JP2023052614A5 - - Google Patents

Info

Publication number

JP2023052614A5

JP2023052614A5 JP2023009286A JP2023009286A JP2023052614A5 JP 2023052614 A5 JP2023052614 A5 JP 2023052614A5 JP 2023009286 A JP2023009286 A JP 2023009286A JP 2023009286 A JP2023009286 A JP 2023009286A JP 2023052614 A5 JP2023052614 A5 JP 2023052614A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

sequence number

antibody

patient

Prior art date

2023-01-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 18
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 10
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 10
• 102100026651 Pro-adrenomedullin Human genes 0.000 claims 5
• 206010019280 Heart failures Diseases 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
• 102000004379 Adrenomedullin Human genes 0.000 claims 2
• 101800004616 Adrenomedullin Proteins 0.000 claims 2
• 206010020772 Hypertension Diseases 0.000 claims 2
• 206010030113 Oedema Diseases 0.000 claims 2
• ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 230000008961 swelling Effects 0.000 claims 2
• 206010007556 Cardiac failure acute Diseases 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 230000004071 biological effect Effects 0.000 claims 1
• 210000001124 body fluid Anatomy 0.000 claims 1
• 239000010839 body fluid Substances 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 208000027744 congestion Diseases 0.000 claims 1
• 239000002934 diuretic Substances 0.000 claims 1
• 238000011863 diuretic therapy Methods 0.000 claims 1
• 229940030606 diuretics Drugs 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 238000001802 infusion Methods 0.000 claims 1
• 208000017169 kidney disease Diseases 0.000 claims 1
• 208000019423 liver disease Diseases 0.000 claims 1