JP2023512237A5 - - Google Patents

Info

Publication number
JP2023512237A5
JP2023512237A5 JP2022545993A JP2022545993A JP2023512237A5 JP 2023512237 A5 JP2023512237 A5 JP 2023512237A5 JP 2022545993 A JP2022545993 A JP 2022545993A JP 2022545993 A JP2022545993 A JP 2022545993A JP 2023512237 A5 JP2023512237 A5 JP 2023512237A5
Authority
JP
Japan
Prior art keywords
cancer
nrg1
fusion
poziotinib
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022545993A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023512237A (ja
JP7777533B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/015686 external-priority patent/WO2021155130A1/en
Publication of JP2023512237A publication Critical patent/JP2023512237A/ja
Publication of JP2023512237A5 publication Critical patent/JP2023512237A5/ja
Application granted granted Critical
Publication of JP7777533B2 publication Critical patent/JP7777533B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022545993A 2020-01-29 2021-01-29 Nrg1融合体を有するがんの治療のためのポジオチニブの使用 Active JP7777533B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062967265P 2020-01-29 2020-01-29
US62/967,265 2020-01-29
PCT/US2021/015686 WO2021155130A1 (en) 2020-01-29 2021-01-29 Use of poziotinib for the treatment of cancers with nrg1 fusions

Publications (3)

Publication Number Publication Date
JP2023512237A JP2023512237A (ja) 2023-03-24
JP2023512237A5 true JP2023512237A5 (https=) 2024-02-08
JP7777533B2 JP7777533B2 (ja) 2025-11-28

Family

ID=77079960

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022545993A Active JP7777533B2 (ja) 2020-01-29 2021-01-29 Nrg1融合体を有するがんの治療のためのポジオチニブの使用

Country Status (7)

Country Link
US (1) US20230069749A1 (https=)
EP (1) EP4096789A4 (https=)
JP (1) JP7777533B2 (https=)
KR (1) KR20220133238A (https=)
CN (1) CN115362005A (https=)
CA (1) CA3166295A1 (https=)
WO (1) WO2021155130A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021155144A1 (en) * 2020-01-29 2021-08-05 Board Of Regents, The University Of Texas System Use of quinazoline-based tyrosine kinase inhibitors for the treatment of cancers with nrg1 fusions
JP2024523001A (ja) * 2021-06-03 2024-06-25 メルス ナムローゼ フェンノートシャップ 新たなnrg1融合体、融合接合部及びそれらを検出するための方法

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824311A (en) 1987-11-30 1998-10-20 Trustees Of The University Of Pennsylvania Treatment of tumors with monoclonal antibodies against oncogene antigens
JP3040121B2 (ja) 1988-01-12 2000-05-08 ジェネンテク,インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
US4870287A (en) 1988-03-03 1989-09-26 Loma Linda University Medical Center Multi-station proton beam therapy system
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
US5851795A (en) 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
US5801029A (en) 1993-02-16 1998-09-01 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
US5801005A (en) 1993-03-17 1998-09-01 University Of Washington Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated
EP0665852A1 (en) 1993-07-09 1995-08-09 Amgen Boulder Inc. Recombinant ctla4 polypeptides and methods for making the same
GB9506466D0 (en) 1994-08-26 1995-05-17 Prolifix Ltd Cell cycle regulated repressor and dna element
US5760395A (en) 1996-04-18 1998-06-02 Universities Research Assoc., Inc. Method and apparatus for laser-controlled proton beam radiology
US5739169A (en) 1996-05-31 1998-04-14 Procept, Incorporated Aromatic compounds for inhibiting immune response
US5844905A (en) 1996-07-09 1998-12-01 International Business Machines Corporation Extensions to distributed MAC protocols with collision avoidance using RTS/CTS exchange
JP2001523958A (ja) 1997-03-21 2001-11-27 ブライハム アンド ウィミンズ ホスピタル,インコーポレイテッド 免疫療法のctla−4結合ペプチド
NZ507557A (en) 1998-05-06 2003-10-31 Genentech Inc Protein purification by ion exchange chromatography
CZ302706B6 (cs) 1998-12-23 2011-09-14 Pfizer Inc. Lidská monoklonální protilátka, farmaceutická kompozice tuto protilátku obsahující, bunecná linie produkující tuto protilátku, izolovaná molekula kódující težký nebo lehký retezec uvedené protilátky, hostitelská bunka obsahující tuto izolovanou molek
US7041292B1 (en) 1999-06-25 2006-05-09 Genentech, Inc. Treating prostate cancer with anti-ErbB2 antibodies
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
EP1212422B1 (en) 1999-08-24 2007-02-21 Medarex, Inc. Human ctla-4 antibodies and their uses
KR20110008112A (ko) 1999-08-27 2011-01-25 제넨테크, 인크. 항-ErbB2 항체 투여 치료 방법
AU2003233451A1 (en) 2002-03-26 2003-10-13 Massachusetts Institute Of Technology Targets, methods, and reagents for diagnosis and treatment of schizophrenia
JP5225069B2 (ja) 2005-03-23 2013-07-03 ゲンマブ エー/エス 多発性骨髄腫の治療のためのcd38に対する抗体
PT2343320T (pt) 2005-03-25 2018-01-23 Gitr Inc Anticorpos anti-gitr e as suas utilizações
DK2439273T3 (da) 2005-05-09 2019-06-03 Ono Pharmaceutical Co Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
TWI377944B (en) 2007-06-05 2012-12-01 Hanmi Holdings Co Ltd Novel amide derivative for inhibiting the growth of cancer cells
BR122017025062B8 (pt) 2007-06-18 2021-07-27 Merck Sharp & Dohme anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento
CN101970499B (zh) 2008-02-11 2014-12-31 治疗科技公司 用于肿瘤治疗的单克隆抗体
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
WO2010014784A2 (en) 2008-08-01 2010-02-04 Bristol-Myers Squibb Company Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases
JP2012500855A (ja) 2008-08-25 2012-01-12 アンプリミューン、インコーポレーテッド Pd−1アンタゴニストおよび感染性疾患を処置するための方法
WO2011066342A2 (en) 2009-11-24 2011-06-03 Amplimmune, Inc. Simultaneous inhibition of pd-l1/pd-l2
HUE030100T2 (en) 2010-02-19 2017-04-28 Xencor Inc New CTLA4-IG immunoadhesins
KR101217526B1 (ko) 2010-06-11 2013-01-02 한미사이언스 주식회사 아마이드 유도체 또는 이의 약학적으로 허용 가능한 염을 포함하는 약제학적 조성물
JP2014022858A (ja) 2012-07-17 2014-02-03 Murata Mfg Co Ltd 電力増幅器
US9308236B2 (en) 2013-03-15 2016-04-12 Bristol-Myers Squibb Company Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
AU2014296887A1 (en) 2013-08-02 2016-01-28 Aduro Biotech Holdings, Europe B.V. Combining CD27 agonists and immune checkpoint inhibition for immune stimulation
EA029661B1 (ru) 2013-09-06 2018-04-30 Ауриген Дискавери Текнолоджиз Лимитед Производные 1,3,4-оксадиазола и 1,3,4-тиадиазола в качестве иммуномодуляторов
HUE038169T2 (hu) 2013-09-06 2018-09-28 Aurigene Discovery Tech Ltd 1,2,4-Oxadiazol származékok mint immunomodulátorok
CN112552401B (zh) 2013-09-13 2023-08-25 广州百济神州生物制药有限公司 抗pd1抗体及其作为治疗剂与诊断剂的用途
WO2015097536A2 (en) 2013-12-24 2015-07-02 Janssen Pharmaceutical Nv Anti-vista antibodies and fragments
HUE057817T2 (hu) 2014-01-28 2022-06-28 Bristol Myers Squibb Co Anti-LAG-3 antitestek haematológiai malignitások kezelésére
MD4733C1 (ro) 2014-08-19 2021-07-31 Merck Sharp & Dohme Corp Anticorpi anti-TIGIT
WO2016059602A2 (en) 2014-10-16 2016-04-21 Glaxo Group Limited Methods of treating cancer and related compositions
RS60614B1 (sr) 2015-03-23 2020-08-31 Jounce Therapeutics Inc Antitela za icos
WO2016201454A1 (en) * 2015-06-12 2016-12-15 The Translational Genomics Research Institute Targeted therapies for cancer
CA2990360C (en) 2015-06-24 2024-02-13 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments
EP3120851A1 (en) * 2015-07-21 2017-01-25 Pangaea Biotech S.L. 4-amino-6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8h)-one for treatment of solid cancers
HUE068868T2 (hu) 2015-07-30 2025-02-28 Macrogenics Inc PD-1-hez kötõdõ molekulák és alkalmazásukra szolgáló eljárások
CN108290936B (zh) 2015-08-14 2022-07-12 默沙东公司 抗tigit抗体
CA2955184A1 (en) 2016-01-25 2017-07-25 Pfizer Inc. Combination of an ox40 agonist and a 4-1bb agonist for treating cancer
WO2017137830A1 (en) 2016-02-12 2017-08-17 Janssen Pharmaceutica Nv Anti-vista (b7h5) antibodies
WO2017175058A1 (en) 2016-04-07 2017-10-12 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
EP3445788B1 (en) 2016-04-22 2022-01-19 Alligator Bioscience AB Novel bispecific polypeptides against cd137
HRP20210602T1 (hr) 2016-06-20 2021-05-14 F-Star Delta Limited Vezujuće molekule koje vežu pd-l1 i lag-3
GB201611530D0 (en) 2016-07-01 2016-08-17 Alligator Bioscience Ab Novel polypeptides
WO2018029124A1 (en) * 2016-08-08 2018-02-15 F. Hoffmann-La Roche Ag Therapeutic and diagnostic methods for cancer
KR102771603B1 (ko) * 2016-11-17 2025-02-24 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Egfr 또는 her2 엑손 20 돌연변이를 갖는 암 세포에 대한 항종양 활성을 갖는 화합물
GB201619648D0 (en) 2016-11-21 2017-01-04 Alligator Bioscience Ab Novel antibodies and uses thereof
IL269656B2 (en) * 2017-03-31 2024-06-01 Merus Nv Bispecific antibodies that bind ERBB-2 and ERBB3 for use in the treatment of cells with NRG1 fusion gene
US20200024351A1 (en) 2017-04-03 2020-01-23 Jounce Therapeutics, Inc. Compositions and Methods for the Treatment of Cancer
SG11201909395TA (en) 2017-04-27 2019-11-28 Tesaro Inc Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof
RU2019138067A (ru) 2017-05-02 2021-06-02 Эллигейтор Биосайенс Аб Биспецифическое антитело против ox40 и ctla-4
EP3679063A4 (en) 2017-09-08 2021-06-02 The Regents of The University of Colorado, A Body Corporate COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATMENT OR PREVENTION OF HER-CONTROLLED DRUG-RESISTANT CANCER

Similar Documents

Publication Publication Date Title
Maggiore et al. The older adult with locoregionally advanced head and neck squamous cell carcinoma: knowledge gaps and future direction in assessment and treatment
Gala et al. Molecular pathways: HER3 targeted therapy
Miller et al. Phase IIa trial of trastuzumab emtansine with pertuzumab for patients with human epidermal growth factor receptor 2–positive, locally advanced, or metastatic breast cancer
Spiridon et al. A comparison of the in vitro and in vivo activities of IgG and F (ab′) 2 fragments of a mixture of three monoclonal anti-Her-2 antibodies
Gunturu et al. Gastric cancer and trastuzumab: first biologic therapy in gastric cancer
Tian et al. The challenge in treating locally recurrent T3-4 nasopharyngeal carcinoma: the survival benefit and severe late toxicities of re-irradiation with intensity-modulated radiotherapy
Jiang et al. Human epidermal growth factor receptor 2 positive (HER2+) metastatic breast cancer: how the latest results are improving therapeutic options
JP2006508336A5 (https=)
Hajj et al. Role of radiotherapy and newer techniques in the treatment of GI cancers
Brufsky Current approaches and emerging directions in HER2-resistant breast cancer
Mendelsohn Antibody-mediated EGF receptor blockade as an anticancer therapy: from the laboratory to the clinic
Francis et al. Pan-HER inhibitor augments radiation response in human lung and head and neck cancer models
JP2023512237A5 (https=)
JP2023513013A5 (https=)
Ristau et al. Simultaneous integrated boost concepts in definitive radiation therapy for esophageal cancer: outcomes and toxicity
Zhang et al. Preclinical study of a novel tri-specific anti-CD3/CD19/CD20 T cell-engaging antibody as a potentially better treatment for NHL
JP2023513006A5 (https=)
Shagisultanova et al. Sequential therapy with HER2 tyrosine kinase inhibitors in patients with HER2-positive metastatic breast cancer
Tobias et al. PD-8 HERIZON: A phase 2 study of HER-Vaxx (IMU-131), a HER2-targeting peptide vaccine plus SOC chemotherapy in patients with HER2+ advanced stomach cancer–correlation of the antibody responses and clinical outcome
Eisenbeis et al. Monoclonal antibodies and Fc fragments for treating solid tumors
Williams H. Michael Shepard, Dennis J. Slamon, and Axel Ullrich honored with the 2019 Lasker~ DeBakey Clinical Medical Research Award
Yu et al. Excellent response with ado-trastuzumab emtansine in a patient with relapsed metastatic breast cancer presenting with pulmonary lymphangitic carcinomatosis
Zeng et al. Severe thrombocytopenia induced by second exposure to trastuzumab can be alleviated by prolonging the interval between treatments
Dou et al. Inetetamab combined with pyrotinib and chemotherapy in the treatment of breast cancer brain metastasis: A case report
Arnedos et al. Anti-HER2 therapies: when more is more