JP2022553376A - Ｍｅｔｔｌ３モジュレーター - Google Patents

Ｍｅｔｔｌ３モジュレーター Download PDF

Info

Publication number
JP2022553376A
JP2022553376A JP2022523864A JP2022523864A JP2022553376A JP 2022553376 A JP2022553376 A JP 2022553376A JP 2022523864 A JP2022523864 A JP 2022523864A JP 2022523864 A JP2022523864 A JP 2022523864A JP 2022553376 A JP2022553376 A JP 2022553376A
Authority
JP
Japan
Prior art keywords
alkyl
cycloalkyl
halo
independently selected
membered heterocycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022523864A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022553376A5 (https=
Inventor
トーマス・アンドリュー・ウィン
ブライアン・ルイス・ホダウス
ポーラ・アン・ボリアック－ショーディン
アーネスト・アレン・シックミアー
ジェームス・エドワード・ジョン・ミルズ
アンドリュー・スチュアート・タスカー
ロバート・エイ・コープランド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Accent Therapeutics Inc
Original Assignee
Accent Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Accent Therapeutics Inc filed Critical Accent Therapeutics Inc
Publication of JP2022553376A publication Critical patent/JP2022553376A/ja
Publication of JP2022553376A5 publication Critical patent/JP2022553376A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2022523864A 2019-10-25 2020-10-22 Ｍｅｔｔｌ３モジュレーター Pending JP2022553376A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962926072P 2019-10-25 2019-10-25
US62/926,072 2019-10-25
PCT/US2020/056873 WO2021081211A1 (en) 2019-10-25 2020-10-22 Mettl3 modulators

Publications (2)

Publication Number Publication Date
JP2022553376A true JP2022553376A (ja) 2022-12-22
JP2022553376A5 JP2022553376A5 (https=) 2023-10-31

Family

ID=73288712

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022523864A Pending JP2022553376A (ja) 2019-10-25 2020-10-22 Ｍｅｔｔｌ３モジュレーター

Country Status (6)

Country Link
US (1) US20220372040A1 (https=)
EP (1) EP4048670A1 (https=)
JP (1) JP2022553376A (https=)
CN (1) CN115279756A (https=)
AU (1) AU2020370281A1 (https=)
WO (1) WO2021081211A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230098872A1 (en) * 2021-03-26 2023-03-30 Cedilla Therapeutics, Inc. Tead inhibitors and uses thereof
CN117157297A (zh) * 2021-07-20 2023-12-01 上海齐鲁制药研究中心有限公司 Prmt5抑制剂
CN116283993B (zh) * 2021-12-20 2024-05-03 艾立康药业股份有限公司 一种嘧啶类化合物及其制备方法和应用
CN118660890A (zh) * 2022-02-11 2024-09-17 西藏海思科制药有限公司 一种mettl3抑制剂及组合物及其在医药上的应用
KR102866487B1 (ko) 2023-01-06 2025-10-01 연세대학교 산학협력단 새로운 인돌리진-피롤로피리미딘 하이브리드 유도체 제조방법 및 이를 포함하는 항암제 조성물
CN120731203A (zh) 2023-01-20 2025-09-30 艾匹克治疗公司 作为mettl3抑制剂的哌啶衍生物
AU2024244637A1 (en) 2023-03-30 2025-10-16 Aqemia Novel mettl3 inhibitors and use thereof in therapy
US12168662B1 (en) 2023-12-15 2024-12-17 King Faisal University Pyrido[4′,3′:4,5]pyrrolo[2,3-c][2,7]naphthyridines compounds as CK2 inhibitors
GB202407738D0 (en) * 2024-05-31 2024-07-17 Storm Therapeutics Ltd Inhibitory compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10506624A (ja) * 1994-09-29 1998-06-30 ノバルティス アクチェンゲゼルシャフト ピロロ〔２，３−ｄ〕ピリミジン及びその使用
JP2009528996A (ja) * 2006-02-24 2009-08-13 インダストリアル リサーチ リミテッド ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
WO2019116302A1 (en) * 2017-12-13 2019-06-20 Lupin Limited Substituted bicyclic heterocyclic compounds as prmt5 inhibitors
WO2019197024A1 (en) * 2018-04-11 2019-10-17 Chemestmed Ltd. A method of modulating the rna methylation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10506624A (ja) * 1994-09-29 1998-06-30 ノバルティス アクチェンゲゼルシャフト ピロロ〔２，３−ｄ〕ピリミジン及びその使用
JP2009528996A (ja) * 2006-02-24 2009-08-13 インダストリアル リサーチ リミテッド ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
WO2019116302A1 (en) * 2017-12-13 2019-06-20 Lupin Limited Substituted bicyclic heterocyclic compounds as prmt5 inhibitors
WO2019197024A1 (en) * 2018-04-11 2019-10-17 Chemestmed Ltd. A method of modulating the rna methylation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"CAS REGISTRY No．1348207-03-3", DATABASE REGISTRY，[ONLINE], vol. [検索日:2024.8.15], JPN7024003872, 2011, pages Retrieved from：STN, ISSN: 0005416633 *

Also Published As

Publication number Publication date
CN115279756A (zh) 2022-11-01
AU2020370281A1 (en) 2022-05-26
US20220372040A1 (en) 2022-11-24
WO2021081211A1 (en) 2021-04-29
EP4048670A1 (en) 2022-08-31

Similar Documents

Publication Publication Date Title
JP2022553376A (ja) Ｍｅｔｔｌ３モジュレーター
AU2011291185C1 (en) Pyrrolopyrimidine compounds and uses thereof
AU2021225251A1 (en) TYK2 inhibitors and uses thereof
JP2022553077A (ja) Ｍｅｔｔｌ３モジュレーター
US9956220B2 (en) Imidazo-pyridazine derivatives as casein kinase 1 δ/ϵ inhibitors
CN102459242B (zh) 苯氧基甲基杂环化合物
KR20100016460A (ko) 포스파티딜이노시톨-3-키나제 억제제로서의 3,6-이치환된-이미다조[1,2-ｂ]피리다진 및 3,5-이치환된 피라졸로[1,5-ａ]피리미딘
EP2788000A1 (en) Pyrrolopyrimidines as janus kinase inhibitors
JP4409174B2 (ja) Ｇａｂａ受容体のためのリガンドとしてのイミダゾ−ピリミジン誘導体
TW201326173A (zh) ５，７－經取代之－咪唑并［１，２－ｃ］嘧啶
KR20170015487A (ko) 포스포이노시타이드 3-키나아제 억제제로서 인돌리진 유도체
JP2022510380A (ja) チロシンキナーゼ阻害剤、組成及びその方法
US11814384B2 (en) Inhibtors of Raf kinases
CN119731177B (zh) 三环杂环衍生物及其组合物和应用
JP7769648B2 (ja) スルホンアミド化合物
EP2935272A1 (en) Pyrazole substituted imidazopyrazines as casein kinase 1 d/e inhibitors
JP2022530371A (ja) ピリミド５員複素環化合物及び変異型ｉｄｈ２阻害薬としてのその使用
WO2023108536A1 (en) Tyk2 inhibitors and compositions and methods thereof
KR20240150419A (ko) 아릴설폰아미드 화합물
WO2024127363A1 (en) Tyk2 pseudokinase ligands and uses thereof
WO2025234404A1 (ja) ピリミジン含有縮合環化合物及びその用途
CN118930543A (zh) 三环类化合物及其药物组合物和用途
HK1180323A (en) Pyrazolopyrimidine kinase inhibitors
HK1179267A (en) Pyrazolopyrazine kinase inhibitors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231023

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20231023

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20240912

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240917

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20250311