JP2023510870A - Icd statシグナル伝達が改変されたcd122 - Google Patents
Icd statシグナル伝達が改変されたcd122 Download PDFInfo
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- JP2023510870A JP2023510870A JP2022542896A JP2022542896A JP2023510870A JP 2023510870 A JP2023510870 A JP 2023510870A JP 2022542896 A JP2022542896 A JP 2022542896A JP 2022542896 A JP2022542896 A JP 2022542896A JP 2023510870 A JP2023510870 A JP 2023510870A
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001116—Receptors for cytokines
- A61K39/001119—Receptors for interleukins [IL]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4214—Receptors for cytokines
- A61K40/4217—Receptors for interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025277551A JP2026053539A (ja) | 2020-01-14 | 2025-12-23 | Icd statシグナル伝達が改変されたcd122 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062961157P | 2020-01-14 | 2020-01-14 | |
| US62/961,157 | 2020-01-14 | ||
| PCT/US2021/013519 WO2021146485A2 (en) | 2020-01-14 | 2021-01-14 | Cd122 with altered icd stat signaling |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025277551A Division JP2026053539A (ja) | 2020-01-14 | 2025-12-23 | Icd statシグナル伝達が改変されたcd122 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023510870A true JP2023510870A (ja) | 2023-03-15 |
| JP2023510870A5 JP2023510870A5 (https=) | 2024-01-22 |
Family
ID=76863264
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022542896A Pending JP2023510870A (ja) | 2020-01-14 | 2021-01-14 | Icd statシグナル伝達が改変されたcd122 |
| JP2025277551A Pending JP2026053539A (ja) | 2020-01-14 | 2025-12-23 | Icd statシグナル伝達が改変されたcd122 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025277551A Pending JP2026053539A (ja) | 2020-01-14 | 2025-12-23 | Icd statシグナル伝達が改変されたcd122 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230027899A1 (https=) |
| EP (1) | EP4090339A4 (https=) |
| JP (2) | JP2023510870A (https=) |
| KR (1) | KR20220131529A (https=) |
| CN (1) | CN115038453A (https=) |
| AU (1) | AU2021208559A1 (https=) |
| CA (1) | CA3165753A1 (https=) |
| IL (1) | IL293822A (https=) |
| MX (1) | MX2022008769A (https=) |
| WO (1) | WO2021146485A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102777151B1 (ko) | 2017-11-21 | 2025-03-05 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 인터루킨-2의 부분 효능제 |
| WO2021146436A2 (en) | 2020-01-14 | 2021-07-22 | Synthekine, Inc. | Biased il2 muteins methods and compositions |
| CA3179414A1 (en) * | 2020-04-06 | 2021-10-14 | Synthekine, Inc. | Human immune cells genomically modified to express orthogonal receptors |
| WO2024235281A1 (zh) * | 2023-05-17 | 2024-11-21 | 北京晶泰科技有限公司 | 白细胞介素-2变体及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018509893A (ja) * | 2015-02-12 | 2018-04-12 | ユニバーシティー ヘルス ネットワーク | キメラ抗原受容体 |
| JP2018526020A (ja) * | 2015-09-11 | 2018-09-13 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 生体関連の直交性サイトカイン/受容体ペア |
| JP2023506223A (ja) * | 2019-12-13 | 2023-02-15 | シンセカイン インコーポレイテッド | Il-2オルソログおよび使用法 |
| JP2023511274A (ja) * | 2020-01-14 | 2023-03-17 | シンセカイン インコーポレイテッド | Il2オルソログおよび使用法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2869459T3 (es) * | 2014-05-16 | 2021-10-25 | Medimmune Llc | Moléculas con unión a receptor de fc de neonato alterada que tiene propiedades terapéuticas y de diagnóstico potenciadas |
| US11655452B2 (en) * | 2015-06-25 | 2023-05-23 | Icell Gene Therapeutics Inc. | Chimeric antigen receptors (CARs), compositions and methods of use thereof |
| WO2018035387A1 (en) * | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| US20230159892A1 (en) * | 2020-04-06 | 2023-05-25 | Synthekine, Inc. | Engineered immune cells |
| KR20240154656A (ko) * | 2022-03-08 | 2024-10-25 | 신테카인, 인크. | 직교 gpc3 키메라 항원 수용체 t 세포 |
-
2021
- 2021-01-14 AU AU2021208559A patent/AU2021208559A1/en active Pending
- 2021-01-14 EP EP21741938.1A patent/EP4090339A4/en active Pending
- 2021-01-14 KR KR1020227027686A patent/KR20220131529A/ko not_active Withdrawn
- 2021-01-14 WO PCT/US2021/013519 patent/WO2021146485A2/en not_active Ceased
- 2021-01-14 CN CN202180009257.1A patent/CN115038453A/zh active Pending
- 2021-01-14 US US17/783,505 patent/US20230027899A1/en active Pending
- 2021-01-14 JP JP2022542896A patent/JP2023510870A/ja active Pending
- 2021-01-14 MX MX2022008769A patent/MX2022008769A/es unknown
- 2021-01-14 CA CA3165753A patent/CA3165753A1/en active Pending
- 2021-01-14 IL IL293822A patent/IL293822A/en unknown
-
2025
- 2025-12-23 JP JP2025277551A patent/JP2026053539A/ja active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018509893A (ja) * | 2015-02-12 | 2018-04-12 | ユニバーシティー ヘルス ネットワーク | キメラ抗原受容体 |
| JP2018526020A (ja) * | 2015-09-11 | 2018-09-13 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 生体関連の直交性サイトカイン/受容体ペア |
| WO2019173773A1 (en) * | 2015-09-11 | 2019-09-12 | The Board Of Trustees Of The Leland Stanford Junior University | Biologically relevant orthogonal cytokine/receptor pairs |
| JP2023506223A (ja) * | 2019-12-13 | 2023-02-15 | シンセカイン インコーポレイテッド | Il-2オルソログおよび使用法 |
| JP2023511274A (ja) * | 2020-01-14 | 2023-03-17 | シンセカイン インコーポレイテッド | Il2オルソログおよび使用法 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL293822A (en) | 2022-08-01 |
| AU2021208559A1 (en) | 2022-07-07 |
| KR20220131529A (ko) | 2022-09-28 |
| WO2021146485A2 (en) | 2021-07-22 |
| JP2026053539A (ja) | 2026-03-25 |
| WO2021146485A3 (en) | 2021-08-19 |
| CA3165753A1 (en) | 2021-07-22 |
| EP4090339A2 (en) | 2022-11-23 |
| EP4090339A4 (en) | 2024-02-14 |
| MX2022008769A (es) | 2022-10-07 |
| US20230027899A1 (en) | 2023-01-26 |
| CN115038453A (zh) | 2022-09-09 |
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