JP2023017847A - バイオフィルム形成を阻害するためのリポソーム - Google Patents
バイオフィルム形成を阻害するためのリポソーム Download PDFInfo
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- 231100000419 toxicity Toxicity 0.000 description 1
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- 231100000765 toxin Toxicity 0.000 description 1
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- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
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Abstract
Description
Claims (15)
- 組成物であって、前記組成物は、
(i)単一の空リポソームであり、前記単一の空リポソームは、
(a)コレステロールを含む空リポソームであり、コレステロールの量は少なくとも30%(重量/重量)であり、好ましくは前記空リポソームはコレステロール及びスフィンゴミエリンを含む(更に好ましくは、から成る)、空リポソーム、若しくは、
(b)スフィンゴミエリンから成る空リポソーム、
から選択される、前記単一の空リポソーム、
又は、
(ii)空リポソーム混合物であり、前記空リポソーム混合物は、
(a)コレステロールを含む空リポソームであり、コレステロールの量は少なくとも30%(重量/重量)であり、好ましくは前記空リポソームはコレステロール及びスフィンゴミエリンを含む(更に好ましくは、から成る)、前記空リポソームと、
(b)スフィンゴミエリンから成る空リポソームと、
(c)ホスファチジルコリン及びスフィンゴミエリンを含む(好ましくは、から成る)空リポソームと、
から選択される、少なくとも1つの空リポソームを含む(好ましくは、から成る)、前記空リポソーム混合物、
を含み(好ましくは、から成り)、
少なくとも1つの空リポソームは、互いに独立して、コレステロールと、スフィンゴミエリンと、セラミドと、ホスファチジルコリンと、ホスファチジルエタノールアミンと、ホスファチジルセリンと、ジアシルグリセロールと、4炭素原子よりも長く最大で28炭素原子の飽和脂肪酸若しくは不飽和脂肪酸を1又は2又はそれ以上含むホスファチジン酸とから選択される脂質又はリン脂質を含む(好ましくは、から成る)空リポソームから選択され、
バイオフィルム形成を防止若しくは低減するための、又は既存のバイオフィルムを根絶若しくは低減するための方法において使用される、
組成物。 - 前記(i)単一の空リポソームは、(a)スフィンゴミエリン及びコレステロールから成る空リポソームであり、コレステロールの量は少なくとも30%(重量/重量)である空リポソーム、又は、(b)スフィンゴミエリンから成る空リポソームから選択され、前記空リポソーム混合物は、(a)スフィンゴミエリン及びコレステロールから成る第1の空リポソームであり、コレステロールの量は少なくとも30%(重量/重量)である第1の空リポソームと、(b)スフィンゴミエリンから成る第2の空リポソームとを含む、
請求項1に記載の使用のための組成物。 - 前記組成物は単一の空リポソームを含み(好ましくは、から成り)、前記単一の空リポソームは、(a)スフィンゴミエリン及びコレステロールから成る空リポソームであり、コレステロールの量は少なくとも30%(重量/重量)である空リポソーム、又は、(b)スフィンゴミエリンから成る空リポソームである、
請求項1に記載の使用のための組成物。 - 前記組成物は空リポソーム混合物を含み(好ましくは、から成り)、前記空リポソーム混合物は、(a)スフィンゴミエリン及びコレステロールから成る第1の空リポソームであり、コレステロールの量は少なくとも30%(重量/重量)である第1の空リポソームと、(b)スフィンゴミエリンから成る第2の空リポソームとを含む(好ましくは、から成る)、
請求項1に記載の使用のための組成物。 - 前記空リポソーム(a)のコレステロールの量は30%~70%(重量/重量)であり、好ましくは前記空リポソーム(a)のコレステロールの量は35%~60%(重量/重量)である、
請求項1~4のいずれか一項に記載の使用のための組成物。 - 前記空リポソーム(a)のコレステロールの量は45%~55%(重量/重量)であり、好ましくは前記空リポソーム(a)のコレステロールの量は約50%(重量/重量)である、
請求項1~5のいずれか一項に記載の使用のための組成物。 - 前記空リポソーム混合物は少なくとも20%(重量/重量)の前記第1及び前記第2の空リポソームを含み、好ましくは前記空リポソーム混合物は少なくとも30%(重量/重量)の前記第1及び前記第2の空リポソームを含む、
請求項2、4~6のいずれか一項に記載の使用のための組成物。 - 前記空リポソーム混合物は少なくとも40%(重量/重量)の前記第1及び前記第2の空リポソームを含む、
請求項2、4~7のいずれか一項に記載の使用のための組成物。 - 前記使用は、表面上でのバイオフィルム形成を防止若しくは低減するための方法における使用、又は、表面上の既存のバイオフィルムを根絶若しくは低減するための方法における使用である、
請求項1~8のいずれか一項に記載の使用のための組成物。 - 前記使用は、状態若しくは疾患の予防又は処置のためであり、好ましくは前記状態又は疾患は、前記バイオフィルムに存在する細菌に起因する、
請求項1~9のいずれか一項に記載の使用のための組成物。 - 前記状態又は疾患は感染症から選択され、好ましくは前記感染症は、気道感染症、性感染症、髄膜炎、尿路感染症、胃腸疾患、自己弁心内膜炎、大腸炎、膣炎、尿道炎、結膜炎、耳炎(好ましくは中耳炎)、嚢胞性線維症、人工呼吸器関連肺炎、菌血症又は創傷感染症である、
請求項10に記載の使用のための組成物。 - 前記状態又は疾患、好ましくは前記感染症は、少なくとも1つのESKAPE病原体に起因する、
請求項10又は請求項11に記載の使用のための組成物。 - 前記状態又は疾患は、肺炎球菌、バシラス属菌、リステリア・モノサイトゲネス、ブドウ球菌属菌、乳酸菌(好ましくはラクトバチルス・プランタルム及びラクトコッカス・ラクティス)、ストレプトコッカス・ソブリナス、ストレプトコッカス・ミュータンス、大腸菌、緑膿菌、腸内細菌科、サルモネラ属菌(好ましくはサルモネラ菌、サルモネラ・エンテリティディス又はチフス菌)、アクチノバシラス・プルロニューモニエ、プロテウス・ミラビリス、シゲラ属菌、モラクセラ(好ましくはカタラリス菌)、ヘリコバクター(好ましくはヘリコバクター・ピロリ)、ステノトロホモナス、デロビブリオ、酢酸菌、レジオネラ(好ましくはレジオネラ・ニューモフィラ)、シアノバクテリア、スピロヘータ、緑色硫黄細菌及び緑色非硫黄細菌、ナイセリア(好ましくは淋菌又は髄膜炎菌)、インフルエンザ菌、エンテロコッカス・フェカリス、黄色ブドウ球菌、クレブシエラ・ニューモニエ、アシネトバクター・バウマンニ、セラチア・マルセセンス、エンテロバクター・クロアカ、並びにエンテロバクター属菌から選択される、グラム陰性菌又はグラム陽性菌に起因する、
請求項10~11のいずれか一項に記載の使用のための組成物。 - 前記使用は抗菌剤と組み合わされ、好ましくは前記抗菌剤は、抗生物質、抗真菌剤、抗毒素剤、抗病原性剤、防腐薬又はそれらの組合わせであり、更に好ましくは、前記抗菌剤は抗生物質である、
請求項1~13のいずれか一項に記載の使用のための組成物。 - 前記方法はエクスビボの方法であり、好ましくは前記方法は、表面、好ましくは医療機器の表面を、請求項1~14のいずれか一項に記載の組成物と接触させることを含む、
請求項1~14のいずれか一項に記載の使用のための組成物。
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