JP2023158585A - Topical skin preparation - Google Patents

Abstract

To provide a topical skin preparation that exhibits superior effects of preventing and improving wrinkles, blotches or freckles for the skin aging phenomenon, keeping the skin in a youthful sound state, while having reduced skin irritation and good feeling of use.SOLUTION: A topical skin preparation includes a combination of niacin amide and bamboo shoot extract as an active ingredient, exhibiting superior effects of preventing wrinkles and whitening the skin.SELECTED DRAWING: Figure 1

Description

The present invention relates to an external skin preparation that exhibits higher effectiveness by combining a plurality of ingredients.

BACKGROUND ART Conventionally, the use of various compounds has been proposed as ingredients that can be incorporated into external skin preparations, and external skin preparations (external drugs, quasi-drugs, cosmetics, etc.) containing these compounds have been put on the market. For example, antioxidants such as vitamin C and vitamin E; anti-inflammatory agents such as glycyrrhizic acid; various ultraviolet absorbers; cell-activating ingredients such as α-hydroxycarboxylic acid, placenta extract, and γ-amino-β-hydroxybutyric acid; Extracellular matrix components such as collagen, elastin, and hyaluronic acid; and humectants such as urea have been proposed. On the other hand, in consideration of safety, external skin preparations containing various plant-derived ingredients have been proposed. However, these compounds and plant-derived ingredients alone are not sufficient in terms of effectiveness, and a combination of ingredients that exhibits high effectiveness is required.

In view of the problems of the prior art described above, the present inventors have conducted extensive research on combinations of compounds and plant-derived ingredients that are highly effective as active ingredients for external skin preparations. As a result, we found that the combination of niacinamide (also known as nicotinamide) and bamboo shoot extract exerts a remarkable effect on promoting hyaluronic acid synthesis as a component of an external skin preparation. Conventionally, the combination of niacinamide and a plant extract or the technique of blending bamboo shoot extract into a skin external preparation is known from Patent Document 1 and Patent Document 2, but combining niacinamide and a bamboo shoot extract is known. However, it was not known that it exerts a synergistic effect in promoting hyaluronic acid synthesis.
JP 2019-210216 JP2015-113291

The present invention is a hyaluronic acid synthesis promoter containing niacinamide and bamboo shoot extract as active ingredients.

The present invention exhibits a synergistic effect of promoting hyaluronic acid synthesis by combining niacinamide and bamboo shoot extract, and therefore, a highly effective skin preparation can be provided by combining them. .

FIG. 1 is a diagram showing the hyaluronic acid synthesis promoting effect of the active ingredient of the skin external preparation according to the present invention. FIG. 2 is a diagram showing the hyaluronic acid synthesis promoting effect of the active ingredient of the skin external preparation according to the present invention.

Next, "bamboo shoots" used in the present invention will be explained. "Takenoko" is the young bud of bamboo, a member of the Poaceae subfamily Bamboo family. The part of the bamboo shoot used in the present invention may be the edible part, the skin of the inedible part, or the bamboo water.

Bamboo belonging to the Poaceae subfamily Bamboo family used in the present invention includes Phyllostachys bambusoides, Phyllostachys pubescens, Phyllostachys nigra, Phyllostachys aurea, Phyllostachys heterocycla, Bambusa multiplex, Examples include Semiarundinaria fastuosa, Sasa kurilensis, Sinobambusa tootsik, Chimonobambusa quadrangularis, Chimonobambusa marmorea, Pseudosasa japonica, and Pleioblastus simonii. , main application The invention is not limited to this.

In the present invention, bamboo shoots refer to young shoots of bamboo belonging to the Poaceae subfamily Bamboo family. Preferable bamboo shoots to be used in the present invention vary depending on the species of bamboo, but for example, in the case of Madake, those with an above-ground part of 10 to 500 cm, which are harvested from June to September, are preferable; More preferably, the length is 30 cm to 200 cm. In addition, in the case of mosochiku, it is preferable to harvest it from early March to late June until young shoots appear on the ground. If the sprout grows beyond the above range, the edible part and skin of the young sprout will become hard and the amount of tyrosine, which is undesirable as a component of cosmetics, will increase, making it unsuitable for the present invention.

To prepare the extract, wash the skin or edible part of the bamboo shoot with water in advance to remove foreign matter, if necessary, then dry it as it is or dry it, then cut or crush it into pieces as necessary, and use a conventional method such as soaking. This can be carried out by contacting with an extraction solvent according to the method.

Extraction solvents include water; lower alcohols such as methanol, ethanol, and propanol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and glycerin; ethyl acetate, butyl acetate, methyl propionate, etc. Esters; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; hydrocarbon solvents such as n-hexane, toluene, and chloroform; these may be used alone or in combination of two or more. used.

Among these extraction solvents, water, water and lower alcohols, or water and polyhydric alcohols are preferred in the present invention because they can be widely applied to external skin preparations (cosmetics or quasi-drugs). It is preferable to use a mixed solvent with

When preparing the extract, there are no particular limitations on the pH of the extract, but it is preferably in the range of pH 2 to 8. Furthermore, it is more preferable to keep the pH within the range of 2 to 4 from the viewpoint of suppressing the dissolution of tyrosine, which is an undesirable component in cosmetics when contained in the extract. The pH is adjusted by adding an acidic adjuster such as lactic acid, citric acid, hydrochloric acid, phosphoric acid, or sulfuric acid to the extraction solvent.

Extraction conditions such as extraction temperature and extraction time vary depending on the type of solvent used and pH, but for example, in the case of the immersion method using water as the extraction solvent, the extraction temperature is generally 1 to 90°C, Preferably, the temperature is in the range of 40°C to 80°C, and the extraction time is generally in the range of 0.5 to 24 hours, preferably 0.5 to 6 hours, when the extraction temperature is 40°C. .

The pH of the extract obtained under the above conditions is generally adjusted to 4 to 8, and it may be used as it is as a component of an external skin preparation, or it may be used at a desired concentration by concentration under reduced pressure or the like.

When the active ingredient according to the present invention is incorporated into a skin external preparation, in addition to the essential ingredients niacinamide and bamboo shoot extract, ingredients normally used in skin external preparations (topical drugs, quasi-drugs, cosmetics), such as Oil-based ingredients, surfactants (synthetic and natural), emulsifiers, emulsification aids, humectants, anti-inflammatory agents, thickeners, preservatives and disinfectants, anti-acne agents, cell activators, powder ingredients, ultraviolet absorption Agents, antioxidants, whitening agents, pigments, fragrances, etc. can be added as appropriate.

Here, examples of oily ingredients include olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, coconut oil, palm oil, cacao oil, meadowfoam oil, shea butter, tea tree oil, and avocado oil. , plant-derived oils and fats such as plant-derived squalane such as macadamia nut oil, bergamot oil, lavender oil, rose oil, bergamot oil, and chamomile oil; vitamin A oil; animal-derived oils and fats such as mink oil and turtle oil; beeswax, Waxes such as carnauba wax, rice wax, and lanolin; Hydrocarbons such as liquid paraffin, petrolatum, paraffin wax, and squalane; Fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, and cis-11-eicosenoic acid. Higher alcohols such as lauryl alcohol, cetanol, pantothenyl alcohol, and stearyl alcohol; Synthesis of isopropyl myristate, isopropyl palmitate, butyl oleate, 2-ethylhexylglyceride, higher fatty acid octyldodecyl (octyldodecyl stearate, etc.) Examples include esters and synthetic triglycerides.

Examples of surfactants include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, and polyoxyethylene hydrogenated castor oil. , nonionic surfactants such as polyoxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ether sulfates Anionic surfactants such as salts, polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene alkyl phenyl ether phosphates; quaternary ammonium salts, primary to tertiary fatty amine salts , trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salts, N,N-dialkylmorphonium salts, polyethylene polyamine fatty acid amide salts, and other cationic surfactants; N,N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N,N,N-trialkyl-N-alkyleneammoniocarboxybetaine, N-acylamidopropyl-N',N'-dimethyl-N Amphoteric surfactants such as '-β-hydroxypropylammoniosulfobetaine and the like can be used.

In addition, as emulsifiers and/or emulsification aids, stevia derivatives such as enzyme-treated stevia, saponin or its derivatives, casein or its salts (sodium, etc.), sugar and protein complexes, sucrose or its esters, lactose, soybean derived water-soluble polysaccharides, complexes of soybean-derived proteins and polysaccharides, lanolin or its derivatives, cholesterol, stevia derivatives (stevia enzyme-treated products, etc.), silicates (aluminum, magnesium, etc.), carbonates (calcium, sodium, etc.) Saponin and its derivatives, lecithin and its derivatives (hydrogenated lecithin, etc.), lactic acid bacteria-fermented rice, lactic acid bacteria-fermented germinated rice, lactic acid bacteria-fermented grains (wheat, beans, millet, etc.), etc. can also be blended.

Examples of moisturizing agents include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and saccharides such as trehalose and raffinose. Saccharides (e.g. hyaluronic acid and its derivatives, hyaluronic acid fermentation liquid, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, collagen peptides, NMF-related substances, lactic acid, urea, higher fatty acids Examples include octyldodecyl, seaweed extract, estradiol, various amino acids and their derivatives.

Thickeners include, for example, ingredients derived from brown algae, green algae, or red algae such as alginic acid, agar, carrageenan, and fucoidan; polysaccharides such as pectin and aloe polysaccharide; gums such as tragacanth gum, locust bean gum, xanthan gum, and guar gum. Cellulose derivatives such as carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose; Synthetic polymers such as carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, acrylic acid/methacrylic acid copolymer; hyaluronic acid and derivatives thereof; examples include polyglutamic acid and derivatives thereof, polyacrylic acid, and the like.

In addition, anti-inflammatory agents include allantoin, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, stearyl glycyrrhetinate, ε-aminocaproic acid, d-camphor, dl-camphor, zinc oxide, panthenol, pyridoxine hydrochloride, and riboflavin or its derivatives.

Examples of preservatives and disinfectants include urea; benzoic acid or its salt, paraoxybenzoic acid esters such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate; phenoxyethanol, dichlorophen, Hexachlorophene, chlorhexidine hydrochloride, benzalkonium chloride, salicylic acid, sodium salicylate, zinc pyrithione, benzalkonium chloride, ethanol, undecylenic acid, phenols, alkylisoquinolinium bromide, resorcinol, jamal (imidazodeinyl urea), Isopropyl methylphenol, triclosan, trichlorocarbanide, trichlorohydroxydiphenol ether, hinokitiol, 1,2-pentanediol, propanediol, concentrated benzalkonium chloride solution 50, essential oils such as mentha oil, eucalyptus oil, bark dry distillate , fermented radish liquid, ethanol or 1,3-butylene glycol derived from plants such as sugar cane and corn.

Furthermore, examples of cell activators include pantothenyl alcohol, menthol, dl-menthol, and γ-oryzanol.

Further, anti-acne agents include sulfur, salicylic acid or its salt, Photosensor No. 201, pyridoxine dicaprylate, and the like.

Powder components include, for example, sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, silk. There are powders, cellulose powders, grains (rice, wheat, corn, millet, etc.) powders, legumes (soybeans, adzuki beans, etc.) powders, etc.

Examples of ultraviolet absorbers include ethyl para-aminobenzoate, ethylhexyl para-dimethylaminobenzoate, amyl salicylate and its derivatives, 2-ethylhexyl para-methoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy -4-methoxybenzophenone-5-sulfonate, 4-tert-butyl-4-methoxybenzoylmethane, 2-(2-hydroxy-5-methylphenyl)benzotriazole, urocanic acid, ethyl urocanate, aloe extract, etc. There is.

Antioxidants include, for example, carotenoids such as butylated hydroxyanisole, butylated hydroxytoluene, propyl gallate, astaxanthin, vitamin E and its derivatives (for example, tocopherol acetate, tocopherol nicotinate), vitamin A or its derivatives ( retinol palmitate, etc.).

In addition, as a whitening agent, kojic acid or its derivatives, ascorbic acid or its derivatives, hydroquinone or its derivatives, ellagic acid and its derivatives, resorcinol derivatives, 4-methoxysalicylic acid potassium salt, vitamin E or its derivatives, nicotinic acid or its derivatives. , magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), hydroxybenzoic acid and its derivatives, vitamin E and its derivatives, α-hydroxy acid, AMP (adenosine monophosphate, adenosine monophosphate) ) may be one or more selected from.

Examples of kojic acid derivatives include kojic acid esters such as kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, and kojic acid dibutyrate, kojic acid sugar derivatives such as kojic acid ethers, and kojic acid glucoside. Examples of ascorbic acid derivatives include sodium L-ascorbic acid 2-phosphate, magnesium L-ascorbic acid 2-phosphate, sodium L-ascorbic acid 2-sulfate, and sodium L-ascorbic acid 2-phosphate. Ascorbic acid ester salts such as magnesium 2-sulfate ester, L-ascorbic acid-2-glucoside (2-O-α-D-glucopyranosyl-L-ascorbic acid), L-ascorbic acid-5-glucoside (5-O- Ascorbic acid sugar derivatives such as α-D-glucopyranosyl-L-ascorbic acid), 6-acylated products of these ascorbic acid sugar derivatives (acyl group is hexanoyl group, octanoyl group, decanoyl group, etc.), L-ascorbic acid tetraiso L-ascorbic acid tetra fatty acid esters such as palmitic acid ester, L-ascorbic acid tetralauric ester, 3-O-ethyl ascorbic acid, sodium L-ascorbic acid-2-phosphate-6-O-palmitate, etc. , Hydroquinone derivatives include arbutin (hydroquinone-β-D-glucopyranoside), α-arbutin (hydroquinone-α-D-glucopyranoside), and resorcinol derivatives include 4-n-butylresorcinol, 4-isoamylresorcinol, etc. However, examples of 2,5-dihydroxybenzoic acid derivatives include 2,5-diacetoxybenzoic acid, 2-acetoxy-5-hydroxybenzoic acid, and 2-hydroxy-5-propionyloxybenzoic acid, and examples of nicotinic acid derivatives include Examples of vitamin E derivatives include vitamin E nicotinate and vitamin E linoleate; examples of α-hydroxy acids include lactic acid, malic acid, succinic acid, citric acid, α- Examples include hydroxyoctanoic acid.

In the present invention, by using niacinamide and bamboo shoot extract in combination with dipotassium glycyrrhizinate, ascorbic acid or its derivatives, kojic acid or its derivatives, tranexamic acid or its derivatives, arbutin, vitamin E or its derivatives, etc. Furthermore, it is also suggested that it exhibits synergistic effects such as wrinkle improvement and whitening effects.

The skin external preparation (including cosmetics, quasi-drugs, and external drugs) containing the combination of niacinamide and bamboo shoot extract according to the present invention can be applied to the skin in general, including the scalp, and is not particularly limited. Therefore, the dosage forms include milky lotions, creams, lotions, essences, packs, lipsticks, foundations, liquid foundations, makeup press powders, blushers, whitening powders, facial cleansers, body shampoos, soaps, mask preparations, and baths. agents, but the present invention is not limited thereto.

Next, the present invention will be explained in more detail with reference to production examples, formulation examples, working examples, and test examples, but the present invention is not limited thereto. In addition, in the following, all parts mean parts by weight, and all percentages mean weight %.

Manufacturing example 1. Bamboo shoot skin extract (1)
Add 1000 g of purified water and 0.92 g of lactic acid to 100 g of dried pulverized bamboo shoot skin of Mosouchiku, perform extraction at 40°C for 4 hours, filter the extract, and add 532 g of light brown bamboo shoot skin extract solution. (solid content concentration 0.6%).

Production example 2. Bamboo shoot skin extract (2)
1000 g of purified water was added to 100 g of dried and crushed bamboo shoot peels of Mosouchiku, and extraction was performed at 40°C for 4 hours. The extract was filtered to obtain 521 g of a pale brown bamboo shoot skin extract solution (solid content concentration 0.5%).

Production example 3. Bamboo shoot skin extract (3)
In Production Example 1, 640 g of light brown transparent Madake extract (solid content Concentration: 0.6%) was obtained.

Test example 1. Fibroblast Cell Hyaluronic Acid Synthesis Promotion Evaluation As for the effectiveness of niacinamide and bamboo shoot extract, the hyaluronic acid synthesis promoting effect was evaluated by the following method. First, human dermis-derived fibroblasts NB1RGB were seeded at 1× ¹⁰ cells/well in a 96-well microplate containing Eagle's minimum essential medium containing 0.5% NCS, and the cells were incubated at 37°C and 5.0% _CO2. After pre-cultured for 1 day, niacinamide (1 mM) and the extract of Production Example 1 were added to the medium as a sample solution of the present invention, and cultured under the same conditions for an additional 5 days. Here, the concentration of the extract of Production Example 1 is as follows: Sample 1 of the present invention, which was added so that the final concentration as a solution was 0.5% based on the amount of the medium, and Sample 1 of the present invention, which was added so that the final concentration as a solution was 1.0%. A sample 2 of the present invention was set in which the amount of the compound was added so as to be %. In addition, as comparative samples instead of the present invention samples, Comparative Sample 1 consisting only of niacinamide (1 mM) and Comparative Samples 2 and 3 consisting only of the extract of Production Example 1 were also tested in the same manner. Here, the concentration of the extract of Production Example 1 in the comparative sample is as follows: Comparative Sample 2, which was added so that the final concentration as a solution was 0.5% based on the amount of the medium, and Comparative Sample 2, which was added so that the final concentration as a solution was 1%. Comparative sample 3 was set in which the amount was added to .0%. As described above, after culturing cells in a medium supplemented with samples 1 and 2 of the present invention and comparative samples 1 to 3, the supernatant was collected from each well, and a hyaluronic acid measurement kit (Quantikine (registered trademark) ELISA Hyaluronan The amount of hyaluronic acid in the supernatant was quantified using Immunoassay, R&D SYSTEMS, USA). In addition, a group in which PBS (-) was added instead of the above-mentioned sample of the present invention was used as a control, and the relative value of the amount of hyaluronic acid synthesized in each sample addition group to the amount of hyaluronic acid synthesized in the control group was calculated, and the effect of promoting hyaluronic acid synthesis was calculated. (%) was calculated.

The results of Test Example 1 are shown in Figures 1 and 2. First, as shown in Figure 1, sample 1 of the present invention "niacinamide 1mM and the extract of Production Example 1 (0.5%)" has a remarkable synergistic effect of promoting hyaluronic acid synthesis compared to comparative samples 1 and 2. Indicated. When the concentration of the extract of Production Example 1 is 0.5%, by using it together with niacinamide, the effect is equal to the additive effect of the extract of Production Example 1 (0.5%) and niacinamide, respectively. In comparison, a synergistic effect that was approximately 1.7 times higher was confirmed. In addition, as shown in Figure 2, sample 2 of the present invention "niacinamide 1mM and the extract of Production Example 1 (1.0%)" has a synergistic effect of promoting hyaluronic acid synthesis that is remarkable compared to comparative samples 1 and 3. Indicated. When the concentration of the extract of Production Example 1 is 1.0%, by using it together with niacinamide, the effect is equal to the additive effect of the extract of Production Example 1 (1.0%) and niacinamide, respectively. In comparison, a synergistic effect that was approximately 1.6 times higher was confirmed.

Prescription example 1. Lotion [Ingredients] Part Eucalyptus oil 0.2
Polyoxyethylene (5.5) Cetyl Alcohol 5.0
Niacinamide 5.0
Extract of Production Example 1 0.5
Tocopherol acetate 0.02
Dipotassium glycyrrhizinate 0.5
Monoammonium glycyrrhizinate 0.5
Stearyl glycyrrhizinate 0.05
Isopropylmethylphenol 0.1
Align in 0.1
D-pantothenyl alcohol 0.1
Salicylic acid 0.5
Urea 5.0
l-menthol 0.9
dl-menthol 0.2
1,3-butylene glycol 5.0
Sodium citrate 0.2
Methylparaben 0.1
Hinokitiol 0.003
Photosensitive element No. 201 0.002
Purified water Amount that makes the total amount 100 parts

Prescription example 2. Lotion [Ingredients] Part Glyceryl caprylate 3.0
Polyglyceryl laurate-10 3.0
Setanol 2.0
Behenyl alcohol 2.0
Methylparaben 0.1
Niacinamide 5.0
Extract of Production Example 1 1.0
Ascorbic acid 3.0
Glycyrrhizic acid 0.5
β-Glycyrrhetinic acid 0.05
Tocopherol nicotinic acid ester 0.1
Resorcinol 0.1
Zinc oxide 2.0
dl-camphor 0.5
Glycerin 2.0
1,3-butylene glycol 5.0
Potassium hydroxide 0.5
Purified water Amount that makes the total amount 100 parts

Prescription example 3. Lotion [Ingredients] Part Jojoba oil 1.0
Polyoxyethylene (5.5) Cetyl Alcohol 5.0
Methylparaben 0.1
Niacinamide 3.0
Ascorbic acid glucoside 2.0
Tranexamic acid 2.0
ε-Aminocaproic acid 0.1
Sulfur 0.2
Estradiol 0.1
Extract of Production Example 1 1.0
Glycerin 5.0
1,3-butylene glycol 5.0
Sodium citrate 0.2
Sodium metabisulfite 0.2
d-camphor 0.1
Purified water Amount that makes the total amount 100 parts

Prescription example 4. Lotion A lotion was obtained in the same manner as in Formulation Example 3, except that 1.0 part of the extract of Production Example 2 was used in place of 1.0 part of the extract of Production Example 1 among the ingredients of Formulation Example 3.

Prescription example 5. Lotion A lotion was obtained in the same manner as in Formulation Example 3, except that 1.0 part of the extract of Production Example 3 was used in place of 1.0 part of the extract of Production Example 1 among the ingredients of Formulation Example 3.

Prescription example 6. Emulsion [Ingredients] Part Squalane 5.0
Cyclopentane siloxane 1.0
Hexalan 3.0
Hexyldecyl isostearate 1.0
Caprylic/capric triglyceride 1.0
Polyglyceryl laurate-10 5.0
Polyglyceryl-10 isostearate 5.0
Ascorbyl dipalmitate 15.0
Hydrogenated soy lecithin 1.5
Niacinamide 5.0
Extract of Production Example 1 1.0
Ascorbic acid glucoside 2.0
Arbutin 3.0
Potassium hydroxide 0.5
Glycerin 3.0
1,3-butylene glycol 2.0
Carboxymethyl cellulose 0.3
Xanthan gum 0.2
White fungus polysaccharide 0.2
Sodium hyaluronate 0.01
Tocopherol acetate 0.3
Tocopherol nicotinic acid ester 0.1
Glycyrrhizic acid 0.1
Dipotassium glycyrrhizinate 0.1
Isopropylmethylphenol 0.1
Water-soluble collagen 1.0
Hydrolyzed collagen 1.0
Sodium hyaluronate 1.0
Purified water Amount that makes the total amount 100 parts

Prescription example 7. Emulsion A milky lotion was obtained in the same manner as in Prescription Example 6, except that 2.0 parts of L-ascorbyl magnesium phosphate was used in place of 2.0 parts of ascorbic acid glucoside.

Prescription example 8. Emulsion A milky lotion was obtained in the same manner as in Formulation Example 6 except that 2.0 parts of 3-O-ethyl ascorbic acid was used in place of 2.0 parts of ascorbic acid glucoside among the components of Formulation Example 6.

Prescription example 9. Cream [Ingredients] Part Olive oil 5.0
Jojoba oil 5.0
Squalane 5.0
Hexyldecyl isostearate 5.0
Di(octyldodecyl/phytosteryl/behenyl) lauroylglutamate 5.0
Glyceryl caprylate 1.0
Glyceryl stearate 1.0
Isostearylglyceryl 3.0
Niacinamide 5.0
Extract of Production Example 2 1.0
γ-oryzanol 0.1
Behenyl alcohol 2.0
Palmitic acid 2.5
D-pantothenyl alcohol 3.0
Allantoin 0.1
Riboflavin 0.01
Resorcinol 0.1
Benzalkonium chloride 0.05
Urea 3.0
β-Glycyrrhetinic acid 0.1
Stearyl glycyrrhetinate 0.1
Ammonium glycyrrhizinate 0.1
Lactic acid bacteria fermented rice 2.0
Hydrogenated lecithin 0.5
Hydrogenated lysolecithin 0.5
Oil-soluble Panax ginseng extract 2.0
Xanthan gum 1.0
Zinc oxide 0.5
dl-camphor 0.3
l-menthol 0.5
Purified water Amount that makes the total amount 100 parts

Prescription example 10. Pack [Ingredients] Part Dipropylene glycol 5.0
Polyoxyethylene (60) hydrogenated castor oil 5.0
Setanol 3.0
Behenyl alcohol 3.0
Allantoin 0.1
Dipotassium glycyrrhizinate 0.1
Ammonium glycyrrhizinate 0.1
β-Glycyrrhetinic acid 0.1
Stearyl glycyrrhetinate 0.1
Salicylic acid 0.1
Tocopherol acetate 0.5
Tocopherol nicotinic acid ester 0.1
D-pantothenyl alcohol 0.3
Resorcinol 0.1
Sulfur 2.0
Estradiol 0.002
Niacinamide 5.0
Extract of Production Example 1 1.0
Xanthan gum 2.0
Polyglyceryl-6 myristate 1.0
Potassium cocoyl glutamate 1.0
Hydrogenated lecithin 3.0
Hydroxylated lecithin 3.0
Purified water Amount that makes the total amount 100 parts

Prescription example 11. Hair shampoo [Ingredients] Part Sodium laureth sulfate 10.0
Glyceryl monostearate 1.0
Coconut oil fatty acid diethanolamide 2.0
Polyoxyethylene (40) hydrogenated castor oil 0.5
Benzalkonium chloride 1.0
Stearyl alcohol 2.0
Behenyl alcohol 2.0
Dimethicone 3.0
Niacinamide 1.0
Extract of Production Example 1 1.0
Allantoin 0.1
Dipotassium glycyrrhizinate 0.1
Salicylic acid 0.1
Sodium salicylate 0.1
Tocopherol acetate 0.1
Pyrithione zinc 0.3
Benzoic acid 0.2
Triclosan 0.2
Citric acid 0.1
Propylene glycol 2.0
Purified water Amount that makes the total amount 100 parts

Prescription example 12. Hair conditioner [Ingredients] Part Polyoxyethylene (10) Hydrogenated castor oil 1.0
Distearyldimethylammonium chloride 1.5
Stearyltrimethylammonium chloride 2.0
Glyceryl 2-ethylhexanoate 1.0
Benzalkonium chloride 1.0
Setanol 3.0
Stearyl alcohol 1.0
Niacinamide 1.0
Extract of Production Example 2 1.0
Allantoin 0.1
Isopropylmethylphenol 0.1
Dipotassium glycyrrhizinate 0.1
Salicylic acid 0.1
Sulfur 0.5
Alkylisoquinolinium bromide liquid (75%) 0.06
Pyrithione zinc 0.3
Methylparaben 0.1
Triclosan 0.2
Resorcinol 0.1
Purified water Amount that makes the total amount 100 parts

Prescription example 13. Cleansing cosmetics [Ingredients] Part Cocoylglycine potassium 5.0
Glycerin 10.0
Glyceryl caprylate 1.0
Sodium lauroyl aspartate 10.0
Niacinamide 1.0
Extract of Production Example 1 1.0
Setanol 3.0
Myristyl alcohol 3.0
Isopropyl methyl alcohol 0.1
Allantoin 0.1
Sulfur 0.5
Glycyrrhizic acid 0.1
Dipotassium glycyrrhizinate 0.1
Monoammonium glycyrrhizinate 0.1
β-Glycyrrhetinic acid 0.05
Stearyl glycyrrhetinate 0.1
Salicylic acid 0.2
Tocopherol acetate 0.2
Triclosan 0.1
Trichlorocarbanide 0.5
Trichlorohydroxydiphenyl ether 0.2
Concentrated benzalkonium chloride solution 50 0.2
Benzalkonium chloride 0.1
Purified water Amount that makes the total amount 100 parts

Prescription example 14. Sheet mask A sheet mask is obtained by impregnating a nonwoven fabric with the following ingredients.
[Ingredients] Part Glycerin 3.0
1,3-butylene glycol 2.0
L-ascorbic acid 2-glucoside 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Xanthan gum 1.0
Water-soluble collagen 1.0
Sodium hyaluronate 1.0
Eelgrass extract 1.0
Niacinamide 5.0
Extract of Production Example 1 1.0
Potassium hydroxide (appropriate amount) Purified water (amount to make 100 parts)

Prescription example 15. Beauty serum [Ingredients] Part Ethanol 2.0
Glycerin 5.0
1,3-butylene glycol 5.0
Methylparaben 0.1
Hyaluronic acid hydrolyzate 1.0
Lactic acid bacteria culture 1.0
Niacinamide 3.0
Extract of Production Example 1 1.0
Citric acid 0.3
Sodium citrate 0.6
Purified water Amount that makes the total amount 100 parts

Prescription example 16. Wrinkle improvement cream [Ingredients] Part Olive oil 5.0
Squalane 5.0
Jojoba oil 5.0
Jojoba wax 1.0
shea butter 2.0
Behenyl alcohol 1.0
Stearyl alcohol 1.5
Candelilla wax 0.5
Niacinamide 5.0
Lactic acid bacteria fermented rice 3.0
Extract of Production Example 1 1.0
Hydrogenated lecithin 2.0
Katamen Kirin Rhino Extract 2.0
Carboxyvinyl polymer 0.3
Sodium alginate 0.2
Glycerin 4.0
Potassium hydroxide Appropriate amount Purified water Amount to make the total amount 100 parts

Prescription example 17. Wrinkle-improving cream Wrinkle-improving cream prepared in the same manner as in Formulation Example 16, except that 1.0 part of the extract of Production Example 2 was used in place of 1.0 part of the extract of Production Example 1 among the ingredients of Formulation Example 16. I got it.

Prescription example 18. Wrinkle-improving cream Wrinkle-improving cream prepared in the same manner as Prescription Example 16 except that 1.0 part of the extract of Production Example 3 was used instead of 1.0 part of the extract of Production Example 1 among the ingredients of Prescription Example 16. I got it.

Claims (2)

Hyaluronic acid synthesis promoter containing niacinamide and bamboo shoot extract as active ingredients. A skin external preparation comprising the hyaluronic acid synthesis promoter according to claim 1.