JP2023176003A5 - - Google Patents
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- JP2023176003A5 JP2023176003A5 JP2023176751A JP2023176751A JP2023176003A5 JP 2023176003 A5 JP2023176003 A5 JP 2023176003A5 JP 2023176751 A JP2023176751 A JP 2023176751A JP 2023176751 A JP2023176751 A JP 2023176751A JP 2023176003 A5 JP2023176003 A5 JP 2023176003A5
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- Japan
- Prior art keywords
- kit
- patient
- virus
- instructions
- lymphocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 244000309459 oncolytic virus Species 0.000 claims 14
- 201000011510 cancer Diseases 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 10
- 230000002519 immonomodulatory effect Effects 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 238000002255 vaccination Methods 0.000 claims 8
- 210000003162 effector t lymphocyte Anatomy 0.000 claims 7
- 210000001744 T-lymphocyte Anatomy 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 230000036210 malignancy Effects 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 230000004936 stimulating effect Effects 0.000 claims 3
- 102000015636 Oligopeptides Human genes 0.000 claims 2
- 108010038807 Oligopeptides Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 230000001093 anti-cancer Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- 241000711404 Avian avulavirus 1 Species 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 241000709687 Coxsackievirus Species 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241001372913 Maraba virus Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 108700011259 MicroRNAs Proteins 0.000 claims 1
- 229940121849 Mitotic inhibitor Drugs 0.000 claims 1
- 241000711386 Mumps virus Species 0.000 claims 1
- 241000125945 Protoparvovirus Species 0.000 claims 1
- 241000702263 Reovirus sp. Species 0.000 claims 1
- 241000837158 Senecavirus A Species 0.000 claims 1
- 241000710960 Sindbis virus Species 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 241000711975 Vesicular stomatitis virus Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 230000002927 anti-mitotic effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- 239000003145 cytotoxic factor Substances 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 108091006086 inhibitor proteins Proteins 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562216062P | 2015-09-09 | 2015-09-09 | |
| US201562216046P | 2015-09-09 | 2015-09-09 | |
| US62/216,062 | 2015-09-09 | ||
| US62/216,046 | 2015-09-09 | ||
| US201562255294P | 2015-11-13 | 2015-11-13 | |
| US62/255,294 | 2015-11-13 | ||
| US201662323065P | 2016-04-15 | 2016-04-15 | |
| US62/323,065 | 2016-04-15 | ||
| JP2018513549A JP2018526428A (ja) | 2015-09-09 | 2016-09-09 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
| JP2021147640A JP2022003043A (ja) | 2015-09-09 | 2021-09-10 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021147640A Division JP2022003043A (ja) | 2015-09-09 | 2021-09-10 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023176003A JP2023176003A (ja) | 2023-12-12 |
| JP2023176003A5 true JP2023176003A5 (enExample) | 2024-06-20 |
Family
ID=58240173
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513549A Withdrawn JP2018526428A (ja) | 2015-09-09 | 2016-09-09 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
| JP2021147640A Pending JP2022003043A (ja) | 2015-09-09 | 2021-09-10 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
| JP2023176751A Pending JP2023176003A (ja) | 2015-09-09 | 2023-10-12 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513549A Withdrawn JP2018526428A (ja) | 2015-09-09 | 2016-09-09 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
| JP2021147640A Pending JP2022003043A (ja) | 2015-09-09 | 2021-09-10 | 養子ｔ細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20190038727A1 (enExample) |
| EP (1) | EP3347473A4 (enExample) |
| JP (3) | JP2018526428A (enExample) |
| WO (1) | WO2017044780A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090098529A1 (en) | 2006-10-16 | 2009-04-16 | Nanhai Chen | Methods for attenuating virus strains for diagnostic and therapeutic uses |
| ES2733211T3 (es) | 2011-04-15 | 2019-11-28 | Genelux Corp | Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas |
| JP2018510143A (ja) | 2015-02-25 | 2018-04-12 | メモリアル スローン ケタリング キャンサー センター | 不活化非複製改変ワクシニアウイルスアンカラ（ｍｖａ）の固形腫瘍のための単独療法又は免疫チェックポイント遮断剤併用における使用 |
| CN107847534B (zh) | 2015-04-17 | 2022-10-04 | 纪念斯隆凯特琳癌症中心 | Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用 |
| WO2017044780A1 (en) * | 2015-09-09 | 2017-03-16 | Tvax Biomedical I, Llc | Methods for combining adoptive t cell therapy with oncolytic virus adjunct therapy |
| BR112018016948A2 (pt) | 2016-02-25 | 2019-01-08 | Memorial Sloan Kettering Cancer Center | mva recombinante ou mva¿e3l que expressa flt3l humano e uso do mesmo como agente imunoterapêutico contra tumores sólidos |
| EP3419648A4 (en) | 2016-02-25 | 2019-09-11 | Memorial Sloan-Kettering Cancer Center | REPLICATING COMPETENTES WEAKENED VACCINIA VIRUSES WITH DELETION OF THYMIDINE KINASE WITH AND WITHOUT EXPRESSION OF HUMAN FLT3L OR GM-CSF FOR CANCER IMMUNOTHERAPY |
| JP2019524667A (ja) | 2016-06-24 | 2019-09-05 | マックマスター ユニヴァーシティ | 養子細胞移入と腫瘍溶解性ウイルスの併用療法 |
| KR20190128050A (ko) | 2017-02-03 | 2019-11-14 | 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 종양용해성 바이러스 요법 |
| US11242509B2 (en) | 2017-05-12 | 2022-02-08 | Memorial Sloan Kettering Cancer Center | Vaccinia virus mutants useful for cancer immunotherapy |
| US20220347244A1 (en) * | 2018-01-19 | 2022-11-03 | Kolon Life Science, Inc. | Recombinant vaccinia virus and pharmaceutical composition comprising same |
| US12252702B2 (en) | 2018-09-15 | 2025-03-18 | Memorial Sloan Kettering Cancer Center | Recombinant poxviruses for cancer immunotherapy |
| WO2020128012A1 (en) * | 2018-12-21 | 2020-06-25 | Glaxosmithkline Biologicals Sa | Methods of inducing an immune response |
| US20220152168A1 (en) * | 2019-03-20 | 2022-05-19 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Sequential heterologous boost oncolytic viral immunotherapy |
| WO2020247547A1 (en) * | 2019-06-03 | 2020-12-10 | Geovax, Inc. | Cancer vaccine compositions and methods for use thereof |
| EP3980356A4 (en) * | 2019-06-05 | 2023-06-28 | Laitram, L.L.C. | Self-stacking spiral belt conveyor with smooth diameter reduction |
| CN110540960A (zh) * | 2019-09-11 | 2019-12-06 | 苏州大学 | 结合有免疫检查点阻断剂的t淋巴细胞及其在制备抗肿瘤药物中的应用 |
| TWI894357B (zh) * | 2020-09-18 | 2025-08-21 | 大陸商成都美杰賽爾生物科技有限公司 | 溶瘤病毒與經改造的免疫細胞聯合治療腫瘤 |
| EP4052716A1 (en) * | 2021-03-04 | 2022-09-07 | Deutsches Krebsforschungszentrum - Stiftung des öffentlichen Rechts / Universität Heidelberg | Cancer therapy involving car-engineered t-cells and parvovirus h-1 |
| WO2024054293A1 (en) * | 2022-09-08 | 2024-03-14 | Research Institute At Nationwide Children's Hospital | Oncolytic virus combination to maximize oncolytic activity |
| WO2024124190A1 (en) | 2022-12-09 | 2024-06-13 | Microbial Machines, Inc. | Engineered microorganisms for delivery of therapeutic agents |
| WO2024259195A1 (en) * | 2023-06-16 | 2024-12-19 | Elias Animal Health | Use of cd200ar-l for enhancing adoptive t-cell therapy |
| WO2024263805A1 (en) | 2023-06-21 | 2024-12-26 | Microbial Machines, Inc. | Genetically engineered microorganisms for detection of diseased cells |
| CN118045162A (zh) * | 2024-02-28 | 2024-05-17 | 北京景达生物科技有限公司 | 核心蛋白聚糖联合nk细胞在治疗实体瘤中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6406699B1 (en) * | 1999-10-05 | 2002-06-18 | Gary W. Wood | Composition and method of cancer antigen immunotherapy |
| EP2300023A2 (en) | 2008-05-16 | 2011-03-30 | Genelux Corporation | Microorganisms for preventing and treating neoplasms accompanying cellular therapy |
| US20110319871A1 (en) | 2009-03-09 | 2011-12-29 | Tvax Biomedical, Llc | Infectious disease cellular immunotherapy |
| ES2733211T3 (es) | 2011-04-15 | 2019-11-28 | Genelux Corp | Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas |
| ES3011466T3 (en) * | 2013-04-18 | 2025-04-07 | Tilt Biotherapeutics Oy | Enhanced adoptive cell therapy |
| US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| WO2017044780A1 (en) * | 2015-09-09 | 2017-03-16 | Tvax Biomedical I, Llc | Methods for combining adoptive t cell therapy with oncolytic virus adjunct therapy |
-
2016
- 2016-09-09 WO PCT/US2016/050994 patent/WO2017044780A1/en not_active Ceased
- 2016-09-09 JP JP2018513549A patent/JP2018526428A/ja not_active Withdrawn
- 2016-09-09 US US15/757,687 patent/US20190038727A1/en not_active Abandoned
- 2016-09-09 EP EP16845141.7A patent/EP3347473A4/en active Pending
-
2020
- 2020-07-27 US US16/939,266 patent/US11633442B2/en active Active
-
2021
- 2021-09-10 JP JP2021147640A patent/JP2022003043A/ja active Pending
-
2023
- 2023-04-05 US US18/295,994 patent/US12419924B2/en active Active
- 2023-10-12 JP JP2023176751A patent/JP2023176003A/ja active Pending
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