JP2023025108A5 - - Google Patents
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- JP2023025108A5 JP2023025108A5 JP2022188263A JP2022188263A JP2023025108A5 JP 2023025108 A5 JP2023025108 A5 JP 2023025108A5 JP 2022188263 A JP2022188263 A JP 2022188263A JP 2022188263 A JP2022188263 A JP 2022188263A JP 2023025108 A5 JP2023025108 A5 JP 2023025108A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- amino acid
- ile
- trp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 89
- 238000000034 method Methods 0.000 claims 50
- 150000001413 amino acids Chemical class 0.000 claims 24
- 229920001184 polypeptide Polymers 0.000 claims 24
- 108090000765 processed proteins & peptides Proteins 0.000 claims 24
- 102000004196 processed proteins & peptides Human genes 0.000 claims 24
- 108091008874 T cell receptors Proteins 0.000 claims 11
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 11
- 210000005260 human cell Anatomy 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 6
- 238000003259 recombinant expression Methods 0.000 claims 6
- 210000000265 leukocyte Anatomy 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims 1
- 108010037618 HLA-C*08 antigen Proteins 0.000 claims 1
- 101000986084 Homo sapiens HLA class I histocompatibility antigen, C alpha chain Proteins 0.000 claims 1
- 210000005104 human peripheral blood lymphocyte Anatomy 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562218688P | 2015-09-15 | 2015-09-15 | |
| US62/218,688 | 2015-09-15 | ||
| JP2018513423A JP7185524B2 (ja) | 2015-09-15 | 2016-09-09 | Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体 |
| PCT/US2016/050875 WO2017048593A1 (en) | 2015-09-15 | 2016-09-09 | T cell receptors recognizing hla-cw8 restricted mutated kras |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513423A Division JP7185524B2 (ja) | 2015-09-15 | 2016-09-09 | Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023025108A JP2023025108A (ja) | 2023-02-21 |
| JP2023025108A5 true JP2023025108A5 (https=) | 2023-04-25 |
| JP7461445B2 JP7461445B2 (ja) | 2024-04-03 |
Family
ID=56985686
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513423A Active JP7185524B2 (ja) | 2015-09-15 | 2016-09-09 | Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体 |
| JP2022188263A Active JP7461445B2 (ja) | 2015-09-15 | 2022-11-25 | Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513423A Active JP7185524B2 (ja) | 2015-09-15 | 2016-09-09 | Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10556940B2 (https=) |
| EP (2) | EP3901169B1 (https=) |
| JP (2) | JP7185524B2 (https=) |
| KR (2) | KR20250117744A (https=) |
| CN (2) | CN115073583A (https=) |
| AU (3) | AU2016323017B2 (https=) |
| DK (1) | DK3350213T3 (https=) |
| ES (1) | ES2879287T3 (https=) |
| IL (1) | IL257840B2 (https=) |
| MX (1) | MX2018003062A (https=) |
| SA (1) | SA518391109B1 (https=) |
| SG (1) | SG10201913868XA (https=) |
| WO (1) | WO2017048593A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2592821B (en) | 2015-07-31 | 2022-01-12 | Univ Minnesota | Modified cells and methods of therapy |
| WO2018026691A1 (en) * | 2016-08-02 | 2018-02-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-kras-g12d t cell receptors |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| WO2018183485A1 (en) * | 2017-03-31 | 2018-10-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating neoantigen-specific t cell receptor sequences |
| US11807662B2 (en) | 2017-05-16 | 2023-11-07 | The Johns Hopkins University | MANAbodies and methods of using |
| WO2019006418A2 (en) | 2017-06-30 | 2019-01-03 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
| EP3684799A1 (en) | 2017-09-20 | 2020-07-29 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Hla class ii restricted t cell receptors against mutated ras |
| AU2018345400B2 (en) | 2017-10-05 | 2024-06-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for selectively expanding cells expressing a TCR with a murine constant region |
| EP3720478A1 (en) * | 2017-12-04 | 2020-10-14 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Hla class i-restricted t cell receptors against mutated ras |
| BR112020025764A2 (pt) * | 2018-06-19 | 2021-05-11 | Biontech Us Inc. | neoantígenos e usos dos mesmos |
| CN112888707B (zh) | 2018-08-16 | 2025-04-25 | 百欧恩泰美国公司 | T细胞受体构建体及其用途 |
| CN113412277B (zh) * | 2019-01-22 | 2025-07-18 | 美国卫生和人力服务部 | 针对含有g12r突变的ras的hla第ii类限制性t细胞受体 |
| WO2020172332A1 (en) | 2019-02-20 | 2020-08-27 | Fred Hutchinson Cancer Research Center | Binding proteins specific for ras neoantigens and uses thereof |
| US20220175899A1 (en) * | 2019-04-11 | 2022-06-09 | The Board Of Trustees Of The Leland Stanford Junior University | Cytotoxic t lymphocytes specific for mutated forms of epidermal growth factor receptor for use in treating cancer |
| CN110172089B (zh) * | 2019-06-11 | 2020-01-07 | 北京鼎成肽源生物技术有限公司 | 一种kras突变多抗原组合、靶向kras突变肿瘤ctl及其应用 |
| CN112110995A (zh) * | 2019-06-19 | 2020-12-22 | 上海交通大学医学院 | 肿瘤新抗原多肽及其用途 |
| WO2021029046A1 (ja) * | 2019-08-14 | 2021-02-18 | 日本電気株式会社 | 情報処理装置、情報処理方法及び記録媒体 |
| CN112759641B (zh) * | 2019-11-01 | 2023-01-20 | 香雪生命科学技术（广东）有限公司 | 一种识别Kras G12V的高亲和力TCR |
| WO2021123832A1 (en) | 2019-12-20 | 2021-06-24 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
| AU2021220957A1 (en) * | 2020-02-14 | 2022-09-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HLA class I-restricted T cell receptors against ras with G12V mutation |
| CN111574616B (zh) * | 2020-06-17 | 2021-02-02 | 深圳豪石生物科技有限公司 | 分离的t细胞受体和应用 |
| CN116348484A (zh) * | 2020-07-16 | 2023-06-27 | 美国卫生和人力服务部 | 针对含有g12v突变的ras的hla-ii类限制性drb t细胞受体 |
| TW202540156A (zh) * | 2020-10-02 | 2025-10-16 | 美國衛生與公眾服務部 | 針對含有g13d突變之ras之hla第ii類限制性dq t細胞受體 |
| IL305393A (en) | 2021-02-25 | 2023-10-01 | Alaunos Therapeutics Inc | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
| US20250145950A1 (en) | 2022-02-01 | 2025-05-08 | Alaunos Therapeutics, Inc. | Methods for Activation and Expansion of T Cells |
| CN114920824B (zh) * | 2022-05-27 | 2023-12-05 | 重庆医科大学 | Tcr或其抗原结合片段及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7301017B2 (en) * | 2002-05-30 | 2007-11-27 | Kolesnick Richard N | Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis |
| AU2003265948B8 (en) | 2002-09-06 | 2009-09-03 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy |
| WO2007017201A1 (en) * | 2005-08-05 | 2007-02-15 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt Gmbh | Generation of antigen specific t cells |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| ES2635335T3 (es) * | 2010-09-20 | 2017-10-03 | Biontech Cell & Gene Therapies Gmbh | Receptores de células T específicos de antígeno y epítopos de células T |
| WO2012129201A1 (en) | 2011-03-22 | 2012-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| ES2834070T3 (es) | 2011-09-15 | 2021-06-16 | Us Health | Receptores de células T que reconocen MAGE restringido por HLA-A1 o HLA-Cw7 |
| GB201314404D0 (en) * | 2013-08-12 | 2013-09-25 | Immunocore Ltd | T Cell Receptors |
| MX384919B (es) * | 2014-11-26 | 2025-03-14 | Us Health | Receptores de células t de kras anti-mutado. |
-
2016
- 2016-09-09 JP JP2018513423A patent/JP7185524B2/ja active Active
- 2016-09-09 CN CN202111083392.9A patent/CN115073583A/zh active Pending
- 2016-09-09 SG SG10201913868XA patent/SG10201913868XA/en unknown
- 2016-09-09 ES ES16770408T patent/ES2879287T3/es active Active
- 2016-09-09 MX MX2018003062A patent/MX2018003062A/es unknown
- 2016-09-09 EP EP21162567.8A patent/EP3901169B1/en active Active
- 2016-09-09 IL IL257840A patent/IL257840B2/en unknown
- 2016-09-09 US US15/758,954 patent/US10556940B2/en active Active
- 2016-09-09 KR KR1020257025325A patent/KR20250117744A/ko active Pending
- 2016-09-09 EP EP16770408.9A patent/EP3350213B1/en active Active
- 2016-09-09 CN CN201680058891.3A patent/CN108350059B/zh active Active
- 2016-09-09 KR KR1020187010326A patent/KR102841067B1/ko active Active
- 2016-09-09 WO PCT/US2016/050875 patent/WO2017048593A1/en not_active Ceased
- 2016-09-09 DK DK16770408.9T patent/DK3350213T3/da active
- 2016-09-09 AU AU2016323017A patent/AU2016323017B2/en active Active
-
2018
- 2018-03-13 SA SA518391109A patent/SA518391109B1/ar unknown
-
2020
- 2020-01-10 US US16/739,310 patent/US11667692B2/en active Active
-
2021
- 2021-02-10 AU AU2021200833A patent/AU2021200833B2/en active Active
-
2022
- 2022-07-26 AU AU2022209229A patent/AU2022209229B2/en active Active
- 2022-11-25 JP JP2022188263A patent/JP7461445B2/ja active Active
-
2023
- 2023-05-01 US US18/310,141 patent/US20230406904A1/en active Pending
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