JP2022105008A - バイオフィルム形成を阻害および妨害するための組成物および方法 - Google Patents
バイオフィルム形成を阻害および妨害するための組成物および方法 Download PDFInfo
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- A01N57/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having alternatively specified atoms bound to the phosphorus atom and not covered by a single one of groups A01N57/10, A01N57/18, A01N57/26, A01N57/34
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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Abstract
Description
a)少なくとも1種の抗微生物活性第四級アンモニウム化合物、および
b)少なくとも1種の抗微生物活性第四級ホスホニウム化合物
の組み合わせを含有し、
成分a)およびb)の組み合わせは1:9~9:1の重量比で存在する、非重合性抗微生物混合物を含む。
[R-N+R1R2R3]X- (I)
(式中、R、R1、R2およびR3は好ましくは、独立して同じか異なる長さの直鎖状もしくは分岐鎖状または環式のC2~C20アルキルラジカルであり、アジリジン、アジリン、オキサジリジン、ジアジリン、アゼチジン、アゼト、ジアゼチジン、ピロリジン、ピロール、イミダゾリジン、イミダゾール、ピラゾリジン、ピラゾール、チアゾリジン、チアゾール、イソチアゾリジン(isothioazolidine)、イソチアゾール、ピペリジン、ピリジン、ピペラジン、ジアジン、モルホリン、オキサジン、チオモルホリン、チアジン、トリアジン、トリアゾール、フラザン(furanzan)、オキサジアゾール、チアジアゾール、ジチアゾール(dithozole)、テトラゾール、アゼパン、アゼピン、ジアゼピン、チアゼピン、アゾカン、アゾシン、アゾナン(azonane)、アゾニンなどの縮合された環式もしくは芳香族環でもあり、
式中、X-は対アニオンであり、これは無機アニオン(Cl-、AlCl4 -、PF6 -、BF4 -、NTf2 -/トリフルオロメタンスルホニル、DCA-/ジシアナミドなど)または有機アニオン(CH3COO-、CH3SO3 -など)であってもよい)
によって表される。これらの第四級アンモニウム化合物は、本発明に係る混合物中に個々にまたは互いとの混合物として存在していてもよい。
[RP+R1R2R3]Y- (II)
(式中、R、R1、R2およびR3は好ましくは、独立して同じか異なる長さの直鎖状、分岐鎖状または環式のC2~C20アルキルラジカルであり、
Y-は対アニオンであり、これは無機アニオン(Cl-、AlCl4 -、PF6 -、BF4 -、NTf2 -/トリフルオロメタンスルホニル、DCA-/ジシアナミドなど)または有機アニオン(CH3COO-、CH3SO3 -など)であってもよい)
に対応する化合物である。
[(R’)3P+R’’]Y- (III)
(式中、R’は、C1~C5アルキルラジカル、C1~C6ヒドロキシアルキルラジカルまたはフェニルラジカルであり、R’’はC3~C18アルキルラジカルであり、かつY-はハロゲン化物アニオン、特に塩化物アニオンまたは臭化物アニオンである。式III中のラジカルR’およびR’’は好ましくは直鎖状もしくは分岐鎖状または環式ラジカルである)
に係る化合物である。第四級ホスホニウム化合物は本発明の混合物中に個々にまたは互いとの混合物として存在してもよい。上記種類の第四級ホスホニウム化合物の例は、トリメチル-n-ドデシルホスホニウムクロリド、トリエチル-n-デシルホスホニウムブロミド、トリ-n-プロピル-n-テトラデシルホスホニウムクロリド、トリメチロール-n-ヘキサデシルホスホニウムクロリド、トリ-n-ブチル-n-デシルホスホニウムクロリド、トリ-n-ブチル-n-ドデシルホスホニウムブロミド、トリ-n-ブチル-n-テトラデシルホスホニウムクロリド、トリ-n-ブチル-n-ヘキサデシルホスホニウムブロミド、トリ-n-ヘキシル-n-デシルホスホニウムクロリド、トリフェニル-n-ドデシルホスホニウムクロリド、トリフェニル-n-テトラデシルホスホニウムブロミドおよびトリフェニル-n-オクタデシルホスホニウムクロリドである。トリ-n-ブチル-n-テトラデシルホスホニウムクロリドが好ましい)
に対応する化合物である。
抗微生物薬/抗菌薬:
作用:脱灰の予防、再石灰化の強化、非フッ化物部分由来の抗菌効果
a)少なくとも1種の抗微生物活性第四級アンモニウム化合物、および
b)少なくとも1種の抗微生物活性第四級ホスホニウム化合物
の組み合わせを含有し、
成分a)およびb)の組み合わせは1:9~9:1の重量比で存在する非重合性抗微生物混合物を含む。
[R-N+R1R2R3]X- (I)
(式中、R、R1、R2およびR3は好ましくは、独立して同じか異なる長さの直鎖状もしくは分岐鎖状または環式のC2~C20アルキルラジカルであり、アジリジン、アジリン、オキサジリジン、ジアジリン、アゼチジン、アゼト、ジアゼチジン、ピロリジン、ピロール、イミダゾリジン、イミダゾール、ピラゾリジン、ピラゾール、チアゾリジン、チアゾール、イソチアゾリジン、イソチアゾール、ピペリジン、ピリジン、ピペラジン、ジアジン、モルホリン、オキサジン、チオモルホリン、チアジン、トリアジン、トリアゾール、フラザン、オキサジアゾール、チアジアゾール、ジチアゾール、テトラゾール、アゼパン、アゼピン、ジアゼピン、チアゼピン、アゾカン、アゾシン、アゾナン、アゾニンなどの縮合された環式もしくは芳香族環でもあり、
X-は対アニオンであり、これは無機アニオン(Cl-、AlCl4 -、PF6 -、BF4 -、NTf2 -、DCA-など)または有機アニオン(CH3COO-、CH3SO3 -など)であってもよい)
によって表される。これらの第四級アンモニウム化合物は、本発明に係る混合物中に個々にまたは互いとの混合物として存在していてもよい。
[RP+R1R2R3]Y- (II)
(式中、R、R1、R2およびR3は好ましくは、独立して同じか異なる長さの直鎖状、分岐鎖状または環式のC2~C20アルキルラジカルであり、
に対応する化合物である。
[(R’)3P+R’’]Y- (III)
(式中、R’は、C1~C5アルキルラジカル、C1~C6ヒドロキシアルキルラジカルまたはフェニルラジカルであり、R’’はC3~C18アルキルラジカルであり、かつY-はハロゲン化物アニオン、特に塩化物アニオンまたは臭化物アニオンである)
に係る化合物である。式II中のラジカルR’’およびR’’’は好ましくは直鎖状もしくは分岐鎖状または環式ラジカルである。第四級ホスホニウム化合物は本発明の混合物中に個々にまたは互いとの混合物として存在してもよい。上記種類の第四級ホスホニウム化合物の例は、トリメチル-n-ドデシルホスホニウムクロリド、トリエチル-n-デシルホスホニウムブロミド、トリ-n-プロピル-n-テトラデシルホスホニウムクロリド、トリメチロール-n-ヘキサデシルホスホニウムクロリド、トリ-n-ブチル-n-デシルホスホニウムクロリド、トリ-n-ブチル-n-ドデシルホスホニウムブロミド、トリ-n-ブチル-n-テトラデシルホスホニウムクロリド、トリ-n-ブチル-n-ヘキサデシルホスホニウムブロミド、トリ-n-ヘキシル-n-デシルホスホニウムクロリド、トリフェニル-n-ドデシルホスホニウムクロリド、トリフェニル-n-テトラデシルホスホニウムブロミドおよびトリフェニル-n-オクタデシルホスホニウムクロリドである。トリ-n-ブチル-n-テトラデシルホスホニウムクロリドが好ましい。
Claims (12)
- バイオフィルムを弱化させるための組成物であって、
以下の式:
[R-N+R1R2R3]X- (I)
(式中、Rは、直鎖状もしくは分岐鎖状または環式のC2~C20アルキルラジカルであり、R1、R2およびR3はイミダゾリウムもしくは置換イミダゾリウム部分を形成し、X-は、ハロゲン化物アニオンである)
を有する部分
を含有する重合性抗微生物混合物であって、R、R1、R2またはR3に連結された少なくとも1つの重合性基をさらに含む、重合性抗微生物混合物
を含む、組成物。 - 前記重合性抗微生物混合物は、バランスの取れた抗菌活性、細胞毒性および機械的性質のために0.1~10重量%以上かつ最大50重量%で最終組成物に添加されている、請求項1に記載の組成物。
- 前記重合性抗微生物混合物は、約0.1重量%~約10重量%の量で組成物、物品およびコーティング中に存在し、その量は、前記組成物、物品およびコーティングのバイオフィルム弱化活性、抗菌活性/微生物細胞毒性および機械的性質の良好なバランスを達成するように選択される、請求項1に記載の組成物。
- 前記重合性抗微生物混合物は、約0.1重量%~約10重量%の量で存在する、請求項1に記載の組成物。
- 前記重合性抗微生物混合物は、固体物品に形成されているか、固体物品の表面に固体もしくはフィルムコーティングとして塗布されているか、他の樹脂および複合材の上、中または全体に分散されているか、あるいは流体懸濁液または濾過に使用される小さい粒子の上に被覆されているかその中に分散されており、かつそれらは流体懸濁液中に自由に分散されていてもよい、請求項1に記載の組成物。
- 前記重合性抗微生物混合物は、製造品、成分、試薬およびキットのうちの1つ以上の中に含まれている、請求項1に記載の組成物。
- 前記重合性抗微生物混合物は物品に形成されており、かつ摩耗期間後または微生物を含む可能性のある流体または他の材料への曝露期間後に、化学的に、あるいは摩擦/加熱または他の処理によって活性化されてもよい、請求項1に記載の組成物。
- 前記重合性抗微生物混合物は、歯科用複合材、歯科用接着剤、歯科用セメント、歯科用シーラント、歯科用ライナー、歯科用バーニッシュ、義歯、根管シーラー、インプラント用セメント、歯科矯正用セメント、自己殺菌性歯科用印象材、装着式すなわち取外し可能な歯垢治療装置(抗菌ナイトガード)のための製造品の表面に1つ以上のコーティングを提供するか、その中に注入するか、その中に分散させるか、あるいはそれを形成するために、製剤化されている、請求項1に記載の組成物。
- 前記重合性抗微生物混合物は、医療およびパーソナルケア用途のための製造品の表面に1つ以上のコーティングを提供するか、その中に注入するか、その中に分散させるか、あるいはそれを形成するために、製剤化されている、請求項1に記載の組成物。
- 前記重合性抗微生物混合物は、バイオフィルム蓄積を減少させるために石油パイプラインの内面のための製造品の表面に1つ以上のコーティングを提供するか、その中に注入するか、その中に分散させるか、あるいはそれを形成するために、製剤化されている、請求項1に記載の組成物。
- 前記重合性抗微生物混合物は、フードサービス、生活用品および他の一般用途品のための製造品の表面に1つ以上のコーティングを提供するか、その中に注入するか、その中に分散させるか、あるいはそれを形成するために製剤化されている、請求項1に記載の組成物。
- バイオフィルムを弱化させるためのキットを含む製造品であって、
前記キットが、
それぞれが1つ以上の治療手段と請求項1~11のいずれか1項に記載の組成物を含む懸濁液とを含む、1種以上の個々に包装された治療製剤と、
前記治療製剤の適用後に表面からバイオフィルムを機械的に除去するための1つ以上の除去手段と、
を含む、
製造品。
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2022
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Publication number | Publication date |
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EP3435766A1 (en) | 2019-02-06 |
JP7480217B2 (ja) | 2024-05-09 |
WO2017173294A1 (en) | 2017-10-05 |
CA3018247A1 (en) | 2017-10-05 |
US20170280725A1 (en) | 2017-10-05 |
US20230022721A1 (en) | 2023-01-26 |
JP2019518785A (ja) | 2019-07-04 |
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