JP2023156365A5 - - Google Patents
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- Publication number
- JP2023156365A5 JP2023156365A5 JP2023122299A JP2023122299A JP2023156365A5 JP 2023156365 A5 JP2023156365 A5 JP 2023156365A5 JP 2023122299 A JP2023122299 A JP 2023122299A JP 2023122299 A JP2023122299 A JP 2023122299A JP 2023156365 A5 JP2023156365 A5 JP 2023156365A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- protein
- linker
- fusion protein
- nuclear localization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962806708P | 2019-02-15 | 2019-02-15 | |
| US62/806,708 | 2019-02-15 | ||
| JP2021547390A JP2022520104A (ja) | 2019-02-15 | 2020-02-13 | Ｃｒｉｓｐｒ／ｃａｓ融合タンパク質およびシステム |
| PCT/US2020/018145 WO2020168102A1 (en) | 2019-02-15 | 2020-02-13 | Crispr/cas fusion proteins and systems |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021547390A Division JP2022520104A (ja) | 2019-02-15 | 2020-02-13 | Ｃｒｉｓｐｒ／ｃａｓ融合タンパク質およびシステム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023156365A JP2023156365A (ja) | 2023-10-24 |
| JP2023156365A5 true JP2023156365A5 (https=) | 2024-04-26 |
Family
ID=70166116
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021547390A Pending JP2022520104A (ja) | 2019-02-15 | 2020-02-13 | Ｃｒｉｓｐｒ／ｃａｓ融合タンパク質およびシステム |
| JP2023122299A Pending JP2023156365A (ja) | 2019-02-15 | 2023-07-27 | Ｃｒｉｓｐｒ／ｃａｓ融合タンパク質およびシステム |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021547390A Pending JP2022520104A (ja) | 2019-02-15 | 2020-02-13 | Ｃｒｉｓｐｒ／ｃａｓ融合タンパク質およびシステム |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10947517B2 (https=) |
| EP (1) | EP3924475A1 (https=) |
| JP (2) | JP2022520104A (https=) |
| KR (1) | KR20210139271A (https=) |
| CN (1) | CN113728099A (https=) |
| AU (2) | AU2020221274B2 (https=) |
| BR (1) | BR112021016019A2 (https=) |
| CA (1) | CA3129835A1 (https=) |
| IL (1) | IL285300A (https=) |
| SG (1) | SG11202108812SA (https=) |
| WO (1) | WO2020168102A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| US10947517B2 (en) | 2019-02-15 | 2021-03-16 | Sigma-Aldrich Co. Llc | CRISPR/Cas fusion proteins and systems |
| AU2022343268A1 (en) * | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| CN116063546B (zh) * | 2021-10-29 | 2026-01-16 | 中科辅酶医科技(深圳)有限公司 | 一种基于共振能量转移的全遗传编码nad+蛋白探针及其制备方法和应用 |
| WO2023163806A1 (en) * | 2022-02-22 | 2023-08-31 | Massachusetts Institute Of Technology | Engineered nucleases and methods of use thereof |
| EP4489772A4 (en) * | 2022-03-08 | 2026-03-25 | Univ Wake Forest Health Sciences | EUKARYOTIC GENE EDITING COMPOSITIONS, SYSTEMS AND METHODS |
| WO2025221793A1 (en) * | 2024-04-16 | 2025-10-23 | Monsanto Technology Llc | Modified cas proteins for nuclear localization and editing activity in plants |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04005010A (es) | 2001-11-26 | 2005-04-08 | Advanced Cell Tech Inc | METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS. |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| PL3360964T3 (pl) * | 2012-12-06 | 2020-03-31 | Sigma-Aldrich Co. Llc | Modyfikacja i regulacja genomu oparta na crispr |
| WO2014186686A2 (en) * | 2013-05-17 | 2014-11-20 | Two Blades Foundation | Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases |
| JP6479777B2 (ja) * | 2013-06-11 | 2019-03-06 | ポルタゲ ファーマシューティカルス エルティーディー． | 生物学的に活性な特異的カーゴペプチドと結合したヒト由来の細胞透過性ペプチドの構造、製造および使用 |
| JP6793547B2 (ja) * | 2013-12-12 | 2020-12-02 | ザ・ブロード・インスティテュート・インコーポレイテッド | 最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物 |
| DK3107562T3 (da) | 2014-02-19 | 2019-12-16 | Bioasis Technologies Inc | P97-ids-fusionsproteiner |
| EP3122880B1 (en) | 2014-03-26 | 2021-05-05 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating sickle cell disease |
| EP3201340B1 (en) | 2014-10-01 | 2020-12-02 | The General Hospital Corporation | Methods for increasing efficiency of nuclease-induced homology-directed repair |
| CN107949400A (zh) * | 2015-06-24 | 2018-04-20 | 西格马-奥尔德里奇有限责任公司 | 细胞周期依赖性基因组调控和修饰 |
| WO2017131150A1 (ja) * | 2016-01-29 | 2017-08-03 | 国立大学法人東京大学 | Ｃａｓ９－ｇＲＮＡ複合体の製造方法、Ｃａｓ９－ｇＲＮＡ複合体の細胞核内への導入方法、及び細胞内における標的遺伝子の改変方法 |
| WO2017173004A1 (en) * | 2016-03-30 | 2017-10-05 | Mikuni Takayasu | A method for in vivo precise genome editing |
| US11236313B2 (en) | 2016-04-13 | 2022-02-01 | Editas Medicine, Inc. | Cas9 fusion molecules, gene editing systems, and methods of use thereof |
| CN107579793A (zh) * | 2016-07-04 | 2018-01-12 | 中兴通讯股份有限公司 | 一种通信网络设备间时间同步的优化方法、装置及设备 |
| CN110214183A (zh) * | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| KR102622411B1 (ko) * | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| BR112019012155A2 (pt) | 2016-12-14 | 2019-11-12 | Wageningen Universiteit | uso de pelo menos uma molécula-guia de rna e uma proteína cas, método de ligação, clivagem, marcação ou modificação de um polinucleotídeo alvo de fita dupla, célula transformada, e, complexo de nucleoproteína |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
| SG11202000840YA (en) | 2017-07-31 | 2020-02-27 | Reflection Biotechnologies Ltd | Cellular models of and therapies for ocular diseases |
| US11071791B2 (en) * | 2018-01-26 | 2021-07-27 | Wisconsin Alumni Research Foundation | Vector for gene silencing and replacement and methods of use thereof |
| KR102465067B1 (ko) | 2018-02-15 | 2022-11-10 | 시그마-알드리치 컴퍼니., 엘엘씨 | 진핵 게놈 변형을 위한 조작된 cas9 시스템 |
| WO2019178427A1 (en) * | 2018-03-14 | 2019-09-19 | Arbor Biotechnologies, Inc. | Novel crispr dna targeting enzymes and systems |
| US10947517B2 (en) | 2019-02-15 | 2021-03-16 | Sigma-Aldrich Co. Llc | CRISPR/Cas fusion proteins and systems |
-
2020
- 2020-02-13 US US16/790,399 patent/US10947517B2/en active Active
- 2020-02-13 BR BR112021016019-1A patent/BR112021016019A2/pt not_active IP Right Cessation
- 2020-02-13 CA CA3129835A patent/CA3129835A1/en active Pending
- 2020-02-13 KR KR1020217029732A patent/KR20210139271A/ko not_active Ceased
- 2020-02-13 JP JP2021547390A patent/JP2022520104A/ja active Pending
- 2020-02-13 CN CN202080029346.8A patent/CN113728099A/zh active Pending
- 2020-02-13 SG SG11202108812SA patent/SG11202108812SA/en unknown
- 2020-02-13 AU AU2020221274A patent/AU2020221274B2/en not_active Ceased
- 2020-02-13 WO PCT/US2020/018145 patent/WO2020168102A1/en not_active Ceased
- 2020-02-13 EP EP20716979.8A patent/EP3924475A1/en not_active Withdrawn
-
2021
- 2021-02-10 US US17/172,734 patent/US11965184B2/en active Active
- 2021-08-02 IL IL285300A patent/IL285300A/en unknown
-
2023
- 2023-04-27 US US18/308,336 patent/US20230287377A1/en not_active Abandoned
- 2023-07-27 JP JP2023122299A patent/JP2023156365A/ja active Pending
-
2024
- 2024-04-09 AU AU2024202275A patent/AU2024202275A1/en not_active Abandoned
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