JP2023172954A5 - - Google Patents

Download PDF

Info

Publication number
JP2023172954A5
JP2023172954A5 JP2023084942A JP2023084942A JP2023172954A5 JP 2023172954 A5 JP2023172954 A5 JP 2023172954A5 JP 2023084942 A JP2023084942 A JP 2023084942A JP 2023084942 A JP2023084942 A JP 2023084942A JP 2023172954 A5 JP2023172954 A5 JP 2023172954A5
Authority
JP
Japan
Prior art keywords
seq
pharmaceutical composition
oligonucleotide molecule
consisting solely
oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2023084942A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023172954A (ja
JP7663873B2 (ja
Filing date
Publication date
Priority claimed from EP22382493.9A external-priority patent/EP4282964A1/en
Application filed filed Critical
Publication of JP2023172954A publication Critical patent/JP2023172954A/ja
Publication of JP2023172954A5 publication Critical patent/JP2023172954A5/ja
Application granted granted Critical
Publication of JP7663873B2 publication Critical patent/JP7663873B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2023084942A 2022-05-23 2023-05-23 オレイン酸にコンジュゲートしたオリゴヌクレオチド及びその使用 Active JP7663873B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP22382493 2022-05-23
EP22382493.9A EP4282964A1 (en) 2022-05-23 2022-05-23 Oligonucleotides conjugated to oleic acid and uses thereof

Publications (3)

Publication Number Publication Date
JP2023172954A JP2023172954A (ja) 2023-12-06
JP2023172954A5 true JP2023172954A5 (enExample) 2025-01-28
JP7663873B2 JP7663873B2 (ja) 2025-04-17

Family

ID=81941129

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2024569113A Pending JP2025522282A (ja) 2022-05-23 2023-05-23 オレイン酸にコンジュゲートしたオリゴヌクレオチド及びその使用
JP2023084942A Active JP7663873B2 (ja) 2022-05-23 2023-05-23 オレイン酸にコンジュゲートしたオリゴヌクレオチド及びその使用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2024569113A Pending JP2025522282A (ja) 2022-05-23 2023-05-23 オレイン酸にコンジュゲートしたオリゴヌクレオチド及びその使用

Country Status (9)

Country Link
US (1) US12116575B2 (enExample)
EP (3) EP4282964A1 (enExample)
JP (2) JP2025522282A (enExample)
CN (1) CN119816594A (enExample)
AU (1) AU2023277730A1 (enExample)
CA (1) CA3255781A1 (enExample)
IL (1) IL317141A (enExample)
TW (1) TW202411424A (enExample)
WO (1) WO2023227622A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4282964A1 (en) * 2022-05-23 2023-11-29 Universitat de Valéncia Oligonucleotides conjugated to oleic acid and uses thereof
WO2025114442A1 (en) * 2023-11-28 2025-06-05 Arthex Biotech S.L. Oligonucleotides conjugated to oleic acid and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1648914A4 (en) * 2003-07-31 2009-12-16 Regulus Therapeutics Inc OLIGOMERIC COMPOUNDS AND COMPOSITIONS USEFUL FOR MODULATING SMALL NON-CODING RNA
CA2889044A1 (en) * 2012-11-15 2014-05-22 Roche Innovation Center Copenhagen A/S Anti apob antisense conjugate compounds
EP3169776B1 (en) * 2014-07-14 2025-09-03 The Regents of The University of California Crispr/cas transcriptional modulation
WO2016201272A1 (en) * 2015-06-12 2016-12-15 King Abdulaziz City For Science And Technology Method of diagnosing patients with conditions caused by mendelian mutations
NZ781029A (en) * 2015-10-09 2025-07-25 Wave Life Sciences Ltd Oligonucleotide compositions and methods thereof
ES2659845B1 (es) 2016-09-19 2019-01-04 Univ Valencia Modulación de microRNAs contra la distrofia miotónica tipo 1 y antagonistas de microRNAs para ello
JP2021531278A (ja) * 2018-07-20 2021-11-18 レグルス セラピューティクス インコーポレイテッド オリゴヌクレオチドの経口送達のための方法
US12037585B2 (en) 2019-12-23 2024-07-16 University Of Massachusetts Oligonucleotides for tissue specific gene expression modulation
EP4282964A1 (en) * 2022-05-23 2023-11-29 Universitat de Valéncia Oligonucleotides conjugated to oleic acid and uses thereof

Similar Documents

Publication Publication Date Title
JP2023172954A5 (enExample)
US8431543B2 (en) Chitosan based polymer conjugate and a method for producing the same
KR102142180B1 (ko) 세포에 핵산을 도입하기 위한 조성물
JP2023123491A5 (enExample)
JP2013525330A5 (enExample)
JP2025032110A5 (enExample)
JP2005500025A5 (enExample)
JP2009517048A5 (enExample)
JP2006502694A5 (enExample)
JP2020526192A (ja) アルファ−ENaCの発現を阻害するためのRNAi剤、および使用方法
US20240417422A1 (en) Arnatar compounds and methods for enhanced cellular uptake
CN115521220A (zh) 长链烷基酯胺类化合物及其制备方法和在核酸递送方面的应用
US20130079383A1 (en) Lipid Compounds Targeting VLA-4
IL317141A (en) Oleic acid-conjugated oligonucleotides and uses thereof
CN115996729A (zh) 用于个人医疗保健应用的适配体
CN118436605A (zh) 一种肺选择性脂质组合物及其构建方法和应用
EP2569328B1 (en) Programmable self-assembled nanostructures based on sidechain-modified pna for the multivalent display of ligands
US20250376684A1 (en) Threose nucleic acid antisense oligonucleotides and methods thereof
CN115960901B (zh) 一种用于抗病毒的磷酰胺吗啉代反义寡核苷酸及其应用
US20220340904A1 (en) Method for the production of a catalytically active DNA molecule having improved activity and its use in a method of treating asthma
Campbell et al. Synthesis of a new disulfide Fmoc monomer for creating biologically susceptible linkages in peptide nucleic acid oligomers
US20190367920A1 (en) Antisense oligonucleotides for modulating nfkb1 expression
CN115702006B (zh) 缀合基团及其缀合物
JPWO2021113851A5 (enExample)
CN118512601A (zh) 双链核酸-半乳糖胺-胆固醇化合物及其应用