JP2023505690A5 - - Google Patents

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Publication number
JP2023505690A5
JP2023505690A5 JP2022535116A JP2022535116A JP2023505690A5 JP 2023505690 A5 JP2023505690 A5 JP 2023505690A5 JP 2022535116 A JP2022535116 A JP 2022535116A JP 2022535116 A JP2022535116 A JP 2022535116A JP 2023505690 A5 JP2023505690 A5 JP 2023505690A5
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JP
Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
compound
group
compound according
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JP2022535116A
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English (en)
Japanese (ja)
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JP7677646B2 (ja
JP2023505690A (ja
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Priority claimed from PCT/US2020/064191 external-priority patent/WO2021119242A1/en
Publication of JP2023505690A publication Critical patent/JP2023505690A/ja
Publication of JP2023505690A5 publication Critical patent/JP2023505690A5/ja
Application granted granted Critical
Publication of JP7677646B2 publication Critical patent/JP7677646B2/ja
Active legal-status Critical Current
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JP2022535116A 2019-12-10 2020-12-10 複製タンパク質a(rpa)-dna相互作用阻害剤 Active JP7677646B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962946100P 2019-12-10 2019-12-10
US62/946,100 2019-12-10
PCT/US2020/064191 WO2021119242A1 (en) 2019-12-10 2020-12-10 Replication protein a (rpa)-dna interaction inhibitors

Publications (3)

Publication Number Publication Date
JP2023505690A JP2023505690A (ja) 2023-02-10
JP2023505690A5 true JP2023505690A5 (https=) 2023-12-14
JP7677646B2 JP7677646B2 (ja) 2025-05-15

Family

ID=76330773

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022535116A Active JP7677646B2 (ja) 2019-12-10 2020-12-10 複製タンパク質a(rpa)-dna相互作用阻害剤

Country Status (6)

Country Link
US (1) US12486246B2 (https=)
EP (1) EP4073055A4 (https=)
JP (1) JP7677646B2 (https=)
BR (1) BR112022011372A2 (https=)
CA (1) CA3162280A1 (https=)
WO (1) WO2021119242A1 (https=)

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070196395A1 (en) 2003-12-12 2007-08-23 Mackerell Alexander Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain
EP2402323A3 (en) * 2004-10-13 2012-05-30 PTC Therapeutics, Inc. Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases
EP1905762A1 (en) 2005-05-30 2008-04-02 Genecare Research Institute Co., Ltd Pyrazolone derivative
US20100055116A1 (en) 2006-04-13 2010-03-04 Liou Hsiou-Chi Methods and Compositions for Targeting c-Rel
WO2008045663A2 (en) * 2006-10-06 2008-04-17 Kalypsys, Inc. Aryl-substituted heterocyclic pde4 inhibitors as antiinflammatory agents
MY150697A (en) 2007-04-10 2014-02-28 Exelixis Inc Methods of treating cancer using pyridopyrimdinone inhibitors of p13k alpha
WO2008148747A2 (en) 2007-06-08 2008-12-11 University Of Copenhagen Pdz domain modulators
US8476458B2 (en) 2007-06-21 2013-07-02 The Wistar Institute Methods and compositions for modulating P300/CBP activity
HRP20161004T1 (hr) 2007-09-27 2016-10-21 Dow Agrosciences Llc Tehnološki konstruirani proteini cinkovi prsti koji imaju kao cilj gene za sintazu 5-enolpiruvilshikimat-3-fosfata
WO2009145829A1 (en) 2008-04-01 2009-12-03 University Of Massachusetts Type iii secretion inhibitors, analogs and uses thereof
WO2009146179A1 (en) 2008-04-15 2009-12-03 University Of Iowa Research Foundation Zinc finger nuclease for the cftr gene and methods of use thereof
US9005670B2 (en) 2010-01-05 2015-04-14 The Johns Hopkins University Use of histone acetyltransferase inhibitors as novel anti-cancer therapies
CA2825680C (en) 2010-02-05 2019-12-03 Indiana University Research And Technology Corporation Materials and method for inhibiting replication protein a and uses thereof
WO2012037573A1 (en) 2010-09-17 2012-03-22 Indiana University Research And Technology Corporation Small molecule inhibitors of replication protein a that also act synergistically with cisplatin
EP2840140B2 (en) 2012-12-12 2023-02-22 The Broad Institute, Inc. Crispr-Cas based method for mutation of prokaryotic cells
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
US10227610B2 (en) 2013-02-25 2019-03-12 Sangamo Therapeutics, Inc. Methods and compositions for enhancing nuclease-mediated gene disruption
JP6482546B2 (ja) 2013-07-19 2019-03-13 ラリクス・バイオサイエンス・リミテッド・ライアビリティ・カンパニーLarix Bioscience, Llc 二重対立遺伝子ノックアウトを生成するための方法および組成物
WO2015021426A1 (en) 2013-08-09 2015-02-12 Sage Labs, Inc. A crispr/cas system-based novel fusion protein and its application in genome editing
ITMI20131410A1 (it) 2013-08-26 2015-02-27 Univ Degli Studi Modena E Reggio Emilia Composti e composizioni per l'uso nella inibizione dell' interazione lbc-rhoa
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
WO2016077752A2 (en) * 2014-11-13 2016-05-19 Indiana University Research And Technology Corporation Materials and method for inhibiting replication protein a and uses thereof
WO2017205503A1 (en) 2016-05-24 2017-11-30 Indiana University Research And Technology Corporation Ku inhibitors and their use
CA3075734A1 (en) 2017-09-19 2019-03-28 Indiana University Research And Technology Corporation Xpa inhibitor compounds and their use

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