JP2023502576A5 - - Google Patents
Info
- Publication number
- JP2023502576A5 JP2023502576A5 JP2022524183A JP2022524183A JP2023502576A5 JP 2023502576 A5 JP2023502576 A5 JP 2023502576A5 JP 2022524183 A JP2022524183 A JP 2022524183A JP 2022524183 A JP2022524183 A JP 2022524183A JP 2023502576 A5 JP2023502576 A5 JP 2023502576A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- item
- disease
- ionizable
- itr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962939326P | 2019-11-22 | 2019-11-22 | |
| US62/939,326 | 2019-11-22 | ||
| US202063026493P | 2020-05-18 | 2020-05-18 | |
| US63/026,493 | 2020-05-18 | ||
| PCT/US2020/061801 WO2021102411A1 (en) | 2019-11-22 | 2020-11-23 | Ionizable lipids and nanoparticle compositions thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023502576A JP2023502576A (ja) | 2023-01-25 |
| JP2023502576A5 true JP2023502576A5 (https=) | 2023-12-01 |
Family
ID=73854943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022524183A Pending JP2023502576A (ja) | 2019-11-22 | 2020-11-23 | イオン化可能な脂質およびそれらのナノ粒子組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20220370357A1 (https=) |
| EP (1) | EP4061797A1 (https=) |
| JP (1) | JP2023502576A (https=) |
| CN (1) | CN114787127B (https=) |
| AU (1) | AU2020385378A1 (https=) |
| BR (1) | BR112022007481A2 (https=) |
| IL (2) | IL293039B2 (https=) |
| MX (1) | MX2022006033A (https=) |
| WO (1) | WO2021102411A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20240586T1 (hr) | 2018-10-09 | 2024-07-19 | The University Of British Columbia | Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima |
| US11613472B2 (en) * | 2019-07-22 | 2023-03-28 | King Fahd University Of Petroleum And Minerals | Dumbbell-shaped calcium hydroxide nanoparticles, an enhanced fuel comprising the nanoparticles, and a method for making |
| IL298241A (en) * | 2020-05-18 | 2023-01-01 | Generation Bio Co | New lipids and their nanoparticle preparations |
| AU2021307952A1 (en) * | 2020-07-17 | 2023-03-02 | Generation Bio Co. | Methods for encapsulating polynucleotides into reduced sizes of Lipid nanoparticles and novel formulation thereof |
| JP2023535632A (ja) | 2020-07-27 | 2023-08-18 | アンジャリウム バイオサイエンシズ エージー | Ｄｎａ分子の組成物、その作製方法、及びその使用方法 |
| WO2022115645A1 (en) | 2020-11-25 | 2022-06-02 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
| EP4310071A4 (en) * | 2021-05-28 | 2024-11-20 | Beijing Tricisionbio Therapeutics Inc. | LIPID COMPOUND AND USE THEREOF IN THE ADMINISTRATION OF NUCLEIC ACID |
| AU2022291742A1 (en) * | 2021-06-14 | 2023-12-21 | Generation Bio Co. | Cationic lipids and compositions thereof |
| EP4124348A1 (en) * | 2021-07-30 | 2023-02-01 | 4basebio UK Ltd | Nanoparticles for cell delivery |
| WO2023015200A1 (en) * | 2021-08-04 | 2023-02-09 | The Trustees Of The University Of Pennsylvania | Amniotic fluid stabilized compositions and methods for in utero delivery of therapeutic agents |
| EP4452942A1 (en) * | 2021-12-20 | 2024-10-30 | Beam Therapeutics Inc. | Nanomaterials comprising disulfides |
| WO2023164544A2 (en) * | 2022-02-24 | 2023-08-31 | Sorrento Therapeutics, Inc. | Novel ionizable cationic lipids |
| WO2023183300A1 (en) * | 2022-03-22 | 2023-09-28 | The Children's Medical Center Corporation | Compositions and methods for prevention and treatment of genetic disease |
| WO2023230098A1 (en) | 2022-05-23 | 2023-11-30 | Logicbio Therapeutics, Inc. | Gene therapy compositions and methods of use thereof |
| CA3256897A1 (en) | 2022-05-25 | 2023-11-30 | Akagera Medicines, Inc. | Lipid nanoparticles for the administration of nucleic acids and their methods of use |
| US20240150306A1 (en) * | 2022-09-27 | 2024-05-09 | Reinvigoron Theratech, Inc. | Compounds with cleavable disulfide moieties |
| WO2024081639A1 (en) * | 2022-10-11 | 2024-04-18 | Seawolf Therapeutics, Inc. | Novel lipid nanoparticle compositions for the delivery of nucleic acids |
| EP4626400A1 (en) | 2022-12-01 | 2025-10-08 | Generation Bio Co. | Novel polyglycerol-conjugated lipids and lipid nanoparticle compositions comprising the same |
| WO2024140893A1 (zh) | 2022-12-29 | 2024-07-04 | 辽宁键凯科技有限公司 | 一种类固醇-阳离子脂质化合物及其应用 |
| CN116444378A (zh) * | 2023-02-14 | 2023-07-18 | 广东优康精细化工有限公司 | 一种n-甲基异丙基胺的合成方法 |
| WO2024183497A1 (zh) * | 2023-03-09 | 2024-09-12 | 北京剂泰医药科技有限公司 | 一种鞘内递送制剂及其用途 |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| EP4727599A2 (en) * | 2023-06-15 | 2026-04-22 | Serina Therapeutics (AL), Inc. | Poly(oxazoline) conjugates with pendant cationic groups and lipid nanoparticles and polyplexes including same |
| CN121263400A (zh) * | 2023-12-15 | 2026-01-02 | 厦门赛诺邦格生物科技股份有限公司 | 一种含二硫键的可降解阳离子脂质及其应用 |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
| WO2026064512A1 (en) | 2024-09-18 | 2026-03-26 | Generation Bio Co. | Polyglycerol-conjugated lipids and lipid nanoparticle compositions comprising the same |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| AU733310C (en) | 1997-05-14 | 2001-11-29 | University Of British Columbia, The | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| US7201898B2 (en) | 2000-06-01 | 2007-04-10 | The University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| WO2002087541A1 (en) | 2001-04-30 | 2002-11-07 | Protiva Biotherapeutics Inc. | Lipid-based formulations for gene transfer |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| EP1664316B1 (en) | 2003-09-15 | 2012-08-29 | Protiva Biotherapeutics Inc. | Polyethyleneglycol-modified lipid compounds and uses thereof |
| US7404969B2 (en) | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| CN101267805A (zh) | 2005-07-27 | 2008-09-17 | 普洛体维生物治疗公司 | 制造脂质体的系统和方法 |
| CA2689042A1 (en) | 2007-02-16 | 2008-08-28 | Merck & Co., Inc. | Compositions and methods for potentiated activity of biologicaly active molecules |
| WO2009086558A1 (en) | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| US8883211B2 (en) | 2008-07-10 | 2014-11-11 | Serina Therapeutics, Inc. | Polyoxazolines with inert terminating groups, polyoxazolines prepared from protected initiating groups and related compounds |
| US9018187B2 (en) * | 2009-07-01 | 2015-04-28 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods for the delivery of therapeutic agents |
| US20130037977A1 (en) | 2010-04-08 | 2013-02-14 | Paul A. Burke | Preparation of Lipid Nanoparticles |
| US20130156845A1 (en) | 2010-04-29 | 2013-06-20 | Alnylam Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
| US9006417B2 (en) | 2010-06-30 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| WO2012024526A2 (en) | 2010-08-20 | 2012-02-23 | Cerulean Pharma Inc. | Conjugates, particles, compositions, and related methods |
| EP3485875A1 (en) | 2011-11-04 | 2019-05-22 | Nitto Denko Corporation | Single use system for sterelily producing lipid-nucleic acid particles |
| WO2013073480A1 (ja) * | 2011-11-18 | 2013-05-23 | 日油株式会社 | 細胞内動態を改善したカチオン性脂質 |
| US10426737B2 (en) | 2013-12-19 | 2019-10-01 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
| HUE060907T2 (hu) | 2014-06-25 | 2023-04-28 | Acuitas Therapeutics Inc | Új lipidek és lipid nanorészecske formulációk nukleinsavak bevitelére |
| PT3313829T (pt) | 2015-06-29 | 2024-07-08 | Acuitas Therapeutics Inc | Formulações de lípidos e de nanopartículas lipídicas para a administração de ácidos nucleicos |
| HRP20230209T1 (hr) | 2015-10-28 | 2023-04-14 | Acuitas Therapeutics Inc. | Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina |
| PL3386484T3 (pl) | 2015-12-10 | 2022-07-25 | Modernatx, Inc. | Kompozycje i sposoby dostarczania środków terapeutycznych |
| WO2017117528A1 (en) | 2015-12-30 | 2017-07-06 | Acuitas Therapeutics, Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| WO2018237369A2 (en) * | 2017-06-23 | 2018-12-27 | Vical Incorporated | Lipid nanoparticle (lnp)-mediated delivery of a crispr-expressing plasmid dna for treating chronic hepatitis b virus infection |
| KR102696307B1 (ko) * | 2017-09-08 | 2024-08-16 | 제너레이션 바이오 컴퍼니 | 비-바이러스성 캡시드-비함유 dna 벡터의 지질 나노입자 제형 |
| CN111902397B (zh) | 2018-03-27 | 2024-04-12 | 日油株式会社 | 改进了细胞内动力学的阳离子脂质 |
-
2020
- 2020-11-23 JP JP2022524183A patent/JP2023502576A/ja active Pending
- 2020-11-23 IL IL293039A patent/IL293039B2/en unknown
- 2020-11-23 BR BR112022007481A patent/BR112022007481A2/pt unknown
- 2020-11-23 AU AU2020385378A patent/AU2020385378A1/en active Pending
- 2020-11-23 MX MX2022006033A patent/MX2022006033A/es unknown
- 2020-11-23 EP EP20825350.0A patent/EP4061797A1/en active Pending
- 2020-11-23 CN CN202080079323.8A patent/CN114787127B/zh active Active
- 2020-11-23 WO PCT/US2020/061801 patent/WO2021102411A1/en not_active Ceased
- 2020-11-23 US US17/642,314 patent/US20220370357A1/en active Pending
-
2025
- 2025-10-13 IL IL323923A patent/IL323923A/en unknown
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