1/es unknown
- 2021-03-12 EP EP21716907.7A patent/EP4132515A1/en active Pending
- 2021-03-12 JP JP2022554833A patent/JP7781764B2/ja active Active
- 2021-03-12 MX MX2022011258A patent/MX2022011258A/es unknown
- 2021-03-12 WO PCT/US2021/022177 patent/WO2021183934A1/en not_active Ceased
- 2021-03-12 KR KR1020227034017A patent/KR20230009873A/ko active Pending
- 2021-03-12 PE PE2022001961A patent/PE20230614A1/es unknown
- 2021-03-12 CA CA3171267A patent/CA3171267A1/en active Pending
- 2021-03-12 TW TW110108930A patent/TW202200132A/zh unknown
- 2021-03-12 AU AU2021236340A patent/AU2021236340A1/en active Pending
- 2021-03-12 CN CN202180034598.4A patent/CN115916188A/zh active Pending
- 2021-03-12 US US17/906,089 patent/US20230121547A1/en active Pending
-
2022
- 2022-09-07 ZA ZA2022/09989A patent/ZA202209989B/en unknown
- 2022-09-12 CL CL2022002479A patent/CL2022002479A1/es unknown
- 2022-10-10 CO CONC2022/0014388A patent/CO2022014388A2/es unknown
-
2025
- 2025-08-25 JP JP2025139609A patent/JP2025168430A/ja active Pending
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