JP2023513797A - Ｕｌｋ１／２阻害剤による単剤療法および併用療法 - Google Patents

Ｕｌｋ１／２阻害剤による単剤療法および併用療法 Download PDF

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JP2023513797A
JP2023513797A JP2022549152A JP2022549152A JP2023513797A JP 2023513797 A JP2023513797 A JP 2023513797A JP 2022549152 A JP2022549152 A JP 2022549152A JP 2022549152 A JP2022549152 A JP 2022549152A JP 2023513797 A JP2023513797 A JP 2023513797A
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cancer
inhibitor
alkyl
ulk
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JP2023513797A5 (https=
JPWO2021163633A5 (https=
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ニコラス ディー．ピー． コスフォード、
ルーベン ジェイ． ショー、
ニコル エー． バカス、
アリソン エス． リンパート、
ソーニャ エヌ． ブラン、
ミッチェル バモス、
Original Assignee
ソーク インスティテュート フォー バイオロジカル スタディーズ
サンフォード バーナム プレビーズ メディカル ディスカバリー インスティテュート
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Publication of JP2023513797A publication Critical patent/JP2023513797A/ja
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2022549152A 2020-02-14 2021-02-12 Ｕｌｋ１／２阻害剤による単剤療法および併用療法 Pending JP2023513797A (ja)

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US202062977041P 2020-02-14 2020-02-14
US62/977,041 2020-02-14
PCT/US2021/018044 WO2021163633A1 (en) 2020-02-14 2021-02-12 Mono and combination therapies with ulk1/2 inhibitors

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JP2023513797A true JP2023513797A (ja) 2023-04-03
JP2023513797A5 JP2023513797A5 (https=) 2024-02-20
JPWO2021163633A5 JPWO2021163633A5 (https=) 2024-02-20

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US (1) US20230130766A1 (https=)
EP (1) EP4103186A4 (https=)
JP (1) JP2023513797A (https=)
KR (1) KR20220154094A (https=)
CN (1) CN115484956A (https=)
AU (1) AU2021218740A1 (https=)
WO (1) WO2021163633A1 (https=)

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KR20220153582A (ko) 2020-02-14 2022-11-18 솔크 인스티튜트 포 바이올로지칼 스터디즈 마크로시클릭 ulk1/2 억제제
WO2022072668A1 (en) * 2020-09-30 2022-04-07 Salk Institute For Biological Studies Patient selection biomarkers for treatment with ulk inhibitors
WO2024140401A1 (zh) * 2022-12-30 2024-07-04 捷思英达控股有限公司 作为激酶抑制剂的杂环化合物以及包括其的组合物
WO2025045182A1 (zh) * 2023-09-01 2025-03-06 深圳众格生物科技有限公司 Ulk1抑制剂及其制备方法和用途
WO2025166124A1 (en) * 2024-02-02 2025-08-07 Deciphera Pharmaceuticals, Llc Ulk inhibitors and methods of use thereof
WO2025166180A1 (en) * 2024-02-02 2025-08-07 Deciphera Pharmaceuticals, Llc Ulk inhibitors and methods of use thereof
WO2025166161A1 (en) * 2024-02-02 2025-08-07 Deciphera Pharmaceuticals, Llc Ulk inhibitors and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
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JP2017526674A (ja) * 2014-08-25 2017-09-14 ソーク インスティテュート フォー バイオロジカル スタディーズ 新規ｕｌｋ１阻害剤およびそれを使用する方法

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MXPA06013165A (es) * 2004-05-14 2007-02-13 Pfizer Prod Inc Derivados de pirimidina para el tratamiento de crecimiento de celulas anormal.
WO2006037117A1 (en) * 2004-09-27 2006-04-06 Amgen Inc. Substituted heterocyclic compounds and methods of use
RS62017B1 (sr) * 2014-09-17 2021-07-30 Celgene Car Llc Mk2 inhibitori i njihova upotreba

Patent Citations (1)

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JP2017526674A (ja) * 2014-08-25 2017-09-14 ソーク インスティテュート フォー バイオロジカル スタディーズ 新規ｕｌｋ１阻害剤およびそれを使用する方法

Non-Patent Citations (2)

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Title
CANCER TREAT. REV., vol. 62, JPN6025002368, 2018, pages 110 - 122, ISSN: 0005651307 *
ONCOL. REP., vol. 37, JPN6025002369, 2017, pages 3449 - 3458, ISSN: 0005651306 *

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US20230130766A1 (en) 2023-04-27
WO2021163633A1 (en) 2021-08-19
KR20220154094A (ko) 2022-11-21
EP4103186A1 (en) 2022-12-21
CN115484956A (zh) 2022-12-16
CA3171335A1 (en) 2021-08-19
EP4103186A4 (en) 2024-03-06

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