JP2023515567A - Ｐｂｐ３結合二環式ペプチドリガンド - Google Patents

Ｐｂｐ３結合二環式ペプチドリガンド Download PDF

Info

Publication number
JP2023515567A
JP2023515567A JP2022551274A JP2022551274A JP2023515567A JP 2023515567 A JP2023515567 A JP 2023515567A JP 2022551274 A JP2022551274 A JP 2022551274A JP 2022551274 A JP2022551274 A JP 2022551274A JP 2023515567 A JP2023515567 A JP 2023515567A
Authority
JP
Japan
Prior art keywords
seq
referred
acid
peptide
pbp3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2022551274A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023515567A5 (enExample
Inventor
バームフォース マシュー
ベスウィック ポール
チェン リューホン
ドーソン マイク
ドッズ レイチェル
ローランド キャサリン
スカイナー マイケル
ヴァン リーツチョーテン カテリーヌ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BicycleTx Ltd
Original Assignee
BicycleTx Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BicycleTx Ltd filed Critical BicycleTx Ltd
Publication of JP2023515567A publication Critical patent/JP2023515567A/ja
Publication of JP2023515567A5 publication Critical patent/JP2023515567A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2022551274A 2020-02-26 2021-02-26 Ｐｂｐ３結合二環式ペプチドリガンド Ceased JP2023515567A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2002706.6A GB202002706D0 (en) 2020-02-26 2020-02-26 Pbp3 binding bicyclic peptide ligands
GB2002706.6 2020-02-26
PCT/GB2021/050491 WO2021171029A1 (en) 2020-02-26 2021-02-26 Pbp3 binding bicyclic peptide ligands

Publications (2)

Publication Number Publication Date
JP2023515567A true JP2023515567A (ja) 2023-04-13
JP2023515567A5 JP2023515567A5 (enExample) 2024-03-01

Family

ID=70108251

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022551274A Ceased JP2023515567A (ja) 2020-02-26 2021-02-26 Ｐｂｐ３結合二環式ペプチドリガンド

Country Status (6)

Country Link
US (1) US20230106511A1 (enExample)
EP (1) EP4110791A1 (enExample)
JP (1) JP2023515567A (enExample)
CN (1) CN115443285A (enExample)
GB (1) GB202002706D0 (enExample)
WO (1) WO2021171029A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ731185A (en) 2014-10-29 2024-03-22 Bicyclerd Ltd Bicyclic peptide ligands specific for mt1-mmp
WO2019002842A1 (en) 2017-06-26 2019-01-03 Bicyclerd Limited BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF
JP7670481B2 (ja) 2017-08-04 2025-04-30 バイスクルテクス・リミテッド Ｃｄ１３７に対して特異的な二環式ペプチドリガンド
CA3091775A1 (en) 2018-02-23 2019-08-29 Bicycletx Limited Multimeric bicyclic peptide ligands
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
WO2020128527A1 (en) 2018-12-21 2020-06-25 Bicyclerd Limited Bicyclic peptide ligands specific for pd-l1
EP3897849A1 (en) 2018-12-21 2021-10-27 BicycleTx Limited Bicyclic peptide ligands specific for pd-l1
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
TWI860386B (zh) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
CN116348476A (zh) 2020-08-03 2023-06-27 拜斯科技术开发有限公司 基于肽的接头

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009098450A2 (en) * 2008-02-05 2009-08-13 Medical Research Council Methods and compositions
WO2018197509A1 (en) * 2017-04-24 2018-11-01 Bicyclerd Limited Modification of polypeptides
WO2019002842A1 (en) * 2017-06-26 2019-01-03 Bicyclerd Limited BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF
JP2022546964A (ja) * 2019-08-28 2022-11-10 バイスクルテクス・リミテッド Ｐｂｐ結合二環式ペプチドリガンド

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
ES2428869T3 (es) 2005-01-24 2013-11-12 Pepscan Systems B.V. Compuestos de unión, compuestos inmunógenos y peptidomiméticos
JP2008220317A (ja) * 2007-03-15 2008-09-25 Meiji Seika Kaisha Ltd ペニシリン結合タンパク質（ｐｂｐ）３トランスペプチダーゼドメイン
JP2018521960A (ja) * 2015-04-28 2018-08-09 エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ（ウペエフエル）Ｅｃｏｌｅ Ｐｏｌｙｔｅｃｈｎｉｑｕｅ Ｆｅｄｅｒａｌｅ ｄｅ Ｌａｕｓａｎｎｅ （ＥＰＦＬ） 酵素で活性化された第ＸＩＩ因子（ＦＸＩＩａ）の新規阻害剤
CN106591265B (zh) * 2016-08-18 2019-08-13 武汉职业技术学院 一种青霉素结合蛋白及其应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009098450A2 (en) * 2008-02-05 2009-08-13 Medical Research Council Methods and compositions
WO2018197509A1 (en) * 2017-04-24 2018-11-01 Bicyclerd Limited Modification of polypeptides
WO2019002842A1 (en) * 2017-06-26 2019-01-03 Bicyclerd Limited BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF
JP2022546964A (ja) * 2019-08-28 2022-11-10 バイスクルテクス・リミテッド Ｐｂｐ結合二環式ペプチドリガンド

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KAYCIE DEYLE; ET AL: "PHAGE SELECTION OF CYCLIC PEPTIDES FOR APPLICATION IN RESEARCH AND DRUG DEVELOPMENT", ACCOUNTS OF CHEMICAL RESEARCH, vol. VOL:50, NR:8, JPN5023005706, 18 July 2017 (2017-07-18), US, pages 1866 - 1874, ISSN: 0005512713 *
RIIKKA KYLVAJA; ET AL: "PENICILLIN BINDING PROTEIN 3 OF STAPHYLOCOCCUS AUREUS NCTC 8325-4 BINDS AND ACTIVATES 以下備考", BMC RESEARCH NOTES, vol. VOL:9, NR:1, JPN5023005708, December 2016 (2016-12-01), pages 389 - 1, ISSN: 0005512715 *
SANDER S VAN BERKEL; ET AL: "BINDING OF (5S)-PENICILLOIC ACID TO PENICILLIN BINDING PROTEIN 3", ACS CHEMICAL BIOLOGY, vol. VOL:8, NR:10, JPN5023005707, 18 October 2013 (2013-10-18), pages 2112 - 2116, ISSN: 0005512714 *

Also Published As

Publication number Publication date
CN115443285A (zh) 2022-12-06
GB202002706D0 (en) 2020-04-08
WO2021171029A1 (en) 2021-09-02
US20230106511A1 (en) 2023-04-06
EP4110791A1 (en) 2023-01-04

Similar Documents

Publication Publication Date Title
JP2022546964A (ja) Ｐｂｐ結合二環式ペプチドリガンド
JP2023514791A (ja) 抗感染性二環式ペプチドコンジュゲート
CN115443285A (zh) 结合pbp3的双环肽配体
JP2022513806A (ja) Ｍｔ１－ｍｍｐに特異的な二環式ペプチドリガンド
JP7519358B2 (ja) Ｍｔ１－ｍｍｐに特異的な二環式ペプチドリガンド
US12491253B2 (en) Bicyclic peptide ligands specific for MT1-MMP
US11753446B2 (en) Beta-hairpin peptidomimetics
US10829520B2 (en) Beta-hairpin peptidomimetics
CN117203219A (zh) 特异性针对p-选择素的双环肽配体
WO2021220011A1 (en) Anti-infective bicyclic peptide conjugates
US11629171B2 (en) Beta-hairpin peptidomimetics
US10259847B2 (en) Beta-hairpin peptidomimetics
EA046810B1 (ru) Бициклические пептидные лиганды, специфичные к mt1-mmp
EA046487B1 (ru) Бициклические пептидные лиганды, специфичные к mt1-mmp

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221128

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240221

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240221

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250128

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250424

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20250708

A045 Written measure of dismissal of application [lapsed due to lack of payment]

Free format text: JAPANESE INTERMEDIATE CODE: A045

Effective date: 20251125